@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4732: (2016-03-01 )
MKHHLTPLDATQLDSWRALAAHRQELQDFRMRQAFIDDPERFKRFSFSACGLFLDFSKNLIRQDTIDLLVKLAEEARLSDAIRAMFDGEAINASERRPVLHTALRRPIGDKVLVDGVDVMPEVHRVLHQMTELVGYVHNGLWRGYTEKPITDVVNIGIGGSFLGPQLVSEALLPFAQKGVRCHYLANIDGSEFHELASRLNAETTLFIVSSKSFGTLETLKNAQAARAWYLAQGGTEEELYRHFIAVSSNKEAAIAFGIREENIFPMWDWVGGRYSLWSAIGLPIAMSIGISNFKELLSGAYNMDQHFQTAPFERNIPVLLGLLGVWYGDFWGANSHAILPYDYYLRNITDHLQQLDMESNGKSVRQDGTPVTSGTGPVIWGGVGCNGQHAYHQLLHQGTQLIPADFIVPVSSYNPVADHHQWLYANCLSQSQALMLGKSREEAEAELRAKGLPEAEVQRLAPHKVIPGNRPSNTLVVERISARRLGALIAMYEHKVYVQSILWGINAFDQWGVELGKELGKGVYSRLVGSEETPAEDASTQGLIDFFRGRHRG
Atome Classification :
(57 SA)
--------------------------------------.........10-----........-.-20-........30.......----.40.......-.-------50------.----.......--.60........70........80........90........100.......110..-......120.......130.......140.......150.......160.......170..---..-----..--.180.......190.......200.......210.......220.....---.---.---230---..-..--.-----.-.-.--240.......250-.......260.......270.......280-.-......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410..-------...------.----.--420........430.......440.......-450-.....-..460.......470.......480.......490.......500.......510.......520.......--530.--------......540.......550..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------MKHHLTPL
D
A
------
T
Q
L
D
S
W
R
A
-
L
-
A
A
-
H
R
Q
E
L
Q
D
F
R
M
R
Q
A
FID
D
----
P
E
R
F
K
R
FSF
S
-
A
-------
C
-------
G
----
L
F
L
D
F
S
K
--
N
L
I
R
Q
D
T
I
D
L
L
V
K
L
A
E
E
A
R
L
S
D
A
I
R
A
M
FDGEAI
N
A
S
ERR
P
V
L
H
T
A
L
RRPIGD
K
-
V
L
-VD
G
V
D
V
M
P
E
V
H
R
V
L
H
Q
M
T
E
L
V
G
Y
V
H
N
G
L
WRGYTEKP
I
T
D
V
V
NIGIGGSFL
G
P
Q
L
V
S
E
A
L
L
P
---
F
A
-----QK--G
V
R
C
H
Y
L
ANI
D
G
S
E
F
H
E
L
A
S
RLNA
E
T
T
L
F
I
V
SSKSFG
T
L
E
T
L
K
N
A
Q
A
A
R
---
A
---
W
---
Y
L
----AQ-GG--
T
-----
E
-
E
-
E
--
L
Y
R
H
F
I
A
VSSNK
E
-
A
A
I
A
F
G
IREENIFP
M
W
DWVGG
R
Y
S
L
W
S
AIG-L-
P
I
A
M
S
I
G
I
S
N
F
K
E
L
L
SGAYN
M
D
Q
H
FQTAPFERN
I
P
V
L
L
G
L
L
G
V
W
Y
G
DFWGANS
H
A
I
L
P
Y
D
Y
Y
L
R
N
I
T
D
H
L
Q
Q
LDMESNGKSVRQDGTPVTSGTG
P
V
I
WGGVGCN
G
Q
H
A
Y
H
Q
L
L
HQGTQLIPA
D
F
I
V
PVSSY-------NPV------A----
D
--
H
-
H
Q
W
L
Y
A
N
C
LSQ
S
Q
A
L
MLGKS
R
E
E
A
E
A
E
L
R-AKG-L
P
E
A
E
-
V
Q
RLAPHKVIPGNRPS
N
T
L
V
V
E
R
I
S
A
R
R
L
G
A
L
I
A
M
Y
E
H
K
V
Y
V
Q
S
I
L
W
G
I
N
A
F
D
Q
W
G
V
E
L
G
K
E
L
G
K
G
V
Y
S
R
L
V--GSEE--------TPAEDA
S
T
Q
G
L
I
D
F
F
RGRHRG-
1
PsiBlast_PDB
99.08
51%
-103
- C3 -
3HJB
12
G6PI_VIBCH
A:
[26-571]
------------------------------------------
L
K
N
I
N
P
------
T
Q
T
Q
A
W
K
A
-
L
-
T
A
-
H
F
E
S
A
Q
D
M
D
L
K
A
L
F
A
Q
D
----
S
E
R
F
A
K
Y
S
A
R
F
G
-------
Q
-------
D
----
I
L
V
D
Y
S
K
--
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
T
A
L
R
N
R
S
N
S
P
-
V
L
-
V
N
G
E
D
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
V
P
---
Y
------
K
N
--
H
L
T
V
H
F
V
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
---
D
---
W
---
F
L
----
K
A
-
A
G
--
D
-----
E
-
A
-
H
--
V
A
K
H
F
A
A
L
S
T
N
G
K
-
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
I
L
S
I
G
Y
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
V
S
H
-------
N
L
V
------
G
----
D
--
H
-
H
Q
K
L
M
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
A
Q
A
V
Q
A
E
L
E
-
K
A
G
-
K
S
A
A
E
-
I
A
A
L
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
--
D
S
A
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
A
F
K
A
-----
21
PsiBlast_CBE
98.73
51%
-102
- C3 -
3HJB
8
G6PI_VIBCH
D:
[26-571]
------------------------------------------
L
K
N
I
N
P
------
T
Q
T
Q
A
W
K
A
-
L
-
T
A
-
H
F
E
S
A
Q
D
M
D
L
K
A
L
F
A
Q
D
----
S
E
R
F
A
K
Y
S
A
R
F
G
-------
Q
-------
D
----
I
L
V
D
Y
S
K
--
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
T
A
L
R
N
R
S
N
S
P
-
V
L
-
V
N
G
E
D
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
V
P
---
Y
------
K
N
--
H
L
T
V
H
F
V
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
---
D
---
W
---
F
L
----
K
A
-
A
G
--
D
-----
E
-
A
-
H
--
V
A
K
H
F
A
A
L
S
T
N
G
K
-
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
I
L
S
I
G
Y
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
V
S
H
-------
N
L
V
------
G
----
D
--
H
-
H
Q
K
L
M
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
A
Q
A
V
Q
A
E
L
E
-
K
A
G
-
K
S
A
A
E
-
I
A
A
L
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
--
D
S
A
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
A
F
K
A
-----
23
PsiBlast_CBE
98.29
51%
-102
- C3 -
3HJB
10
G6PI_VIBCH
B:
[26-571]
------------------------------------------
L
K
N
I
N
P
------
T
Q
T
Q
A
W
K
A
-
L
-
T
A
-
H
F
E
S
A
Q
D
M
D
L
K
A
L
F
A
Q
D
----
S
E
R
F
A
K
Y
S
A
R
F
G
-------
Q
-------
D
----
I
L
V
D
Y
S
K
--
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
T
A
L
R
N
R
S
N
S
P
-
V
L
-
V
N
G
E
D
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
V
P
---
Y
------
K
N
--
H
L
T
V
H
F
V
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
---
D
---
W
---
F
L
----
K
A
-
A
G
--
D
-----
E
-
A
-
H
--
V
A
K
H
F
A
A
L
S
T
N
G
K
-
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
I
L
S
I
G
Y
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
V
S
H
-------
N
L
V
------
G
----
D
--
H
-
H
Q
K
L
M
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
A
Q
A
V
Q
A
E
L
E
-
K
A
G
-
K
S
A
A
E
-
I
A
A
L
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
--
D
S
A
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
A
F
K
A
-----
74
HHSearch
98.27
51%
-102
- C3 -
3HJB
12
G6PI_VIBCH
A:
[25-573]
