@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4569: (2016-02-28 )
MQPQAFYRVVAEDFTAVDGIIRRQLTSRVPLVEKIGDYIISAGGKRLRPLLVLLAGKTLGYKGDDLCLLAATIEFLHTSTLLHDDVVDASGLRRGRSTANALWGNAPSVLVGDFLYARSFEMMVELGSMPVMRIISQATRVIAEGEVLQLSKVRDASTTEETYMEVIRGKTAMLFEASTHSAAALCQAGEEQSEALRRFGDYLGIAFQLVDDLLDYRGDAATLGKNVGDDLAEGKPTLPLIVTMRDGTEEQAALVRKAIQQGGSQDLESVCAAVEAAGALDYTANLARDYAARAIACLDTLPDNEYRSALVELSEFAVARTH
Atome Classification :
(38 SA)
--.........10......-..20......-..30........40.--.......50........60.--.-----......--70-.........80.....--...90........100.......110.......120....--.-----.-.130....-----...-..140......--.150.......160-.......---.-170.......180.......190-.......200.......210.......220.......230.......240.......250---........--260-.---.-.....270...---....280.......290.......300...------....310.......320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MQ
P
Q
A
F
Y
R
V
V
A
E
D
F
T
A
V
-
D
G
I
I
R
R
Q
L
T
S-RV
P
L
V
E
K
I
G
D
Y
I
I
SA--GGKR
L
R
P
L
L
V
L
L
AGKTLGYK--G-----D
D
L
C
L
L
--
A
--
A
T
I
E
F
L
H
T
S
T
LLHDDV--V
D
A
S
G
LRRGRS
T
A
N
A
LWGNA
P
S
V
L
V
G
D
F
L
Y
A
R
S
F
E
M
M
V
E
L--G-----S-
M
P
--
V
M
R
I
-----
I
S
Q
-
A
T
R
V
IAEG
E
V
L
--
Q
L
S
KVRDAST
T
E
E
--
T
Y
M
E
V
IR---G-K
T
A
M
L
F
EAST
H
S
A
A
A
L
C
QAG
E
E
Q
-
S
E
A
L
R
R
F
G
D
Y
L
G
I
A
F
Q
L
V
D
D
L
L
DYRG
D
A
A
T
L
GKNV
G
D
D
LAEGKPT
L
P
L
I
V
T
MRDG
T
E
E
Q
----
A
A
L
V
R
K
A
I
--QQG-G---
S
-
Q
D
L
E
S
V
C
A
A
V
E
---AAGA
L
D
Y
T
A
N
L
A
R
D
Y
A
A
R
A
I
A
C
L
DTLP
D
N
E
------
Y
R
S
A
L
V
E
L
S
E
F
A
VARTH
21
PsiBlast_CBE
95.22
52%
-117
- C1 -
3WJN
1
?
B:
[15-335]
--
M
N
L
E
K
I
N
E
L
T
A
Q
D
M
A
G
V
-
N
A
A
I
L
E
Q
L
N
S
-
D
V
Q
L
I
N
Q
L
G
Y
Y
I
V
S
G
--
G
G
K
R
I
R
P
M
I
A
V
L
A
A
R
A
V
G
Y
E
--
G
-----
N
A
H
V
T
I
--
A
--
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
------------
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
M
M
T
S
L
--
G
-----
S
-
L
K
--
V
L
E
V
-----
M
S
E
-
A
V
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
V
N
D
P
D
I
T
E
E
--
N
Y
M
R
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
C
T
P
E
E
-
E
K
G
L
Q
D
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
-------
K
N
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
H
H
G
T
P
E
Q
----
A
Q
M
I
R
T
A
I
--
E
Q
G
N
G
---
R
-
H
L
L
E
P
V
L
E
A
M
N
---
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
Q
V
L
P
D
T
P
------
W
R
E
A
L
I
G
L
A
H
I
A
V
Q
R
--
23
PsiBlast_CBE
92.82
52%
-109
- C1 -
4JYX
3
?
