@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4524: (2016-02-28 )
MPNLTLADLQGEIQANVRTALAEDVGGGDLTAQLIDPQREAEARVITREHATIAGRAWVDEVFRQVDPRVLVTWQVEDGQRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLVAGTAVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIDRAIAEARRIAPGKPVEVEVENLDELRQALEAGADIVMLDELSLDDMRTAVALTAGRAKLEASGGINEGTLRNIAETGVDYISIGTLTKDVRAVDLSMRLTL
Atome Classification :
(40 SA)
--.........10........20.....-.-----.-.------30..-......-40........50........60-.....--.--..70........80.....------...90........100.......110..--.....120.......--130--.......140.......150.......160.......170.......180.......190.-..-.....200.--......210.......220......-.230..---.--...---.---240.......250.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MPN
L
T
L
A
D
LQ
G
E
I
Q
A
N
V
R
T
A
L
A
E
DVG-G-----G-D------
L
T
A
Q
-LIDPQR-EAE
A
R
V
I
T
REHATIA
G
R
A
W
V
D
E
-
V
F
R
QV--D--P
R
V
L
V
T
W
QVEDGQRVEPN
Q
------
M
L
F
Q
LKGPARALLTG
E
R
S
A
L
N
F
L
Q
L
L
SG--TATR
S
Q
H
Y
A
D
L
V
A
G
T
--
A
V
K
--
L
LDTRKTLP
G
L
R
L
A
Q
K
Y
A
V
T
CGGCHNHRIGL
Y
D
A
F
L
I
KEN
H
I
AACG
G
I
D
R
A
I
A
E
A
RRIA-P-GK-
P
V
E
V
E
V
E
N
L
--
D
E
L
R
Q
A
L
EAGA
D
I
V
M
L
DEL
S
L
D
D
M
R
-
T
A
V
ALT---A--G
R
A
---
K
---
L
EASGGIN
E
G
T
L
R
N
I
A
E
TGV
D
Y
I
S
I
GTL
T
K
D
V
R
A
V
D
L
S
M
R
LTL
72
HHSearch
95.31
56%
-103
- C3 -
3PAJ
-
?
A:
[14-295]
------
L
K
Q
Q
L
P
A
D
I
T
R
S
V
I
D
T
L
K
E
D
L
G
-
G
TLDPA
A
-
D
------
I
T
A
S
-
L
I
P
A
D
R
-
I
S
T
A
T
I
I
T
R
E
A
G
V
F
C
G
Q
L
W
A
D
E
-
V
F
K
Q
L
--
G
--
G
Q
V
S
I
E
W
H
V
Q
D
G
D
T
L
T
P
N
Q
------
T
L
C
T
L
T
G
P
A
R
I
L
L
T
G
E
R
N
A
M
N
F
I
Q
T
L
S
G
--
C
A
T
A
T
A
R
Y
V
Q
E
L
K
G
T
--
Q
C
R
--
L
L
D
T
R
K
T
I
P
G
L
R
S
A
L
K
Y
A
V
A
C
G
G
G
Y
N
H
R
I
G
V
F
D
A
Y
L
I
K
E
N
H
I
I
A
C
G
G
I
R
Q
A
I
S
T
A
K
Q
L
N
-
P
-
G
K
-
P
V
E
V
E
T
E
T
L
--
A
E
L
E
E
A
I
S
A
G
A
D
I
I
M
L
D
N
F
S
L
E
M
M
R
-
E
A
V
K
I
N
---
A
--
G
R
A
---
A
---
L
E
N
S
G
N
I
T
L
D
N
L
K
E
C
A
E
T
G
V
D
Y
I
S
V
G
A
L
T
K
H
L
K
A
L
D
L
S
M
R
F
K
-
2
PsiBlast_PDB
93.55
55%
-107
- C3 -
3PAJ
-
?