-----------------------------------------
M
L
K
N
I
N
P
------
T
Q
T
Q
A
W
K
A
-
L
-
T
A
-
H
F
E
S
A
Q
D
M
D
L
K
A
L
F
A
Q
D
----
S
E
R
F
A
K
Y
S
A
R
-
F
G
------
Q
-------
D
----
I
L
V
D
Y
S
K
--
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
T
A
L
R
N
R
S
N
S
P
-
V
L
-
V
N
G
E
D
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
V
P
---
Y
K
-----
N
---
H
L
T
V
H
F
V
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
---
D
---
W
---
F
L
----
K
A
-
A
G
--
D
-----
E
-
A
-
H
--
V
A
K
H
F
A
A
L
S
T
N
G
K
-
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
S
I
I
L
S
I
-
G
Y
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
V
S
H
-------
N
L
V
------
G
----
D
--
H
-
H
Q
K
L
M
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
A
Q
A
V
Q
A
E
L
E
-
K
A
G
-
K
S
A
A
E
-
I
A
A
L
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
--
D
S
A
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
A
F
K
A
F
R
---
58
PsiBlast_CBE
96.81
48%
-104
- C3 -
2O2C
3
G6PI_TRYBB
A:
[51-601]
------------------------------------------------------
T
S
C
A
S
W
T
Q
-
L
-
Q
K
-
L
Y
E
Q
Y
G
D
E
P
I
K
K
H
F
E
T
D
----
S
E
R
G
Q
R
Y
S
V
K
-
V
-------
S
LGSKDE
N
F
----
L
F
L
D
Y
S
K
--
S
H
I
N
D
E
I
K
C
A
L
L
R
L
A
E
E
R
G
I
R
Q
F
V
Q
S
V
F
R
G
E
R
V
N
T
T
E
N
R
P
V
L
H
I
A
L
R
N
R
S
N
R
P
-
I
Y
-
V
D
G
K
D
V
M
P
A
V
N
K
V
L
D
Q
M
R
S
F
S
E
K
V
R
T
G
E
W
K
G
H
T
G
K
A
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
E
A
L
K
P
---
F
S
-----
Q
R
--
D
L
S
L
H
F
V
S
N
V
D
G
T
H
I
A
E
V
L
K
S
I
D
I
E
A
T
L
F
I
V
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
---
R
---
A
L
L
D
Y
L
----
R
S
-
R
G
--
I
-----
D
-
E
-
K
G
S
V
A
K
H
F
V
A
L
S
T
N
N
Q
-
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
M
W
S
A
I
G
-
L
-
P
I
M
I
S
I
G
Y
E
N
F
V
E
L
L
T
G
A
H
V
I
D
E
H
F
A
N
A
P
P
E
Q
N
V
P
L
L
L
A
L
V
G
V
W
Y
I
N
F
F
G
A
V
T
H
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
Y
V
T
R
S
G
K
T
V
S
T
L
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
N
L
I
P
C
D
F
I
G
A
I
Q
S
Q
-------
N
K
I
------
G
----
D
--
H
-
H
K
I
F
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
S
P
S
E
V
R
R
E
L
E
-
A
A
G
-
E
R
S
A
E
K
I
N
A
L
L
P
H
K
T
F
I
G
G
R
P
S
N
T
L
L
I
K
S
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
D
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
R
--
P
G
M
R
--------
V
N
N
H
D
S
S
T
N
G
L
I
N
M
F
-------
45
PsiBlast_CBE
96.66
48%
-107
- C3 -
2CXN
3
G6PI_MOUSE
B:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NHGH
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
55
PsiBlast_CBE
96.64
48%
-103
* C3 *
2O2D
2
G6PI_TRYBB
A:
[51-601]
------------------------------------------------------
T
S
C
A
S
W
T
Q
-
L
-
Q
K
-
L
Y
E
Q
Y
G
D
E
P
I
K
K
H
F
E
T
D
----
S
E
R
G
Q
R
Y
S
V
K
-
V
-------
S
LGSKDE
N
F
----
L
F
L
D
Y
S
K
--
S
H
I
N
D
E
I
K
C
A
L
L
R
L
A
E
E
R
G
I
R
Q
F
V
Q
S
V
F
R
G
E
R
V
N
T
T
E
N
R
P
V
L
H
I
A
L
R
N
R
S
N
R
P
-
I
Y
-
V
D
G
K
D
V
M
P
A
V
N
K
V
L
D
Q
M
R
S
F
S
E
K
V
R
T
G
E
W
K
G
H
T
G
K
A
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
E
A
L
K
P
---
F
S
-----
Q
R
--
D
L
S
L
H
F
V
S
N
V
D
G
T
H
I
A
E
V
L
K
S
I
D
I
E
A
T
L
F
I
V
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
---
R
---
A
L
L
D
Y
L
----
R
S
-
R
G
--
I
-----
D
-
E
-
K
G
S
V
A
K
H
F
V
A
L
S
T
N
N
Q
-
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
M
W
S
A
I
G
-
L
-
P
I
M
I
S
I
G
Y
E
N
F
V
E
L
L
T
G
A
H
V
I
D
E
H
F
A
N
A
P
P
E
Q
N
V
P
L
L
L
A
L
V
G
V
W
Y
I
N
F
F
G
A
V
T
H
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
Y
V
T
R
S
G
K
T
V
S
T
L
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
N
L
I
P
C
D
F
I
G
A
I
Q
S
Q
-------
N
K
I
------
G
----
D
--
H
-
H
K
I
F
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
S
P
S
E
V
R
R
E
L
E
-
A
A
G
-
E
R
S
A
E
K
I
N
A
L
L
P
H
K
T
F
I
G
G
R
P
S
N
T
L
L
I
K
S
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
D
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
R
--
P
G
M
R
--------
V
N
N
H
D
S
S
T
N
G
L
I
N
M
F
-------
78
HHSearch
96.58
48%
-104
- C3 -
2CXN
4
G6PI_MOUSE
A:
[1-553]
--------------------------------------------
M
A
A
L
------
T
R
N
P
Q
F
Q
K
-
L
-
L
E
W
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
NTNH---
G
-------
H
----
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
RK----
G
----
L
--
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
---
5
PsiBlast_PDB
96.56
50%
-104
- C3 -
1JIQ
-
G6PI_HUMAN
A:
[20-550]
--------------------------------------------------------------------
H
R
S
E
L
N
---
L
R
R
L
F
D
A
N
----
K
D
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
Y
V
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
Q
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
T
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
R
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
A
Q
--------
V
T
S
H
D
A
S
T
N
G
L
I
N
F
I
K
------
33
PsiBlast_CBE
96.37
48%
-107
- C3 -
2CXU
3
G6PI_MOUSE
B:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NHGH
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
24
PsiBlast_CBE
96.37
48%
-103
- C3 -
3NBU
1
G6PI_ECOLI
D:
[4-546]
---------------------------------------------
I
N
P
------
T
Q
T
A
A
W
Q
A
-
L
-
Q
K
-
H
F
D
E
M
K
D
V
T
I
A
D
L
F
A
K
D
----
G
D
R
F
S
K
F
S
A
T
-
F
-------
D
-------
D
Q---
M
L
V
D
Y
S
K
--
N
R
I
T
E
E
T
L
A
K
L
Q
D
L
A
K
E
C
D
L
A
G
A
I
K
S
M
F
S
G
E
K
I
N
R
T
E
N
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
-
V
D
G
K
D
V
M
P
E
V
N
A
V
L
E
K
M
K
T
F
S
E
A
I
I
S
G
E
W
K
G
Y
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
