@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4694: (2016-02-29 )
MRVFYDKDCDLSIIQGKKVAIIGYGSQGHAHACNLKDSGVDVTVGLRSGSATVAKAEAHGLKVADVKTAVAAADVVMILTPDEFQGRLYKEEIEPNLKKGATLAFAHGFSIHYNQVVPRADLDVIMIAPKAPGHTVRSEFVKGGGIPDLIAIYQDASGNAKNVALSYACGVGGGRTGIIETTFKDETETDLFGEQAVLCGGCVELVKAGFETLVEAGYAPEMAYFECLHELKLIVDLMYEGGIANMNYSISNNAEYGEYVTGPEVINAESRAAMRNALKRIQDGEYAKMFITEGAANYPSMTAYRRNNAAHPIEQIGEKLRAMMPWIAANKIVDKSKN
Atome Classification :
(22 SA)
.........10.....-...20........30.......------.40......-----..50----.........60.-----.-----......70........80........90........100.......110...---.----...120.......130.......140.-----......150.--......160.......170.......180.......190.......200.......----210.......220.......230-....-....240.......250.......260.......270------........280.......290...-----....300.......310.......320.......330......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
V
F
YDKDC
D
L
S
I
IQG-
K
K
V
A
I
I
G
YGSQGH
A
H
ACNLKDS------G
V
D
V
T
V
G
LR-----SGS-----
A
T
V
A
KAEAHG
L
K
-----
V
-----
A
D
V
K
T
AVAA
A
D
V
V
M
I
LT
P
D
E
FQG
R
L
Y
K
E
E
IEP
N
L
KK
G
A
T
L
A
F
A
HG
F
S
I
H
Y
NQ---V----VPRADL
D
V
I
M
I
APKAPG
H
T
V
R
S
E
F
V
KG-----GGI
P
D
L
I
A
IY--QDASGNA
K
N
V
A
L
S
Y
A
CGVGGGRT
G
I
I
E
T
TFKDETETDLFGEQ
A
V
L
C
G
G
C
V
E
L
V
K
A
G
----
F
E
T
L
V
EAGYA
P
E
M
A
Y
F
E
C
L
H
E
L
--
K
L
I
V
-
D
L
M
YEGGIAN
M
N
Y
SISNNAEYGEYVTGPEVIN
A
E
S
R
-------
A
A
M
R
N
A
L
K
RIQDGE
Y
A
K
M
F
I
TEGA-----ANYPS
M
T
A
YRRNNAAH
P
I
E
Q
I
G
E
K
L
R
A
M
M
P
W
I
A
A
N
KIVDKSKN
62
Fugue
96.18
100%
-111
- C3 -
1NP3
-
ILVC_PSEAE
A:
[1-327]
M
R
V
F
Y
D
K
D
C
D
L
S
I
I
Q
G
-
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
T
V
G
L
R
-----
S
G
S
-----
A
T
V
A
K
A
E
A
H
G
L
K
-----
V
-----
A
D
V
K
T
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
K
E
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
----
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
K
G
-----
G
G
I
P
D
L
I
A
I
Y
--
Q
D
A
S
G
N
A
K
N
V
A
L
S
Y
A
C
G
V
G
G
G
R
T
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
----
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
--
K
L
I
V
-
D
L
M
Y
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
A
E
S
R
-------
A
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
-----
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
P
I
E
Q
I
G
E
K
L
R
A
M
M
P
W
I
-----------
1
PsiBlast_PDB
96.18
100%
-111
- C3 -
1NP3
-
ILVC_PSEAE
A:
[1-327]
M
R
V
F
Y
D
K
D
C
D
L
S
I
I
Q
G
-
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
T
V
G
L
R
-----
S
G
S
-----
A
T
V
A
K
A
E
A
H
G
L
K
-----
V
-----
A
D
V
K
T
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
K
E
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
----
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
K
G
-----
G
G
I
P
D
L
I
A
I
Y
--
Q
D
A
S
G
N
A
K
N
V
A
L
S
Y
A
C
G
V
G
G
G
R
T
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
----
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
--
K
L
I
V
-
D
L
M
Y
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
A
E
S
R
-------
A
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
-----
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
P
I
E
Q
I
G
E
K
L
R
A
M
M
P
W
I
-----------
73
HHSearch
96.17
100%
-111
- C3 -
1NP3
-
ILVC_PSEAE
A:
[1-327]
M
R
V
F
Y
D
K
D
C
D
L
S
I
I
Q
G
-
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
T
V
G
L
R
-----
S
G
S
-----
A
T
V
A
K
A
E
A
H
G
L
K
-----
V
-----
A
D
V
K
T
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
K
E
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
----
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
K
G
-----
G
G
I
P
D
L
I
A
I
Y
--
Q
D
A
S
G
N
A
K
N
V
A
L
S
Y
A
C
G
V
G
G
G
R
T
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
----
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
--
K
L
I
V
-
D
L
M
Y
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
A
E
S
R
-------
A
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
-----
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
P
I
E
Q
I
G
E
K
L
R
A
M
M
P
W
I
-----------
21
PsiBlast_CBE
93.52
93%
-111
- C3 -
4XIY
4
ILVC_AZOVD
D:
[1-328]
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
-
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
L
R
-----
A
G
S
-----
A
S
V
A
K
A
E
A
H
G
L
T
-----
V
-----
K
S
V
K
D
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
----