A:
[18-294]
----------
L
P
A
D
I
T
R
S
V
I
D
T
L
K
E
D
L
G
-
G
TLDPA
A
-
D
------
I
T
A
S
-
L
I
P
A
D
R
-
I
S
T
A
T
I
I
T
R
E
A
G
V
F
C
G
Q
L
W
A
D
E
-
V
F
K
Q
L
--
G
--
G
Q
V
S
I
E
W
H
V
Q
D
G
D
T
L
T
P
N
Q
------
T
L
C
T
L
T
G
P
A
R
I
L
L
T
G
E
R
N
A
M
N
F
I
Q
T
L
S
G
--
C
A
T
A
T
A
R
Y
V
Q
E
L
K
G
T
--
Q
C
R
--
L
L
D
T
R
K
T
I
P
G
L
R
S
A
L
K
Y
A
V
A
C
G
G
G
Y
N
H
R
I
G
V
F
D
A
Y
L
I
K
E
N
H
I
I
A
C
G
G
I
R
Q
A
I
S
T
A
K
Q
L
N
-
P
-
G
K
-
P
V
E
V
E
T
E
T
L
--
A
E
L
E
E
A
I
S
A
G
A
D
I
I
M
L
D
N
F
S
L
E
M
M
R
-
E
A
V
K
I
N
---
A
--
G
R
A
---
A
---
L
E
N
S
G
N
I
T
L
D
N
L
K
E
C
A
E
T
G
V
D
Y
I
S
V
G
A
L
T
K
H
L
K
A
L
D
L
S
M
R
F
--
75
HHSearch
90.40
57%
-102
- C3 -
1QAP
2
NADC_SALTY
A:
[12-296]
----
D
A
L
L
E
R
I
N
L
D
I
P
A
A
V
A
Q
A
L
R
E
D
L
G
-
G
EVDAG
N
-
D
------
I
T
A
Q
-
L
L
P
A
D
T
-
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
-
V
F
I
Q
L
--
A
G-
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
------
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
--
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
--
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
-
P
-
D
V
-
P
V
E
V
E
V
E
N
L
--
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
R
-
E
A
V
K
R
V
---
N
--
G
Q
A
---
R
---
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
C
-
21
PsiBlast_CBE
90.07
57%
-109
- C3 -
1QAP
1
NADC_SALTY
B:
[21-295]
-------------
D
I
P
A
A
V
A
Q
A
L
R
E
D
L
G
-
G
EVDAG
N
-
D
------
I
T
A
Q
-
L
L
P
A
D
T
-
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
-
V
F
I
Q
L
A-
G
--
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
------
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
--
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
--
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
-
P
-
D
V
-
P
V
E
V
E
V
E
N
L
--
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
R
-
E
A
V
K
R
V
---
N
--
G
Q
A
---
R
---
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
--
1
PsiBlast_PDB
89.81
57%
-106
- C3 -
1QAP
2
NADC_SALTY
A:
[21-295]
-------------
D
I
P
A
A
V
A
Q
A
L
R
E
D
L
G
-
G
EVDAG
N
-
D
------
I
T
A
Q
-
L
L
P
A
D
T
-
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
-
V
F
I
Q
L
A-
G
--
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
------
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
--
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
--
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
-
P
-
D
V
-
P
V
E
V
E
V
E
N
L
--
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
R
-
E
A
V
K
R
V
---
N
--
G
Q
A
---
R
---
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
--
93
Fugue
89.63
55%
-103
- C3 -
1QAP
2
NADC_SALTY
A:
[8-296]
DD
R
R
D
A
L
L
E
R
I
N
L
D
I
P
A
A
V
A
Q
A
L
R
E
D
L
G
-
G
-----
E
-
V
DAGNDI
T
A
Q
L
--
L
P
A
D
T
-
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
-
V
F
I
Q
L
AG---
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
------
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
--
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
T
--
Q
T
Q
--
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
H
-
P
-
D
V
-
P
V
E
V
E
V
E
N
L
--
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
T
D
Q
M
R
-
E
A
V
K
R
V
---
N
-----GQA
R
---
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
C
-
73
HHSearch
88.27
50%
-105
- C3 -
3TQV
2
?
A:
[17-286]
------------
D
I
V
T
R
L
V
R
E
S
L
A
E
D
I
A
-
T
-----
G
-
D
------
I
T
A
Q
-
L
A
-
E
D
I
-
D
T
T
A
F
C
I
T
R
E
E
M
I
L
C
G
Q
D
F
A
N
E
-
V
I
N
Q
L
--
D
--
K
N
I
Q
I
T
W
L
Y
S
D
A
Q
K
V
P
A
N
A
------
R
I
F
E
L
K
G
N
V
R
S
I
L
T
A
E
R
T
I
L
N
F
I
Q
M
L
S
G
--
T
A
T
V
T
N
K
L
V
K
L
I
S
Q
Y
--
K
T
K
--
L
L
D
T
R
K
T
I
P
G
F
R
L
A
Q
K
Y
A
V
R
C
G
G
G
F
N
H
R
I
G
L
F
D
A
Y
L
I
K
E
N
H
I
----
G
I
A
K
A
V
T
K
A
K
K
L
D
-
S
-
N
K
-
V
V
E
V
E
V
T
N
L
--
D
E
L
N
Q
A
I
A
A
K
A
D
I
V
M
L
D
N
F
S
G
E
D
I
D
-
I
A
V
S
I
A
---
R
--
G
K
V
---
A
---
L
E
V
S
G
N
I
D
R
N
S
I
V
A
I
A
K
T
G
V
D
F
I
S
V
G
A
I
T
K
H
I
K
A
I
D
L
S
L
Q
V
Q
-
4
PsiBlast_PDB
87.70
50%
-108
- C3 -
3TQV
2
?
