@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4557: (2016-02-28 )
MQIKLANPRGFCAGVDRAIEIVNRALDVFGPPIYVRHEVVHNKFVVDNLRQRGAIFVEELDQVPNNVIVIFSAHGVSQAVRKEAEGRGLKVFDATCPLVTKVHMEVVRYSRDGHECVLIGHEGHPEVEGTMGQYDASNGGAIYLVEDEADVAALEVRKPEALHYVTQTTLSMDDTSKVIDALRAKFPQIQGPRKNDICYATQNRQDAVKELADQCDMVLVVGSPNSSNSNRLRELAERMGTPAYLIDGAEDMQRGWFDGVRRIGITAGASAPEVLVRGVIAQLREWGASEEQELEGREENITFSMPKELRVKAL
Atome Classification :
(60 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
Q
I
KLANPRG
F
C
A
G
V
D
R
A
I
E
I
V
N
R
A
L
D
VFGP
P
I
Y
V
R
H
E
V
VH
N
K
F
V
V
D
N
L
R
QRG
A
I
F
V
E
E
L
D
QVPN
N
V
I
V
I
F
SAHG
V
S
Q
A
V
R
K
EAEGR
G
L
K
V
F
DATC
P
L
V
T
K
V
H
M
E
V
V
RYSRDG
H
E
C
V
L
IGHEGHPEVEGTMGQYDASNG
G
A
I
Y
L
VEDEA
D
V
A
A
L
E
VRKPE
A
L
H
Y
V
T
Q
T
TLSMD
D
T
S
K
V
I
D
A
L
R
A
KFPQIQGPRKND
I
C
Y
ATQ
N
R
Q
D
A
V
K
E
L
A
DQC
D
M
V
L
V
VGSPNSS
N
S
N
R
L
R
E
L
A
E
R
MGT
P
A
Y
L
ID
G
A
E
D
M
Q
R
G
W
F
D
G
V
R
R
IGITAGAS
A
P
E
V
L
V
R
G
V
I
A
Q
L
R
E
WGAS
E
E
Q
E
LEGREEN
I
T
FSM
P
K
E
L
RVKAL
49
PsiBlast_CBE
99.05
67%
-104
- C9 -
3UTC
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
39
PsiBlast_CBE
98.88
67%
-101
- C9 -
3UWM
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
30
PsiBlast_CBE
98.84
67%
-102
- C9 -
3ZGL
2
ISPH_ECOLI
B:
[17-325]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
41
PsiBlast_CBE
98.74
67%
-102
- C9 -
3UV7
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
28
PsiBlast_CBE
98.72
67%
-102
- C9 -
3F7T
6
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
47
PsiBlast_CBE
98.71
67%
-103
- C9 -
3UTD
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
14
PsiBlast_PDB
98.70
67%
-104
- C9 -
4MUX
2
?
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
6
PsiBlast_PDB
98.68
67%
-100
- C9 -
3F7T
7
ISPH_ECOLI
A:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
26
PsiBlast_CBE
98.64
67%
-102
- C9 -
3SZO
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
31
PsiBlast_CBE
98.44
67%
-105
- C9 -
4MV5
2
?
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
20
PsiBlast_PDB
98.43
67%
-102
- C9 -
3UTC
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
33
PsiBlast_CBE
98.36
67%
-104
- C9 -
4MUY
2
?
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
43
PsiBlast_CBE
98.35
67%
-103
- C9 -
3UV6
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
37
PsiBlast_CBE
98.26
67%
-103
- C9 -
4H4D
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
44
PsiBlast_CBE
98.24
67%
-102
- C9 -
3UV6
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
36
PsiBlast_CBE
98.24
67%
-101
- C9 -
4H4E
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
18
PsiBlast_PDB
98.21
67%
-104
- C9 -
4H4E
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
48
PsiBlast_CBE
98.20
67%
-99
- C9 -
3UTD
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
27
PsiBlast_CBE
98.18
67%
-104
- C9 -
3SZL
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
9
PsiBlast_PDB
98.13
67%
-100
- C9 -
3ZGL
2
ISPH_ECOLI
A:
[17-325]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
45
PsiBlast_CBE
98.12
67%
-101
- C9 -
3UV3
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
29
PsiBlast_CBE
98.09
67%
-102
- C9 -
3ZGN
2
ISPH_ECOLI
B:
[17-325]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
35
PsiBlast_CBE
98.08
67%
-105
- C9 -
4EB3
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
17
PsiBlast_PDB
98.06
67%
-101
- C9 -
4H4D
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
24
PsiBlast_CBE
98.03
67%
-100
- C9 -
3KE9
2
ISPH_ECOLI
B:
[11-320]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
15
PsiBlast_PDB
98.03
67%
-106
- C9 -
4MV5
2
?
