@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4587: (2016-02-28 )
MQSSQLLPLGSLLLSFATPLAQADALHDQASALFKPIPEQVTELRGQPISEQQRELGKKLFFDPRLSRSHVLSCNTCHNVGTGGADNVPTSVGHGWQKGPRNSPTVFNAVFNAAQFWDGRAKDLGEQAKGPIQNSVEMHSTPQLVEQTLGSIPEYVDAFRKAFPKAGKPVSFDNMALAIEAYEATLVTPDSPFDLYLKGDDKALDAQQKKGLKAFMDSGCSACHNGINLGGQAYFPFGLVKKPDASVLPSGDKGRFAVTKTQSDEYVFRAAPLRNVALTAPYFHSGQVWELKDAVAIMGNAQLGKQLAPDDVENIVAFLHSLSGKQPRVEYPLLPASTETTPRPAE
Atome Classification :
(37 SA)
.........10........20-........30........40....-------....50...-.....60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQSSQL
L
P
L
G
S
L
L
L
S
F
ATPL
A
-
Q
A
D
A
L
H
D
Q
A
S
A
L
FKPI
P
E
Q
V
T
E
LR-------GQPI
S
E
Q
Q
R
-
E
L
G
K
K
LFFDPRLSR
S
H
V
L
SCNTCHNVGTGGADNVPTSVGHGWQKGPRNS
P
T
V
F
N
A
V
F
N
A
A
Q
FWD
G
R
A
K
D
L
G
E
Q
AKGPIQNSVEMHS
T
P
Q
L
V
E
Q
T
LGS
I
P
E
Y
V
D
A
F
R
K
AFPKAGKPVSFD
N
M
A
L
A
I
E
A
Y
E
A
T
LVTPDSP
F
D
L
Y
L
KGDDKAL
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
HNGINLGG
Q
A
Y
F
PFGLVKKPDASVLPSGDKG
R
F
A
V
T
KTQSD
E
Y
V
F
R
AAPLR
N
V
A
L
TAPYFHSGQ
V
W
E
L
K
D
A
V
A
IMG
N
A
Q
LGKQLA
P
D
D
V
E
N
I
V
A
F
L
H
S
LSGKQPRVEYPLLPASTETTPRPAE-
2
PsiBlast_PDB
96.68
100%
-67
- C2 -
2VHD
3
CCPR_PSEAE
A:
[1-323]
------------------------
D
A
L
H
D
Q
A
S
A
L
F
K
P
I
P
E
Q
V
T
E
L
R
-------
G
Q
P
I
S
E
Q
Q
R
-
E
L
G
K
K
L
F
F
D
P
R
L
S
R
S
H
V
L
S
C
N
T
C
H
N
V
G
T
G
G
A
D
N
V
P
T
S
V
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
K
D
L
G
E
Q
A
K
G
P
I
Q
N
S
V
E
M
H
S
T
P
Q
L
V
E
Q
T
L
G
S
I
P
E
Y
V
D
A
F
R
K
A
F
P
K
A
G
K
P
V
S
F
D
N
M
A
L
A
I
E
A
Y
E
A
T
L
V
T
P
D
S
P
F
D
L
Y
L
K
G
D
D
K
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
H
N
G
I
N
L
G
G
Q
A
Y
F
P
F
G
L
V
K
K
P
D
A
S
V
L
P
S
G
D
K
G
R
F
A
V
T
K
T
Q
S
D
E
Y
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
I
M
G
N
A
Q
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
S
G
K
Q
P
R
V
E
Y
P
L
L
P
A
S
T
E
T
T
P
R
P
A
E
-
37
HHSearch
96.52
100%
-68
- C2 -
2VHD
3
CCPR_PSEAE
A:
[2-323]
-------------------------
A
L
H
D
Q
A
S
A
L
F
K
P
I
P
E
Q
V
T
E
L
R
-------
G
Q
P
I
S
E
Q
Q
R
-
E
L
G
K
K
L
F
F
D
P
R
L
S
R
S
H
V
L
S
C
N
T
C
H
N
V
G
T
G
G
A
D
N
V
P
T
S
V
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
K
D
L
G
E
Q
A
K
G
P
I
Q
N
S
V
E
M
H
S
T
P
Q
L
V
E
Q
T
L
G
S
I
P
E
Y
V
D
A
F
R
K
A
F
P
K
A
G
K
P
V
S
F
D
N
M
A
L
A
I
E
A
Y
E
A
T
L
V
T
P
D
S
P
F
D
L
Y
L
K
G
D
D
K
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
H
N
G
I
N
L
G
G
Q
A
Y
F
P
F
G
L
V
K
K
P
D
A
S
V
L
P
S
G
D
K
G
R
F
A
V
T
K
T
Q
S
D
E
Y
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
I
M
G
N
A
Q
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
S
G
K
Q
P
R
V
E
Y
P
L
L
P
A
S
T
E
T
T
P
R
P
A
E
-
64
Fugue
96.08
99%
-76
- C2 -
1EB7
3
CCPR_PSEAE
A:
[1-323]
------------------------
D
A
L
H
D
Q
A
S
A
L
F
K
P
I
P
E
Q
V
T
E
L
R
-------
G
Q
P
I
S
E
Q
Q
R
-
E
L
G
K
K
L
F
F
D
P
R
L
S
R
S
H
V
L
S
C
N
T
C
H
N
V
G
T
G
G
A
D
N
V
P
T
S
V
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
K
D
L
G
E
Q
A
K
G
P
I
Q
N
S
V
E
M
H
S
T
P
Q
L
V
E
Q
T
L
G
S
I
P
E
Y
V
D
A
F
R
K
A
F
P
K
A
G
K
P
V
S
F
D
N
M
A
L
A
I
E
A
Y
E
A
T
L
V
T
P
D
S
P
F
D
L
Y
L
K
G
D
D
K
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
H
N
G
I
N
L
G
G
Q
A
Y
F
P
F
G
L
V
K
K
P
D
------
A
D
K
G
R
F
A
V
T
K
T
Q
S
D
E
Y
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
I
M
G
N
A
Q
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
S
G
K
Q
P
R
V
E
Y
P
L
L
P
A
S
T
E
T
T
P
R
P
A
E
-
1
PsiBlast_PDB
96.01
100%
-76
- C2 -
1EB7
3
CCPR_PSEAE
A:
[1-323]
------------------------
D
A
L
H
D
Q
A
S
A
L
F
K
P
I
P
E
Q
V
T
E
L
R
-------
G
Q
P
I
S
E
Q
Q
R
-
E
L
G
K
K
L
F
F
D
P
R
L
S
R
S
H
V
L
S
C
N
T
C
H
N
V