A:
[23-286]
------------------
V
R
E
S
L
A
E
D
I
A
-
T
-----
G
-
D
------
I
T
A
Q
-
L
A
E
D
I
--
D
T
T
A
F
C
I
T
R
E
E
M
I
L
C
G
Q
D
F
A
N
E
-
V
I
N
Q
L
--
D
--
K
N
I
Q
I
T
W
L
Y
S
D
A
Q
K
V
P
A
N
A
------
R
I
F
E
L
K
G
N
V
R
S
I
L
T
A
E
R
T
I
L
N
F
I
Q
M
L
S
G
--
T
A
T
V
T
N
K
L
V
K
L
I
S
Q
Y
--
K
T
K
--
L
L
D
T
R
K
T
I
P
G
F
R
L
A
Q
K
Y
A
V
R
C
G
G
G
F
N
H
R
I
G
L
F
D
A
Y
L
I
K
E
N
H
I
----
G
I
A
K
A
V
T
K
A
K
K
L
D
-
S
-
N
K
-
V
V
E
V
E
V
T
N
L
--
D
E
L
N
Q
A
I
A
A
K
A
D
I
V
M
L
D
N
F
S
G
E
D
I
D
-
I
A
V
S
I
A
---
R
--
G
K
V
---
A
---
L
E
V
S
G
N
I
D
R
N
S
I
V
A
I
A
K
T
G
V
D
F
I
S
V
G
A
I
T
K
H
I
K
A
I
D
L
S
L
Q
V
Q
-
80
HHSearch
82.90
45%
-99
- C3 -
1X1O
-
?
A:
[13-284]
-------------
G
L
E
E
A
L
R
A
W
L
R
E
D
L
G
-
Q
-----
G
-
D
------
L
T
S
L
L
V
V
P
E
D
L
-
E
G
E
A
V
I
L
A
K
E
G
G
V
L
A
G
L
W
V
A
E
R
-
V
F
A
L
A
--
D
--
P
R
T
A
F
T
P
L
V
A
E
G
A
R
V
A
E
G
T
------
E
V
A
R
V
R
G
P
L
R
G
I
L
A
G
E
R
L
A
L
N
L
L
Q
R
L
S
G
--
I
A
T
L
T
R
A
Y
V
E
A
L
A
G
T
--
K
A
Q
--
I
L
D
T
R
K
T
T
P
G
L
R
A
L
E
K
Y
A
V
R
V
G
G
G
R
N
H
R
Y
G
L
F
D
G
I
L
L
K
E
N
H
V
R
A
A
G
G
V
G
E
A
V
R
R
A
K
A
R
A
P
H
-
Y
L
-
K
V
E
V
E
V
R
S
L
--
E
E
L
E
E
A
L
E
A
G
A
D
L
I
L
L
D
N
F
P
L
E
A
L
R
-
E
A
V
R
R
V
---
G
--
G
R
V
---
P
---
L
E
A
S
G
N
M
T
L
E
R
A
K
A
A
A
E
A
G
V
D
Y
V
S
V
G
A
L
T
H
S
A
K
A
L
D
L
S
L
L
V
V
-
5
PsiBlast_PDB
82.49
47%
-96
- C3 -
1X1O
-
?
A:
[11-281]
-----------
Q
G
G
L
E
E
A
L
R
A
W
L
R
E
D
L
G
-
Q
-----
G
-
D
------
L
T
S
L
-
L
V
V
P
E
D
L
E
G
E
A
V
I
L
A
K
E
G
G
V
L
A
G
-
L
W
V
A
E
R
V
F
A
L
A
--
D
--
P
R
T
A
F
T
P
L
V
A
E
G
A
R
V
A
E
G
T
------
E
V
A
R
V
R
G
P
L
R
G
I
L
A
G
E
R
L
A
L
N
L
L
Q
R
L
S
G
--
I
A
T
L
T
R
A
Y
V
E
A
L
A
G
T
--
K
A
Q
--
I
L
D
T
R
K
T
T
P
G
L
R
A
L
E
K
Y
A
V
R
V
G
G
G
R
N
H
R
Y
G
L
F
D
G
I
L
L
K
E
N
H
V
R
A
A
G
G
V
G
E
A
V
R
R
A
K
A
R
A
-
P
-
H
Y
L
K
V
E
V
E
V
R
S
L
--
E
E
L
E
E
A
L
E
A
G
A
D
L
I
L
L
D
N
F
P
L
E
A
L
R
-
E
A
V
R
R
V
---
G
--
G
R
V
---
P
---
L
E
A
S
G
N
M
T
L
E
R
A
K
A
A
A
E
A
G
V
D
Y
V
S
V
G
A
L
T
H
S
A
K
A
L
D
L
S
L
----
3
PsiBlast_PDB
80.66
55%
-108
- C3 -
3GNN
1
?
