@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4742: (2016-03-01 )
MAQVKRIRRSISGILVLDKPRGMSSNQALQKVRWLLNAEKAGHTGSLDPLATGVLPLCFGEATKFSQYLLDADKGYETVMRMGITTTTGDAEGELLAERDVTVGRDDLEQALPRFRGDIEQVPPMYSALKKDGQPLYKLARAGEVVEREARSVTITRLDLLSFEPPCATLAVSCSKGTYVRTLVEDLGQVLGCGAHVAALRRTQAGPFALAQAITLETLERVHAEGGPEALDQFLMPEDSGLLHWPVLQLSEHSAYYWLHGQPVRAPEAPKFGWLRVQDHTGRFIGIGEVTDDGRIAPRRLIRS
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100-.......110.......120.......130.......140.......150.......160..----.--....170.......180.......190.......200.......210..-......----220.----.----.----.------.------.--.230.......240........250.......260.......270-----..------..-----....-.-280.......290..----.....300..-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
Q
V
K
R
I
R
R
SIS
G
I
L
V
L
DKPRGMS
S
N
Q
A
L
Q
K
V
R
W
L
L
NAEKAGHTGSL
D
P
L
A
T
G
V
L
P
L
CFG
E
A
T
K
F
S
Q
Y
L
L
D
ADK
G
Y
E
T
V
M
R
MG
I
T
TTTGDAEG
E
L
L
A
ERDVT-V
G
R
D
D
L
E
Q
A
L
P
R
FRG
D
I
E
QV
P
P
M
Y
S
A
L
KKDG
Q
P
L
Y
K
L
A
RA
G
E
V
V
E
REAR
S
V
T
I
T
R
L
D
L
LSFE----P--PC
A
T
L
A
V
SCSKG
T
Y
V
R
T
L
V
E
D
L
G
Q
V
LGC
G
A
H
V
A
A
L
R
RTQA
G
P
F
A
L
A
-
Q
A
-
I
T
L
E
T
L
----
E
R
V
H----A----E----G------
G
------
P
--
E
A
L
D
Q
F
LMPEDS-G
L
L
HWP
V
L
QLSEHS
A
Y
Y
W
LHGQPVRAPEAP-------KF------
G
W
-----
L
R
V
Q-D-HT
G
R
F
I
G
I
G
EVTDDG----R
I
A
P
R
R
LIRS-------
46
Fugue
97.42
51%
-97
- C3 -
1K8W
11
TRUB_ECOLI
A:
[22-324]
--------
M
D
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
-
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
----
G
--
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
T
L
E
H
L
----
R
E
L
V
----
E
----
Q
----
A
------
E
Q
Q
DIP
A
A
--
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
G
A
P
-------
L
E
------
G
L
-----
V
R
V
T
E
G
-
E
N
G
K
F
I
G
M
G
E
I
D
D
E
G
----
R
V
A
P
R
R
L
V
V
E
-------
26
HHSearch
97.13
51%
-96
- C3 -
1K8W
11
TRUB_ECOLI
A:
[22-323]
--------
M
D
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
-
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
----
G
--
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
T
L
E
H
L
----
R
E
L
V
----
E
----
Q
----
A
E
Q
Q
DIP
A
------
A
--
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
G
A
P
-------
L
E
------
G
L
-----
V
R
V
T
-
E
G
E
N
G
K
F
I
G
M
G
E
I
D
D
E
G
----
R
V
A
P
R
R
L
V
V
--------
2
PsiBlast_PDB
95.88
51%
-100
- C3 -
1K8W
11
TRUB_ECOLI
A:
[24-322]
----------
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
-
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
----
G
--
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
T
L
E
H
L
R
E
L
V
E
Q
A
E
----
Q
----
Q
----
D
------
I
------
P
A
A
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
G
A
P
-------
L
E
------
G
L
-----
V
R
V
T
-
E
G
E
N
G
K
F
I
G
M
G
E
I
D
D
E
G
----
R
V
A
P
R
R
L
V
---------
3
PsiBlast_PDB
94.28
51%
-98
- C3 -
1ZL3
4
TRUB_ECOLI
A:
[24-322]
----------
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
N
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
-
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
----
G
--
