@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4728: (2016-02-29 )
MIQRVYVALGSNLAEPREQIQAALDAFERLPETRLVAVSPLYISDPLGPADQPRFVNGVAALDTNLAPLDLLDALQAIELEQGRVRDLRWGPRTLDLDILLFGEQLLDLPRLKVPHYHMQARAFVLYPLADLAPDLRLPDGRHLPELLAACPFEGIERLPGA
Atome Classification :
(61 SA)
.........10........20........30........40........50..-----......60........70........80..-....-.-.-.---90........100----..-----...-..110.......120.......130.-......140-.......150.......160
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
Q
R
V
Y
V
A
LGSNLA
E
P
R
E
Q
I
Q
A
A
L
D
A
F
E
RLPE
T
R
L
V
A
V
S
P
L
Y
ISDPLGPADQP-----
R
F
VN
G
V
A
A
LDTNL
A
P
L
D
L
L
D
A
L
Q
A
I
EL-EQ-GRVR-D-L-R---WGP
R
T
L
D
L
D
I
L
L
F
----
G
E
-----
Q
L
L-DLPRLKVP
H
Y
H
M
Q
A
R
A
F
V
L
Y
P
L
A
DLA-PDLRLPDG
R
-
H
L
P
E
L
L
A
AC
P
F
E
G
I
E
RLPGA
84
HHSearch
96.59
59%
-128
- C7 -
2QX0
5
?
A:
[1-158]
-
M
I
R
V
Y
I
A
L
G
S
N
L
A
M
P
L
Q
Q
V
S
A
A
R
E
A
L
A
H
L
P
R
S
R
L
V
A
C
S
P
L
Y
R
T
K
P
L
G
P
Q
D
Q
P
-----
D
F
L
N
A
V
V
A
L
D
T
S
L
P
P
E
Q
L
L
D
H
T
Q
A
I
E
R
-
N
Q
-
G
R
V
R
-
K
E
Q
-
R
---
W
G
P
R
T
L
D
L
D
I
M
L
Y
----
G
D
-----
Q
V
I
-
K
T
D
R
L
T
I
P
H
Y
G
L
K
A
R
E
F
M
L
Y
P
L
A
D
I
A
-
P
D
L
I
F
P
D
G
E
-
S
L
S
E
C
L
K
R
V
D
K
N
G
L
V
L
----
1
PsiBlast_PDB
94.97
59%
-132
- C7 -
2QX0
5
?
A:
[3-156]
---
R
V
Y
I
A
L
G
S
N
L
A
M
P
L
Q
Q
V
S
A
A
R
E
A
L
A
H
L
P
R
S
R
L
V
A
C
S
P
L
Y
R
T
K
P
L
G
P
Q
D
Q
P
-----
D
F
L
N
A
V
V
A
L
D
T
S
L
P
P
E
Q
L
L
D
H
T
Q
A
I
E
R
-
N
Q
-
G
R
V
R
K
E
-
Q
-
R
---
W
G
P
R
T
L
D
L
D
I
M
L
Y
----
G
D
-----
Q
V
I
-
K
T
D
R
L
T
I
P
H
Y
G
L
K
A
R
E
F
M
L
Y
P
L
A
D
I
A
-
P
D
L
I
F
P
D
G
E
-
S
L
S
E
C
L
K
R
V
D
K
N
G
L
------
83
HHSearch
93.40
51%
-129
- C7 -
1CBK
2
HPPK_HAEIN
A:
[1-159]
-
M
I
T
A
Y
I
A
L
G
S
N
L
N
T
P
V
E
Q
L
H
A
A
L
K
A
I
S
Q
L
S
N
T
H
L
V
T
T
S
S
F
Y
K
S
K
P
L
G
P
Q
D
Q
P
-----
D
Y
V
N
A
V
A
K
I
E
T
E
L
S
P
L
K
L
L
D
E
L
Q
R
I
E
N
-
E
Q
-
G
R
V
R
-
L
-
R
-
R
---
W
G
E
R
T
L
D
L
D
I
L
L
Y
----
G
N
-----
E
I
I
-
Q
N
E
R
L
T
I
P
H
Y
D
M
H
N
R
E
F
V
I
V
P
L
F
E
I
A
-
S
D
L
V
L
P
N
S
Q
-
I
I
T
E
L
V
K
Q
F
A
D
H
K
M
I
K
L
N
--
9
PsiBlast_PDB
93.09
51%
-129
- C7 -
4M5N
4
HPPK_ECOLI
A:
[8-161]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
43
PsiBlast_CBE
92.83
50%
-138
- C7 -
3HD1
5
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
A
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
24
PsiBlast_CBE
92.77
51%
-137
- C7 -
3UDE
2
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
------E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
73
Fugue
92.76
50%
-131
- C7 -
1CBK
2
HPPK_HAEIN
A:
[1-160]
-
M
I
T
A
Y
I
A
L
G
S
N
L
N
T
P
V
E
Q
L
H
A
A
L
K
A
I
S
Q
L
S
N
T
H
L
V
T
T
S
S
F
Y
K
S
K
P
L
G
P
Q
D
Q
P
-----
D
Y
V
N
A
V
A
K
I
E
T
E
L
S
P
L
K
L
L
D
E
L
Q
R
I
E
N
-
E
Q
-
G
R
V
R
L--
R
-
R
---
W
G
E
R
T
L
D
L
D
I
L
L
Y
----
G
N
-----
E
I
I
-
Q
N
E
R
L
T
I
P
H
Y
D
M
H
N
R
E
F
V
I
V
P
L
F
E
I
A
-
S
D
L
V
L
P
N
S
Q
-
I
I
T
E
L
V
K
Q
F
A
D
H
K
M
I
K
L
N
P
-
7
PsiBlast_PDB
92.36
51%
-129
- C7 -
4M5L
6
HPPK_ECOLI
A:
[8-161]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
30
PsiBlast_CBE
92.19
51%
-136
- C7 -
3HSD
8
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
A