A:
[23-296]
--------
A
A
F
D
A
A
I
A
R
N
V
A
D
A
L
A
E
D
V
G
-
S
-----
G
-------------
L
V
P
D
G
A
-
P
R
R
A
R
V
I
V
R
E
D
A
V
L
C
G
V
P
W
F
D
A
-
V
V
R
A
V
--
D
--
P
S
I
E
V
D
W
R
H
R
E
G
D
R
M
S
A
D
S
------
T
V
C
E
L
R
G
P
A
R
A
L
L
T
A
E
R
N
A
L
N
F
L
Q
L
L
S
G
--
V
A
S
A
T
R
Q
Y
V
D
R
I
A
D
T
--
R
A
R
--
I
L
D
T
R
K
T
L
P
G
L
R
L
A
Q
K
Y
A
V
R
V
G
G
G
A
N
Q
-------------------
G
V
G
E
A
L
D
A
A
F
A
L
N
----
V
-
P
V
Q
I
E
V
E
T
L
--
D
Q
L
R
T
A
L
A
H
G
A
R
S
V
L
L
D
N
F
T
L
D
M
M
R
-
D
A
V
R
V
T
---
E
--
G
R
A
---
V
---
L
E
V
S
G
G
V
N
F
D
T
V
R
A
I
A
E
T
G
V
D
R
I
S
I
G
A
L
T
K
D
V
R
A
T
D
Y
S
M
R
I
--
77
HHSearch
80.27
55%
-108
- C3 -
3GNN
1
?
A:
[24-297]
---------
A
F
D
A
A
I
A
R
N
V
A
D
A
L
A
E
D
V
G
-
S
-----
G
-------------
L
V
P
D
G
A
-
P
R
R
A
R
V
I
V
R
E
D
A
V
L
C
G
V
P
W
F
D
A
-
V
V
R
A
V
--
D
--
P
S
I
E
V
D
W
R
H
R
E
G
D
R
M
S
A
D
S
------
T
V
C
E
L
R
G
P
A
R
A
L
L
T
A
E
R
N
A
L
N
F
L
Q
L
L
S
G
--
V
A
S
A
T
R
Q
Y
V
D
R
I
A
D
T
--
R
A
R
--
I
L
D
T
R
K
T
L
P
G
L
R
L
A
Q
K
Y
A
V
R
V
G
G
G
A
N
Q
-------------------
G
V
G
E
A
L
D
A
A
F
A
L
N
----
V
-
P
V
Q
I
E
V
E
T
L
--
D
Q
L
R
T
A
L
A
H
G
A
R
S
V
L
L
D
N
F
T
L
D
M
M
R
-
D
A
V
R
V
T
---
E
--
G
R
A
---
V
---
L
E
V
S
G
G
V
N
F
D
T
V
R
A
I
A
E
T
G
V
D
R
I
S
I
G
A
L
T
K
D
V
R
A
T
D
Y
S
M
R
I
V
-
74
HHSearch
79.36
35%
-100
* C3 *
3L0G
2
?
A:
[24-295]
------------
I
S
F
S
E
I
I
H
N
A
L
K
E
D
L
G
D
K
-----
G
-
D
------
I
T
T
N
-
S
I
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
-
V
F
N
M
N
--
K
--
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
------
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
--
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
--
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
-
K
-
N
E
-
Y
I
A
I
E
C
D
N
I
--
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
-
K
A
V
D
I
V
---
N
--
G
K
S
---
V
---
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
E
-
79
HHSearch
79.34
41%
-85
- C3 -
1QPO
1
NADC_MYCTU
A:
[7-284]
-----------
L
A
A
A
R
A
A
I
A
R
G
L
D
E
D
L
R
-
Y
-----
G
P
D
------
V
T
T
L
A
T
V
P
A
S
A
-
T
T
T
A
S
L
V
T
R
E
A
G
V
V
A
G
L
D
V
A
L
L
-
T
L
N
E
V
--
L
GT
N
G
Y
R
V
L
D
R
V
E
D
G
A
R
V
P
P
G
E
------
A
L
M
T
L
E
A
Q
T
R
G
L
L
T
A
E
R
T
M
L
N
L
V
G
H
L
S
G
--
I
A
T
A
T
A
A
W
V
D
A
V
R
G
T
--
K
A
K
--
I
R
D
T
R
K
T
L
P
G
L
R
A
L
Q
K
Y
A
V
R
T
G
G
G
V
N
H
R
L
G
L
G
D
A
A
L
I
K
D
N
H
V
A
A
A
G
S
V
V
D
A
L
R
A
V
R
N
A
A
-
P
-
D
L
-
P
C
E
V
E
V
D
S
L
--
E
Q
L
D
A
V
L
P
E
K
P
E
L
I
L
L
D
N
F
A
V
W
Q
T
Q
-
T
A
V
Q
R
R
D
S
R
A
--
P
T
V
---
M
---
L
E
S
S
G
G
L
S
L
Q
T
A
A
T
Y
A
E
T
G
V
D
Y
L
A
V
G
A
L
T
H
S
V
R
V
L
D
I
G
L
D
M
--
6
PsiBlast_PDB
79.25
36%
-102
- C3 -
3L0G
2
?