R
P
---
Y
------
K
N
--
H
L
N
M
H
F
V
S
N
V
D
G
T
H
I
A
E
V
L
K
K
V
N
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
S
A
R
---
D
---
W
---
F
L
----
K
A
-
A
G
--
D
-----
E
-
K
-
H
--
V
A
K
H
F
T
A
L
S
T
N
A
K
-
A
V
G
E
F
G
I
D
T
A
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
V
L
S
I
G
F
D
N
F
V
E
L
L
S
G
A
H
A
M
D
K
H
F
S
T
T
P
A
E
K
N
L
P
V
L
L
A
L
I
G
I
W
Y
N
N
F
F
G
A
E
T
E
A
I
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
V
V
D
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
V
P
C
D
F
I
A
P
A
I
T
H
-------
N
P
L
------
S
----
D
--
H
-
H
Q
K
L
L
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
R
E
V
V
E
Q
E
Y
R
-
D
Q
G
-
K
D
P
A
T
-
L
D
Y
V
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
L
R
E
I
T
P
F
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
T
Q
G
V
I
L
N
I
F
T
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
R
I
L
P
E
L
K
--
D
D
K
E
--------
I
S
S
H
D
S
S
T
N
G
L
I
N
R
Y
K
A
-----
36
PsiBlast_CBE
96.32
48%
-106
- C3 -
2CXT
5
G6PI_MOUSE
A:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
57
PsiBlast_CBE
96.26
48%
-106
- C3 -
2O2C
5
G6PI_TRYBB
B:
[51-601]
------------------------------------------------------
T
S
C
A
S
W
T
Q
-
L
-
Q
K
-
L
Y
E
Q
Y
G
D
E
P
I
K
K
H
F
E
T
D
----
S
E
R
G
Q
R
Y
S
V
K
-
V
-------
S
LGSKDE
N
F
----
L
F
L
D
Y
S
K
--
S
H
I
N
D
E
I
K
C
A
L
L
R
L
A
E
E
R
G
I
R
Q
F
V
Q
S
V
F
R
G
E
R
V
N
T
T
E
N
R
P
V
L
H
I
A
L
R
N
R
S
N
R
P
-
I
Y
-
V
D
G
K
D
V
M
P
A
V
N
K
V
L
D
Q
M
R
S
F
S
E
K
V
R
T
G
E
W
K
G
H
T
G
K
A
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
E
A
L
K
P
---
F
S
-----
Q
R
--
D
L
S
L
H
F
V
S
N
V
D
G
T
H
I
A
E
V
L
K
S
I
D
I
E
A
T
L
F
I
V
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
---
R
---
A
L
L
D
Y
L
----
R
S
-
R
G
--
I
-----
D
-
E
-
K
G
S
V
A
K
H
F
V
A
L
S
T
N
N
Q
-
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
M
W
S
A
I
G
-
L
-
P
I
M
I
S
I
G
Y
E
N
F
V
E
L
L
T
G
A
H
V
I
D
E
H
F
A
N
A
P
P
E
Q
N
V
P
L
L
L
A
L
V
G
V
W
Y
I
N
F
F
G
A
V
T
H
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
Y
V
T
R
S
G
K
T
V
S
T
L
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
N
L
I
P
C
D
F
I
G
A
I
Q
S
Q
-------
N
K
I
------
G
----
D
--
H
-
H
K
I
F
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
S
P
S
E
V
R
R
E
L
E
-
A
A
G
-
E
R
S
A
E
K
I
N
A
L
L
P
H
K
T
F
I
G
G
R
P
S
N
T
L
L
I
K
S
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
D
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
R
--
P
G
M
R
--------
V
N
N
H
D
S
S
T
N
G
L
I
N
M
F
-------
43
PsiBlast_CBE
96.25
48%
-107
- C3 -
2CXP
5
G6PI_MOUSE
B:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NHGH
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
65
PsiBlast_CBE
96.21
49%
-99
- C3 -
4EM6
5
G6PI_BRUME
A:
[8-552]
----------------------------------------------
D
A
------
T
K
L
E
A
T
V
A
K
L
-
K
K
-
H
W
A
E
S
A
P
R
D
M
R
A
A
F
S
A
D
----
P
G
R
F
G
R
Y
S
L
C
-
L
-------
D
-------
D
----
L
L
F
D
W
S
K
--
C
R
V
N
D
E
T
M
A
L
L
K
E
L
A
V
A
A
D
V
E
G
R
R
A
A
M
F
A
G
E
H
I
N
N
T
E
D
R
A
V
L
H
V
A
L
R
D
T
S
S
K
E
-
V
L
-
V
D
G
H
N
V
L
P
D
V
K
H
V
L
D
R
M
A
A
F
A
D
G
I
R
S
G
A
L
K
G
A
T
G
R
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
L
A
L
A
P
---
Y
H
-----
D
E
---
P
R
A
H
F
V
S
N
I
D
G
A
H
I
A
D
T
L
S
P
L
D
P
A
S
T
L
I
I
V
A
S
K
T
F
T
T
I
E
T
M
T
N
A
Q
T
A
R
---
K
---
W
----
V
----
A
D
-
T
L
--
G
-----
E
-
A
-
A
--
V
G
A
H
F
A
A
V
S
T
A
L
D
-
K
V
A
A
F
G
I
P
E
D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
-
P
V
M
I
A
V
G
P
D
N
F
R
K
F
L
A
G
A
H
A
M
D
V
H
F
R
D
A
P
L
E
K
N
L
P
V
M
L
G
L
I
G
Y
W
H
R
A
I
C
G
Y
G
S
R
A
I
I
P
Y
D
Q
R
L
S
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
S
V
T
L
D
G
K
P
V
S
G
P
T
G
P
V
V
W
G
E
P
G
T
N
G
Q
H
A
F
F
Q
L
L
H
Q
G
T
D
T
I
P
L
E
F
I
V
A
A
K
G
H
-------
E
P
T
------
L
----
D
--
H
Q
H
E
M
L
M
A
N
C
L
A
Q
S
E
A
L
M
K
G
R
T
L
D
E
A
R
A
Q
L
Q
-
A
K
N
-
L
P
A
S
Q
-
V
E
R
I
A
P
H
R
V
F
S
G
N
R
P
S
L
T
L
I
H
D
M
L
D
P
Y
T
L
G
R
L
I
A
L
Y
E
H
R
V
F
V
E
A
Q
I
F
G
I
N
A
F
D
Q
W
G
V
E
L
G
K
E
L
A
T
E
L
L
P
V
V
S
--
G
K
E
G
--------
A
S
G
R
D
A
S
T
Q
G
L
V
A
H
L
H
A
R
R
K
--
2
PsiBlast_PDB
96.20
48%
-101
- C3 -
3NBU
-
G6PI_ECOLI
A:
[4-546]
---------------------------------------------
I
N
P
------
T
Q
T
A
A
W
Q
A
-
L
-
Q
K
-
H
F
D
E
M
K
D
V
T
I
A
D
L
F
A
K
D
----
G
D
R
F
S
K
F
S
A
T
-
F
-------
D
-------
D
Q---
M
L
V
D
Y
S
K
--
N
R
I
T
E
E
T
L
A
K
L
Q
D
L
A
K
E
C
D
L
A
G
A
I
K
S
M
F
S
G
E
K
I
N
R
T
E
N
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
-
V
D
G
K
D
V
M
P
E
V
N
A
V
L
E
K
M
K
T
F
S
E
A
I
I
S
G
E
W
K
G
Y
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
R
P
---
Y
------
K
N
--
H
L
N
M
H
F
V
S
N
V
D
G
T
H
I
A
E
V
L
K
K
V
N
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
S
A
R
---
D
---
W
---
F
L
----
K
A
-
A
G
--
D
-----
E
-
K
-
H
--
V
A
K
H
F
T
A
L
S
T
N
-----
G
E
F
G
I
D
T
A
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
V
L
S
I
G
F
D
N
F
V
E
L
L
S
G
A
H
A
M
D
K
H
F
S
T
T
P
A
E
K
N
L
P
V
L
L
A
L
I
G
I
W
Y
N
N
F
F
G
A
E
T
E
A
I
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
V
V
D
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
V
P
C
D
F
I
A
P
A
I
T
H
-------
N
P
L
------
S
----
D
--
H
-
H
Q
K
L
L
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
R
E
V
V
E
Q
E
Y
R
-
D
Q
G
-
K
D
P
A
T
-
L
D
Y
V
V
P
F
K
V
F
E
G
N
R
P
T
N
S
I
L
L
R
E
I
T
P
F
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
T
Q
G
V
I
L
N
I
F
T
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
R
I
L
P
E
L
K
--
D
D
K
E