G:
[35-343]
--------------
D
M
L
A
V
-
N
Q
L
I
Q
K
Q
V
N
S
-
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
--
G
G
K
R
L
R
P
L
L
T
V
L
A
A
R
A
L
N
I
Q
--
T
-----
E
Q
H
H
T
L
--
A
--
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
T
M
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
L
--
D
-----
S
-
M
R
--
V
M
Q
I
-----
L
S
D
-
A
T
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
C
N
D
P
D
T
T
E
E
--
S
Y
M
E
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
Q
S
E
A
I
-
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
-------
N
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
E
Q
Q
----
T
A
I
I
R
E
A
I
--
E
T
G
N
G
---
M
-
D
N
L
T
P
I
L
E
T
M
E
---
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
------
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
--
28
PsiBlast_CBE
92.32
52%
-110
- C1 -
4JYX
3
?
B:
[35-343]
--------------
D
M
L
A
V
-
N
Q
L
I
Q
K
Q
V
N
S
-
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
--
G
G
K
R
L
R
P
L
L
T
V
L
A
A
R
A
L
N
I
Q
--
T
-----
E
Q
H
H
T
L
--
A
--
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
T
M
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
L
--
D
-----
S
-
M
R
--
V
M
Q
I
-----
L
S
D
-
A
T
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
C
N
D
P
D
T
T
E
E
--
S
Y
M
E
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
Q
S
E
A
I
-
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
--------
N
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
E
Q
Q
----
T
A
I
I
R
E
A
I
--
E
T
G
N
G
---
M
-
D
N
L
T
P
I
L
E
T
M
E
---
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
------
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
--
2
PsiBlast_PDB
92.26
52%
-108
- C1 -
4JYX
4
?
A:
[35-343]
--------------
D
M
L
A
V
-
N
Q
L
I
Q
K
Q
V
N
S
-
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
--
G
G
K
R
L
R
P
L
L
T
V
L
A
A
R
A
L
N
I
Q
--
T
-----
E
Q
H
H
T
L
--
A
--
A
I
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F
I
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T
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T
L
L
H
D
D
V
--
V
D
E
S
T
M
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
L
--
D
-----
S
-
M
R
--
V
M
Q
I
-----
L
S
D
-
A
T
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
C
N
D
P
D
T
T
E
E
--
S
Y
M
E
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
Q
S
E
A
I
-
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
-------
N
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
E
Q
Q
----
T
A
I
I
R
E
A
I
--
E
T
G
N
G
---
M
-
D
N
L
T
P
I
L
E
T
M
E
---
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
------
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
--
22
PsiBlast_CBE
91.83
52%
-109
- C1 -
4JYX
3
?
H:
[35-343]
--------------
D
M
L
A
V
-
N
Q
L
I
Q
K
Q
V
N
S
-
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
--
G
G
K
R
L
R
P
L
L
T
V
L
A
A
R
A
L
N
I
Q
--
T
-----
E
Q
H
H
T
L
--
A
--
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
T
M
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
L
--
D
-----
S
-
M
R
--
V
M
Q
I
-----
L
S
D
-
A
T
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
C
N
D
P
D
T
T
E
E
--
S
Y
M
E
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
Q
S
E
A
I
-
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
-------
N
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
E
Q
Q
----
T
A
I
I
R
E
A
I
--
E
T
G
N
G
---
M
-
D
N
L
T
P
I
L
E
T
M
E
---
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
------
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
--
25
PsiBlast_CBE
90.49
52%
-112
- C1 -
4JYX
2
?
E:
[35-343]
--------------
D
M
L
A
V
-
N
Q
L
I
Q
K
Q
V
N
S
-
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
--
G
-
K
R
L
R
P
L
L
T
V
L
A
A
R
A
L
N
I
Q
--
T
-----
E
Q
H
H
T
L
--
A
--
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
--------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
L
--
D
-----
S
-
M
R
--
V
M
Q
I
-----
L
S
D
-
A
T
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
C
N
D
P
D
T
T
E
E
--
S
Y
M
E
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
Q
S
E
A
I
-
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
----------
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
E
Q
Q
----
T
A
I
I
R
E
A
I
--
E
T
G
N
G
---
M
-
D
N
L
T
P
I
L
E
T
M
E
---
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
------
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
--
24
PsiBlast_CBE
90.37
52%
-114
- C1 -
4JYX
2
?