A:
[30-294]
------------------
I
H
N
A
L
K
E
D
L
G
D
K
-----
G
-
D
------
I
T
T
N
-
S
I
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
-
V
F
N
M
N
--
K
--
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
------
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
--
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
--
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
-
K
-
N
E
-
Y
I
A
I
E
C
D
N
I
--
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
-
K
A
V
D
I
V
---
N
--
G
K
S
---
V
---
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
--
25
PsiBlast_CBE
79.07
36%
-100
- C3 -
3L0G
2
?
B:
[30-294]
------------------
I
H
N
A
L
K
E
D
L
G
D
K
-----
G
-
D
------
I
T
T
N
-
S
I
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
-
V
F
N
M
N
--
K
--
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
------
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
--
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
--
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
-
K
-
N
E
-
Y
I
A
I
E
C
D
N
I
--
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
-
K
A
V
D
I
V
---
N
--
G
K
S
---
V
---
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
--
58
PsiBlast_CBE
78.65
35%
-94
- C3 -
2JBM
2
NADC_HUMAN
F:
[12-287]
--
L
P
P
V
T
L
A
A
L
-------
V
D
S
W
L
R
E
D
C
P
-
G
-----
L
-
N
------
Y
A
A
--
L
V
S
G
A
G
-
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
-
I
F
T
Q
L
--
N
--
C
Q
V
--
S
W
F
L
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
IA
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
--
T
G
H
--
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
-
D
F
A
L
-
K
V
E
V
E
C
S
S
L
--
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
H
P
T
A
T
V
L
K
---
A
QF
P
S
V
---
A
---
V
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
--
59
PsiBlast_CBE
78.53
35%
-92
- C3 -
2JBM
2
NADC_HUMAN
E:
[12-287]
--
L
P
P
V
T
L
A
A
L
-------
V
D
S
W
L
R
E
D
C
P
-
G
-----
L
-
N
------
Y
A
A
--
L
V
S
G
A
G
-
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
-
I
F
T
Q
L
--
N
--
C
Q
V
--
S
W
F
L
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
IA
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
--
T
G
H
--
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
-
D
F
A
L
-
K
V
E
V
E
C
S
S
L
--
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
H
P
T
A
T
V
L
K
---
A
QF
P
S
V
---
A
---
V
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
--
52
PsiBlast_CBE
78.46
35%
-92
- C3 -
2JBM
2
NADC_HUMAN
L:
[12-287]
--
L
P
P
V
T
L
A
A
L
-------
V
D
S
W
L
R
E
D
C
P
-
G
-----
L
-
N
------
Y
A
A
--
L
V
S
G
A
G
-
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
-
I
F
T
Q
L
--
N
--
C
Q
V
--
S
W
F
L
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
IA
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
--
T
G
H
--
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
-
D
F
A
L
-
K
V
E
V
E
C
S
S
L
--
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
H
P
T
A
T
V
L
K
---
A
QF
P
S
V
---
A
---
V
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
--
55
PsiBlast_CBE
78.36
35%
-93
- C3 -
2JBM
2
NADC_HUMAN
I:
[12-287]
--
L
P
P
V
T
L
A
A
L
-------
V
D
S
W
L
R
E
D
C
P
-
G
-----
L
-
N
------
Y
A
A
--
L
V
S
G
A
G
-
P
S
Q
A
A
L
W
A
K
S
P
G
V
L
A
G
Q
P
F
F
D
A
-
I
F
T
Q
L
--
N
--
C
Q
V
--
S
W
F
L
P
E
G
S
K
L
V
P
V
A
------
R
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
T
L
A
R
C
S
G
IA
S
A
A
A
A
A
V
E
A
A
R
G
A
G
W
--
T
G
H
--
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
A
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
E
K
A
V
R
A
A
R
Q
A
A
-
D
F
A
L
-
K
V
E
V
E
C
S
S
L
--
Q
E
A
V
Q
A
A
E
A
G
A
D
L
V
L
L
D
N
F
K
P
E
E
L
H
P
T
A
T
V
L
K
---
A
QF
P
S
V
---
A
---
V
E
A
S
G
G
I
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
M
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
--
24
PsiBlast_CBE
77.98
36%
-100
- C3 -
3L0G
2
?