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
--
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
R
T
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
----
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
--
K
L
I
V
-
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
-------
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
-----
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
W
I
A
----------
22
PsiBlast_CBE
93.23
93%
-115
- C3 -
4XIY
5
ILVC_AZOVD
C:
[1-328]
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
-
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
L
R
-----
A
G
S
-----
A
S
V
A
K
A
E
A
H
G
L
T
-----
V
-----
K
S
V
K
D
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
----
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
--
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
R
T
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
----
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
--
K
L
I
V
-
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
-------
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
-----
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
W
I
A
----------
23
PsiBlast_CBE
91.88
93%
-111
- C3 -
4XIY
6
ILVC_AZOVD
B:
[1-328]
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
-
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
L
R
-----
A
G
S
-----
A
S
V
A
K
A
E
A
H
G
L
T
-----
V
-----
K
S
V
K
D
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
----
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
--
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
R
T
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
----
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
--
K
L
I
V
-
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
-------
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
-----
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
W
I
A
----------
2
PsiBlast_PDB
86.52
93%
-130
- C- -
4XIY
5
ILVC_AZOVD
A:
[1-328]
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
-
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
L
R
-----
A
G
S
-----
A
S
V
A
K
A
E
A
H
G
L
T
-----
V
-----
K
S
V
K
D
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
----
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
--
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
R
T
G
I
I
E
T
T
F
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
----
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
--
K
L
I
V
-
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
-------
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
-----
A
N
Y
P
S
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
W
I
A
----------
3
PsiBlast_PDB
84.96
60%
-105
- C3 -
4KQW
8
?
A:
[14-338]
--
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
-
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
L
R
-----
E
G
S
-----
S
S
W
K
T
A
E
E
A
G
L
K
-----
V
-----
T
D
M
D
T
A
A
E
E
A
D
V
I
M
V
L
V
P
D
E
I
Q
P
K
V
Y
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
---
I
----
V
P
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
--
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
R
S
G
I
I
K
A
T
F
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
----
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
--
K
M
I
V
-
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
-------
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
-----
N
G
H
K
R
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
S
W
I
-----------
25
PsiBlast_CBE
83.76
60%
-103
- C3 -
4KQX
11
?
B:
[14-338]
--
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
-
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
L
R
-----
E
G
D
-----
S
D
W
K
T
A
E
E
A
G
L
K
-----
V
-----
T
D
M
D
T
A
A
E
E
A
D
V
I
M
V
L
V
P
D
E
V
Q
P
K
V
Y
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
---
I
----
V
P
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
--
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
R
S
G
I
I
K
A
T
F
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
----
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
--
K
M
I
V
-
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
-------
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
-----
N
G
H
K
R
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
S
W
I
-----------
5
PsiBlast_PDB
83.20
58%
-103
- C3 -
4TSK
5
?