F:
[35-343]
--------------
D
M
L
A
V
-
N
Q
L
I
Q
K
Q
V
N
S
-
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
--
G
G
K
R
L
R
P
L
L
T
V
L
A
A
R
A
L
N
I
Q
--
T
-----
E
Q
H
H
T
L
--
A
--
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
--------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
L
--
D
-----
S
-
M
R
--
V
M
Q
I
-----
L
S
D
-
A
T
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
C
N
D
P
D
T
T
E
E
--
S
Y
M
E
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
Q
S
E
A
I
-
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
---------
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
E
Q
Q
----
T
A
I
I
R
E
A
I
--
E
T
G
N
G
---
M
-
D
N
L
T
P
I
L
E
T
M
E
---
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
------
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
--
29
PsiBlast_CBE
89.86
46%
-102
* C1 *
3OYR
4
?
B:
[29-343]
---------
R
L
A
E
A
D
M
A
G
V
-
N
R
L
I
T
D
R
M
Q
S
-
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
--
G
G
K
R
L
R
P
L
M
T
V
A
A
A
R
L
A
G
A
D
--
N
-----
D
H
F
Q
K
L
--
A
--
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
G
S
Q
L
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
E
T
--
N
-----
S
-
M
K
--
A
L
E
I
-----
L
A
R
-
A
S
R
V
I
A
E
G
E
V
L
--
Q
L
M
R
S
H
D
L
N
L
S
Q
A
--
V
Y
L
E
I
I
Q
---
A
-
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
A
K
-
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
K
A
T
L
P
L
L
L
A
I
A
R
S
G
P
R
E
----
A
E
F
W
E
R
A
I
GR
R
E
Q
-
T
---
E
-
A
D
F
R
R
A
R
E
L
I
I
---
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
------
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
3
PsiBlast_PDB
89.75
52%
-113
- C1 -
4JXY
2
?
A:
[35-343]
--------------
D
M
L
A
V
-
N
Q
L
I
Q
K
Q
V
N
S
-
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
--
G
G
K
R
L
R
P
L
L
T
V
L
A
A
R
A
L
N
I
Q
--
T
-----
E
Q
H
H
T
L
--
A
--
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
---------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
L
--
D
-----
S
-
M
R
--
V
M
Q
I
-----
L
S
D
-
A
T
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
C
N
D
P
D
T
T
E
E
--
S
Y
M
E
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
Q
S
E
A
I
-
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
----------
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
E
Q
Q
----
T
A
I
I
R
E
A
I
--
E
T
G
N
G
---
M
-
D
N
L
T
P
I
L
E
T
M
E
---
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
------
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
--
27
PsiBlast_CBE
89.38
52%
-112
- C1 -
4JYX
2
?
C:
[35-343]
--------------
D
M
L
A
V
-
N
Q
L
I
Q
K
Q
V
N
S
-
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
--
G
G
K
R
L
R
P
L
L
T
V
L
A
A
R
A
L
N
I
Q
--
T
-----
E
Q
H
H
T
L
--
A
--
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
--------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
L
--
D
-----
S
-
M
R
--
V
M
Q
I
-----
L
S
D
-
A
T
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
C
N
D
P
D
T
T
E
E
--
S
Y
M
E
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
Q
S
E
A
I
-
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
----------
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
E
Q
Q
----
T
A
I
I
R
E
A
I
--
E
T
G
N
G
---
M
-
D
N
L
T
P
I
L
E
T
M
E
---
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
------
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
--
26
PsiBlast_CBE
88.49
52%
-111
- C1 -
4JYX
2
?
D:
[35-343]
--------------
D
M
L
A
V
-
N
Q
L
I
Q
K
Q
V
N
S
-
D
V
S
L
I
N
Q
L
G
F
Y
I
V
N
S
--
G
G
K
R
L
R
P
L
L
T
V
L
A
A
R
A
L
N
I
Q
--
T
-----
E
Q
H
H
T
L
--
A
--
A
I
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
--------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
V
T
L
--
D
-----
S
-
M
R
--
V
M
Q
I
-----
L
S
D
-
A
T
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
C
N
D
P
D
T
T
E
E
--
S
Y
M
E
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
Q
S
E
A
I
-
E
N
A
M
Q
D
Y
G
K
Y
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
---------
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
H
G
N
E
Q
Q
----
T
A
I
I
R
E
A
I
--
E
T
G
N
G
---
M
-
D
N
L
T
P
I
L
E
T
M
E
---
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
------
Y
K
E
A
L
I
G
L
A
H
I
S
V
E
R
--
1
PsiBlast_PDB
88.46
52%
-112
- C1 -
3WJO
2
?