C:
[30-294]
------------------
I
H
N
A
L
K
E
D
L
G
D
K
-----
G
-
D
------
I
T
T
N
-
S
I
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
-
V
F
N
M
N
--
K
--
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
------
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
--
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
--
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
-
K
-
N
E
-
Y
I
A
I
E
C
D
N
I
--
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
-
K
A
V
D
I
V
---
N
--
G
K
S
---
V
---
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
--
23
PsiBlast_CBE
77.64
36%
-98
- C3 -
3L0G
2
?
D:
[30-294]
------------------
I
H
N
A
L
K
E
D
L
G
D
K
-----
G
-
D
------
I
T
T
N
-
S
I
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
E
-
V
F
N
M
N
--
K
--
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
------
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
--
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
T
--
K
V
K
--
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
L
-
K
-
N
E
-
Y
I
A
I
E
C
D
N
I
--
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
I
S
E
I
K
-
K
A
V
D
I
V
---
N
--
G
K
S
---
V
---
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
--
12
PsiBlast_PDB
77.27
34%
-97
- C3 -
2B7P
2
NADC_HELPY
A:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
-
D
------
L
F
E
R
-
V
L
E
K
D
F
-
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
-
L
L
E
M
T
--
G
--
I
E
C
V
Q
T
--
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
--
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
-
P
-
F
T
A
K
I
E
I
E
C
E
S
F
--
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
-
E
I
A
A
Y
R
---
D
--
A
H
Y
---
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
--
22
PsiBlast_CBE
76.85
55%
-100
- C3 -
3GNN
1
?
B:
[23-295]
--------
A
A
F
D
A
A
I
A
R
N
V
A
D
A
L
A
E
D
V
G
-
S
-----
G
-
D
------
Q
---------
A
-
P
R
R
A
R
V
I
V
R
E
D
A
V
L
C
G
V
P
W
F
D
A
-
V
V
R
A
V
--
D
--
P
S
I
E
V
D
W
R
H
R
E
G
D
R
M
S
A
D
S
------
T
V
C
E
L
R
G
P
A
R
A
L
L
T
A
E
R
N
A
L
N
F
L
Q
L
L
S
G
--
V
A
S
A
T
R
Q
Y
V
D
R
I
A
D
T
--
R
A
R
--
I
L
D
T
R
K
T
L
P
G
L
R
L
A
Q
K
Y
A
V
R
V
G
G
G
A
-----------------------------------------
V
Q
I
E
V
E
T
L
--
D
Q
L
R
T
A
L
A
H
G
A
R
S
V
L
L
D
N
F
T
L
D
M
M
R
-
D
A
V
R
V
T
---
E
--
G
R
A
---
V
---
L
E
V
S
G
G
V
N
F
D
T
V
R
A
I
A
E
T
G
V
D
R
I
S
I
G
A
L
T
K
D
V
R
A
T
D
Y
S
M
R
---
11
PsiBlast_PDB
76.78
34%
-100
- C3 -
2B7N
2
NADC_HELPY
A:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
-
D
------
L
F
E
R
-
V
L
E
K
D
F
-
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
-
L
L
E
M
T
--
G
--
I
E
C
V
Q
T
--
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
--
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
-
P
-
F
T
A
K
I
E
I
E
C
E
S
F
--
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
-
E
I
A
A
Y
R
---
D
--
A
H
Y
---
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
--
76
HHSearch
76.37
34%
-100
- C3 -
2B7N
2
NADC_HELPY
A:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
-
D
------
L
F
E
R
-
V
L
E
K
D
F
-
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
-
L
L
E
M
T
------
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
--
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
P
F
-
T
A
-
K
I
E
I
E
C
E
S
F
--
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
-
E
I
A
A
Y
R
D
A
H
Y
--
P
F
V
---
L
---
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
--
50
PsiBlast_CBE
76.27
34%
-96
- C3 -
2B7N
2
NADC_HELPY
C:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
-
D
------
L
F
E
R
-
V
L
E
K
D
F
-
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
-
L
L
E
M
T
--
G
--
I
E
C
V
Q
T
--
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
--
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
-
P
-
F
T
A
K
I
E
I
E
C
E
S
F
--
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
-
E
I
A
A
Y
R
---
D
--
A
H
Y
---
P
FVL
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
--
46
PsiBlast_CBE
75.97
34%
-98
- C3 -
2B7Q
1
NADC_HELPY
C:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
-
D
------
L
F
E
R
-
V
L
E
K
D
F
-
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
-
L
L
E
M
T
--
G
--
I
E
C
V
Q
T
--
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
--
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
-
P
-
F
T
A
K
I
E
I
E
C
E
S
F
--
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
-
E
I
A
A
Y
R
---
D
--
A
H
Y
---
P
FVL
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
--
51
PsiBlast_CBE
75.80
34%
-100
- C3 -
2B7N
2
NADC_HELPY
B:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
-
D
------
L
F
E
R
-
V
L
E
K
D
F
-
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
-
L
L
E
M
T
--
G
--
I
E
C
V
Q
T
--
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
--
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
-
P
-
F
T
A
K
I
E
I
E
C
E
S
F
--
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
-
E
I
A
A
Y
R
---
D
--
A
H
Y
---
P
FVL
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
--
70
PsiBlast_CBE
75.47
36%
-94
- C3 -
4I9A
1
?
