@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4615: (2016-02-29 )
MTASEEKFTRQTLLDVQPLTPNLFTLRTSRDAGFRFRAGQFARLGVYKPSGSIVWRAYSMVSAPHDEFLDFFSIVVPDGEFTSELSRLREGDQLLVDRQAFGFLTLDRFVDGRDLWLLATGTGVAPFVSILQDFEVWERFESIKLVYSVRESKELAYRELIAGLAEREYLAEHAHKLQFIPVVTREQVPGCLNGRITTLIENGDLERAADLELTPEHSRVMLCGNPQMIEDTRAVLKARGMNLSLTRRPGQVAVENYW
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........70......---------..80........90......-.-.100.......110.......120.......130.......140.......150.....-..160-.-......170..-------.-....180.......190.......200...-....210-........220.......230.....-..-240...-....250......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTA
S
E
E
K
F
T
R
Q
TLLDVQPLTP
N
L
F
T
L
RTSRDAG
F
R
FRAG
Q
F
A
R
L
G
V
YKPSG
S
I
V
W
R
A
Y
S
M
VSA
P
H
D
E
F
L
D
F
F
S
I
VVP---------D
G
E
F
T
S
E
L
S
R
LREGD
Q
L
L
V
D
-
R
-QA
F
G
F
L
T
L
D
R
FVDG
R
D
L
W
L
L
ATGT
G
V
A
P
F
V
S
I
L
Q
D
F
E
V
W
E
R
F
E
S
I
K
L
V
Y
S
V
R
E
S
K
E
L
A
Y
-
R
E
L
I
A
-
G
-
L
A
E
R
E
Y
L
A
E
H
A-------H-K
L
Q
F
I
P
V
V
T
R
EQVPGCLN
G
R
I
T
T
L
I
ENGDL-ERAAD-L-ELTPEH
S
R
V
M
LCGN
P
Q
M
I
E
D
T
R
A
V
L
K
-AR-GM
N
L
S
L
-TRRPG
Q
V
AVENYW
21
PsiBlast_CBE
94.56
43%
-128
- C3 -
3FPK
3
?
B:
[15-251]
---------------
V
Q
N
W
T
D
A
L
F
S
L
-
T
V
H
A
P
I
N
P
F
T
A
G
Q
F
T
K
L
G
L
-
E
I
D
G
E
R
V
Q
R
A
Y
S
Y
V
N
A
P
D
N
P
N
L
E
F
Y
L
V
T
V
P
---------
Q
G
K
L
S
P
R
L
A
A
L
K
P
G
D
E
V
Q
V
V
-
S
-
D
A
S
G
F
F
V
L
D
E
V
P
D
C
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
Q
Y
G
Q
D
V
A
R
F
K
N
L
V
L
V
H
A
A
R
F
A
A
D
L
S
Y
-
L
P
L
M
L
-
E
-
L
Q
Q
R
-----
Y
E
-------
G
-
K
L
R
I
Q
T
V
V
S
R
E
N
V
P
G
S
L
T
G
R
V
P
A
L
I
E
N
G
E
L
-
E
K
A
V
G
-
L
-
P
M
D
K
E
T
S
H
V
M
L
C
G
N
P
Q
M
V
R
D
T
Q
Q
L
L
K
E
T
R
-
Q
M
T
K
H
L
-
R
R
R
P
G
H
M
T
A
E
H
Y
W
1
PsiBlast_PDB
94.49
43%
-128
- C3 -
3FPK
2
?