G
T
G
G
A
D
N
V
P
T
S
V
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
K
D
L
G
E
Q
A
K
G
P
I
Q
N
S
V
E
M
H
S
T
P
Q
L
V
E
Q
T
L
G
S
I
P
E
Y
V
D
A
F
R
K
A
F
P
K
A
G
K
P
V
S
F
D
N
M
A
L
A
I
E
A
Y
E
A
T
L
V
T
P
D
S
P
F
D
L
Y
L
K
G
D
D
K
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
H
N
G
I
N
L
G
G
Q
A
Y
F
P
F
G
L
V
K
K
P
D
A
------
D
K
G
R
F
A
V
T
K
T
Q
S
D
E
Y
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
I
M
G
N
A
Q
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
S
G
K
Q
P
R
V
E
Y
P
L
L
P
A
S
T
E
T
T
P
R
P
A
E
-
21
PsiBlast_CBE
95.60
100%
-66
- C2 -
2VHD
3
CCPR_PSEAE
B:
[1-323]
------------------------
D
A
L
H
D
Q
A
S
A
L
F
K
P
I
P
E
Q
V
T
E
L
R
-------
G
Q
P
I
S
E
Q
Q
R
-
E
L
G
K
K
L
F
F
D
P
R
L
S
R
S
H
V
L
S
C
N
T
C
H
N
V
G
T
G
G
A
D
N
V
P
T
S
V
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
K
D
L
G
E
Q
A
K
G
P
I
Q
N
S
V
E
M
H
S
T
P
Q
L
V
E
Q
T
L
G
S
I
P
E
Y
V
D
A
F
R
K
A
F
P
K
A
G
K
P
V
S
F
D
N
M
A
L
A
I
E
A
Y
E
A
T
L
V
T
P
D
S
P
F
D
L
Y
L
K
G
D
D
K
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
H
N
G
I
N
L
G
G
Q
A
Y
F
P
F
G
L
V
K
K
P
D
A
S
V
L
P
S
G
D
K
G
R
F
A
V
T
K
T
Q
S
D
E
Y
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
I
M
G
N
A
Q
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
S
G
K
Q
P
R
V
E
Y
P
L
L
P
A
S
T
E
T
T
P
R
P
A
E
-
65
Fugue
92.77
96%
-71
- C2 -
1EB7
3
CCPR_PSEAE
A:
[1-323]
------------------------
D
A
L
H
D
Q
A
S
A
L
F
K
P
I
P
E
Q
V
T
E
L
R
-------
G
Q
P
I
S
E
Q
Q
R
-
E
L
G
K
K
L
F
F
D
P
R
L
S
R
S
H
V
L
S
C
N
T
C
H
N
V
G
T
G
G
A
D
N
V
P
T
S
V
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
K
D
L
G
E
Q
A
K
G
P
I
Q
N
S
V
E
M
H
S
T
P
Q
L
V
E
Q
T
L
G
S
I
P
E
Y
V
D
A
F
R
K
A
F
P
K
A
G
K
P
V
S
F
D
N
M
A
L
A
I
E
A
Y
E
A
T
L
V
T
P
D
S
P
F
D
L
Y
L
K
G
D
D
K
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
H
N
G
I
N
L
G
G
Q
A
Y
F
P
F
G
L
V
K
K
P
D
A
D
-
K
G
R
F
A
V
T
K
T
Q
-----
S
D
E
Y
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
I
M
G
N
A
Q
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
S
G
K
Q
P
R
V
E
Y
P
L
L
P
A
S
T
E
T
T
P
R
P
A
-E
25
PsiBlast_CBE
87.11
60%
-68
- C2 -
2C1V
5
?
B:
[9-335]
-------------------------
A
L
R
E
E
A
K
G
V
F
E
A
I
P
E
K
M
T
A
I
K
QTEDNPE
G
V
P
L
T
A
E
K
I
-
E
L
G
K
V
L
F
F
D
P
R
M
S
S
S
G
L
I
S
C
Q
T
C
H
N
V
G
L
G
G
V
D
G
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
N
A
P
T
M
L
N
A
I
F
N
A
A
Q
F
W
D
G
R
A
A
D
L
A
E
Q
A
K
G
P
V
Q
A
G
V
E
M
S
N
T
P
D
Q
V
V
K
T
I
N
S
M
P
E
Y
V
E
A
F
K
A
A
F
P
E
E
A
D
P
V
T
F
D
N
F
A
A
A
I
E
Q
F
E
A
T
L
I
T
P
N
S
A
F
D
R
F
L
A
G
D
D
A
A
M
T
D
Q
E
K
R
G
L
Q
A
F
M
E
T
G
C
T
A
C
H
Y
G
V
N
F
G
G
Q
D
Y
H
P
F
G
L
I
A
K
P
G
A
E
V
L
P
A
G
D
T
G
R
F
E
V
T
R
T
T
D
D
E
Y
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
V
V
W
E
L
A
E
A
V
K
I
M
S
S
A
Q
I
G
T
E
L
T
D
Q
Q
A
E
D
I
T
A
F
L
G
T
L
T
G
E
Q
P
V
I
D
H
P
I
L
P
V
R
T
G
T
T
P
L
P
---
6
PsiBlast_PDB
86.30
64%
-73
- C2 -
1RZ6
6
?
A:
[1-322]
------------------------
D
N
L
M
E
R
A
N
S
M
F
E
P
I
P
K
Y
P
P
V
I
D
-------
G
N
E
L
T
Q
A
K
V
-
E
L
G
K
M
E
F
F
E
P
R
L
S
S
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
D
D
E
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
A
D
L
A
E
Q
A
K
G
P
V
Q
A
G
V
E
M
S
S
T
P
D
R
V
V
A
T
L
K
S
M
P
E
Y
I
E
R
F
E
D
A
F
P
G
Q
E
N
P
V
T
F
D
N
M
A
V
A
I
E
A
Y
E
A
T
L
I
T
P
E
A
P
F
D
K
Y
L
R
G
D
T
S
A
L
N
E
S
E
K
E
G
L
A
L
F
M
D
R
G
C
T
A
C
H
S
G
V
N
L
G
G
Q
N
Y
Y
P
F
G
L
V
A
K
----------
K
G
R
F
S
V
T
E
T
A
S
D
E
Y
V
F
R
A
S
P
L
R
N
I
E
L
T
A
P
Y
F
H
S
G
A
V
W
S
L
E
E
A
V
A
V
M
G
T
A
Q
L
G
T
E
L
N
N
D
E
V
K
S
I
V
A
F
L
K
T
L
T
G
N
V
P
E
V
T
Y
P
V
L
P
P
S
T
A
N
T
P
K
P
V
--
8
PsiBlast_PDB
86.24
60%
-64
- C2 -
2C1V
5
?