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
T
L
E
H
L
R
E
L
V
E
Q
A
E
----
Q
----
Q
----
D
------
I
------
P
A
A
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
G
A
P
-------
L
E
------
G
L
-----
V
R
V
T
-
E
G
E
N
G
K
F
I
G
M
G
E
I
D
D
E
G
----
R
V
A
P
R
R
L
V
---------
1
PsiBlast_PDB
92.45
51%
-109
- C3 -
1R3F
-
TRUB_ECOLI
A:
[8-309]
-------
G
R
D
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
-
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
-----------------------------
I
T
V
Y
E
L
L
F
I
R
H
E
----
G
--
N
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
V
E
-
R
M
-
V
T
L
E
H
L
R
E
L
V
E
Q
A
E
----
Q
----
Q
----
D
------
I
------
P
A
A
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
G
A
P
-------
L
E
------
G
L
-----
V
R
V
T
-
E
G
E
N
G
K
F
I
G
M
G
E
I
D
D
E
G
----
R
V
A
P
R
R
L
V
---------
47
Fugue
83.09
31%
-89
- C3 -
1R3E
3
TRUB_THEMA
A:
[1-309]
---------
M
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
N
V
F
E
A
----
A
-------------------------------
P
--
E
E
I
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
-------
E
W
DGFKKG
E
V
-----
V
R
V
F
-
N
-
E
E
G
R
L
L
A
L
A
E
A
E
R
N
S
SFLE
T
L
R
K
E
R
V
L
T
L
RKVFNTR
27
HHSearch
80.10
33%
-89
- C3 -
1R3E
3
TRUB_THEMA
A:
[2-284]
----------
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
N
V
F
E
A
----
A
P
E
---------------------------------
E
I
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
EWDGFK-
K
G
------
E
V
-----
V
R
V
F
-
N
-
E
E
G
R
L
L
A
L
A
E
A
-------------------------
7
PsiBlast_PDB
79.77
32%
-92
- C3 -
1ZE2
2
TRUB_THEMA
A:
[4-287]
------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
N
V
---------------
F
----
E
----
A
------
A
------
P
--
E
E
I
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
-------
E
W
D-----
G
F
K
K
G
E
V
V
R
V
F
-
N
-
E
E
G
R
L
L
A
L
A
E
--------------------------
6
PsiBlast_PDB
79.26
32%
-87
- C3 -
1R3E
3
TRUB_THEMA
A:
[4-283]
------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
N
V
---------------
F
----
E
----
A
------
A
------
P
--
E
E
I
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
-------
E
W
D-----
G
F
KKG
E
V
V
R
V
F
-
N
-
E
E
G
R
L
L
A
L
A
E
--------------------------
5
PsiBlast_PDB
79.08
32%
-85
- C3 -
1ZE1
1
TRUB_THEMA
A:
[4-279]
------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
N
V
---------------
F
----
E
----
A
------
A
------
P
--
E
E
I
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
-------
E
W
D-----
G
F
KKG
E
V
V
R
V
F
-
N
-
E
E
G
R
L
L
A
L
A
E
--------------------------
8
PsiBlast_PDB
78.53
32%
-88
- C3 -
2AB4
2
TRUB_THEMA
A:
[4-287]
------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
F
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
N
V
---------------
F
----
E
----
A
------
A
------
P
--
E
E
I
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
-------
E
W
D
-----
G
F
K
KG
E
V
V
R
V
F
-
N
-
E
E
G
R
L
L
A
L
A
E
--------------------------
23
PsiBlast_CBE
78.23
32%
-81
- C3 -
1ZE1
1
TRUB_THEMA
B:
[4-279]
------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
N
V