A:
[15-251]
---------------
V
Q
N
W
T
D
A
L
F
S
L
-
T
V
H
A
P
I
N
P
F
T
A
G
Q
F
T
K
L
G
L
-
E
I
D
G
E
R
V
Q
R
A
Y
S
Y
V
N
A
P
D
N
P
N
L
E
F
Y
L
V
T
V
P
---------
Q
G
K
L
S
P
R
L
A
A
L
K
P
G
D
E
V
Q
V
V
-
S
-
D
A
S
G
F
F
V
L
D
E
V
P
D
C
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
Q
Y
G
Q
D
V
A
R
F
K
N
L
V
L
V
H
A
A
R
F
A
A
D
L
S
Y
-
L
P
L
M
L
-
E
-
L
Q
Q
R
-----
Y
E
-------
G
-
K
L
R
I
Q
T
V
V
S
R
E
N
V
P
G
S
L
T
G
R
V
P
A
L
I
E
N
G
E
L
-
E
K
A
V
G
-
L
-
P
M
D
K
E
T
S
H
V
M
L
C
G
N
P
Q
M
V
R
D
T
Q
Q
L
L
K
E
T
R
-
Q
M
T
K
H
L
-
R
R
R
P
G
H
M
T
A
E
H
Y
W
55
HHSearch
93.23
41%
-122
- C3 -
1FDR
1
FENR_ECOLI
A:
[2-248]
-----
A
D
W
V
T
G
K
V
T
K
V
Q
N
W
T
D
A
L
F
S
L
T
V
H
A
P
-
V
L
P
F
T
A
G
Q
F
T
K
L
G
L
E
I
----
R
V
Q
R
A
Y
S
Y
V
N
S
P
D
N
P
D
L
E
F
Y
L
V
T
V
P
---------
D
G
K
L
S
P
R
L
A
A
L
K
P
G
D
E
V
Q
V
V
-
S
-
E
A
A
G
F
F
V
L
D
E
V
P
H
C
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
R
L
G
K
D
L
D
R
F
K
N
L
V
L
V
H
A
A
R
Y
A
A
D
L
S
Y
-
L
P
L
M
Q
-
E
-
L
E
K
R
-----
Y
E
-------
G
-
K
L
R
I
Q
T
V
V
S
R
E
T
A
A
G
S
L
T
G
R
I
P
A
L
I
E
S
G
E
L
-
E
S
T
I
G
-
L
-
P
M
N
K
E
T
S
H
V
M
L
C
G
N
P
Q
M
V
R
D
T
Q
Q
L
L
K
-
E
T
R
Q
M
T
K
H
L
-
R
R
R
P
G
H
M
T
A
E
H
Y
W
2
PsiBlast_PDB
92.36
42%
-117
- C3 -
2QDX
2
?
A:
[6-251]
----------
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
G
L
R
F
K
T
G
Q
F
V
M
I
G
L
-
E
V
D
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
-
R
-
K
P
T
G
T
L
V
H
D
D
L
L
P
G
K
H
L
Y
L
L
S
T
G
T
G
M
A
P
F
L
S
V
I
Q
D
P
E
T
Y
E
R
Y
E
K
V
I
L
V
H
G
V
R
W
V
S
E
L
A
Y
-
A
D
F
I
T
-
K
V
L
P
E
H
E
Y
F
G
D
Q
V
K
------
E
-
K
L
I
Y
Y
P
L
V
T
R
E
--
P
F
R
N
Q
G
R
Q
T
D
L
M
R
S
G
K
L
F
E
D
I
G
L
-
P
-
P
M
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
E
E
T
S
A
V
L
D
-
S
F
-
G
L
K
I
S
P
R
M
G
E
P
G
D
Y
L
I
E
---
3
PsiBlast_PDB
91.85
42%
-117
- C3 -
3CRZ
2
?
A:
[6-251]
----------
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
G
L
R
F
K
T
G
Q
F
V
M
I
G
L
-
E
V
D
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
-
R
-
K
P
T
G
T
L
V
H
D
D
L
L
P
G
K
H
L
Y
L
L
S
T
G
T
G
M
A
P
F
L
S
V
I
Q
D
P
E
T
Y
E
R
Y
E
K
V
I
L
V
H
G
V
R
W
V
S
E
L
A
Y
-
A
D
F
I
T
-
K
V
L
P
E
H
E
Y
F
G
D
Q
V
K
------
E
-
K
L
I
Y
Y
P
L
V
T
R
E
--
P
F
R
N
Q
G
R
Q
T
D
L
M
R
S
G
K
L
F
E
D
I
G
L
-
P
-
P
M
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
E
E
T
S
A
V
L
D
-
S
F
-
G
L
K
I
S
P
R
M
G
E
P
G
D
Y
L
I
E
---
23
PsiBlast_CBE
91.44
39%
-125
- C3 -
2XNJ
12
FENR_ECOLI
B:
[22-266]
---------------