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
2
PsiBlast_PDB
92.16
51%
-128
- C7 -
4M5G
8
HPPK_ECOLI
A:
[8-161]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
45
PsiBlast_CBE
92.11
50%
-139
- C7 -
3HT0
4
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
A
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
8
PsiBlast_PDB
92.09
51%
-130
- C7 -
4M5M
7
HPPK_ECOLI
A:
[8-161]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
19
PsiBlast_PDB
92.03
51%
-133
- C7 -
1HKA
-
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
11
PsiBlast_PDB
91.96
51%
-127
- C7 -
1EX8
3
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
47
PsiBlast_CBE
91.92
50%
-127
- C7 -
3KUH
6
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
A
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
4
PsiBlast_PDB
91.91
51%
-127
- C7 -
4M5I
6
HPPK_ECOLI
A:
[8-161]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
37
PsiBlast_CBE
91.86
50%
-127
- C7 -
1F9H
5
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
A
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
21
PsiBlast_CBE
91.86
51%
-131
- C7 -
4M5N
4
HPPK_ECOLI
B:
[8-161]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
29
PsiBlast_CBE
91.73
51%
-135
- C7 -
3HSD
7
HPPK_ECOLI
B:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
A
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
15
PsiBlast_PDB
91.71
51%
-137
- C7 -
1RAO
2
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
12
PsiBlast_PDB
91.67
51%
-133
- C7 -
1EQM
3
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
16
PsiBlast_PDB
91.65
51%
-127
- C7 -
1RB0
1
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
31
PsiBlast_CBE
91.63
50%
-137
- C7 -
3HD2
5
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
A
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
28
PsiBlast_CBE
91.57
51%
-132
- C7 -
3HSG
8
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
A
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
6
PsiBlast_PDB
91.56
51%
-129
- C7 -
4M5K
6
HPPK_ECOLI
A:
[8-161]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
3
PsiBlast_PDB
91.52
51%
-126
- C7 -
4M5H
9
HPPK_ECOLI
A:
[8-161]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
10
PsiBlast_PDB
91.36
51%
-129
- C7 -
1DY3
4
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
23
PsiBlast_CBE
91.29
51%
-138
- C7 -
3UDV
2
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
------E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
14
PsiBlast_PDB
91.24
51%
-127
- C7 -
1Q0N
9
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
20
PsiBlast_PDB
91.22
51%
-141
- C7 -
3UD5
3
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
38
PsiBlast_CBE
91.20
50%
-129
- C7 -
3ILO
5
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
A
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
42
PsiBlast_CBE
90.99
50%
-135
- C7 -
3HSJ
4
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
A
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
5
PsiBlast_PDB
90.81
51%
-133
- C7 -
4M5J
6
HPPK_ECOLI
A:
[8-161]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