A:
[3-331]
-
K
I
Y
Y
D
A
D
I
S
I
Q
P
L
A
D
-
K
R
I
A
V
I
G
Y
G
S
Q
G
H
A
H
A
Q
N
L
R
D
S
------
G
F
D
V
V
I
G
L
R
-----
P
G
S
------
S
W
A
K
A
E
A
D
G
F
R
-----
V
-----
M
A
V
G
E
A
V
E
E
S
D
V
I
M
I
L
L
P
D
E
R
Q
P
A
V
Y
E
R
E
I
R
P
Y
L
T
A
G
K
A
L
A
F
A
H
G
F
N
I
H
F
S
Q
---
I
----
Q
P
P
K
D
V
D
V
F
M
V
A
P
K
G
P
G
H
L
V
R
R
V
Y
E
A
G
-----
G
G
V
P
A
L
I
A
V
H
--
Q
D
A
S
G
Q
A
K
D
L
A
L
A
Y
A
R
G
I
G
A
G
R
A
G
I
L
T
T
T
F
R
E
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
L
S
A
L
I
K
A
G
----
F
E
T
L
V
E
A
G
Y
Q
P
E
I
A
Y
F
E
C
L
H
E
M
--
K
L
I
V
-
D
L
I
Y
E
G
G
L
E
Y
M
R
Y
S
I
S
D
T
A
Q
W
G
D
F
T
S
G
P
R
I
I
N
E
E
T
K
-------
K
E
M
R
R
I
L
A
D
I
Q
S
G
A
F
A
K
S
W
I
L
E
N
Q
-----
A
N
R
P
M
F
N
A
I
N
R
R
E
L
E
H
P
I
E
V
V
G
R
K
L
R
S
M
M
P
F
I
K
A
K
R
-------
4
PsiBlast_PDB
83.14
60%
-102
- C3 -
4KQX
10
?
A:
[14-335]
--
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
-
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
L
R
-----
E
G
D
-----
S
D
W
K
T
A
E
E
A
G
L
K
-----
V
-----
T
D
M
D
T
A
A
E
E
A
D
V
I
M
V
L
V
P
D
E
V
Q
P
K
V
Y
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
---
I
----
V
P
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
--
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
R
S
G
I
I
K
A
T
F
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
----
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
--
K
M
I
V
-
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
-------
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
-----
N
G
H
K
R
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
--------------
7
PsiBlast_PDB
80.54
47%
-101
- C3 -
4XDZ
11
?
A:
[3-325]
-
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
-
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
L
E
-----
R
Q
G
-----
D
S
W
R
R
A
I
D
D
G
F
K
-----
P
-----
M
Y
T
K
D
A
V
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
W
L
N
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
---
I
----
E
P
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
--
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
R
A
G
V
I
E
S
T
F
K
E
E
T
E
T
D
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
----
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
--
K
L
I
V
-
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
-------
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
-----
R
G
M
P
T
V
F
K
E
L
S
E
L
E
G
S
T
I
E
T
V
G
R
K
L
R
E
M
M
--------------
27
PsiBlast_CBE
80.19
47%
-99
- C3 -
4XDZ
10
?
B:
[3-325]
-
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
-
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
L
E
-----
R
Q
G
-----
D
S
W
R
R
A
I
D
D
G
F
K
-----
P
-----
M
Y
T
K
D
A
V
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
W
L
N
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
---
I
----
E
P
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
--
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
R
A
G
V
I
E
S
T
F
K
E
E
T
E
T
D
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
----
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
--
K
L
I
V
-
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
-------
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
-----
R
G
M
P
T
V
F
K
E
L
S
E
L
E
G
S
T
I
E
T
V
G
R
K
L
R
E
M
M
--------------
8
PsiBlast_PDB
80.19
47%
-103
- C3 -
4XEH
-
?
A:
[3-325]
-
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
-
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
L
E
-----
R
Q
G
-----
D
S
W
R
R
A
I
D
D
G
F
K
-----
P
-----
M
Y
T
K
D
A
V
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
W
L
N
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
---
I
----
E
P
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
--
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
R
A
G
V
I
E
S
T
F
K
E
E
T
E
T
D
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
----
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
--
K
L
I
V
-
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
-------
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
-----
R
G
M
P
T
V
F
K
E
L
S
E
L
E
G
S
T
I
E
T
V
G
R
K
L
R
E
M
M
--------------
24
PsiBlast_CBE
78.54
60%
-37
- C- -
4KQW
8
?