A:
[9-335]
-------------------------
A
L
R
E
E
A
K
G
V
F
E
A
I
P
E
K
M
T
A
I
K
QTEDNPE
G
V
P
L
T
A
E
K
I
-
E
L
G
K
V
L
F
F
D
P
R
M
S
S
S
G
L
I
S
C
Q
T
C
H
N
V
G
L
G
G
V
D
G
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
N
A
P
T
M
L
N
A
I
F
N
A
A
Q
F
W
D
G
R
A
A
D
L
A
E
Q
A
K
G
P
V
Q
A
G
V
E
M
S
N
T
P
D
Q
V
V
K
T
I
N
S
M
P
E
Y
V
E
A
F
K
A
A
F
P
E
E
A
D
P
V
T
F
D
N
F
A
A
A
I
E
Q
F
E
A
T
L
I
T
P
N
S
A
F
D
R
F
L
A
G
D
D
A
A
M
T
D
Q
E
K
R
G
L
Q
A
F
M
E
T
G
C
T
A
C
H
Y
G
V
N
F
G
G
Q
D
Y
H
P
F
G
L
I
A
K
P
G
A
E
V
L
P
A
G
D
T
G
R
F
E
V
T
R
T
T
D
D
E
Y
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
V
V
W
E
L
A
E
A
V
K
I
M
S
S
A
Q
I
G
T
E
L
T
D
Q
Q
A
E
D
I
T
A
F
L
G
T
L
T
G
E
Q
P
V
I
D
H
P
I
L
P
V
R
T
G
T
T
P
L
P
---
4
PsiBlast_PDB
85.93
64%
-71
- C2 -
1NML
6
?
A:
[1-323]
------------------------
D
N
L
M
E
R
A
N
S
M
F
E
P
I
P
K
Y
P
P
V
I
D
-------
G
N
E
L
T
Q
A
K
V
-
E
L
G
K
M
E
F
F
E
P
R
L
S
S
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
D
D
E
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
A
D
L
A
E
Q
A
K
G
P
V
Q
A
G
V
E
M
S
S
T
P
D
R
V
V
A
T
L
K
S
M
P
E
Y
I
E
R
F
E
D
A
F
P
G
Q
E
N
P
V
T
F
D
N
M
A
V
A
I
E
A
Y
E
A
T
L
I
T
P
E
A
P
F
D
K
Y
L
R
G
D
T
S
A
L
N
E
S
E
K
E
G
L
A
L
F
M
D
R
G
C
T
A
C
H
S
G
V
N
L
G
G
Q
N
Y
Y
P
F
G
L
V
A
K
----------
K
G
R
F
S
V
T
E
T
A
S
D
E
Y
V
F
R
A
S
P
L
R
N
I
E
L
T
A
P
Y
F
H
S
G
A
V
W
S
L
E
E
A
V
A
V
M
G
T
A
Q
L
G
T
E
L
N
N
D
E
V
K
S
I
V
A
F
L
K
T
L
T
G
N
V
P
E
V
T
Y
P
V
L
P
P
S
T
A
N
T
P
K
P
V
D
-
3
PsiBlast_PDB
85.89
65%
-68
- C2 -
3HQ6
3
?
A:
[22-343]
-----------------------
A
D
E
L
Q
Q
R
A
Q
G
L
F
K
P
V
P
A
K
A
P
T
L
K
-------
G
N
P
A
S
P
V
K
V
-
E
L
G
K
M
L
Y
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
G
D
L
Q
A
T
S
T
G
H
G
W
Q
K
G
P
R
N
A
P
T
V
L
N
S
V
F
N
T
A
Q
F
W
D
G
R
A
K
D
L
A
E
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
T
P
D
Q
V
V
K
T
L
N
S
I
P
D
Y
V
A
L
F
K
K
A
F
P
G
E
K
D
P
V
T
F
D
N
M
A
K
A
I
E
V
F
E
A
T
L
I
T
P
D
S
P
F
D
Q
Y
L
K
G
K
K
K
A
L
D
G
K
Q
T
A
G
L
K
L
F
L
D
K
G
C
V
A
C
H
G
G
L
N
L
G
G
T
G
Y
F
P
F
G
V
V
E
K
P
A
E
N
I
L
P
L
G
D
K
G
R
F
A
V
T
N
T
A
K
D
E
Y
V
F
R
A
P
S
L
R
N
V
A
I
T
Y
P
Y
F
H
S
G
V
V
W
S
L
K
E
A
V
A
V
M
G
S
A
Q
F
G
I
K
L
S
D
D
E
S
E
A
I
A
A
F
L
G
S
L
T
G
K
Q
P
K
V
V
Y
P
I
M
P
A
S
T
D
A
T
P
R
P
---
24
PsiBlast_CBE
85.35
64%
-73
- C2 -
3HQ8
4
?
B:
[22-343]
-----------------------
A
D
E
L
Q
Q
R
A
Q
G
L
F
K
P
V
P
A
K
A
P
T
L
K
-------
G
N
P
A
S
P
V
K
V
-
E
L
G
K
M
L
Y
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
G
D
L
Q
A
T
S
T
G
H
G
W
Q
K
G
P
R
N
A
P
T
V
L
N
S
V
F
N
T
A
Q
F
W
D
G
R
A
K
D
L
A
E
Q
A
K
G
P
V
Q
A
P
K
E
M
N
N
T
P
D
Q
V
V
K
T
L
N
S
I
P
D
Y
V
A
L
F
K
K
A
F
P
G
E
K
D
P
V
T
F
D
N
M
A
K
A
I
E
V
F
E
A
T
L
I
T
P
D
S
P
F
D
Q
Y
L
K
G
K
K
K
A
L
D
G
K
Q
T
A
G
L
K
L
F
L
D
K
G
C
V
A
C
H
G
G
L
N
L
G
G
T
G
Y
F
P
F
G
V
V
E
K
-----------
G
R
F
A
V
T
N
T
A
K
D
E
Y
V
F
R
A
P
S
L
R
N
V
A
I
T
Y
P
Y
F
H
S
G
V
V
W
S
L
K
E
A
V
A
V
M
G
S
A
Q
F
G
I
K
L
S
D
D
E
S
E
A
I
A
A
F
L
G
S
L
T
G
K
Q
P
K
V
V
Y
P
I
M
P
A
S
T
D
A
T
P
R
P
---
22
PsiBlast_CBE
85.11
65%
-74
- C2 -
3HQ6
3
?