V
Q
N
W
T
D
A
L
F
S
L
-
T
V
H
A
P
V
L
P
F
T
A
G
Q
F
T
K
L
G
L
-
E
I
D
G
E
R
V
Q
R
A
Y
S
Y
V
N
S
P
D
N
P
D
L
E
F
Y
L
V
T
V
V
YTNDAGEVV
K
G
K
L
S
P
R
L
A
A
L
K
P
G
D
E
V
Q
V
V
-
S
-
E
A
A
G
F
F
V
L
D
E
V
P
H
C
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
R
L
G
K
D
L
D
R
F
K
N
L
V
L
V
H
A
A
R
Y
A
A
D
L
S
Y
-
L
P
L
M
Q
-
E
-
L
E
K
R
-----
Y
E
-------
G
-
K
L
R
I
Q
T
V
V
S
R
E
T
A
A
G
S
L
T
G
R
I
P
A
L
I
E
S
G
E
L
-
E
S
T
I
G
-
L
-
P
M
N
K
E
T
S
H
V
M
L
C
G
N
P
Q
M
V
R
D
T
Q
Q
L
L
K
E
T
R
-
Q
M
T
K
H
------
G
H
M
T
A
E
H
Y
-
9
PsiBlast_PDB
91.40
39%
-124
- C3 -
2XNJ
10
FENR_ECOLI
A:
[22-266]
---------------
V
Q
N
W
T
D
A
L
F
S
L
-
T
V
H
A
P
V
L
P
F
T
A
G
Q
F
T
K
L
G
L
-
E
I
D
G
E
R
V
Q
R
A
Y
S
Y
V
N
S
P
D
N
P
D
L
E
F
Y
L
V
T
V
V
Y
T
N
DAG
E
V
V
K
G
K
L
S
P
R
L
A
A
L
K
P
G
D
E
V
Q
V
V
-
S
-
E
A
A
G
F
F
V
L
D
E
V
P
H
C
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
R
L
G
K
D
L
D
R
F
K
N
L
V
L
V
H
A
A
R
Y
A
A
D
L
S
Y
-
L
P
L
M
Q
-
E
-
L
E
K
R
-----
Y
E
-------
G
-
K
L
R
I
Q
T
V
V
S
R
E
T
A
A
G
S
L
T
G
R
I
P
A
L
I
E
S
G
E
L
-
E
S
T
I
G
-
L
-
P
M
N
K
E
T
S
H
V
M
L
C
G
N
P
Q
M
V
R
D
T
Q
Q
L
L
K
E
T
R
-
Q
M
T
K
H
L
-
R
R
R
P
G
H
M
T
A
E
H
Y
-
7
PsiBlast_PDB
91.33
41%
-125
- C3 -
4B4D
2
?
A:
[8-244]
-------
F
G
A
E
T
V
L
E
V
R
H
W
T
D
A
Y
F
S
F
T
T
T
R
D
A
G
F
R
F
E
N
G
Q
F
V
M
I
G
L
E
T
E
T
R
P
L
L
-
R
A
Y
S
I
A
S
A
N
W
E
E
H
L
E
F
F
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
Q
P
G
D
K
V
L
V
G
-
K
-
K
P
T
G
T
L
L
I
S
D
L
H
P
G
R
N
L
Y
L
L
G
T
G
T
G
L
A
P
W
L
S
I
I
K
D
P
E
T
Y
E
R
F
D
K
V
I
L
T
Q
G
V
R
F
V
Q
D
L
A
Y
-
R
D
Y
F
E
R
E
-
L
P
Q
H
E
F
L
G
D
L
L
R
------
E
-
K
L
L
Y
Y
P
A
V
T
R
E
T
F
A
N
--
Q
G
R
L
T
E
L
M
A
D
G
R
M
-
Q
Q
T
L
G
-
L
P
T
L
D
P
A
N
D
R
F
M
I
C
G
S
P
Q
M
L
A
D
L
R
S
L
L
D
-
S
R
-
G
F
Q
T
S
---------------
4
PsiBlast_PDB
91.24
41%
-126
- C3 -
1FDR
1
FENR_ECOLI
A:
[12-248]
---------------
V
Q
N
W
T
D
A
L
F
S
L
-
T
V
H
A
P
V
L
P
F
T
A
G
Q
F
T
K
L
G
L
-
E
I
---
R
V
Q
R
A
Y
S
Y
V
N
S
P
D
N
P
D
L
E
F
Y
L
V
T
V
P
---------
D
G
K
L
S
P
R
L
A
A
L
K
P
G
D
E
V
Q
V
V
-
S
-
E
A
A
G
F
F
V
L
D
E
V
P
H
C
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
R
L
G
K
D
L
D
R
F
K
N
L
V
L
V
H
A
A
R
Y
A
A
D
L
S
Y
-
L
P
L
M
Q
-
E
-
L
E
K
R
-----
Y
E
-------
G
-
K
L
R
I
Q
T
V
V
S
R
E
T
A
A
G
S
L
T
G
R
I
P
A
L
I
E
S
G
E
L
-
E
S
T
I
G
-
L
-
P
M
N
K
E
T
S
H
V
M
L
C
G
N
P
Q
M
V
R
D
T
Q
Q
L
L
K
E
T
R
-
Q
M
T
K
H
L
-
R
R
R
P
G
H
M
T
A
E
H
Y
W
61
HHSearch
91.00
41%
-115
* C3 *
2QDX
2
?