B:
[14-337]
--
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
-
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
L
R
-----
E
G
S
-----
S
S
W
K
T
A
E
E
A
G
L
K
-----
V
-----
T
D
M
D
T
A
A
E
E
A
D
V
I
M
V
L
V
P
D
E
I
Q
P
K
V
Y
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
---
I
----
V
P
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
--
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
R
S
G
I
I
K
A
T
F
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
----
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
--
K
M
I
V
-
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
-------
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
-----
N
G
H
K
R
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
S
W
------------
26
PsiBlast_CBE
77.99
45%
-95
- C3 -
4XDY
9
?
B:
[1-329]
M
E
I
L
H
D
E
D
V
D
D
S
I
L
R
D
-
K
T
I
A
V
M
G
Y
G
A
Q
G
D
A
Q
A
N
C
L
K
D
S
------
G
I
N
V
V
I
G
E
T
EILGG
N
K
N
-----
P
S
W
E
K
A
K
E
D
G
F
E
-----
V
-----
L
P
I
D
K
A
A
E
K
G
D
V
V
H
I
L
L
P
D
E
V
Q
P
A
I
Y
E
N
Q
I
K
P
Q
L
K
A
G
K
A
L
C
F
S
H
G
F
N
I
C
F
K
R
---
I
----
V
P
P
E
D
V
D
V
I
M
V
A
P
K
A
P
G
T
E
E
R
K
A
Y
L
E
G
-----
F
G
V
P
G
L
V
A
V
K
--
Q
N
P
S
G
E
A
R
E
V
A
L
A
M
T
K
A
M
H
W
T
K
A
G
I
L
E
C
T
F
E
Q
E
T
Y
E
D
L
F
G
E
Q
C
V
L
C
G
G
L
V
E
L
M
R
N
G
----
F
E
V
L
V
E
A
G
Y
P
P
E
M
A
Y
F
E
C
V
H
E
M
--
K
L
I
V
-
D
L
V
W
Q
G
G
I
K
R
M
A
E
V
I
S
N
T
A
E
Y
G
M
W
A
V
G
H
Q
I
I
G
P
E
V
K
-------
E
K
M
K
E
A
L
K
R
V
E
N
G
E
F
A
N
E
W
V
D
E
Y
K
-----
R
G
I
P
F
L
K
A
S
R
E
K
M
G
E
H
Q
V
E
T
V
G
A
E
I
R
K
L
F
--------------
6
PsiBlast_PDB
77.50
45%
-98
- C3 -
4XDY
9
?
A:
[1-329]
M
E
I
L
H
D
E
D
V
D
D
S
I
L
R
D
-
K
T
I
A
V
M
G
Y
G
A
Q
G
D
A
Q
A
N
C
L
K
D
S
------
G
I
N
V
V
I
G
E
T
EILGG
N
K
N
-----
P
S
W
E
K
A
K
E
D
G
F
E
-----
V
-----
L
P
I
D
K
A
A
E
K
G
D
V
V
H
I
L
L
P
D
E
V
Q
P
A
I
Y
E
N
Q
I
K
P
Q
L
K
A
G
K
A
L
C
F
S
H
G
F
N
I
C
F
K
R
---
I
----
V
P
P
E
D
V
D
V
I
M
V
A
P
K
A
P
G
T
E
E
R
K
A
Y
L
E
G