B:
[23-285]
----------------------
L
R
E
D
C
P
-
G
-----
L
-
N
------
P
V
A
--
L
V
T
G
A
A
-
P
S
Q
A
V
L
W
A
K
S
P
G
I
L
A
G
R
P
F
F
D
A
-
I
F
A
Q
V
--
N
--
C
Q
V
--
S
W
F
L
P
E
G
S
K
L
V
P
V
A
------
K
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
M
L
A
R
C
S
G
--
V
A
S
A
A
A
T
A
V
E
T
A
R
G
T
GW
A
G
H
--
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
T
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
K
Q
A
V
Q
G
A
R
R
A
A
-
N
F
A
L
-
K
V
E
V
E
C
S
S
L
--
Q
E
A
L
E
A
A
E
A
G
A
D
L
V
L
L
D
N
F
R
P
E
E
L
H
P
T
A
A
A
L
K
---
A
QF
P
T
V
---
G
---
V
E
A
S
G
G
V
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
L
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
--
49
PsiBlast_CBE
75.38
34%
-98
- C3 -
2B7P
2
NADC_HELPY
B:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
-
D
------
L
F
E
R
-
V
L
E
K
D
F
-
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
-
L
L
E
M
T
--
G
--
I
E
C
V
Q
T
--
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
--
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
-
P
-
F
T
A
K
I
E
I
E
C
E
S
F
--
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
-
E
I
A
A
Y
R
---
D
--
A
H
Y
---
P
FVL
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
--
71
PsiBlast_CBE
74.24
36%
-93
- C3 -
4I9A
1
?
A:
[23-285]
----------------------
L
R
E
D
C
P
-
G
-----
L
-
N
------
P
V
A
--
L
V
T
G
A
A
-
P
S
Q
A
V
L
W
A
K
S
P
G
I
L
A
G
R
P
F
F
D
A
-
I
F
A
Q
V
--
N
--
C
Q
V
--
S
W
F
L
P
E
G
S
K
L
V
P
V
A
------
K
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
M
L
A
R
C
S
G
--
V
A
S
A
A
A
T
A
V
E
T
A
R
G
T
GW
A
G
H
--
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
T
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
K
Q
A
V
Q
G
A
R
R
A
A
-
N
F
A
L
-
K
V
E
V
E
C
S
S
L
--
Q
E
A
L
E
A
A
E
A
G
A
D
L
V
L
L
D
N
F
R
P
E
E
L
H
P
T
A
A
A
L
K
---
A
Q
F
P
T
V
---
G
---
V
E
A
S
G
G
V
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
L
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
--
48
PsiBlast_CBE
74.19
34%
-98
- C3 -
2B7P
2
NADC_HELPY
C:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
-
D
------
L
F
E
R
-
V
L
E
K
D
F
-
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
-
L
L
E
M
T
--
G
--
I
E
C
V
Q
T
--
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
--
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
-
P
-
F
T
A
K
I
E
I
E
C
E
S
F
--
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
-
E
I
A
A
Y
R
---
D
--
A
H
Y
---
P
FVL
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
--
47
PsiBlast_CBE
73.73
34%
-98
- C3 -
2B7Q
1
NADC_HELPY
B:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
-
D
------
L
F
E
R
-
V
L
E
K
D
F
-
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
-
L
L
E
M
T
--
G
--
I
E
C
V
Q
T
--
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
--
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
-
P
-
F
T
A
K
I
E
I
E
C
E
S
F
--
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
-
E
I
A
A
Y
R
---
D
--
A
H
Y
---
P
FVL
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
--
13
PsiBlast_PDB
72.87
34%
-94
- C3 -
2B7Q
1
NADC_HELPY
A:
[2-272]
-------------
E
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-
H
-----
G
-
D
------
L
F
E
R
-
V
L
E
K
D
F
-
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
E
-
L
L
E
M
T
--
G
--
I
E
C
V
Q
T
--
I
K
D
K
E
R
F
K
P
K
D
------
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
--
I
A
T
L
T
S
R
F
V
E
A
L
N
S
H
--
K
V
R
--