----E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
46
PsiBlast_CBE
90.76
50%
-130
- C7 -
3HSZ
3
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
A
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
44
PsiBlast_CBE
90.67
50%
-135
- C7 -
3HCX
2
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
A
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
40
PsiBlast_CBE
90.35
50%
-127
- C7 -
3ILJ
4
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
A
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
22
PsiBlast_CBE
90.04
51%
-126
- C7 -
4F7V
1
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
54
PsiBlast_CBE
89.81
49%
-143
- C7 -
1RTZ
8
HPPK_ECOLI
A:
[4-151]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
--------
R
---
G
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
49
PsiBlast_CBE
89.61
50%
-122
- C7 -
1TMM
11
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
A
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
48
PsiBlast_CBE
89.53
50%
-122
- C7 -
1TMM
7
HPPK_ECOLI
B:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
R
V
R
-
K
-
A
E
R
---
A
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
34
PsiBlast_CBE
89.48
50%
-124
- C7 -
1HQ2
9
HPPK_ECOLI
A:
[4-157]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
A
V
R
-
K
-
A
E
R
---
W
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
52
PsiBlast_CBE
88.31
49%
-134
- C7 -
1RU1
4
HPPK_ECOLI
B:
[4-151]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
L
G
P
Q
D
Q
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
--------
R
---
G
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
51
PsiBlast_CBE
88.08
49%
-145
- C7 -
1RU2
5
HPPK_ECOLI
A:
[4-151]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
------
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
--------
R
---
G
G
P
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
25
PsiBlast_CBE
86.20
55%
-128
- C7 -
1CBK
2
HPPK_HAEIN
B:
[5-147]
-----
Y
I
A
L
G
S
N
L
N
T
P
V
E
Q
L
H
A
A
L
K
A
I
S
Q
L
S
N
T
H
L
V
T
T
S
S
F
Y
K
S
K
P
L
G
P
Q
D
Q
P
-----
D
Y
V
N
A
V
A
K
I
E
T
E
L
S
P
L
K
L
L
D
E
L
Q
R
I
E
N
-
E
Q
-
G
R
V
R
-
L
-
R
-
R
---
W
G
E
R
T
L
D
L
D
I
L
L
Y
----
G
N
-----
E
I
I
-
Q
N
E
R
L
T
I
P
H
Y
D
M
H
N
R
E
F
V
I
V
P
L
F
E
I
A
-
S
D
L
V
L
P
N
S
Q
-
I
I
T
E
L
V
--------------
26
PsiBlast_CBE
85.80
55%
-128
- C7 -
1CBK
2
HPPK_HAEIN
A:
[5-147]
-----
Y
I
A
L
G
S
N
L
N
T
P
V
E
Q
L
H
A
A
L
K
A
I
S
Q
L
S
N
T
H
L
V
T
T
S
S
F
Y
K
S
K
P
L
G
P
Q
D
Q
P
-----
D
Y
V
N
A
V
A
K
I
E
T
E
L
S
P
L
K
L
L
D
E
L
Q
R
I
E
N
-
E
Q
-
G
R
V
R
-
L
-
R
-
R
---
W
G
E
R
T
L
D
L
D
I
L
L
Y
----
G
N
-----
E
I
I
-
Q
N
E
R
L
T
I
P
H
Y
D
M
H
N
R
E
F
V
I
V
P
L
F
E
I
A
-
S
D
L
V
L
P
N
S
Q
-
I
I
T
E
L
V
--------------
53
PsiBlast_CBE
85.66
49%
-144
- C7 -
1RU1
5
HPPK_ECOLI
A:
[4-151]
-----
Y
I
A
I
G
S
N
L
A
S
P
L
E
Q
V
N
A
A
L
K
A
L
G
D
I
P
E
S
H
I
L
T
V
S
S
F
Y
R
T
P
P
------
P
-----
D
Y
L
N
A
A
V
A
L
E
T
S
L
A
P
E
E
L
L
N
H
T
Q
R
I
E
L
-
Q
Q
-
G
--------
R
------
R
T
L
D
L
D
I
M
L
F
----
G
N
-----
E
V
I
-
N
T
E
R
L
T
V
P
H
Y
D
M
K
N
R
G
F
M
L
W
P
L
F
E
I
A
-
P
E
L
V
F
P
D
G
E
-
M
L
R
Q
I
L
H
T
R
A
F
D
K
L
N
K
----
64
PsiBlast_CBE
78.12
41%
-124
- C7 -
3QBC
2
?