--------
I
S
S
H
D
S
S
T
N
G
L
I
N
R
Y
K
A
-----
64
PsiBlast_CBE
96.12
49%
-99
- C3 -
4EM6
5
G6PI_BRUME
B:
[8-552]
----------------------------------------------
D
A
------
T
K
L
E
A
T
V
A
K
L
-
K
K
-
H
W
A
E
S
A
P
R
D
M
R
A
A
F
S
A
D
----
P
G
R
F
G
R
Y
S
L
C
-
L
-------
D
-------
D
----
L
L
F
D
W
S
K
--
C
R
V
N
D
E
T
M
A
L
L
K
E
L
A
V
A
A
D
V
E
G
R
R
A
A
M
F
A
G
E
H
I
N
N
T
E
D
R
A
V
L
H
V
A
L
R
D
T
S
S
K
E
-
V
L
-
V
D
G
H
N
V
L
P
D
V
K
H
V
L
D
R
M
A
A
F
A
D
G
I
R
S
G
A
L
K
G
A
T
G
R
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
L
A
L
A
P
---
Y
H
-----
D
E
---
P
R
A
H
F
V
S
N
I
D
G
A
H
I
A
D
T
L
S
P
L
D
P
A
S
T
L
I
I
V
A
S
K
T
F
T
T
I
E
T
M
T
N
A
Q
T
A
R
---
K
---
W
----
V
----
A
D
-
T
L
--
G
-----
E
-
A
-
A
--
V
G
A
H
F
A
A
V
S
T
A
L
D
-
K
V
A
A
F
G
I
P
E
D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
-
P
V
M
I
A
V
G
P
D
N
F
R
K
F
L
A
G
A
H
A
M
D
V
H
F
R
D
A
P
L
E
K
N
L
P
V
M
L
G
L
I
G
Y
W
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R
A
I
C
G
Y
G
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R
A
I
I
P
Y
D
Q
R
L
S
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
S
V
T
L
D
G
K
P
V
S
G
P
T
G
P
V
V
W
G
E
P
G
T
N
G
Q
H
A
F
F
Q
L
L
H
Q
G
T
D
T
I
P
L
E
F
I
V
A
A
K
G
H
-------
E
P
T
------
L
----
D
--
H
Q
H
E
M
L
M
A
N
C
L
A
Q
S
E
A
L
M
K
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R
T
L
D
E
A
R
A
Q
L
Q
-
A
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N
-
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Q
-
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I
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L
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Y
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L
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L
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A
Q
I
F
G
I
N
A
F
D
Q
W
G
V
E
L
G
K
E
L
A
T
E
L
L
P
V
V
S
--
G
K
E
G
--------
A
S
G
R
D
A
S
T
Q
G
L
V
A
H
L
H
A
R
R
K
--
54
PsiBlast_CBE
96.09
48%
-103
- C3 -
2O2D
3
G6PI_TRYBB
B:
[51-601]
------------------------------------------------------
T
S
C
A
S
W
T
Q
-
L
-
Q
K
-
L
Y
E
Q
Y
G
D
E
P
I
K
K
H
F
E
T
D
----
S
E
R
G
Q
R
Y
S
V
K
-
V
-------
S
LGSKDE
N
F
----
L
F
L
D
Y
S
K
--
S
H
I
N
D
E
I
K
C
A
L
L
R
L
A
E
E
R
G
I
R
Q
F
V
Q
S
V
F
R
G
E
R
V
N
T
T
E
N
R
P
V
L
H
I
A
L
R
N
R
S
N
R
P
-
I
Y
-
V
D
G
K
D
V
M
P
A
V
N
K
V
L
D
Q
M
R
S
F
S
E
K
V
R
T
G
E
W
K
G
H
T
G
K
A
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
E
A
L
K
P
---
F
S
-----
Q
R
--
D
L
S
L
H
F
V
S
N
V
D
G
T
H
I
A
E
V
L
K
S
I
D
I
E
A
T
L
F
I
V
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
---
R
---
A
L
L
D
Y
L
----
R
S
-
R
G
--
I
-----
D
-
E
-
K
GS
V
A
K
H
F
V
A
L
S
T
N
N
Q
-
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
M
W
S
A
I
G
-
L
-
P
I
M
I
S
I
G
Y
E
N
F
V
E
L
L
T
G
A
H
V
I
D
E
H
F
A
N
A
P
P
E
Q
N
V
P
L
L
L
A
L
V
G
V
W
Y
I
N
F
F
G
A
V
T
H
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
Y
V
T
R
S
G
K
T
V
S
T
L
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
N
L
I
P
C
D
F
I
G
A
I
Q
S
Q
-------
N
K
I
------
G
----
D
--
H
-
H
K
I
F
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
S
P
S
E
V
R
R
E
L
E
-
A
A
G
-
E
R
S
A
E
K
I
N
A
L
L
P
H
K
T
F
I
G
G
R
P
S
N
T
L
L
I
K
S
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
D
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
R
--
P
G
M
R
--------
V
N
N
H
D
S
S
T
N
G
L
I
N
M
F
-------
7
PsiBlast_PDB
96.09
50%
-105
- C3 -
1JLH
-
G6PI_HUMAN
A:
[19-549]
--------------------------------------------------------------------
H
R
S
E
L
N
---
L
R
R
L
F
D
A
N
----
K
D
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
Y
V
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
Q
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
T
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
E
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
R
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
A
Q
--------
V
T
S
H
D
A
S
T
N
G
L
I
N
F
I
K
------
49
PsiBlast_CBE
96.06
48%
-108
- C3 -
1U0F
12
G6PI_MOUSE
B:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NHGH
I
L
V
D
Y
S
K
--
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
44
PsiBlast_CBE
96.02
48%
-109
- C3 -
2CXO
5
G6PI_MOUSE
B:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NHGH
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
35
PsiBlast_CBE
96.01
48%
-106
- C3 -
2CXT
5
G6PI_MOUSE
B:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NHGH
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
20
PsiBlast_PDB
96.01
48%
-105
- C3 -
2CXP
5
G6PI_MOUSE
A:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
39
PsiBlast_CBE
95.91
48%
-107
- C3 -
2CXR
5
G6PI_MOUSE
B:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NHGH
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
47
PsiBlast_CBE
95.87
48%
-108
- C3 -
1U0G
10
G6PI_MOUSE
B:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NHGH
I
L
V
D
Y
S
K
--
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
3
PsiBlast_PDB
95.83
50%
-105
- C3 -
1IAT
3
G6PI_HUMAN
A:
[19-549]
--------------------------------------------------------------------
H
R
S
E
L
N
---
L
R
R
L
F
D
A
N
----
K
D
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
Y
V
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
Q
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
T
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
R
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
A
Q
--------
V
T
S
H
D
A
S
T
N
G
L
I
N
F
I
K
------
59
PsiBlast_CBE
95.74
47%
-102
- C3 -
4QFH
2
?