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
16
PsiBlast_PDB
98.02
67%
-102
- C9 -
4H4C
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
42
PsiBlast_CBE
97.97
67%
-101
- C9 -
3UV7
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
40
PsiBlast_CBE
97.97
67%
-102
- C9 -
3UWM
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
54
PsiBlast_CBE
97.96
66%
-103
- C9 -
3T0F
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
D
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
46
PsiBlast_CBE
97.94
67%
-101
- C9 -
3UV3
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
12
PsiBlast_PDB
97.93
67%
-103
- C9 -
4MUY
2
?
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
4
PsiBlast_PDB
97.88
67%
-103
- C9 -
3KEL
2
ISPH_ECOLI
A:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
32
PsiBlast_CBE
97.86
67%
-104
- C9 -
4MV0
2
?
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
3
PsiBlast_PDB
97.86
67%
-104
- C9 -
3KEF
2
ISPH_ECOLI
A:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
34
PsiBlast_CBE
97.84
67%
-105
- C9 -
4MUX
2
?
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
10
PsiBlast_PDB
97.84
67%
-101
- C9 -
3ZGN
2
ISPH_ECOLI
A:
[17-325]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
11
PsiBlast_PDB
97.80
67%
-102
- C9 -
4EB3
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
1
PsiBlast_PDB
97.77
67%
-98
- C9 -
3KE8
2
ISPH_ECOLI
A:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
13
PsiBlast_PDB
97.75
67%
-105
- C9 -
4MV0
2
?
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
25
PsiBlast_CBE
97.66
67%
-102
- C9 -
3KE8
2
ISPH_ECOLI
B:
[11-320]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
19
PsiBlast_PDB
97.66
67%
-103
- C9 -
3URK
2
ISPH_ECOLI
A:
[9-317]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
7
PsiBlast_PDB
97.59
67%
-101
- C9 -
3SZL
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
56
PsiBlast_CBE
97.50
66%
-103
- C9 -
3T0G
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
C
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
21
PsiBlast_CBE
97.47
67%
-101
- C9 -
3KEM
2
ISPH_ECOLI
B:
[11-320]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
38
PsiBlast_CBE
97.43
67%
-101
- C9 -
4H4C
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
23
PsiBlast_CBE
97.42
67%
-103
- C9 -
3KEF
2
ISPH_ECOLI
B:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
51
PsiBlast_CBE
97.40
66%
-101
- C9 -
3SZU
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
Q
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
5
PsiBlast_PDB
97.37
67%
-101
- C9 -
3KEM
2
ISPH_ECOLI
A:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
2
PsiBlast_PDB
97.37
67%
-102
- C9 -
3KE9
2
ISPH_ECOLI
A:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
50
PsiBlast_CBE
97.32
67%
-101
- C9 -
3URK
2
ISPH_ECOLI
B:
[9-318]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
22
PsiBlast_CBE
97.20
67%
-104
- C9 -
3KEL
2
ISPH_ECOLI
B:
[11-319]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
8
PsiBlast_PDB
96.98
67%
-99
- C9 -
3SZO
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
55
PsiBlast_CBE
96.77
66%
-103
* C9 *
3T0G
2
ISPH_ECOLI
B:
[13-322]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
C
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
V
---
52
PsiBlast_CBE
96.31
66%
-103
- C9 -
3SZU
2
ISPH_ECOLI
A:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
Q
V
E
G
T
M
G
Q
Y
S
N
P
E
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
53
PsiBlast_CBE
92.80
66%
-115
- C9 -
3T0F
2
ISPH_ECOLI
B:
[13-321]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
------
T
M
G
Q
-----
G
G
-
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
G
E
A
I
P
L
E
G
R
E
E
N
I
V
F
E
V
P
K
E
L
R
----
57
PsiBlast_CBE
76.32
34%
-107
- C9 -
3DNF
2
ISPH_AQUAE
B:
[2-280]
-
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
-
V
F
P
S
Q
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
C
N
G
K
G
I
-
V
V
E
T
L
E
D
I
G
--
E
A
L
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
--
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
-----------------------------
59
Fugue
75.69
34%
-107
- C9 -
3DNF
2
ISPH_AQUAE
A:
[1-281]
M
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
-
V
F
P
S
Q
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
C
N
G
K
-
G
I
V
V
E
T
L
E
D
I
G
--
E
A
L
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
V
--
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
----------------------------
58
PsiBlast_CBE
75.36
34%
-105
- C9 -
3DNF
2
ISPH_AQUAE
A:
[2-280]
-
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
-
V
F
P
S
Q
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
C
N
G
K
G
I
-
V
V
E
T
L
E
D
I
G
--
E
A
L
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
--
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
-----------------------------
69
HHSearch
74.74
34%
-100
- C9 -
3DNF
2
ISPH_AQUAE
A:
[2-281]
-
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
V
F
P
S
Q
-
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
C
N
G
K
G
-
I
V
V
E
T
L
E
D
I
G
E
A
L
--
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
--
V
K
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
----------------------------