A:
[2-242]
------
N
L
Y
T
E
R
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
G
L
R
F
K
T
G
Q
F
V
M
I
G
L
E
V
-
D
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
R
K
-
P
T
G
T
L
V
H
D
D
L
L
-
P
G
K
H
L
Y
L
L
S
T
G
T
G
M
A
P
F
L
S
V
I
Q
D
P
E
T
Y
E
R
Y
E
K
V
I
L
V
H
G
V
R
W
V
S
E
L
A
Y
-
A
D
F
I
T
-
K
-
V
L
P
E
-----
H
E
YF
G
D
Q
V
K
E
-
K
L
I
Y
Y
P
L
V
T
R
E
P
--
F
R
N
Q
G
R
Q
T
D
L
M
R
S
G
K
L
-
F
E
D
I
G
-
L
P
P
M
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
E
E
T
S
A
V
L
D
-
S
F
-
G
L
K
I
S
P
-
R
M
-----------
8
PsiBlast_PDB
90.42
39%
-120
- C3 -
1A8P
1
FENR_AZOVI
A:
[9-252]
------------
V
L
S
V
H
H
W
N
D
T
L
F
S
F
K
T
T
R
N
P
S
L
R
F
E
N
G
Q
F
V
M
I
G
L
-
E
V
D
G
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
---------
N
G
P
L
T
S
R
L
Q
H
L
K
E
G
D
E
L
M
V
S
-
R
-
K
P
T
G
T
L
V
T
S
D
L
L
P
G
K
H
L
Y
M
L
S
T
G
T
G
L
A
P
F
M
S
L
I
Q
D
P
E
V
Y
E
R
F
E
K
V
V
L
I
H
G
V
R
Q
V
N
E
L
A
Y
-
Q
Q
F
I
T
E
H
-
L
P
Q
S
E
Y
F
G
E
A
V
K
------
E
-
K
L
I
Y
Y
P
T
V
T
R
E
S
F
H
N
--
Q
G
R
L
T
D
L
M
R
S
G
K
L
-
F
E
D
I
G
-
L
P
P
I
N
P
Q
D
D
R
A
M
I
C
G
S
P
S
M
L
D
E
S
C
E
V
L
D
-
G
F
-
G
L
K
I
S
P
R
M
G
E
P
G
D
Y
L
I
E
---
26
PsiBlast_CBE
89.38
35%
-118
- C3 -
2VNK
2
?
C:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
25
PsiBlast_CBE
89.26
35%
-118
- C3 -
2VNK
2
?
D:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
29
PsiBlast_CBE
88.98
35%
-117
- C3 -
2BGJ
1
?
C:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
27
PsiBlast_CBE
88.91
35%
-118
- C3 -
2VNK
2
?
B:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
15
PsiBlast_PDB
88.63
35%
-118
- C3 -
2VNK
2
?
A:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
24
PsiBlast_CBE
88.43
35%
-114
- C3 -
4K1X
1
?
B:
[4-251]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
Y
-
14
PsiBlast_PDB
88.41
35%
-119
- C3 -
2VNJ
3
?
A:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
30
PsiBlast_CBE
87.35
35%
-115
- C3 -
2BGJ
1
?
B:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
13
PsiBlast_PDB
87.32
35%
-115
- C3 -
2VNI
3
?
A:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
11
PsiBlast_PDB
87.31
35%
-117
- C3 -
2BGJ
1
?
A:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
22
PsiBlast_CBE
86.83
39%
-117
- C3 -
4FK8
1
?