B:
[60-613]
------------------------------------------------------
T
S
C
P
S
W
R
R
-
L
------
Q
E
L
Y
E
I
H
G
S
E
S
I
L
K
N
F
D
E
C
K
D
R
F
Q
R
Y
S
L
E
-
V
D
LRSSDK
N
-------
F
----
V
F
L
D
Y
S
K
--
T
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
R
G
I
R
A
F
M
R
A
L
F
A
G
E
K
V
N
T
A
E
N
R
S
V
L
H
I
A
L
R
N
R
S
N
R
P
-
I
F
-
V
N
G
H
D
V
M
P
L
V
N
K
V
L
E
Q
M
K
K
L
S
E
K
V
R
R
G
E
W
K
G
Q
S
G
K
P
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
M
M
A
C
E
A
L
R
P
---
F
S
-----
D
R
--
R
I
S
M
H
F
V
S
N
I
D
G
T
H
L
S
E
V
L
N
L
V
D
L
E
S
T
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
---
N
---
E
---
F
L
K
F
L
S
S
R
-
G
I
--
S
-----
E
-
A
G
A
--
V
A
K
H
F
V
A
L
S
T
N
A
E
-
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
V
M
I
S
I
G
Y
D
N
F
V
E
L
L
T
G
A
H
I
M
D
E
H
F
I
N
A
P
T
E
N
N
L
P
I
I
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
A
T
K
N
G
R
M
V
S
T
H
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
G
A
I
Q
T
Q
-------
N
Y
I
------
G
----
E
--
H
-
H
R
I
L
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
T
P
E
E
V
K
R
E
L
E
S
A
G
G
-
K
S
E
D
E
-
I
Q
L
L
I
P
Q
K
T
F
T
G
G
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
K
S
I
L
L
Q
L
Q
--
P
G
Q
K
--------
V
T
N
H
D
S
S
T
N
G
L
I
E
L
F
N
E
R
----
37
PsiBlast_CBE
95.74
48%
-106
- C3 -
2CXS
5
G6PI_MOUSE
B:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NHGH
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
50
PsiBlast_CBE
95.70
48%
-106
- C3 -
1U0F
15
G6PI_MOUSE
A:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
38
PsiBlast_CBE
95.68
48%
-105
- C3 -
2CXS
5
G6PI_MOUSE
A:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
41
PsiBlast_CBE
95.58
48%
-107
- C3 -
2CXQ
5
G6PI_MOUSE
B:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NHGH
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
42
PsiBlast_CBE
95.30
48%
-104
- C3 -
2CXQ
5
G6PI_MOUSE
A:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
92
Fugue
95.27
47%
-105
- C3 -
1DQR
2
G6PI_RABIT
A:
[1-555]
---------------------------------------------
A
A
L
------
T
R
N
P
Q
F
Q
K
-
L
-
Q
Q
W
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
N
TNH---
G
-------
H
----
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
KG--
L
--
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
93
Fugue
95.20
47%
-103
- C3 -
1DQR
2
G6PI_RABIT
A:
[1-555]
---------------------------------------------
A
A
L
------
T
R
N
P
Q
F
Q
K
-
L
Q
Q
W
-
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
N
TNH---
G
-------
H
----
I
L
L
D
Y
S
K
NL--
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
----
P
Y
-----
S
S
G-
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
--
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
--------IRKG
L
--
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
A
K
40
PsiBlast_CBE
95.17
48%
-104
- C3 -
2CXR
5
G6PI_MOUSE
A:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
31
PsiBlast_CBE
95.06
48%
-103
- C3 -
1HOX
2
G6PI_RABIT
B:
[17-550]
--------------------------------------------------------------------
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NHGH
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
------
94
Fugue
95.00
47%
-102
- C3 -
4QFH
2
?
A:
[6-615]
H
H
H
M
K
D
Q
Y
L
K
D
L
T
V
H
L
N
E
SNAAPAN
T
S
M
A
V
A
S
F
N
M
P
H
E
I
T
R
R
M
R
P
L
G
V
D
A
D
TSL
T
S
C
P
S
W
R
R
-
L
-
Q
E
-
L
Y
E
I
H
G
S
E
S
I
L
K
N
F
D
E
C
----
K
D
R
F
Q
R
Y
S
L
E
-
V
D
LRSSDK
N
-------
F
----
V
F
L
D
Y
S
K
--
T
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
R
G
I
R
A
F
M
R
A
L
F
A
G
E
K
V
N
T
A
E
N
R
S
V
L
H
I
A
L
R
N
R
S
N
R
P
-
I
F
-
V
N
G
H
D
V
M
P
L
V
N
K
V
L
E
Q
M
K
K
L
S
E
K
V
R
R
G
E
W
K
G
Q
S
G
K
P
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
M
M
A
C
E
A
L
R
P
---
F
S
-----
D
R
--
R
I
S
M
H
F
V
S
N
I
D
G
T
H
L
S
E
V
L
N
L
V
D
L
E
S
T
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
---
N
E
F
L
K
---
F
L
----
S
S
-
R
G
--
I
-----
S
-
E
-
A
G
A
V
A
K
H
F
V
A
L
S
T
N
A
E
-
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
V
M
I
S
I
G
Y
D
N
F
V
E
L
L
T
G
A
H
I
M
D
E
H
F
I
N
A
P
T
E
N
N
L
P
I
I
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
A
T
K
N
G
R
M
V
S
T
H
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
G
A
I
Q
T
Q
-------
N
Y
I
------
G
----
E
--
H
-
H
R
I
L
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
T
P
E
E
V
K
R
E
L
E
-
S
A
G
G
K
S
E
D
E
-
I
Q
L
L
I
P
Q
K
T
F
T
G
G
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
K
S
I
L
L
Q
L
Q
--
P
G
Q
K
--------
V
T
N
H
D
S
S
T
N
G
L
I
E
L
F
N
E
R
S
H
--
19
PsiBlast_PDB
94.96
48%
-105
- C3 -
2CXO
5
G6PI_MOUSE
A:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
48
PsiBlast_CBE
94.93
48%
-105
- C3 -
1U0G
14
G6PI_MOUSE
A:
[12-550]
------------------------------------------------------------
K
L
-
L
-
E
W
-
H
R
A
N
S
A
N
L
K
L
R
E
L
F
E
A
D
----
P
E
R
F
N
N
F
S
L
N
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
K
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
E
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
--
G
S
S
A
--------
V
T
S
H
D
S
S
T
N
G
L
I
S
F
I
K
------
6
PsiBlast_PDB
94.91
50%
-104
- C3 -
1NUH
7
G6PI_HUMAN
A:
[20-550]
--------------------------------------------------------------------
H
R
S
E
L
N
---
L
R
R
L
F
D
A
N
----
K
D
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NH
G
H
I
L
V
D
Y
S
K
--
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
Y
V
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
---
E
---
W
---
F
L
----
Q
A
-
A
K
--
D
-----
P
-
S
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
T
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
E
R
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
A
Q
--------
V
T
S
H
D
A
S
T
N
G
L
I
N
F
I
K
------
60
PsiBlast_CBE
94.85
47%
-103
- C3 -
4QFH
2
?