A:
[15-333]
--
M
N
L
E
K
I
N
E
L
T
A
Q
D
M
A
G
V
-
N
A
A
I
L
E
Q
L
N
S
-
D
V
Q
L
I
N
Q
L
G
Y
Y
I
V
S
G
--
G
G
K
R
I
R
P
M
I
A
V
L
A
A
R
A
V
G
Y
E
--
G
-----
N
A
H
V
T
I
--
A
--
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
D
M
R
R
G
K
A
T
A
N
A
A
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
M
M
T
S
L
--
G
-----
S
-
L
K
--
V
L
E
V
-----
M
S
E
-
A
V
N
V
I
A
E
G
E
V
L
--
Q
L
M
N
-----------
N
Y
M
R
V
I
Y
---
S
-
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
C
T
P
E
E
-
E
K
G
L
Q
D
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
A
--------
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
H
H
G
T
P
E
Q
----
A
Q
M
I
R
T
A
I
--
E
Q
G
N
G
---
R
-
H
L
L
E
P
V
L
E
A
M
N
---
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
Q
V
L
P
D
T
P
------
W
R
E
A
L
I
G
L
A
H
I
A
V
----
4
PsiBlast_PDB
84.89
49%
-109
- C1 -
4LOB
4
?
A:
[35-345]
-----------
V
A
T
D
F
A
A
M
-
D
H
L
I
N
E
G
I
S
S
-
K
V
G
L
V
M
S
V
S
K
H
V
V
E
A
--
G
G
K
R
M
R
P
I
M
C
L
L
A
A
R
A
C
D
L
D
--
N
M----
Q
N
A
Q
R
L
--
A
--
A
I
I
E
M
L
H
T
A
T
L
V
H
D
D
V
--
V
D
--------------
W
N
N
Q
T
A
V
L
V
G
D
F
L
I
A
R
A
F
D
L
L
V
D
L
--
N
-----
N
-
M
T
--
L
L
K
D
-----
F
S
T
-
G
T
C
E
I
A
E
G
E
V
L
--
Q
L
Q
S
Q
H
Q
P
D
T
T
E
E
--
T
Y
L
K
I
I
H
---
G
-
K
T
S
R
L
F
E
L
A
T
E
G
A
A
I
L
--
A
G
Q
E
A
Y
R
E
P
L
R
L
F
A
G
H
F
G
N
A
F
Q
I
I
D
D
I
L
D
Y
T
S
D
A
E
T
L
G
K
N
I
G
D
D
L
M
E
G
K
P
T
L
P
L
I
S
A
L
A
H
S
T
G
E
E
----
H
A
I
I
R
R
S
I
--
A
T
G
-
G
---
V
-
D
Q
L
P
K
V
I
E
I
V
Q
---
K
S
G
A
L
D
Y
C
Q
R
R
A
Q
E
E
T
E
A
A
L
Q
A
L
S
I
L
P
D
T
P
------
Y
R
Q
A
L
I
N
L
T
R
L
A
L
H
R
--
73
HHSearch
83.98
46%
-118
- C1 -
3OYR
1
?
A:
[25-343]
-----
D
R
L
V
R
L
A
E
A
D
M
A
G
V
-
N
R
L
I
T
D
R
M
Q
S
-
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
--
G
G
K
R
L
R
P
L
M
T
V
A
A
A
R
L
A
G
A
D
--
N
-----
D
H
F
Q
K
L
--
A
--
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
---------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
E
T
--
N
-----
S
-
M
K
--
A
L
E
I
-----
L
A
R
-
A
S
R
V
I
A
E
G
E
V
L
--
Q
L
M
R
S
H
D
L
N
L
S
Q
A
--
V
Y
L
E
I
I
Q
---
A
-
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
A
K
-
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
A
I
A
R
S
G
P
R
E
----
A
E
F
W
E
R
A
I
--
G
----T--
E
-
A
D
F
R
R
A
R
E
L
I
I
---
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
------
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
62
Fugue
83.91
44%
-116
- C1 -
3OYR
1
?