B:
[22-343]
-----------------------
A
D
E
L
Q
Q
R
A
Q
G
L
F
K
P
V
P
A
K
A
P
T
L
K
-------
G
N
P
A
S
P
V
K
V
-
E
L
G
K
M
L
Y
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
G
D
L
Q
A
T
S
T
G
H
G
W
Q
K
G
P
R
N
A
P
T
V
L
N
S
V
F
N
T
A
Q
F
W
D
G
R
A
K
D
L
A
E
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
T
P
D
Q
V
V
K
T
L
N
S
I
P
D
Y
V
A
L
F
K
K
A
F
P
G
E
K
D
P
V
T
F
D
N
M
A
K
A
I
E
V
F
E
A
T
L
I
T
P
D
S
P
F
D
Q
Y
L
K
G
K
K
K
A
L
D
G
K
Q
T
A
G
L
K
L
F
L
D
K
G
C
V
A
C
H
G
G
L
N
L
G
G
T
G
Y
F
P
F
G
V
V
E
K
-----------
G
R
F
A
V
T
N
T
A
K
D
E
Y
V
F
R
A
P
S
L
R
N
V
A
I
T
Y
P
Y
F
H
S
G
V
V
W
S
L
K
E
A
V
A
V
M
G
S
A
Q
F
G
I
K
L
S
D
D
E
S
E
A
I
A
A
F
L
G
S
L
T
G
K
Q
P
K
V
V
Y
P
I
M
P
A
S
T
D
A
T
P
R
P
---
39
HHSearch
84.99
65%
-72
- C2 -
1NML
6
?
A:
[5-322]
----------------------------
E
R
A
N
S
M
F
E
P
I
P
K
Y
P
P
V
I
D
-------
G
N
E
L
T
Q
A
K
V
-
E
L
G
K
M
E
F
F
E
P
R
L
S
S
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
D
D
E
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
A
D
L
A
E
Q
A
K
G
P
V
Q
A
G
V
E
M
S
S
T
P
D
R
V
V
A
T
L
K
S
M
P
E
Y
I
E
R
F
E
D
A
F
P
G
Q
E
N
P
V
T
F
D
N
M
A
V
A
I
E
A
Y
E
A
T
L
I
T
P
E
A
P
F
D
K
Y
L
R
G
D
T
S
A
L
N
E
S
E
K
E
G
L
A
L
F
M
D
R
G
C
T
A
C
H
S
G
V
N
L
G
G
Q
N
Y
Y
P
F
G
L
V
A
K
----------
K
G
R
F
S
V
T
E
T
A
S
D
E
Y
V
F
R
A
S
P
L
R
N
I
E
L
T
A
P
Y
F
H
S
G
A
V
W
S
L
E
E
A
V
A
V
M
G
T
A
Q
L
G
T
E
L
N
N
D
E
V
K
S
I
V
A
F
L
K
T
L
T
G
N
V
P
E
V
T
Y
P
V
L
P
P
S
T
A
N
T
P
K
P
V
--
5
PsiBlast_PDB
84.87
64%
-77
- C2 -
1RZ5
3
?
A:
[1-323]
------------------------
D
N
L
M
E
R
A
N
S
M
F
E
P
I
P
K
Y
P
P
V
I
D
-------
G
N
E
L
T
Q
A
K
V
-
E
L
G
K
M
E
F
F
E
P
R
L
S
S
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
D
D
E
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
-------
A
K
G
P
V
Q
A
G
V
E
M
S
S
T
P
D
R
V
V
A
T
L
K
S
M
P
E
Y
I
E
R
F
E
D
A
F
P
G
Q
E
N
P
V
T
F
D
N
M
A
V
A
I
E
A
Y
E
A
T
L
I
T
P
E
A
P
F
D
K
Y
L
R
G
D
T
S
A
L
N
E
S
E
K
E
G
L
A
L
F
M
D
R
G
C
T
A
C
H
S
G
V
N
L
G
G
Q
N
Y
Y
P
F
G
L
V
A
K
----------
K
G
R
F
S
V
T
E
T
A
S
D
E
Y
V
F
R
A
S
P
L
R
N
I
E
L
T
A
P
Y
F
H
S
G
A
V
W
S
L
E
E
A
V
A
V
M
G
T
A
Q
L
G
T
E
L
N
N
D
E
V
K
S
I
V
A
F
L
K
T
L
T
G
N
V
P
E
V
T
Y
P
V
L
P
P
S
T
A
N
T
P
K
P
V
D
-
23
PsiBlast_CBE
84.05
64%
-75
- C2 -
3HQ9
10
?
B:
[21-343]
----------------------
A
A
D
E
L
Q
Q
R
A
Q
G
L
F
K
P
V
P
A
K
A
P
T
L
K
-------
G
N
P
A
S
P
V
K
V
-
E
L
G
K
M
L
Y
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
G
D
L
Q
A
T
S
T
G
H
G
W
Q
K
G
P
R
N
A
P
T
V
L
N
S
V
F
N
T
A
Q
F
W
D
G
R
A
K
D
L
--------
Q
A
P
V
E
M
N
N
T
P
D
Q
V
V
K
T
L
N
S
I
P
D
Y
V
A
L
F
K
K
A
F
P
G
E
K
D
P
V
T
F
D
N
M
A
K
A
I
E
V
F
E
A
T
L
I
T
P
D
S
P
F
D
Q
Y
L
K
G
K
K
K
A
L
D
G
K
Q
T
A
G
L
K
L
F
L
D
K
G
C
V
A
C
H
G
G
L
N
L
G
G
T
G
Y
F
P
F
G
V
V
E
K
-----------
G
R
F
A
V
T
N
T
A
K
D
E
Y
V
F
R
A
P
S
L
R
N
V
A
I
T
Y
P
Y
F
H
S
G
V
V
W
S
L
K
E
A
V
A
V
M
G
S
A
Q
F
G
I
K
L
S
D
D
E
S
E
A
I
A
A
F
L
G
S
L
T
G
K
Q
P
K
V
V
Y
P
I
M
P
A
S
T
D
A
T
P
R
P
---
29
PsiBlast_CBE
83.57
58%
-72
- C2 -
4AAL
9
?
B:
[18-338]
------------------------
E
D
V
M
K
R
A
Q
G
L
F
K
P
I
P
A
K
P
P
V
M
K
-------
D
N
P
A
S
P
S
R
V
-
E
L
G
R
M
L
F
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
T
D
I
L
E
T
S
I
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
L
N
A
V
Y
N
I
A
Q
F
W
D
G
R
A
E
D
L
A
A
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
K
P
E
N
L
V
A
T
L
K
S
I
P
G
Y
P
P
L
F
R
K
A
F
P
G
Q
G
D
P
V
T
F
D
N
V
A
K
A
I
E
V
F
E
A
T
L
V
T
P
D
A
P
F
D
K
Y
L
K
G
N
R
K
A
I
S
S
T
A
E
Q
G
L
A
L
F
L
D
K
G
C
A
A
C
H
S
G
V
N
M
G
G
T
G
Y
F
P
F
G
V
R
E
D
P
G
-----
V
D
D
T
G
R
Y
K
V
T
S
T
A
A
D
K
Y
V
F
R
S
P
S
L
R
N
V
A
I
T
M
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
D
A
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
---
10
PsiBlast_PDB
82.51
58%
-69
- C2 -
4AAL
17
?