A:
[60-613]
------------------------------------------------------
T
S
C
P
S
W
R
R
-
L
------
Q
E
L
Y
E
I
H
G
S
E
S
I
L
K
N
F
D
E
C
K
D
R
F
Q
R
Y
S
L
E
-
V
D
LRSSDK
N
-------
F
----
V
F
L
D
Y
S
K
--
T
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
R
G
I
R
A
F
M
R
A
L
F
A
G
E
K
V
N
T
A
E
N
R
S
V
L
H
I
A
L
R
N
R
S
N
R
P
-
I
F
-
V
N
G
H
D
V
M
P
L
V
N
K
V
L
E
Q
M
K
K
L
S
E
K
V
R
R
G
E
W
K
G
Q
S
G
K
P
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
M
M
A
C
E
A
L
R
P
---
F
S
-----
D
R
--
R
I
S
M
H
F
V
S
N
I
D
G
T
H
L
S
E
V
L
N
L
V
D
L
E
S
T
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
---
N
---
E
---
F
L
K
F
L
S
S
R
-
G
I
--
S
-----
E
-
A
G
A
--
V
A
K
H
F
V
A
L
S
T
N
A
E
-
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
V
M
I
S
I
G
Y
D
N
F
V
E
L
L
T
G
A
H
I
M
D
E
H
F
I
N
A
P
T
E
N
N
L
P
I
I
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
A
T
K
N
G
R
M
V
S
T
H
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
G
A
I
Q
T
Q
-------
N
Y
I
------
G
----
E
--
H
-
H
R
I
L
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
T
P
E
E
V
K
R
E
L
E
S
A
G
G
-
K
S
E
D
E
-
I
Q
L
L
I
P
Q
K
T
F
T
G
G
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
K
S
I
L
L
Q
L
Q
--
P
G
Q
K
--------
V
T
N
H
D
S
S
T
N
G
L
I
E
L
F
N
E
R
----
30
PsiBlast_CBE
94.63
48%
-105
- C3 -
1XTB
2
G6PI_RABIT
B:
[17-550]
--------------------------------------------------------------------
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NHGH
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
------
32
PsiBlast_CBE
94.46
48%
-104
- C3 -
1G98
2
G6PI_RABIT
B:
[17-550]
--------------------------------------------------------------------
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NHGH
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
------
13
PsiBlast_PDB
94.43
48%
-103
- C3 -
1HOX
2
G6PI_RABIT
A:
[17-550]
--------------------------------------------------------------------
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NH
G
H
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
------
15
PsiBlast_PDB
94.37
48%
-106
- C3 -
1XTB
2
G6PI_RABIT
A:
[17-550]
--------------------------------------------------------------------
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NH
G
H
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
------
28
PsiBlast_CBE
94.35
48%
-101
- C3 -
1KOJ
2
G6PI_RABIT
B:
[16-549]
--------------------------------------------------------------------
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NHGH
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
------
12
PsiBlast_PDB
94.11
48%
-103
- C3 -
1G98
2
G6PI_RABIT
A:
[17-550]
--------------------------------------------------------------------
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NH
G
H
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
------
10
PsiBlast_PDB
93.99
48%
-106
- C3 -
1DQR
2
G6PI_RABIT
A:
[16-549]
--------------------------------------------------------------------
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NH
G
H
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
------
61
PsiBlast_CBE
93.85
46%
-104
- C3 -
1T10
1
G6PI_LEIME
A:
[52-602]
-------------------------------------------------------
N
L
P
A
W
K
R
-
L
-
Q
S
-
L
Y
E
K
Y
G
N
D
S
I
L
S
H
F
E
K
D
----
H
Q
R
F
Q
R
Y
S
I
E
-
I
D
LHSDD-
N
-------
F
----
L
F
L
D
Y
S
K
--
S
H
I
N
D
E
I
K
D
A
L
V
A
L
A
E
E
R
G
V
R
A
F
A
K
A
M
F
D
G
Q
R
V
N
S
T
E
N
R
A
V
L
H
V
A
L
R
N
R
S
N
R
P
-
I
I
-
V
D
G
K
D
V
M
S
D
V
N
N
V
L
A
Q
M
K
D
F
T
E
R
V
R
S
G
E
W
K
G
Q
T
G
K
S
I
Y
N
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
V
T
E
A
L
K
P
---
F
S
-----
K
R
--
D
L
H
C
F
F
V
S
N
V
D
G
T
H
M
A
E
V
L
K
Q
V
N
L
E
E
T
I
F
I
I
A
S
K
T
F
T
T
Q
E
T
L
T
N
A
M
S
A
R
N
A
L
M
---
S
---
Y
L
----
K
E
-
N
G
IS
T
-----
D
-
G
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
E
-
K
V
R
E
F
G
I
D
T
V
N
M
F
A
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
-
S
V
M
L
S
I
G
Y
D
N
F
V
E
F
L
T
G
A
H
V
M
D
N
H
F
A
S
T
P
T
E
Q
N
L
P
M
M
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
V
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
V
T
K
K
S
G
A
V
A
V
Q
T
G
P
I
V
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
I
I
P
C
D
F
I
G
C
V
Q
T
Q
-------
N
R
V
------
G
----
D
--
H
-
H
R
T
L
M
S
N
F
F
A
Q
T
E
A
L
M
V
G
K
N
A
E
E
V
R
Q
E
L
V
-
K
S
G
-
M
S
G
D
A
-
I
E
N
M
I
P
H
K
T
F
T
G
S
R
P
S
N
S
I
L
V
N
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
K
--
S
G
N
I
--------
V
S
D
H
D
G
S
T
N
G
L
I
N
M
F
N
T
R
----
11
PsiBlast_PDB
93.80
48%
-105
- C3 -
1KOJ
2
G6PI_RABIT
A:
[16-549]
--------------------------------------------------------------------
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NH
G
H
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
G
L
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
------
29
PsiBlast_CBE
93.66
48%
-102
- C3 -
1DQR
2
G6PI_RABIT
B:
[16-549]
--------------------------------------------------------------------
H
R
E
H
G
S
E
L
N
L
R
H
L
F
D
T
D
----
K
E
R
F
N
H
F
S
L
T
-
L
-------
N
-------
T
NHGH
I
L
L
D
Y
S
K
--
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
P
---
Y
S
-----
S
G
--
G
P
R
V
W
F
V
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
---
D
---
W
---
F
L
----
L