A:
[20-343]
KS
G
S
V
D
R
L
V
R
L
A
E
A
D
M
A
G
V
-
N
R
L
I
T
D
R
M
Q
S
-
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
--
G
G
K
R
L
R
P
L
M
T
V
A
A
A
R
L
A
G
A
D
--
N
-----
D
H
F
Q
K
L
--
A
--
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
V
---------
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
E
T
--
N
-----
S
-
M
K
--
A
L
E
I
-----
L
A
R
-
A
S
R
V
I
A
E
G
E
V
L
--
Q
L
M
R
S
H
D
L
N
L
S
Q
A
--
V
Y
L
E
I
I
Q
---
A
-
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
A
K
-
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
A
I
A
R
S
G
P
R
E
----
A
E
F
W
E
R
A
I
--
G
T
E
-
A
------
D
F
R
R
A
R
E
L
I
I
---
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
------
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
5
PsiBlast_PDB
82.70
46%
-115
- C1 -
3OYR
1
?
A:
[29-343]
---------
R
L
A
E
A
D
M
A
G
V
-
N
R
L
I
T
D
R
M
Q
S
-
D
V
A
I
I
P
A
L
A
E
H
L
I
A
A
--
G
G
K
R
L
R
P
L
M
T
V
A
A
A
R
L
A
G
A
D
--
N
-----
D
H
F
Q
K
L
--
A
--
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
---------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
E
T
--
N
-----
S
-
M
K
--
A
L
E
I
-----
L
A
R
-
A
S
R
V
I
A
E
G
E
V
L
--
Q
L
M
R
S
H
D
L
N
L
S
Q
A
--
V
Y
L
E
I
I
Q
---
A
-
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
A
K
-
S
E
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
A
I
A
R
S
G
P
R
E
----
A
E
F
W
E
R
A
I
G-----
T
---
E
-
A
D
F
R
R
A
R
E
L
I
I
---
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
------
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
78
HHSearch
76.14
31%
-97
- C1 -
1WY0
2
?
A:
[5-341]
-----
E
E
L
F
A
R
I
K
E
K
A
K
L
I
-
D
E
K
I
F
E
L
I
P
E
K
D
P
R
V
L
Y
E
A
A
R
H
Y
P
L
A
--
G
G
K
R
V
R
P
F
V
V
L
T
S
T
E
A
V
G
G
D
--
P
-----
L
R
A
I
Y
P
--
A
--
V
A
I
E
L
I
H
N
Y
S
L
V
H
D
D
I
--
M
D
M
D
E
T
R
R
G
K
P
T
V
H
R
I
W
G
V
N
M
A
I
L
A
G
D
L
L
F
S
K
A
F
E
A
V
A
R
A
--
E
IP
P
E
K
K
-
A
R
--
V
L
E
V
-----
I
V
K
-
A
S
N
E
L
C
E
G
Q
A
R
--
D
L
E
F
E
K
K
S
T
V
T
I
E
--
E
Y
M
E
M
I
S
---
G
-
K
T
G
A
L
F
E
A
S
A
K
V
G
G
I
I
G
T
D
N
E
E
Y
-
I
K
A
L
S
S
W
G
R
N
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
D
E
K
K
L
G
K
P
V
G
S
D
I
R
K
G
K
K
T
L
I
V
A
H
F
F
E
N
A
D
E
K
D
----
K
Q
R
F
L
K
I
F
--
G
K
---D
I
-
K
-
S
D
V
M
E
A
I
D
L
L
K
---
K
Y
G
S
I
D
Y
A
A
E
I
A
K
D
M
I
K
K
A
N
E
A
L
R
I
L
P
K
S
K
------
A
R
M
D
L
E
L
L
A
K
F
I
V
E
R
E
-
15
PsiBlast_PDB
69.15
30%
-85
- C1 -
3N3D
4
?