---------------
F
----
E
----
A
------
A
------
P
--
E
E
I
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
-------
E
W
D-----
G
F
KKG
E
V
V
R
V
F
-
N
-
E
E
G
R
L
L
A
L
A
E
--------------------------
29
HHSearch
77.98
33%
-95
* C3 *
2APO
2
TRUB_METJA
A:
[57-321]
--
E
R
K
I
E
D
L
I
K
Y
G
V
V
V
V
D
K
P
R
G
P
T
S
H
E
V
S
T
W
V
K
K
I
L
N
L
D
K
A
G
H
G
G
T
L
D
P
K
V
T
G
V
L
P
V
A
L
E
R
A
T
K
T
I
P
M
W
H
I
P
P
K
E
Y
V
C
L
M
H
L
H
R
---------------
D
---
A
S
E
E
D
I
L
R
V
F
K
E
F
T
G
R
I
Y
Q
R
----------------------------
R
I
R
K
I
H
E
L
E
L
L
D
K
D
----
G
--
K
D
V
L
F
R
V
K
C
Q
S
G
T
Y
I
R
K
L
C
E
D
I
G
E
A
L
G
T
S
A
H
M
Q
E
L
R
R
T
K
S
G
C
F
E
E
K
-
D
A
-
V
Y
L
Q
D
L
----
L
D
A
Y
----
V
F
W
K
E
D
----
G
------
D
------
E
--
E
E
L
R
R
V
I
K
P
M
E
Y
-
G
L
R
H
L
K
K
V
V
V
K
D
S
A
V
D
A
I
C
H
G
A
D
V
Y
V
R
G
I
A
K
L
S
K
GIG
K
G
------
E
T
-----
V
L
V
E
-
T
-
L
K
G
E
A
V
A
V
G
K
A
-------------------------
22
PsiBlast_CBE
77.68
32%
-83
- C3 -
1ZE1
1
TRUB_THEMA
C:
[4-279]
------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
N
V
---------------
F
----
E
----
A
------
A
------
P
--
E
E
I
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
-------
E
W
D-----
G
F
KKGEV
V
R
V
F
-
N
-
E
E
G
R
L
L
A
L
A
E
--------------------------
28
HHSearch
77.24
38%
-103
- C3 -
1SGV
-
TRUB_MYCTU
A:
[3-281]
--------
A
T
G
P
G
I
V
V
I
D
K
P
A
G
M
T
S
H
D
V
V
G
R
C
R
R
I
F
A
T
R
R
V
G
H
A
G
T
L
D
P
M
A
T
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
T
A
A
P
K
S
Y
A
A
T
I
R
L
G
Q
T
T
S
T
E
D
A
E
G
Q
V
L
Q
S
V
P
A
K
H
L
T
I
E
A
I
D
A
A
M
E
R
L
R
G
E
I
----------------------------
L
E
A
R
P
I
R
I
D
R
F
E
L
L
A
A
R
R
RDQ
L
--
I
D
I
D
V
E
I
D
C
S
S
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
L
G
V
G
G
H
V
T
A
L
R
R
T
R
V
G
R
F
E
L
D
-
Q
A
-
R
S
L
D
D
L
----
A
E
R
P
----
A
-------------------------------
L
S
L
S
L
D
E
A
C
L
L
M
F
A
R
R
D
L
T
A
A
E
A
S
A
A
A
N
G
R
S
L
P
A
V
G
I
---------
D
------
G
V
-----
Y
A
A
C
-
D
-
A
D
G
R
V
I
A
L
L
R
D
E
G
-----------------------
21
PsiBlast_CBE
75.96
32%
-89
- C3 -
1ZE1
1
TRUB_THEMA
D:
[4-279]
------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
------------------------
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
I
E
-
E
S
-
L
N
V
---------------
F
----
E
----
A
------
A
------
P
--
E
E
I
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
I
H
L
E
M
L
K
-------
E
W
D-----
G
F
KKGEV
V
R
V
F
-
N
-
E
E
G
R
L
L
A
L
A
E
--------------------------
31
HHSearch
74.12
31%
-107
- C3 -
2AUS
2
TRUB_PYRAB
C:
[39-302]
----
P
I
E
L
H
I
Q
Y
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
R
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
R
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
---------------
D
---
V
P
E
D
K
I
R
A
V
M
K
E
F
E
G
E
I
I
Q
R
-----------------------------
T
R
K
V
Y
Y
I
E
I
L
E
I
D
----
G
--
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
A
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
V
T
L
H
D
L
----
V
D
Y
Y
----
H
----
F
----
W
KEDG--
I
------
E
--
E
Y
I
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