S
-
A
K
--
D
-----
P
-
S
-
T
--
V
A
K
H
F
V
A
L
S
T
N
T
A
-
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
T
Q
-------
H
P
I
------
R
----
K
GL
H
-
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
-
A
A
G
-
K
S
P
E
D
-
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
--
G
S
S
P
--------
V
T
S
H
D
S
S
T
N
G
L
I
N
F
I
K
------
75
HHSearch
92.82
45%
-99
- C3 -
1T10
1
G6PI_LEIME
A:
[49-604]
----------------------------------------------
S
L
------
L
N
L
P
A
W
K
R
-
L
-
Q
S
-
L
Y
E
K
Y
G
N
D
S
I
L
S
H
F
E
K
D
----
H
Q
R
F
Q
R
Y
S
I
E
-
I
D
LHSDD-
N
-------
F
----
L
F
L
D
Y
S
K
--
S
H
I
N
D
E
I
K
D
A
L
V
A
L
A
E
E
R
G
V
R
A
F
A
K
A
M
F
D
G
Q
R
V
N
S
T
E
N
R
A
V
L
H
V
A
L
R
N
R
S
N
R
P
-
I
I
-
V
D
G
K
D
V
M
S
D
V
N
N
V
L
A
Q
M
K
D
F
T
E
R
V
R
S
G
E
W
K
G
Q
T
G
K
S
I
Y
N
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
V
T
E
A
L
K
P
---
F
S
-----
K
R
--
D
L
H
C
F
F
V
S
N
V
D
G
T
H
M
A
E
V
L
K
Q
V
N
L
E
E
T
I
F
I
I
A
S
K
T
F
T
T
Q
E
T
L
T
N
A
M
S
A
R
---
N
---
A
---
L
M
----
S
Y
-
L
K
--
E
N
GIST
D
-
G
-
A
--
V
A
K
H
F
V
A
L
S
T
N
T
E
-
K
V
R
E
F
G
I
D
T
V
N
M
F
A
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
S
V
M
L
S
I
-
G
Y
D
N
F
V
E
F
L
T
G
A
H
V
M
D
N
H
F
A
S
T
P
T
E
Q
N
L
P
M
M
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
V
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
V
T
K
K
S
G
A
V
A
V
Q
T
G
P
I
V
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
I
I
P
C
D
F
I
G
C
V
Q
T
Q
-------
N
R
V
------
G
----
D
--
H
-
H
R
T
L
M
S
N
F
F
A
Q
T
E
A
L
M
V
G
K
N
A
E
E
V
R
Q
E
L
V
-
K
S
G
-
M
S
G
D
A
-
I
E
N
M
I
P
H
K
T
F
T
G
S
R
P
S
N
S
I
L
V
N
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
K
S
I
L
P
Q
L
K
--
S
G
N
I
--------
V
S
D
H
D
G
S
T
N
G
L
I
N
M
F
N
T
R
A
H
--
66
PsiBlast_CBE
91.03
47%
-98
- C3 -
3Q88
6
G6PI_FRATT
A:
[17-537]
-------------------------------------------------------------------------
Q
N
I
N
L
K
N
E
F
D
K
D
----
D
K
R
V
E
K
F
S
L
K
-
H
-------
Q
-------
N
----
I
Y
F
D
Y
S
K
--
N
L
I
N
D
Y
I
L
K
S
L
L
E
S
A
E
K
S
S
L
K
D
K
I
K
Q
M
F
N
G
A
K
I
N
S
T
E
H
R
A
V
L
H
T
A
L
R
D
L
S
S
T
P
-
L
I
-
V
D
G
Q
D
I
R
Q
E
V
T
K
E
K
Q
R
V
K
E
L
V
E
K
V
V
S
G
R
W
R
G
F
S
G
K
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
K
M
V
V
R
A
L
Q
P
---
Y
H
-----
C
T
--
D
L
K
V
H
F
V
S
N
V
D
A
D
S
L
L
Q
A
L
H
V
V
D
P
E
T
T
L
L
I
I
A
S
K
S
F
S
T
E
E
T
L
L
N
S
I
S
A
R
---
E
---
W
---
L
L
----
D
H
-
Y
E
--
D
-----
E
-
K
-
A
--
V
A
N
H
F
V
A
I
S
S
K
L
D
-
K
V
K
E
F
G
I
D
L
E
H
C
Y
K
M
W
D
W
V
G
G
R
Y
S
L
W
S
S
I
G
-
M
-
S
I
A
F
A
I
G
Y
D
N
F
E
K
L
L
A
G
A
Y
S
V
D
K
H
F
K
E
T
E
F
S
K
N
I
P
V
I
M
A
L
L
A
S
Y
Y
S
C
T
Y
N
S
Q
S
Q
A
L
L
P
Y
D
E
R
L
C
Y
F
V
D
Y
L
Q
Q
A
D
M
E
S
N
G
K
S
V
N
I
A
G
E
T
V
N
Y
Q
T
G
V
V
L
W
G
G
V
G
T
N
G
Q
H
A
F
H
Q
L
L
H
Q
G
N
I
F
I
P
V
D
F
I
A
I
A
T
S
H
-------
H
N
Y
------
D
----
N
--
H
-
Q
Q
A
L
L
A
N
C
F
A
Q
S
Q
A
L
M
F
G
Q
S
Y
D
M
V
Y
N
E
L
L
-
K
S
G
-
L
N
E
T
Q
-
A
K
E
L
A
A
H
K
V
I
P
G
N
R
P
S
T
T
I
L
L
D
E
L
S
P
Y
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
V
Q
G
V
L
W
D
I
N
S
Y
D
Q
W
G
V
E
L
G
K
K
L
G
K
N
I
L
K
A
M
N
DD
S
S
D
E
--------
Y
Q
N
L
D
D
S
T
R
Q
L
I
----------
70
PsiBlast_CBE
90.66
41%
-96
- C3 -
3UJH
3
?
A:
[5-547]
------------------------------------------
M
A
P
T
Q
L
------
E
Q
C
A
S
H
G
K
-
L
-
L
Q
-
E
K
K
K
L
E
K
L
H
L
R
D
L
L
K
D
E
----
A
R
N
D
L
L
I
R
S
T
-
D
-------
Q
-------
G
----
V
Y
L
D
F
S
R
--
Q
K
I
T
L
E
T
L
Q
H
L
V
N
L
A
H
E
R
Q
V
P
A
M
V
K
R
M
F
S
G
E
K
I
N
Q
T
E
N
R
A
V
L
H
V
A
L
R
M
P
E
G
S
E
P
V
H
-
V
D
G
K
N
V
L
D
E
V
H
A
V
L
R
R
I
R
V
F
S
E
K
V
R
S
G
E
I
R
G
H
T
G
K
K
L
V
N
V
I
S
I
G
I
G
G
S
Y
L
G
T
E
F
V
H
L
A
L
A
A
E
G
Y
A
A
-----
E
K
A
H
G
R
Q
I
H
F
L
A
N
V
D
P
V
D
V
W
L
A
E
R
G
F
D
P
E
E
T
L
V
V
V
I
S
K
T
F
T
T
A
E
T
M
M
N
A
R
S
V
R
---
D
---
W
---
Y
L
----
H
H
Y
K
G
--
D
-----
E
-
R
-
A
--
L
G
A
H
F
C
A
V
S
T
N
L
D
-
G
T
S
K
F
G
I
Q
S
D
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F
G
F
W
D
W
V
G
G
R
Y
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S
A
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I
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-
P
L
A
L
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A
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A
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A
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L
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M
L
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L
I
S
V
W
N
A
T
F
F
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Y
S
N
V
A
V
L
P
Y
A
Q
A
L
L
R
F
P
A
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I
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Q
L
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E
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N
G
K
R
V
T
M
D
G
K
T
L
D
F
D
V
G
E
I
F
F
G
E
P
G
T
N
G
Q
H
S
F
Y
Q
L
I
H
Q
G
-
R
V
I
P
A
E
F
I
G
F
C
K
S
Q
R
A
I
K
L
KE
E
P
V
------
S
----
N
--
H
-
D
E
-
L
M
S
N
F
F
A
Q
P
D
A
L
A
F
G
K
T
P
E
----
E
L
R
-
K
E
G
-
I
P
E
-----
K
L
V
P
H
K
T
F
P
G
D
R
P
S
C
M
L
L
F
P
E
I
S
P
F
H
I
G
Q
L
L
A
L
Y
E
H
R
V
A
V
E
G
W
L
W
G
I
N
S
F
D
Q
W
G
V
E
L
G
K
V
L
A
K
G
V
R
G
I
L
Q
--
K
R
R
E
--------
G
K
A
P
H
E
S
G
Q
-------------
69
PsiBlast_CBE
90.49
41%
-99
- C3 -
3UJH
4
?