A:
[14-325]
-----------
V
E
P
Q
L
T
A
L
Q
D
Y
L
L
R
T
V
Q
L
D
-
N
Q
P
I
H
H
K
I
L
-
A
L
L
K
S
--
G
G
K
L
L
R
P
G
Y
F
Y
L
F
S
-
T
F
G
N
A
--
A
-----
T
P
A
Q
L
Q
--
A
G
A
A
A
I
E
I
L
H
V
G
T
L
I
H
D
D
V
--
I
D
D
S
P
T
R
R
G
V
R
T
I
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
L
K
S
--
T
-----
T
D
R
S
--
L
I
Q
N
-----
H
I
D
-
A
M
H
R
I
L
Q
G
E
L
H
--
Q
M
D
L
N
Y
R
E
D
I
T
L
D
--
A
Y
L
N
E
I
A
---
G
-
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
A
P
Q
S
V
-
I
D
R
T
R
D
I
G
I
A
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
V
Y
S
L
P
L
L
L
S
L
S
H
A
P
R
D
F
----
H
K
L
L
K
K
K
---
Q
A
M
-
T
---
L
-
E
D
I
K
H
V
Q
A
L
V
A
---
Q
Y
D
G
V
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
S
------
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
--
77
HHSearch
68.77
27%
-106
- C1 -
3APZ
-
SPS3_ARATH
A:
[8-348]
-----
L
D
P
F
S
L
V
A
D
E
L
S
L
L
-
S
N
K
L
R
E
M
V
L
A
-
E
V
P
------------GV
Q
G
K
Q
F
R
S
T
I
L
L
L
M
A
T
A
L
D
V
----T
S
E
L
R
V
R
Q
R
G
I
--
A
--
E
I
T
E
M
I
H
V
A
S
L
L
H
D
D
------------------
V
M
G
N
K
M
S
V
L
A
G
D
F
L
L
S
R
A
C
G
A
L
A
A
L
--
K
-----
N
-
T
E
--
V
V
A
L
-----
L
A
T
-
A
V
E
H
L
V
T
G
E
T
M
--
E
I
T
S
S
T
E
Q
R
Y
S
M
D
--
Y
Y
M
Q
K
T
Y
---
Y
-
K
T
A
S
L
I
S
N
S
C
K
A
V
A
V
L
T
G
Q
T
A
E
V
-
A
V
L
A
F
E
Y
G
R
N
L
G
L
A
F
Q
L
I
D
D
I
L
D
F
T
G
T
S
A
S
L
G
K
G
S
L
S
D
I
R
H
G
V
I
T
A
P
I
L
F
A
M
E
E
F
P
Q
---------
L
R
E
V
V
--
D
Q
V
-
E
KD-
P
-
R
N
V
D
I
A
L
E
Y
L
G
---
K
S
K
G
I
Q
R
A
R
E
L
A
M
E
H
A
N
L
A
A
A
A
I
G
S
L
P
E
T
D
N
E
D
V
K
R
S
R
R
A
L
I
D
L
T
H
R
V
I
T
R
N
K
76
HHSearch
68.48
28%
-94
- C1 -
3AQB
3
HEXB_MICLU
B:
[6-324]
-------
Y
K
A
F
L
N
P
Y
I
I
E
V
-
E
K
R
L
Y
E
C
I
Q
S
-
D
S
E
T
I
N
K
A
A
H
H
I
L
S
S
--
G
G
K
R
V
R
P
M
F
V
L
L
S
G
F
L
N
D
T
Q
--
K
-----
D
D
L
I
R
T
--
A
--
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
A
T
I
--
N
-----
N
-
S
K
--
F
H
Q
I
-----
F
S
K
-
T
I
L
E
V
C
F
G
E
F
D
--
Q
M
A
D
R
F
N
Y
P
V
S
F
T
--
A
Y
L
R
R
I
N
---
R
-
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
L
D
E
Q
S
-
T
Y
H
I
K
Q
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
A
I
A
N
L
K
E
Q
D
----
D
D
K
L
E
A
V
V
--
K
H
L
-
T
STS
D
D
E
V
Y
Q
Y
I
V
S
Q
V
K
---
Q
Y
G
-
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
------
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
-
10
PsiBlast_PDB
64.89
33%
-94
- C1 -
3Q2Q
5
?
A:
[47-350]
------------------
V
-
E
E
L
L
H
T
E
L
S
S
-
G
E
D
F
L
V
D
I
V
M
H
L
T
R
A
--
G
G
K
R
F
R
P
M
F
A
L
L
A
S
E
-
F
G
E
K
PL
S
-----
E
N
V
I
K
A
--
A
--
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
--
M
D
E
A
-------
S
A
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
H
A
S
G
L
M
S
Q
L
--
G
-----
T
-
D
T
--
V
A
H
F
-----
A
E
T
-
F
G
E
L
V
T
-
G
Q
M
R
--
E
T
V
G
P
R
D
T
D
P
I
E
H
---
Y
T
N
V
I
R
---
E
-
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
G
A
A
P
E
H
-
I
D
A
L
K
N
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
E
T
H
----
T
P
G
T
D
L
R
E
G
V
F
T
L
P
V
L
Y
A
L
R
E
D
T
P
V
G
----
A
E
L
--
R
D
I
--
L
T
G
-
P
---
L
-
E
D
D
E
T
V
N
H
V
L
E
L
L
S
Q
S
G
G
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
R
L
P
D
S
T
------
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
16
PsiBlast_PDB
64.75
30%
-83
- C1 -
3PKO
2
?