A:
[18-338]
------------------------
E
D
V
M
K
R
A
Q
G
L
F
K
P
I
P
A
K
P
P
V
M
K
-------
D
N
P
A
S
P
S
R
V
-
E
L
G
R
M
L
F
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
T
D
I
L
E
T
S
I
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
L
N
A
V
Y
N
I
A
Q
F
W
D
G
R
A
E
D
L
A
A
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
K
P
E
N
L
V
A
T
L
K
S
I
P
G
Y
P
P
L
F
R
K
A
F
P
G
Q
G
D
P
V
T
F
D
N
V
A
K
A
I
E
V
F
E
A
T
L
V
T
P
D
A
P
F
D
K
Y
L
K
G
N
R
K
A
I
S
S
T
A
E
Q
G
L
A
L
F
L
D
K
G
C
A
A
C
H
S
G
V
N
M
G
G
T
G
Y
F
P
F
G
V
R
E
D
P
G
----
P
V
D
D
T
G
R
Y
K
V
T
S
T
A
A
D
K
Y
V
F
R
S
P
S
L
R
N
V
A
I
T
M
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
D
A
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
---
11
PsiBlast_PDB
82.39
58%
-62
- C2 -
4AAM
5
?
A:
[18-338]
------------------------
E
D
V
M
K
R
A
Q
G
L
F
K
P
I
P
A
K
P
P
V
M
K
-------
D
N
P
A
S
P
S
R
V
-
E
L
G
R
M
L
F
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
T
D
I
L
E
T
S
I
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
L
N
A
V
Y
N
I
A
Q
F
W
D
G
R
A
E
D
L
A
A
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
K
P
E
N
L
V
A
T
L
K
S
I
P
G
Y
P
P
L
F
R
K
A
F
P
G
Q
G
D
P
V
T
F
D
N
V
A
K
A
I
E
V
F
E
A
T
L
V
T
P
D
A
P
F
D
K
Y
L
K
G
N
R
K
A
I
S
S
T
A
E
Q
G
L
A
L
F
L
D
K
G
C
A
A
C
H
S
G
V
N
M
G
G
T
G
Y
F
P
F
G
V
R
E
D
P
G
P
V
V
R
P
V
D
D
T
G
R
Y
K
V
T
S
T
A
A
D
K
Y
V
F
R
S
P
S
L
R
N
V
A
I
T
M
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
D
A
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
---
7
PsiBlast_PDB
82.30
64%
-74
- C2 -
3HQ7
3
?
A:
[20-343]
---------------------F
A
A
D
E
L
Q
Q
R
A
Q
G
L
F
K
P
V
P
A
K
A
P
T
L
K
-------
G
N
P
A
S
P
V
K
V
-
E
L
G
K
M
L
Y
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
G
D
L
Q
A
T
S
T
G
H
K
W
Q
Q
G
P
I
N
A
P
T
V
L
N
S
V
F
N
T
A
-------------
A
K
G
P
V
Q
A
S
V
E
M
N
N
T
P
D
Q
V
V
K
T
L
N
S
I
P
D
Y
V
A
L
F
K
K
A
F
P
G
E
K
D
P
V
T
F
D
N
M
A
K
A
I
E
V
F
E
A
T
L
I
T
P
D
S
P
F
D
Q
Y
L
K
G
K
K
K
A
L
D
G
K
Q
T
A
G
L
K
L
F
L
D
K
G
C
V
A
C
H
G
G
L
N
L
G
G
T
G
Y
F
P
F
G
V
V
E
K
P
---------
K
G
R
F
A
V
T
N
T
A
K
D
E
Y
V
F
R
A
P
S
L
R
N
V
A
I
T
Y
P
Y
F
H
S
G
V
V
W
S
L
K
E
A
V
A
V
M
G
S
A
Q
F
G
I
K
L
S
D
D
E
S
E
A
I
A
A
F
L
G
S
L
T
G
K
Q
P
K
V
V
Y
P
I
M
P
A
S
T
D
A
T
P
R
P
---
26
PsiBlast_CBE
82.23
59%
-75
- C2 -
1ZZH
4
?
D:
[4-324]
-------------------------
A
L
R
E
E
A
K
G
L
F
E
V
I
P
M
Q
A
P
Q
------------
V
T
R
D
K
I
-
D
L
G
A
M
L
F
F
D
P
R
M
S
K
S
G
V
F
S
C
Q
S
C
H
N
V
G
L
G
G
V
D
G
L
E
T
S
I
G
H
G
W
Q
K
G
P
R
N
A
P
T
A
L
N
A
V
F
N
V
A
Q
F
W
D
G
R
A
P
D
L
A
A
Q
A
---------
M
N
N
T
P
E
N
L
V
A
T
V
Q
S
M
P
G
Y
V
E
A
F
A
K
A
F
P
G
Q
K
D
P
I
S
F
D
N
F
A
L
A
V
E
A
F
E
A
T
L
I
T
P
N
S
K
F
D
Q
W
L
M
G
A
D
G
A
M
S
A
D
E
K
A
G
L
K
L
F
I
D
T
G
C
A
A
C
H
N
G
I
N
I
G
G
N
G
Y
Y
P
F
G
V
V
E
K
P
----------
G
R
F
A
V
T
A
T
A
D
D
E
Y
V
F
R
A
G
P
L
R
N
I
A
L
T
A
P
Y
F
H
S
G
K
V
W
D
L
R
E
A
V
S
V
M
A
N
S
Q
L
G
A
T
L
D
D
T
Q
V
D
Q
I
T
A
F
L
G
T
L
T
G
E
Q
P
E
V
V
H
P
I
L
P
V
R
S
A
Q
T
P
R
P
---
28
PsiBlast_CBE
82.21
59%
-71
- C2 -
1ZZH
7
?
B:
[4-324]
-------------------------
A
L
R
E
E
A
K
G
L
F
E
V
I
P
M
Q
A
P
Q
----------
N
T
V
T
R
D
K
I
-
D
L
G
A
M
L
F
F
D
P
R
M
S
K
S
G
V
F
S
C
Q
S
C
H
N
V
G
L
G
G
V
D
G
L
E
T
S
I
G
H
G
W
Q
K
G
P
R
N
A
P
T
A
L
N
A
V
F
N
V
A
Q
F
W
D
G
R
A
P
D
L
A
A
Q
A
---------
M
N
N
T
P
E
N
L
V
A
T
V
Q
S
M
P
G
Y
V
E
A
F
A
K
A
F
P
G
Q
K
D
P
I
S
F
D
N
F
A
L
A
V
E
A
F
E
A
T
L
I
T
P
N
S
K
F
D
Q
W
L
M
G
A
D
G
A
M
S
A
D
E
K
A
G
L
K
L
F
I
D
T
G
C
A
A
C
H
N
G
I
N
I
G
G
N
G
Y
Y
P
F
G
V
V
E
K
P
G
A
E
V
L
P
--
D
K
G
R
F
A
V
T
A
T
A
D
D
E
Y
V
F
R
A
G
P
L
R
N
I
A
L
T
A
P
Y
F
H
S
G
K
V
W
D
L
R
E
A
V
S
V
M
A
N
S
Q
L
G
A
T
L
D
D
T
Q
V
D
Q
I
T
A
F
L
G
T
L
T
G
E
Q
P
E
V
V
H
P
I
L
P
V
R
S
A
Q
T
P
R
P
---
27
PsiBlast_CBE
82.09
59%
-71
- C2 -
1ZZH
4
?