-----
F
G
V
P
G
L
V
A
V
K
--
Q
N
P
S
G
E
A
R
E
V
A
L
A
M
T
K
A
M
H
W
T
K
A
G
I
L
E
C
T
F
E
Q
E
T
Y
E
D
L
F
G
E
Q
C
V
L
C
G
G
L
V
E
L
M
R
N
G
----
F
E
V
L
V
E
A
G
Y
P
P
E
M
A
Y
F
E
C
V
H
E
M
--
K
L
I
V
-
D
L
V
W
Q
G
G
I
K
R
M
A
E
V
I
S
N
T
A
E
Y
G
M
W
A
V
G
H
Q
I
I
G
P
E
V
K
-------
E
K
M
K
E
A
L
K
R
V
E
N
G
E
F
A
N
E
W
V
D
E
Y
K
-----
R
G
I
P
F
L
K
A
S
R
E
K
M
G
E
H
Q
V
E
T
V
G
A
E
I
R
K
L
F
--------------
9
PsiBlast_PDB
70.35
33%
-92
- C3 -
1YRL
3
ILVC_ECOLI
A:
[33-340]
-----------
S
Y
L
Q
G
-
K
K
V
V
I
V
G
C
G
A
Q
G
L
N
Q
G
L
N
M
R
D
S
------
G
L
D
I
S
Y
A
L
R
-----
K
E
A
I
A
E
KR
A
S
W
R
K
A
T
E
N
G
F
K
-----
V
-----
G
T
Y
E
E
L
I
P
Q
A
D
L
V
I
N
L
T
P
D
K
Q
H
S
D
V
V
R
T
-
V
Q
P
L
M
K
D
G
A
A
L
G
Y
S
H
G
F
N
I
V
E
V
G
---
E
----
Q
I
R
K
D
I
T
V
V
M
V
A
P
K
C
P
G
T
E
V
R
E
E
Y
K
R
G
-----
F
G
V
P
T
L
I
A
V
H
PE
N
D
P
K
G
E
G
M
A
I
A
K
A
W
A
A
A
T
G
G
H
R
A
G
V
L
E
S
S
F
V
A
E
V
K
S
D
L
M
G
E
Q
T
I
L
C
G
----
M
L
Q
A
G
S
L
L
C
F
D
K
L
V
E
E
G
T
D
P
--
A
Y
A
E
K
L
I
Q
F
G
W
E
T
I
T
-
E
A
L
K
Q
G
G
I
T
L
M
M
D
R
L
S
N
P
A
K
L
R
A
Y
A
L
S
-
E
Q
L
K
E
I
M
A
-------
P
L
F
Q
K
H
M
D
D
I
I
S
G
E
F
S
S
G
M
M
A
D
W
A
-----
N
D
D
K
K
L
L
T
W
R
E
E
T
G
K
T
A
F
E
------------------------
74
HHSearch
68.62
30%
-91
- C3 -
3FR7
2
ILV5_ORYSJ
A:
[48-385]
----------
P
E
A
F
K
G
I
K
Q
I
G
V
I
G
W
G
S
Q
G
P
A
Q
A
Q
N
L
R
D
S
L
A
E
A
KS
D
I
V
V
K
I
G
L
R
-----
K
G
S
-----
K
S
F
D
E
A
R
A
A
G
F
T
-----
E
ESGT
L
G
D
I
W
E
T
V
S
G
S
D
L
V
L
L
L
I
S
D
A
A
Q
A
D
N
Y
E
K
-
I
F
S
H
M
K
P
N
S
I
L
G
L
S
H
G
F
L
L
G
H
L
Q
S
A
G
L
----
D
F
P
K
N
I
S
V
I
A
V
C
P
K
G
M
G
P
S
V
R
R
L
Y
V
Q
G
K
EING
A
G
I
N
S
S
F
A
V
H
--
Q
D
V
D
G
R
A
T
D
V
A
L
G
W
S
V
A
L
G
S
P
--
F
T
F
A
T
T
L
E
Q
E
Y
K
S
D
I
F
G
E
R
G
I
L
L
G
A
V
H
G
I
V
E
A
L
----
F
R
R
Y
T
E
Q
G
M
D
E
E
M
A
Y
K
N
T
V
E
G
I
--
T
G
I
I
S
K
T
I
S
K
K
G
M
L
E
V
Y
N
S
L
T
E
E
--------
G
K
K
E
F
N
K
A
Y
S
A
S
F
Y
P
C
M
D
I
L
Y
E
C
Y
E
D
V
A
S
G
S
E
I
R
S
V
V
L
A
G
R
R
FYEK
E
G
L
P
A
F
P
--
M
G
N