B:
[9-547]
----------------------------------------------
Q
L
------
E
Q
C
A
S
H
G
K
-
L
-
L
Q
-
E
K
K
K
L
E
K
L
H
L
R
D
L
L
K
D
E
----
A
R
N
D
L
L
I
R
S
T
-
D
-------
Q
-------
G
----
V
Y
L
D
F
S
R
--
Q
K
I
T
L
E
T
L
Q
H
L
V
N
L
A
H
E
R
Q
V
P
A
M
V
K
R
M
F
S
G
E
K
I
N
Q
T
E
N
R
A
V
L
H
V
A
L
R
M
P
E
G
S
E
P
V
H
-
V
D
G
K
N
V
L
D
E
V
H
A
V
L
R
R
I
R
V
F
S
E
K
V
R
S
G
E
I
R
G
H
T
G
K
K
L
V
N
V
I
S
I
G
I
G
G
S
Y
L
G
T
E
F
V
H
L
A
L
A
A
E
G
Y
A
A
-----
E
K
A
H
G
R
Q
I
H
F
L
A
N
V
D
P
V
D
V
W
L
A
E
R
G
F
D
P
E
E
T
L
V
V
V
I
S
K
T
F
T
T
A
E
T
M
M
N
A
R
S
V
R
---
D
---
W
---
Y
L
----
H
H
Y
K
G
--
D
-----
E
-
R
-
A
--
L
G
A
H
F
C
A
V
S
T
N
L
D
-
G
T
S
K
F
G
I
Q
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D
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V
F
G
F
W
D
W
V
G
G
R
Y
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V
T
S
A
V
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I
L
-
P
L
A
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Y
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Y
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L
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A
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K
T
A
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N
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M
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M
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L
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W
N
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Y
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N
V
A
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A
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A
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Q
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N
G
K
R
V
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D
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T
L
D
F
D
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F
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G
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N
G
Q
H
S
F
Y
Q
L
I
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Q
G
-
R
V
I
P
A
E
F
I
G
F
C
K
S
Q
R
A
I
K
L
KE
E
P
V
------
S
----
N
--
H
-
D
E
-
L
M
S
N
F
F
A
Q
P
D
A
L
A
F
G
K
T
P
E
----
E
L
R
-
K
E
G
-
I
P
E
-----
K
L
V
P
H
K
T
F
P
G
D
R
P
S
C
M
L
L
F
P
E
I
S
P
F
H
I
G
Q
L
L
A
L
Y
E
H
R
V
A
V
E
G
W
L
W
G
I
N
S
F
D
Q
W
G
V
E
L
G
K
V
L
A
K
G
V
R
G
I
L
Q
--
K
R
R
E
--------
G
K
A
P
H
E
S
G
Q
-------------
76
HHSearch
89.97
41%
-98
- C3 -
3UJH
3
?
A:
[4-565]
-----------------------------------------
S
M
A
P
T
Q
L
------
E
Q
C
A
S
H
G
K
-
L
-
L
Q
-
E
K
K
K
L
E
K
L
H
L
R
D
L
L
K
-
D
----
E
A
R
N
D
L
L
I
R
S
-
T
D------
Q
-------
G
----
V
Y
L
D
F
S
R
--
Q
K
I
T
L
E
T
L
Q
H
L
V
N
L
A
H
E
R
Q
V
P
A
M
V
K
R
M
F
S
G
E
K
I
N
Q
T
E
N
R
A
V
L
H
V
A
L
R
M
P
E
G
S
E
-
P
V
H
V
D
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K
N
V
L
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A
V
L
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G
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K
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N
V
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G
I
G
G
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Y
L
G
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V
H
L
A
L
A
A
---
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G
Y
A
A
E
K
A
H
--
G
R
Q
I
H
F
L
A
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D
P
V
D
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L
A
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D
P
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V
V
I
S
K
T
F
T
T
A
E
T
M
M
N
A
R
S
V
R
---
D
---
W
---
Y
L
----
H
H
-
Y
K
--
G
-----
D
E
R
-
A
--
L
G
A
H
F
C
A
V
S
T
N
L
D
G
T
S
-
K
F
G
I
Q
S
D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
V
T
S
A
V
G
-
I
L
P
L
A
L
Q
Y
G
Y
D
V
A
Q
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F
L
N
G
A
H
A
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V
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F
K
T
A
E
L
A
D
N
L
P
M
L
M
G
L
I
S
V
W
N
A
T
F
F
G
Y
S
N
V
A
V
L
P
Y
A
Q
A
L
L
R
F
P
A
H
I
Q
Q
L
T
M
E
S
N
G
K
R
V
T
M
D
G
K
T
L
D
F
D
V
G
E
I
F
F
G
E
P
G
T
N
G
Q
H
S
F
Y
Q
L
I
H
Q
G
R
-
V
I
P
A
E
F
I
G
F
C
K
S
Q
-------
R
A
I
K
L
KEEP
V
----
S
--
N
-
H
D
E
L
M
S
N
F
F
A
Q
P
D
A
L
A
F
G
K
T
P
E
E
L
R
K
E
----------
G
I
-
P
E
K
L
V
P
H
K
T
F
P
G
D
R
P
S
C
M
L
L
F
P
E
I
S
P
F
H
I
G
Q
L
L
A
L
Y
E
H
R
V
A
V
E
G
W
L
W
G
I
N
S
F
D
Q
W
G
V
E
L
G
K
V
L
A
K
G
V
R
G
I
L
Q
--
K
R
R
E
GKAPHESG
Q
S
E
L
C
S
S
T
R
K
I
L
E
H
Y
V
Q
Q
S
---
67
PsiBlast_CBE
89.63
47%
-97
- C3 -
3Q7I
6
G6PI_FRATT
A:
[17-537]
-------------------------------------------------------------------------
Q
N
I
N
L
K
N
E
F
D
K
D
----
D
K
R
V
E
K
F
S
L
K
-
H
-------
Q
-------
N
----
I
Y
F
D
Y
S
K
--
N
L
I
N
D
Y
I
L
K
S
L
L
E
S
A
E
K
S
S
L
K
D
K
I
K
Q
M
F
N
G
A
K
I
N
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T
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H
R
A
V
L
H
T
A
L
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D
L
S
S
T
P
-
L
I
-
V
D
G
Q
D
I
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Q
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V
T
K
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K
Q
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K
E
L
V
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K
V
V
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G
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W
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G
F
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K
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V
N
I
G
I
G
G
S
D
L
G
P
K
M
V
V
R
A
L
Q
P
---
Y
H
-----
C
T
--
D
L
K
V
H
F
V
S
N
V
D
A
D
S
L
L
Q
A
L
H
V
V
D
P
E
T
T
L
L
I
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A
S
K
S
F
S
T
E
E
T
L
L
N
S
I
S
A
R
---
E
---
W
---
L
L
----
D
H
-
Y
E
--
D
-----
E
-
K
-
A
--
V
A
N
H
F
V
A
I
S
S
K
L
D
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K
V
K
E
F
G
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D
L
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M
W
D
W
V
G
G
R
Y
S
L
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S
S
I
G
-
M
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I
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A
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L
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N
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L
L
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L
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L
L
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G
N
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F
I
A
I
A
T
S
H
-------
H
N
Y
------
D
----
N
--
H
-
Q
Q
A
L
L
A
N
C
F
A
Q
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Q
A
L
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F
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Q
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Y
D
M
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Y
N
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L
L
-
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A
A
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L
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K
K
L
G
K
N
I
L
K
A
M
N
D
D
S
S
D
E
--------
Y
Q
N
L
D
D
S
T
R
Q
L
I
----------