B:
[17-266]
-----
S
K
F
D
T
A
T
V
L
S
V
H
H
W
T
D
T
L
F
S
F
T
C
T
R
D
Q
A
L
R
F
N
N
G
E
F
T
M
V
G
L
-
E
V
D
G
K
P
L
T
R
A
Y
S
I
V
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
---------
N
G
P
L
T
S
R
L
Q
H
L
K
V
G
D
P
V
L
I
G
-
K
-
K
P
T
G
T
L
V
A
D
N
L
L
P
G
K
T
L
W
M
L
S
T
G
T
G
L
A
P
F
M
S
I
I
R
D
P
D
I
Y
E
R
F
D
K
V
V
L
T
H
T
C
R
L
K
G
E
L
A
Y
-
M
D
Y
I
K
H
D
-
L
P
G
H
E
Y
L
G
D
V
I
R
------
E
-
K
L
V
Y
Y
P
T
V
-----------
R
I
T
D
L
I
A
S
G
K
L
-
F
T
D
L
D
-
M
P
P
F
S
P
E
Q
D
R
V
M
L
C
G
S
T
A
M
L
K
D
T
T
E
L
L
K
-
K
A
-
G
L
V
E
G
K
-
N
S
A
P
G
H
Y
V
I
E
---
28
PsiBlast_CBE
86.82
35%
-115
- C3 -
2BGJ
1
?
D:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
6
PsiBlast_PDB
86.56
39%
-113
- C3 -
4FK8
1
?
A:
[18-266]
------
K
F
D
T
A
T
V
L
S
V
H
H
W
T
D
T
L
F
S
F
T
C
T
R
D
Q
A
L
R
F
N
N
G
E
F
T
M
V
G
L
-
E
V
D
G
K
P
L
T
R
A
Y
S
I
V
S
P
N
Y
E
E
H
L
E
F
F
S
I
K
V
Q
---------
N
G
P
L
T
S
R
L
Q
H
L
K
V
G
D
P
V
L
I
G
-
K
-
K
P
T
G
T
L
V
A
D
N
L
L
P
G
K
T
L
W
M
L
S
T
G
T
G
L
A
P
F
M
S
I
I
R
D
P
D
I
Y
E
R
F
D
K
V
V
L
T
H
T
C
R
L
K
G
E
L
A
Y
-
M
D
Y
I
K
H
D
-
L
P
G
H
E
Y
L
G
D
V
I
R
------
E
-
K
L
V
Y
Y
P
T
V
---------
E
G
R
I
T
D
L
I
A
S
G
K
L
-
F
T
D
L
D
-
M
P
P
F
S
P
E
Q
D
R
V
M
L
C
G
S
T
A
M
L
K
D
T
T
E
L
L
K
-
K
A
-
G
L
V
E
G
K
-
N
S
A
P
G
H
Y
V
I
E
---
12
PsiBlast_PDB
86.01
35%
-114
- C3 -
2VNH
3
?
A:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
10
PsiBlast_PDB
85.84
35%
-114
- C3 -
2BGI
7
?
A:
[19-265]
----------
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
-
K
P
V
G
T
L
V
I
D
A
L
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
G
R
Q
L
V
E
-
A
-
L
Q
E
D
P
L
I
G
E
L
V
-------
E
G
K
L
K
Y
Y
P
T
T
T
R
E
E
F
H
H
M
--
G
R
I
T
D
N
L
A
S
G
K
V
F
E
D
L
G
I
-
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
--
60
HHSearch
81.91
32%
-104
- C3 -
2BGI
7
?
A:
[16-267]
-------
P
D
A
Q
T
V
T
S
V
R
H
W
T
D
T
L
F
S
F
R
V
T
R
P
Q
T
L
R
F
R
S
G
E
F
V
M
I
G
L
L
D
D
N
G
K
P
I
M
R
A
Y
S
I
A
S
P
A
W
D
E
E
L
E
F
Y
S
I
K
V
P
---------
D
G
P
L
T
S
R
L
Q
H
I
K
V
G
E
Q
I
I
L
R
-
P
K
P
V
G
T
L
V
I
D
A
L
-
L
P
G
K
R
L
W
F
L
A
T
G
T
G
I
A
P
F
A
S
L
M
R
E
P
E
A
Y
E
K
F
D
E
V
I
M
M
H
A
C
R
T
V
A
E
L
E
Y
-
G
R
Q
L
V
-
E
-
A
L
Q
E
-----
D
P
LIGELVE
G
-
K
L
K
Y
Y
P
T
T
T
R
E
E
--
F
H
H
M
G
R
I
T
D
N
L
A
S
G
K
V
-
F
E
D
L
G
I
A
-
P
M
N
P
E
T
D
R
A
M
V
C
G
S
L
A
F
N
V
D
V
M
K
V
L
E
-
S
Y
-
G
L
R
E
G
A
-
N
S
E
P
R
E
F
V
V
E
K
A
F