I
D
Q
T
R
M
W
K
V
G
E
K
V
R
S
T
R
P
E
N
D
----------
31
PsiBlast_CBE
61.11
34%
-96
- C3 -
3FR7
2
ILV5_ORYSJ
B:
[55-278]
-----------------
K
Q
I
G
V
I
G
W
G
S
Q
G
P
A
Q
A
Q
N
L
R
D
S
LAEAKS
D
I
V
V
K
I
G
L
R
-----
K
G
S
-----
K
S
F
D
E
A
R
A
A
G
F
T
EESGT
L
-----
G
D
I
W
E
T
V
S
G
S
D
L
V
L
L
L
I
S
D
A
A
Q
A
D
N
Y
-
E
K
I
F
S
H
M
K
P
N
S
I
L
G
L
S
H
G
F
L
L
G
H
L
Q
---
S
AGLD
F
P
K
-
N
I
S
V
I
A
V
C
P
K
G
M
G
P
S
V
R
R
L
Y
V
Q
G
KEING
A
G
I
N
S
S
F
A
V
H
--
Q
D
V
D
G
R
A
T
D
V
A
L
G
W
S
V
A
L
G
S
P
F
T
--
F
A
T
T
L
E
Q
E
Y
K
S
D
I
F
G
E
R
G
I
L
L
G
A
V
H
G
I
V
E
A
L
----
F
R
R
Y
T
E
Q
G
M
D
E
E
M
A
Y
---------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
60.26
34%
-91
- C3 -
3FR8
4
ILV5_ORYSJ
B:
[55-278]
-----------------
K
Q
I
G
V
I
G
W
G
S
Q
G
P
A
Q
A
Q
N
L
R
D
S
LAEAKS
D
I
V
V
K
I
G
L
R
-----
K
G
S
-----
K
S
F
D
E
A
R
A
A
G
F
T
EESGT
L
-----
G
D
I
W
E
T
V
S
G
S
D
L
V
L
L
L
I
S
D
A
A
Q
A
D
N
Y
-
E
K
I
F
S
H
M
K
P
N
S
I
L
G
L
S
H
G
F
L
L
G
H
L
Q
---
S
A
GLD
F
P
K
-
N
I
S
V
I
A
V
C
P
K
G
M
G
P
S
V
R
R
L
Y
V
Q
G
K
EIN
G
A
G
I
N
S
S
F
A
V
H
--
Q
D
V
D
G
R
A
T
D
V
A
L
G
W
S
V
A
L
G
S
P
F
T
--
F
A
T
T
L
E
Q
E
Y
K
S
D
I
F
G
E
R
G
I
L
L
G
A
V
H
G
I
V
E
A
L
----
F
R
R
Y
T
E
Q
G
M
D
E
E
M
A
Y
---------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.07
34%
-90
- C3 -
3FR8
4
ILV5_ORYSJ
A:
[55-278]
-----------------
K
Q
I
G
V
I
G
W
G
S
Q
G
P
A
Q
A
Q
N
L
R
D
S
L
A
E
A
KS
D
I
V
V
K
I
G
L
R
-----
K
G
S
-----
K
S
F
D
E
A
R
A
A
G
F
T
EESGT
L
-----
G
D
I
W
E
T
V
S
G
S
D
L
V
L
L
L
I
S
D
A
A
Q
A
D
N
Y
-
E
K
I
F
S
H
M
K
P
N
S
I
L
G
L
S
H
G
F
L
L
G
H
L
Q
---
S
A
GLD
F
P
K
-
N
I
S
V
I
A
V
C
P
K
G
M
G
P
S
V
R
R
L
Y
V
Q
G
K
E
ING
A
G
I
N
S
S
F
A
V
H
--
Q
D
V
D
G
R
A
T
D
V
A
L
G
W
S
V
A
L
G
S
P
F
T
--
F
A
T
T
L
E
Q
E
Y
K
S
D
I
F
G
E
R
G
I
L
L
G
A
V
H
G
I
V
E
A
L
----
F
R
R
Y
T
E
Q
G
M
D
E
E
M
A
Y
---------------------------------------------------------------------------------------------------------------------------------