A:
[4-144]
M
I
Q
-
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
-----
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
-
C
L
-
H
R
I
R
-
K
-
E
-
R
---
W
G
P
R
T
L
D
V
D
I
L
L
Y
----
G
E
-----
E
M
I
-
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
-
A
N
V
V
E
P
R
S
K
---------------------
63
PsiBlast_CBE
77.90
41%
-125
- C7 -
3QBC
2
?
B:
[4-144]
M
I
Q
-
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
-----
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
-
C
L
-
H
R
I
R
-
K
-
E
-
R
---
W
G
P
R
T
L
D
V
D
I
L
L
Y
----
G
E
-----
E
M
I
-
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
-
A
N
V
V
E
P
R
S
K
---------------------
87
HHSearch
77.80
35%
-132
* C7 *
2BMB
1
A:
[17-183]
S
W
K
R
A
F
L
A
F
G
S
N
I
G
D
R
F
K
H
I
Q
M
A
L
Q
L
L
S
R
E
K
T
V
K
L
R
N
I
S
S
I
F
E
S
E
P
M
Y
F
K
D
Q
T
-----
P
F
M
N
G
C
V
E
V
E
T
L
L
T
P
S
E
L
L
K
L
C
K
K
I
E
Y
E
E
L
-
Q
---------------
R
T
I
D
L
D
I
V
M
F
----
L
N
SAG
E
D
I
I
V
-
N
E
P
D
L
N
I
P
H
P
R
M
L
E
R
T
F
V
L
E
P
L
C
E
L
I
S
P
V
H
L
H
P
V
T
A
E
P
I
V
D
H
L
K
Q
L
Y
----------
61
PsiBlast_CBE
77.74
41%
-124
- C7 -
4AD6
2
?
B:
[4-144]
M
I
Q
-
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
-----
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
-
C
L
-
H
R
I
R
-
K
-
E
-
R
---
W
G
P
R
T
L
D
V
D
I
L
L
Y
----
G
E
-----
E
M
I
-
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
-
A
N
V
V
E
P
R
S
K
---------------------
62
PsiBlast_CBE
77.66
41%
-126
- C7 -
4AD6
2
?
A:
[4-144]
M
I
Q
-
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
-----
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
-
C
L
-
H
R
I
R
-
K
-
E
-
R
---
W
G
P
R
T
L
D
V
D
I
L
L
Y
----
G
E
-----
E
M
I
-
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
-
A
N
V
V
E
P
R
S
K
---------------------
60
PsiBlast_CBE
77.60
41%
-121
- C7 -
4CRJ
5
?
A:
[4-144]
M
I
Q
-
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
-----
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
-
C
L
-
H
R
I
R
-
K
-
E
-
R
---
W
G
P
R
T
L
D
V
D
I
L
L
Y
----
G
E
-----
E
M
I
-
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
-
A
N
V
V
E
P
R
S
K
---------------------
56
PsiBlast_CBE
77.32
41%
-120
- C7 -
4CYU
3
?
D:
[4-144]
M
I
Q
-
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
-----
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
-
C
L
-
H
R
I
R
-
K
-
E
-
R
---
W
G
P
R
T
L
D
V
D
I
L
L
Y
----
G
E
-----
E
M
I
-
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
-
A
N
V
V
E
P
R
S
K
---------------------
59
PsiBlast_CBE
76.99
41%
-119
- C7 -
4CWB
5
?
A:
[4-144]
M
I
Q
-
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
-----
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
-
C
L
-
H
R
I
R
-
K
-
E
-
R
---
W
G
P
R
T
L
D
V
D
I
L
L
Y
----
G
E
-----
E
M
I
-
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
-
A
N
V
V
E
P
R
S
K
---------------------
58
PsiBlast_CBE
76.49
41%
-122
- C7 -
4CYU
4
?
B:
[4-144]
M
I
Q
-
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
---
T
E
Q
P
-----
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
-
C
L
-
H
R
I
R
-
K
-
E
-
R
---
W
G
P
R
T
L
D
V
D
I
L
L
Y
----
G
E
-----
E
M
I
-
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
-
A
N
V
V
E
P
R
S
K
---------------------
55
PsiBlast_CBE
76.44
41%
-124
- C7 -
4CYU
5
?
A:
[4-144]
M
I
Q
-
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
----
T
E
Q
P
-----
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
-
C
L
-
H
R
I
R
-
K
-
E
-
R
---
W
G
P
R
T
L
D
V
D
I
L
L
Y
----
G
E
-----
E
M
I
-
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
-
A
N
V
V
E
P
R
S
K
---------------------
57
PsiBlast_CBE
76.36
41%
-118
- C7 -
4CYU
3
?