A:
[30-333]
--------------------
D
Y
L
L
R
T
V
Q
L
D
-
N
Q
P
I
H
H
K
I
L
A
-
L
L
K
S
--
G
G
K
L
L
R
P
G
Y
F
Y
L
F
S
-
T
F
G
N
A
--
A
-----
T
P
A
Q
L
Q
--
A
G
A
A
A
I
E
I
L
H
V
G
T
L
I
H
D
D
V
--
I
D
D
S
P
T
R
R
G
V
R
T
I
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
L
K
S
--
T
-----
T
D
R
S
--
L
I
Q
N
-----
H
I
D
-
A
M
H
R
I
L
Q
G
E
L
H
--
Q
M
D
L
N
Y
R
E
D
I
T
L
D
--
A
Y
L
N
E
I
A
---
G
-
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
A
P
Q
S
V
-
I
D
R
T
R
D
I
G
I
A
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
V
Y
S
L
P
L
L
L
S
L
S
H
A
P
R
D
F
----
H
K
L
L
K
K
K
---
Q
A
M
-
T
---
L
-
E
D
I
K
H
V
Q
A
L
V
A
---
Q
Y
D
G
V
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
S
------
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
D
-
8
PsiBlast_PDB
61.95
30%
-89
- C1 -
3AQC
5
HEXB_MICLU
B:
[32-325]
-----------------------------------
I
N
K
A
A
H
H
I
L
S
S
--
G
G
K
R
V
R
P
M
F
V
L
L
S
G
F
L
N
D
T
Q
--
K
-----
D
D
L
I
R
T
--
A
--
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
A
T
I
--
N
-----
N
-
S
K
--
F
H
Q
I
-----
F
S
K
-
T
I
L
E
V
C
F
G
E
F
D
--
Q
M
A
D
R
F
N
Y
P
V
S
F
T
--
A
Y
L
R
R
I
N
---
R
-
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
L
D
E
Q
S
-
T
Y
H
I
K
Q
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
A
I
A
N
L
K
E
Q
D
DD
K
L
E
A
V
V
K
H
L
T
--
S
T
S
-
D
---
D
-
E
V
Y
Q
Y
I
V
S
Q
V
K
---
Q
Y
G
-
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
------
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
33
PsiBlast_CBE
33.73
34%
-68
- C1 -
3KRP
3
?
D:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
PA
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
ER
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G-
Q
V
V
D
V
C
S
E
G
M
A
E
V
GL
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
-----------
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
40
PsiBlast_CBE
33.62
34%
-72
- C1 -
3KRC
1
?
A:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
P
A
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
E
R
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G
-
Q
V
V
D
V
C
S
E
G
M
A
E
V
G
L
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
31
PsiBlast_CBE
33.03
34%
-58
- C1 -
3OAB
4
?
D:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
PA
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
ER
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G-
Q
V
V
D
V
C
S
E
G
M
A
E
V
GL
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
39
PsiBlast_CBE
32.81
34%
-72
- C1 -
3KRC
1
?
D:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
PA
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
ER
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G-
Q
V
V
D
V
C
S
E
G
M
A
E
V
GL
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
------------------
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
38
PsiBlast_CBE
32.59
34%
-69
- C1 -
3KRF
4
?
A:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
P
A
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
E
R
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G
-
Q
V
V
D
V
C
S
E
G
M
A
E
V
G
L
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
36
PsiBlast_CBE
31.74
34%
-68
- C1 -
3KRO
4
?
A:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
P
A
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
E
R
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G
-
Q
V
V
D
V
C
S
E
G
M
A
E
V
G
L
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
35
PsiBlast_CBE
31.31
34%
-56
- C1 -
3KRO
4
?
D:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
PA
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
ER
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G-
Q
V
V
D
V
C
S
E
G
M
A
E
V
GL
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
30
PsiBlast_CBE
31.21
34%
-55
- C1 -
3OAC
4
?
D:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
PA
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
ER
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G-
Q
V
V
D
V
C
S
E
G
M
A
E
V
GL
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
37
PsiBlast_CBE
31.01
34%
-53
- C1 -
3KRF
4
?
D:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
PA
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
ER
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G-
Q
V
V
D
V
C
S
E
G
M
A
E
V
GL
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
34
PsiBlast_CBE
30.73
34%
-67
- C1 -
3KRP
3
?
A:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
P
A
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
E
R
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G
-
Q
V
V
D
V
C
S
E
G
M
A
E
V
G
L
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
43
PsiBlast_CBE
30.01
34%
-56
- C1 -
4LLT
5
?
B:
[49-265]
--------------------------------
L
P
I
V
E
A
M
A
H
--
A
T
S
--
G
G
K
R
L
R
G
F
L
V
L
E
T
A
R
L
H
D
I
A
--
A
-----
G
E
A
I
W
S
--
A
--
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
H
P
--
G
-----
A
-
S
A
--
S
A
E
V
R
A
D
L
A
L
S
L
-
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
A
E
T
A
R
A
P
L
--
S
L
D
E
I
T
R
L
Q
Q
G
-
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
Q
A
---
D
-
T
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
--------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
28.78
34%
-68
- C1 -
3OAB
4
?
A:
[37-271]
-----------------------------------------
Y
S
L
L
A
--
G
G
K
R
V
R
P
M
L
C
I
A
A
C
E
L
V
G
----
G
-----
D
E
S
T
A
M
P
A
A
--
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
-----
A
-
P
P
E
R
I
V
R
V
-----
L
G
E
L
A
V
S
I
G
S
E
G
L
V
A
G
-
Q
V
V
D
V
C
S
E
G
M
A
E
V
G
L
D
H
L
E
F
I
H
---
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
G
K
E
E
E
-
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
K
S
K
E
F
A
----
D
R
L
N
R
E
A
Q
--
E
Q
---------------------------------------------------------------------------
45
PsiBlast_CBE
28.59
34%
-54
- C1 -
4LLS
6
?
B:
[49-265]
--------------------------------
L
P
I
V
E
A
M
A
H
--
A
T
S
--
G
G
K
R
L
R
G
F
L
V
L
E
T
A
R
L
H
D
I
A
--
A
-----
G
E
A
I
W
S
--
A
--
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
H
P
--
G
-----
A
-
S
A
--
S
A
E
V
R
A
D
L
A
L
S
L
-
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
A
E
T
A
R
A
P
L
--
S
L
D
E
I
T
R
L
Q
Q
G
-
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
Q
A
---
D
-
T
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
--------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
27.31
34%
-54
- C1 -
4LLT
5
?
A:
[49-265]
--------------------------------
L
P
I
V
E
A
M
A
H
--
A
T
S
--
G
G
K
R
L
R
G
F
L
V
L
E
T
A
R
L
H
D
I
A
--
A
-----
G
E
A
I
W
S
--
A
--
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
H
P
--
G
-----
A
-
S
A
--
S
A
E
V
R
A
D
L
A
L
S
L
-
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
A
E
T
A
R
A
P
L
--
S
L
D
E
I
T
R
L
Q
Q
G
-
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
Q
A
---
D
-
T
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
--------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
27.22
34%
-55
- C1 -
4LLS
6
?
A:
[49-265]
--------------------------------
L
P
I
V
E
A
M
A
H
--
A
T
S
--
G
G
K
R
L
R
G
F
L
V
L
E
T
A
R
L
H
D
I
A
--
A
-----
G
E
A
I
W
S
--
A
--
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
PC
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
H
P
--
G
-----
A
-
S
A
--
S
A
E
V
R
A
D
L
A
L
S
L
-
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
I
A
A
E
T
A
R
A
P
L
--
S
L
D
E
I
T
R
L
Q
Q
G
-
K
T
G
A
L
I
G
W
S
A
Q
A
G
A
R
L
A
Q
A
---
D
-
T
A
A
L
K
R
Y
A
Q
A
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
--------------------------------------------------------------------------------------------------------