C:
[4-324]
-------------------------
A
L
R
E
E
A
K
G
L
F
E
V
I
P
M
Q
A
P
Q
----------
N
T
V
T
R
D
K
I
-
D
L
G
A
M
L
F
F
D
P
R
M
S
K
S
G
V
F
S
C
Q
S
C
H
N
V
G
L
G
G
V
D
G
L
E
T
S
I
G
H
G
W
Q
K
G
P
R
N
A
P
T
A
L
N
A
V
F
N
V
A
Q
F
W
D
G
R
A
P
D
L
A
A
Q
A
---------
M
N
N
T
P
E
N
L
V
A
T
V
Q
S
M
P
G
Y
V
E
A
F
A
K
A
F
P
G
Q
K
D
P
I
S
F
D
N
F
A
L
A
V
E
A
F
E
A
T
L
I
T
P
N
S
K
F
D
Q
W
L
M
G
A
D
G
A
M
S
A
D
E
K
A
G
L
K
L
F
I
D
T
G
C
A
A
C
H
N
G
I
N
I
G
G
N
G
Y
Y
P
F
G
V
V
E
K
P
G
A
E
V
L
P
A
G
---
R
F
A
V
T
A
T
A
D
D
E
Y
V
F
R
A
G
P
L
R
N
I
A
L
T
A
P
Y
F
H
S
G
K
V
W
D
L
R
E
A
V
S
V
M
A
N
S
Q
L
G
A
T
L
D
D
T
Q
V
D
Q
I
T
A
F
L
G
T
L
T
G
E
Q
P
E
V
V
H
P
I
L
P
V
R
S
A
Q
T
P
R
P
---
9
PsiBlast_PDB
81.42
59%
-76
- C2 -
1ZZH
5
?
A:
[4-324]
-------------------------
A
L
R
E
E
A
K
G
L
F
E
V
I
P
M
Q
A
P
-------------
V
T
R
D
K
I
-
D
L
G
A
M
L
F
F
D
P
R
M
S
K
S
G
V
F
S
C
Q
S
C
H
N
V
G
L
G
G
V
D
G
L
E
T
S
I
G
H
G
W
Q
K
G
P
R
N
A
P
T
A
L
N
A
V
F
N
V
A
Q
F
W
D
G
R
A
P
D
L
A
A
Q
A
---------
M
N
N
T
P
E
N
L
V
A
T
V
Q
S
M
P
G
Y
V
E
A
F
A
K
A
F
P
G
Q
K
D
P
I
S
F
D
N
F
A
L
A
V
E
A
F
E
A
T
L
I
T
P
N
S
K
F
D
Q
W
L
M
G
A
D
G
A
M
S
A
D
E
K
A
G
L
K
L
F
I
D
T
G
C
A
A
C
H
N
G
I
N
I
G
G
N
G
Y
Y
P
F
G
V
V
E
K
P
----------
G
R
F
A
V
T
A
T
A
D
D
E
Y
V
F
R
A
G
P
L
R
N
I
A
L
T
A
P
Y
F
H
S
G
K
V
W
D
L
R
E
A
V
S
V
M
A
N
S
Q
L
G
A
T
L
D
D
T
Q
V
D
Q
I
T
A
F
L
G
T
L
T
G
E
Q
P
E
V
V
H
P
I
L
P
V
R
S
A
Q
T
P
R
P
---
30
PsiBlast_CBE
81.02
57%
-76
- C2 -
4AAO
8
?
B:
[18-338]
------------------------
E
D
V
M
K
R
A
Q
G
L
F
K
P
I
P
A
K
P
P
V
M
K
-------
D
N
P
A
S
P
S
R
V
-
E
L
G
R
M
L
F
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
T
D
I
L
E
T
S
-------
G
P
R
N
S
P
T
V
L
N
A
V
Y
N
I
A
Q
F
W
D
G
R
A
E
D
L
A
A
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
K
P
E
N
L
V
A
T
L
K
S
I
P
G
Y
P
P
L
F
R
K
A
F
P
G
Q
G
D
P
V
T
F
D
N
V
A
K
A
I
E
V
F
E
A
T
L
V
T
P
D
A
P
F
D
K
Y
L
K
G
N
R
K
A
I
S
S
T
A
E
Q
G
L
A
L
F
L
D
K
G
C
A
A
C
H
S
G
V
N
M
G
G
T
G
Y
F
P
F
G
V
R
E
D
-----------
G
R
Y
K
V
T
S
T
A
A
D
K
Y
V
F
R
S
P
S
L
R
N
V
A
I
T
M
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
D
A
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
---
13
PsiBlast_PDB
80.55
57%
-75
- C2 -
4AAO
9
?
A:
[18-338]
------------------------
E
D
V
M
K
R
A
Q
G
L
F
K
P
I
P
A
K
P
P
V
M
K
-------
D
N
P
A
S
P
S
R
V
-
E
L
G
R
M
L
F
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
T
D
I
L
E
T
S
-------
G
P
R
N
S
P
T
V
L
N
A
V
Y
N
I
A
Q
F
W
D
G
R
A
E
D
L
A
A
-
A
K
G
P
V
Q
A
S
V
E
M
N
N
K
P
E
N
L
V
A
T
L
K
S
I
P
G
Y
P
P
L
F
R
K
A
F
P
G
Q
G
D
P
V
T
F
D
N
V
A
K
A
I
E
V
F
E
A
T
L
V
T
P
D
A
P
F
D
K
Y
L
K
G
N
R
K
A
I
S
S
T
A
E
Q
G
L
A
L
F
L
D
K
G
C
A
A
C
H
S
G
V
N
M
G
G
T
G
Y
F
P
F
G
V
R
E
D
-------------
Y
K
V
T
S
T
A
A
D
K
Y
V
F
R
S
P
S
L
R
N
V
A
I
T
M
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
D
A
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
---
43
HHSearch
73.76
49%
-50
- C2 -
3O5C
3
?