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
L
-
P
-
F
T
A
K
I
E
I
E
C
E
S
F
--
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
-
E
I
A
A
Y
R
---
D
--
A
H
Y
---
P
F
V
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
--
20
PsiBlast_PDB
69.56
32%
-91
- C3 -
3C2F
1
NADC_YEAST
A:
[6-292]
-------
L
L
P
V
N
G
A
W
R
Q
D
V
T
N
W
L
S
E
D
V
P
-
S
-----
F
-
D
------
F
G
G
Y
-
V
V
G
S
D
L
-
K
-
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
-
V
F
N
Q
C
--
E
----
L
Q
V
E
W
L
F
K
E
G
S
F
L
E
P
S
K
NDSGKI
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
--
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
--
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
---
G
F
-
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
---------------------------H
F
L
L
E
C
S
G
G
L
N
L
------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
L
--
19
PsiBlast_PDB
68.99
32%
-92
- C3 -
3C2O
1
NADC_YEAST
A:
[6-292]
-------
L
L
P
V
N
G
A
W
R
Q
D
V
T
N
W
L
S
E
D
V
P
-
S
-----
F
-
D
------
F
G
G
Y
-
V
V
G
S
D
L
-
K
-
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
-
V
F
N
Q
C
--
E
----
L
Q
V
E
W
L
F
K
E
G
S
F
L
E
P
S
K
NDSGKI
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
--
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
--
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
---
G
F
-
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
---------------------------H
F
L
L
E
C
S
G
G
L
N
-------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
L
--
17
PsiBlast_PDB
68.76
32%
-89
- C3 -
3C2R
2
NADC_YEAST
A:
[7-293]
-------
L
L
P
V
N
G
A
W
R
Q
D
V
T
N
W
L
S
E
D
V
P
-
S
-----
F
-
D
------
F
G
G
Y
-
V
V
G
S
D
L
-
K
-
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
-
V
F
N
Q
C
--
E
--
L
Q
V
--
E
W
L
F
K
E
G
S
F
L
E
P
S
K
NDSGKI
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
--
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
--
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
---
G
F
-
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
---------------------------H
F
L
L
E
C
S
G
G
L
N
L
------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
L
--
68
PsiBlast_CBE
67.08
32%
-83
- C3 -
3C2R
2
NADC_YEAST
B:
[7-293]
-------
L
L
P
V
N
G
A
W
R
Q
D
V
T
N
W
L
S
E
D
V
P
-
S
-----
F
-
D
------
F
G
G
Y
-
V
V
G
S
D
L
-
K
-
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
-
V
F
N
Q
C
--
E
--
L
Q
V
--
E
W
L
F
K
E
G
S
F
L
E
P
S
K
NDSGKI
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
--
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
--
G
Y
K
GT
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
---
G
F
-
A
V
K
I
E
V
E
C
L
SE
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
---------------------------HFL
L
E
C
S
G
G
L
N
L
------
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
L
--
69
PsiBlast_CBE
66.73
32%
-86
- C3 -
3C2V
2
NADC_YEAST
A:
[6-292]
-------
L
L
P
V
N
G
A
W
R
Q
D
V
T
N
W
L
S
E
D
V
P
-
S
-----
F
-
D
------
F
G
G
Y
-
V
V
G
S
D
L
-
K
-
E
A
N
L
Y
C
K
Q
D
G
M
L
C
G
V
P
F
A
Q
E
-
V
F
N
Q
C
--
E
----
L
Q
V
E
W
L
F
K
E
G
S
F
L
E
P
S
K
NDSGKI
V
V
A
K
I
T
G
P
A
K
N
I
L
L
A
E
R
T
A
L
N
I
L
S
R
S
S
G
--
I
A
T
A
S
H
K
I
I
S
L
A
R
S
T
--
G
Y
K
G
T
I
A
G
T
R
K
T
T
P
G
L
R
R
L
E
K
Y
S
M
L
V
G
G
C
D
T
H
R
Y
D
L
S
S
M
V
M
L
K
D
N
H
I
W
A
T
G
S
I
T
N
A
V
K
N
A
R
A
V
C
---
G
F
-
A
V
K
I
E
V
E
C
L
S
E
D
E
A
T
E
A
I
E
A
G
A
D
V
I
M
L
D
N
---------------------------H
F
L
L
E
C
S
G
G
L
N
L
D
N
L
--
Y
L
C
D
D
I
D
I
Y
S
T
S
S
I
H
Q
G
T
P
V
I
D
F
S
L
K
L
--