C:
[4-144]
M
I
Q
-
A
Y
L
G
L
G
S
N
I
G
D
R
E
S
Q
L
N
D
A
I
K
I
L
N
E
Y
D
G
I
S
V
S
N
I
S
P
I
Y
E
T
A
P
V
G
Y
T
E
Q
P
-----
N
F
L
N
L
C
V
E
I
Q
T
T
L
T
V
L
Q
L
L
E
C
C
L
K
T
E
E
-
C
L
-
H
R
I
R
-
K
-
E
-
R
---
W
G
P
R
T
L
D
V
D
I
L
L
Y
----
G
E
-----
E
M
I
-
D
L
P
K
L
S
V
P
H
P
R
M
N
E
R
A
F
V
L
I
P
L
N
D
I
A
-
A
N
V
V
E
P
R
S
K
---------------------
65
PsiBlast_CBE
75.25
37%
-131
- C7 -
2BMB
1
A:
[19-167]
--
K
R
A
F
L
A
F
G
S
N
I
G
D
R
F
K
H
I
Q
M
A
L
Q
L
L
S
R
E
K
T
V
K
L
R
N
I
S
S
I
F
E
S
E
P
M
Y
F
K
D
Q
T
-----
P
F
M
N
G
C
V
E
V
E
T
L
L
T
P
S
E
L
L
K
L
C
K
K
I
E
Y
-
E
E
L
Q
---------------
R
T
I
D
L
D
I
V
M
F
L
N
SA
G
E
-----
D
I
I
V
N
E
P
D
L
N
I
P
H
P
R
M
L
E
R
T
F
V
L
E
P
L
C
E
L
I
-
S
P
V
H
L
-------------------------
68
PsiBlast_CBE
73.13
33%
-117
- C7 -
3MCO
4
?
A:
[21-188]
M
V
Q
Y
I
-
I
G
I
G
T
N
S
G
F
T
I
E
N
I
H
L
A
I
T
A
L
E
S
Q
Q
N
I
R
I
I
R
K
A
S
L
Y
S
S
K
A
V
L
K
--
A
P
KEWD
I
R
F
L
N
T
A
V
K
I
S
S
S
L
K
P
D
E
L
L
V
L
L
K
D
I
E
L
-
K
I
-
G
R
---
D
-
L
-
N
APA
W
S
P
R
V
I
D
L
D
I
L
A
A
----
E
D
-----
L
I
L
-
E
T
D
K
L
T
I
P
H
K
E
L
I
N
R
S
F
A
L
A
P
L
-------
L
E
L
S
K
G
W
-
H
H
P
K
----------------
67
PsiBlast_CBE
70.25
33%
-127
- C7 -
3MCO
4
?
B:
[21-181]
M
V
Q
Y
I
-
I
G
I
G
T
N
S
G
F
T
I
E
N
I
H
L
A
I
T
A
L
E
S
Q
Q
N
I
R
I
I
R
K
A
S
L
Y
S
S
K
A
V
------I----
R
F
L
N
T
A
V
K
I
S
S
S
L
K
P
D
E
L
L
V
L
L
K
D
I
E
L
-
K
I
-----------------
R
V
I
D
L
D
I
L
A
A
----
E
D
-----
L
I
L
-
E
T
D
K
L
T
I
P
H
K
E
L
I
N
R
S
F
A
L
A
P
L
-------
L
E
L
S
K
G
W
-
H
H
P
K
----------------
69
PsiBlast_CBE
69.98
33%
-120
- C7 -
3MCN
3
?
B:
[21-184]
M
V
Q
Y
I
-
I
G
I
G
T
N
S
G
F
T
I
E
N
I
H
L
A
I
T
A
L
E
S
Q
Q
N
I
R
I
I
R
K
A
S
L
Y
S
S
K
A
-------I----
R
F
L
N
T
A
V
K
I
S
S
S
L
K
P
D
E
L
L
V
L
L
K
D
I
E
L
-
K
I
-
G
R
-------------
P
R
V
I
D
L
D
I
L
A
A
----
E
D
-----
L
I
L
-
E
T
D
K
L
T
I
P
H
K
E
L
I
N
R
S
F
A
L
A
P
L
-------
L
E
L
S
K
G
W
-
H
H
P
K
----------------