A:
[20-313]
------------------------------------------------------
K
I
T
E
P
E
K
V
-
E
L
G
K
M
L
F
F
E
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
T
G
G
V
D
A
L
P
T
S
I
G
H
H
W
Q
E
G
P
I
N
S
P
T
V
L
N
A
D
F
M
L
A
Q
F
W
D
G
R
A
S
N
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
G
F
T
H
E
L
A
T
E
T
I
A
S
M
P
A
Y
R
A
R
F
A
K
V
Y
G
D
E
K
--
V
D
I
D
R
L
T
D
A
I
A
A
F
E
K
T
L
V
T
P
N
S
P
F
D
Q
Y
L
L
G
K
Q
D
A
I
S
G
D
A
K
A
G
Y
Q
L
F
K
D
K
G
C
V
S
C
H
N
G
P
A
V
G
G
T
M
F
M
K
M
G
L
I
K
P
F
H
---
T
N
N
P
A
E
G
R
K
G
V
T
G
K
D
A
D
K
F
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
T
M
A
D
I
Q
L
G
Q
K
L
T
E
K
E
T
K
E
M
V
A
F
L
N
S
L
T
G
E
Q
P
Q
I
S
L
P
I
L
P
P
S
N
K
E
T
P
R
P
V
--
32
PsiBlast_CBE
73.46
49%
-54
- C2 -
3O5C
4
?
C:
[21-312]
--------------------------------------------------------
I
T
E
P
E
K
V
E
L
G
K
M
L
F
F
E
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
T
G
G
V
D
A
L
P
T
S
I
G
H
H
W
Q
E
G
P
I
N
S
P
T
V
L
N
A
D
F
M
L
A
Q
F
W
D
G
R
A
S
N
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
G
F
T
H
E
L
A
T
E
T
I
A
S
M
P
A
Y
R
A
R
F
A
K
V
Y
--
G
D
E
K
V
D
I
D
R
L
T
D
A
I
A
A
F
E
K
T
L
V
T
P
N
S
P
F
D
Q
Y
L
L
G
K
Q
D
A
I
S
G
D
A
K
A
G
Y
Q
L
F
K
D
K
G
C
V
S
C
H
N
G
P
A
V
G
G
T
M
F
M
K
M
G
L
I
-
K
P
F
H
T
N
N
P
A
--
E
G
R
K
G
V
T
G
K
D
A
D
K
F
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
T
M
A
D
I
Q
L
G
Q
K
L
T
E
K
E
T
K
E
M
V
A
F
L
N
S
L
T
G
E
Q
P
Q
I
S
L
P
I
L
P
P
S
N
K
E
T
P
R
P
---
14
PsiBlast_PDB
73.26
49%
-54
- C2 -
3O5C
3
?
A:
[21-312]
--------------------------------------------------------
I
T
E
P
E
K
V
E
L
G
K
M
L
F
F
E
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
T
G
G
V
D
A
L
P
T
S
I
G
H
H
W
Q
E
G
P
I
N
S
P
T
V
L
N
A
D
F
M
L
A
Q
F
W
D
G
R
A
S
N
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
G
F
T
H
E
L
A
T
E
T
I
A
S
M
P
A
Y
R
A
R
F
A
K
V
Y
--
G
D
E
K
V
D
I
D
R
L
T
D
A
I
A
A
F
E
K
T
L
V
T
P
N
S
P
F
D
Q
Y
L
L
G
K
Q
D
A
I
S
G
D
A
K
A
G
Y
Q
L
F
K
D
K
G
C
V
S
C
H
N
G
P
A
V
G
G
T
M
F
M
K
M
G
L
I
-
K
P
F
H
T
N
N
P
A
--
E
G
R
K
G
V
T
G
K
D
A
D
K
F
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
T
M
A
D
I
Q
L
G
Q
K
L
T
E
K
E
T
K
E
M
V
A
F
L
N
S
L
T
G
E
Q
P
Q
I
S
L
P
I
L
P
P
S
N
K
E
T
P
R
P
---
42
HHSearch
72.92
48%
-50
- C2 -
1IQC
5
CCPR_NITEU
A:
[12-304]
------------------------------------------------------
T
P
E
N
A
D
M
A
-
E
L
G
K
M
L
F
F
D
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
M
G
G
T
D
N
I
T
T
S
I
G
H
K
W
Q
Q
G
P
I
N
A
P
T
V
L
N
S
S
M
N
L
A
Q
F
W
D
G
R
A
K
D
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
A
S
T
H
E
I
A
E
K
V
V
A
S
M
P
Q
Y
R
E
R
F
K
K
V
F
G
S
D
--
E
V
T
I
D
R
I
T
T
A
I
A
Q
F
E
E
T
L
V
T
P
G
S
K
F
D
K
W
L
E
G
D
K
N
A
L
N
Q
D
E
L
E
G
Y
N
L
F
K
G
S
G
C
V
Q
C
H
N
G
P
A
V
G
G
S
S
Y
Q
K
M
G
V
F
K
P
Y
E
---
T
K
N
P
A
A
G
R
M
D
V
T
G
N
E
A
D
R
N
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
G
A
A
T
L
E
Q
A
V
E
T
M
G
R
I
Q
L
N
R
E
F
N
K
D
E
V
S
K
I
V
A
F
L
K
T
L
T
G
D
Q
P
D
F
K
L
P
I
L
P
P
S
N
N
D
T
P
R
S
---
35
PsiBlast_CBE
72.90
48%
-48
- C2 -
1IQC
3
CCPR_NITEU
C:
[13-303]
-------------------------------------------------------
P
E
N
A
D
M
A
-
E
L
G
K
M
L
F
F
D
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
M
G
G
T
D
N
I
T
T
S
I
G
H
K
W
Q
Q
G
P
I
N
A
P
T
V
L
N
S
S
M
N
L
A
Q
F
W
D
G
R
A
K
D
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
A
S
T
H
E
I
A
E
K
V
V
A
S
M
P
Q
Y
R
E
R
F
K
K
V
F
--
G
S
D
E
V
T
I
D
R
I
T
T
A
I
A
Q
F
E
E
T
L
V
T
P
G
S
K
F
D
K
W
L
E
G
D
K
N
A
L
N
Q
D
E
L
E
G
Y
N
L
F
K
G
S
G
C
V
Q
C
H
N
G
P
A
V
G
G
S
S
Y
Q
K
M
G
-
V
F
K
P
Y
E
T
K
N
P
A
A
--
G
R
M
D
V
T
G
N
E
A
D
R
N
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
G
A
A
T
L
E
Q
A
V
E
T
M
G
R
I
Q
L
N
R
E
F
N
K
D
E
V
S
K
I
V
A
F
L
K
T
L
T
G
D
Q
P
D
F
K
L
P
I
L
P
P
S
N
N
D
T
P
R
----
36
PsiBlast_CBE
72.81
48%
-46
- C2 -
1IQC
4
CCPR_NITEU
B:
[13-303]
-------------------------------------------------------
P
E
N
A
D
M
A
-
E
L
G
K
M
L
F
F
D
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
M
G
G
T
D
N
I
T
T
S
I
G
H
K
W
Q
Q
G
P
I
N
A
P
T
V
L
N
S
S
M
N
L
A
Q
F
W
D
G
R
A
K
D
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
A
S
T
H
E
I
A
E
K
V
V
A
S
M
P
Q
Y
R
E
R
F
K
K
V
F
--
G
S
D
E
V
T
I
D
R
I
T
T
A
I
A
Q
F
E
E
T
L
V
T
P
G
S
K
F
D
K
W
L
E
G
D
K
N
A
L
N
Q
D
E
L
E
G
Y
N
L
F
K
G
S
G
C
V
Q
C
H
N
G
P
A
V
G
G
S
S
Y
Q
K
M
G
-
V
F
K
P
Y
E
T
K
N
P
A
A
--
G
R
M
D
V
T
G
N
E
A
D
R
N
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
G
A
A
T
L
E
Q
A
V
E
T
M
G
R
I
Q
L
N
R
E
F
N
K
D
E
V
S
K
I
V
A
F
L
K
T
L
T
G
D
Q
P
D
F
K
L
P
I
L
P
P
S
N
N
D
T
P
R
----
34
PsiBlast_CBE
72.64
48%
-49
- C2 -
1IQC
4
CCPR_NITEU
D:
[13-303]
-------------------------------------------------------
P
E
N
A
D
M
A
-
E
L
G
K
M
L
F
F
D
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
M
G
G
T
D
N
I
T
T
S
I
G
H
K
W
Q
Q
G
P
I
N
A
P
T
V
L
N
S
S
M
N
L
A
Q
F
W
D
G
R
A
K
D
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
A
S
T
H
E
I
A
E
K
V
V
A
S
M
P
Q
Y
R
E
R
F
K
K
V
F
--
G
S
D
E
V
T
I
D
R
I
T
T
A
I
A
Q
F
E
E
T
L
V
T
P
G
S
K
F
D
K
W
L
E
G
D
K
N
A
L
N
Q
D
E
L
E
G
Y
N
L
F
K
G
S
G
C
V
Q
C
H
N
G
P
A
V
G
G
S
S
Y
Q
K
M
G
-
V
F
K
P
Y
E
T
K
N
P
A
A
--
G
R
M
D
V
T
G
N
E
A
D
R
N
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
G
A
A
T
L
E
Q
A
V
E
T
M
G
R
I
Q
L
N
R
E
F
N
K
D
E
V
S
K
I
V
A
F
L
K
T
L
T
G
D
Q
P
D
F
K
L
P
I
L
P
P
S
N
N
D
T
P
R
----
15
PsiBlast_PDB
72.63
48%
-50
- C2 -
1IQC
5
CCPR_NITEU
A:
[13-303]
-------------------------------------------------------
P
E
N
A
D
M
A
-
E
L
G
K
M
L
F
F
D
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
M
G
G
T
D
N
I
T
T
S
I
G
H
K
W
Q
Q
G
P
I
N
A
P
T
V
L
N
S
S
M
N
L
A
Q
F
W
D
G
R
A
K
D
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
A
S
T
H
E
I
A
E
K
V
V
A
S
M
P
Q
Y
R
E
R
F
K
K
V
F
--
G
S
D
E
V
T
I
D
R
I
T
T
A
I
A
Q
F
E
E
T
L
V
T
P
G
S
K
F
D
K
W
L
E
G
D
K
N
A
L
N
Q
D
E
L
E
G
Y
N
L
F
K
G
S
G
C
V
Q
C
H
N
G
P
A
V
G
G
S
S
Y
Q
K
M
G
-
V
F
K
P
Y
E
T
K
N
P
A
A
--
G
R
M
D
V
T
G
N
E
A
D
R
N
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
G
A
A
T
L
E
Q
A
V
E
T
M
G
R
I
Q
L
N
R
E
F
N
K
D
E
V
S
K
I
V
A
F
L
K
T
L
T
G
D
Q
P
D
F
K
L
P
I
L
P
P
S
N
N
D
T
P
R
----
31
PsiBlast_CBE
72.31
49%
-55
- C2 -
3O5C
3
?
D:
[21-312]
--------------------------------------------------------
I
T
E
P
E
K
V
E
L
G
K
M
L
F
F
E
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
T
G
G
V
D
A
L
P
T
S
I
G
H
H
W
Q
E
G
P
I
N
S
P
T
V
L
N
A
D
F
M
L
A
Q
F
W
D
G
R
A
S
N
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
G
F
T
H
E
L
A
T
E
T
I
A
S
M
P
A
Y
R
A
R
F
A
K
V
Y
--
G
D
E
K
V
D
I
D
R
L
T
D
A
I
A
A
F
E
K
T
L
V
T
P
N
S
P
F
D
Q
Y
L
L
G
K
Q
D
A
I
S
G
D
A
K
A
G
Y
Q
L
F
K
D
K
G
C
V
S
C
H
N
G
P
A
V
G
G
T
M
F
M
K
M
G
L
I
-
K
P
F
H
T
N
N
P
A
--
E
G
R
K
G
V
T
G
K
D
A
D
K
F
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
T
M
A
D
I
Q
L
G
Q
K
L
T
E
K
E
T
K
E
M
V
A
F
L
N
S
L
T
G
E
Q
P
Q
I
S
L
P
I
L
P
P
S
N
K
E
T
P
R
P
---
66
Fugue
66.06
100%
-65
- C2 -
1EB7
3
CCPR_PSEAE
A:
[1-170]
------------------------
D
A
L
H
D
Q
A
S
A
L
F
K
P
I
P
E
Q
V
T
E
L
R
-------
G
Q
P
I
S
E
Q
Q
R
-
E
L
G
K
K
L
F
F
D
P
R
L
S
R
S
H
V
L
S
C
N
T
C
H
N
V
G
T
G
G
A
D
N
V
P
T
S
V
G
H
G
W
Q
K
G
P
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
K
D
L
G
E
Q
A
K
G
P
I
Q
N
S
V
E
M
H
S
T
P
Q
L
V
E
Q
T
L
G
S
I
P
E
Y
V
D
A
F
R
K
A
F
P
K
A
G
K
P
V
S
F
D
N
M
A
L
A
I
E
A
Y
E
A
T
L
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Fugue
65.32
90%
-89
- C2 -
1EB7
3
CCPR_PSEAE
A:
[165-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
D
S
P
F
D
L
Y
L
K
G
D
D
K
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
H
N
G
I
N
L
G
G
Q
A
Y
F
P
F
G
L
V
K
K
P
D
A
D
-
K
G
R
F
A
V
T
K
T
Q
----
S
D
E
Y
-
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
I
M
G
N
A
Q
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
S
G
K
Q
P
R
V
E
Y
P
L
L
P
A
S
T
E
T
T
P
R
P
A
-E