I
W
I
K
D
S
A
V
A
A
V
A
H
G
A
N
L
T
V
P
G
I
V
K
L
N
A
GIK
K
G
------
D
L
-----
V
A
I
M
-
T
-
L
K
D
E
L
V
A
L
G
K
A
-------------------------
25
PsiBlast_CBE
74.04
31%
-102
- C3 -
2APO
2
TRUB_METJA
A:
[67-288]
------------
G
V
V
V
V
D
K
P
R
G
P
T
S
H
E
V
S
T
W
V
K
K
I
L
N
L
D
K
A
G
H
G
G
T
L
D
P
K
V
T
G
V
L
P
V
A
L
E
R
A
T
K
T
I
P
M
W
H
I
P
P
K
E
Y
V
C
L
M
H
L
---------------
H
R
D
A
S
---
E
E
D
I
L
R
V
F
K
E
F
T
G
R
I
Y
Q
R
----------------------------
R
I
R
K
I
H
E
L
E
L
L
D
K
D
----
G
--
K
D
V
L
F
R
V
K
C
Q
S
G
T
Y
I
R
K
L
C
E
D
I
G
E
A
L
G
T
S
A
H
M
Q
E
L
R
R
T
K
S
G
C
F
E
E
K
-
D
A
-
V
Y
L
Q
D
L
----
L
D
A
Y
----
V
F
W
K
E
D
----
G
------
D
------
E
--
E
E
L
R
R
V
I
K
P
M
E
Y
-
G
L
R
H
L
K
K
V
V
V
K
D
S
A
V
D
A
I
C
H
G
A
D
V
-----------------------------------------------------------------------
13
PsiBlast_PDB
72.94
30%
-113
- C3 -
3LWO
1
TRUB_PYRFU
A:
[47-272]
------------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
-----
H
G
D
-------------
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
----
G
--
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
I
T
L
H
D
L
----
V
D
Y
Y
Y
F
W
K
E
----
D
----
G
------
I
------
E
--
E
Y
F
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--------------------------------------------------------------------
30
HHSearch
72.85
27%
-93
- C3 -
3U28
-
CBF5_YEAST
A:
[51-318]
---
R
D
L
K
S
Y
I
S
S
G
V
I
N
L
D
K
P
S
N
P
S
S
H
E
V
V
A
W
I
K
R
I
L
R
C
E
K
T
G
H
S
G
T
L
D
P
K
V
T
G
C
L
I
V
C
I
D
R
A
T
R
L
V
K
S
Q
Q
G
A
G
K
E
Y
V
C
I
V
R
L
H
D
A
L
-----------------
K
D
E
K
D
L
G
R
S
L
E
N
L
T
G
A
L
F
Q
R
P
P
-----
K
R
Q
-----------------
L
R
V
R
T
I
Y
E
S
N
L
I
E
F
D
----
N
KR
N
L
G
V
F
W
A
S
C
E
A
G
T
Y
M
R
T
L
C
V
H
L
G
M
L
L
G
V
G
G
H
M
Q
E
L
R
R
V
R
S
G
A
L
S
E
N
D
N
M
-
V
T
L
H
D
V
----
M
D
A
Q
----
W
----
V
Y
D
N
T
R
------
D
------
E
--
S
Y
L
R
S
I
I
Q
P
L
E
T
-
L
L
V
G
Y
K
R
I
V
V
K
D
S
A
V
N
A
V
C
Y
G
A
K
L
M
I
P
G
L
L
R
Y
E
E
GIE
L
Y
------
D
E
-----
I
V
L
I
-
T
-
T
K
G
E
A
I
A
V
A
I
A
-------------------------
16
PsiBlast_PDB
72.59
30%
-114
- C3 -
3LWR
1
TRUB_PYRFU
A:
[47-272]
------------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
-----
H
G
D
-------------
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
----
G
--
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
I
T
L
H
D
L
----
V
D
Y
Y
Y
F
W
K
E
----
D
----
G
------
I
------
E
--
E
Y
F
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--------------------------------------------------------------------
11
PsiBlast_PDB
72.46
30%
-108
- C3 -
3HAX
5
TRUB_PYRFU
A:
[47-272]
------------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
-----
H
G
D
-------------
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
-----------------
R
R
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
----
G
--
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
I
T
L
H
D
L
----
V
D
Y
Y
Y
F
W
K
E
----
D
----
G
------
I
------
E
--
E
Y
F
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--------------------------------------------------------------------
14
PsiBlast_PDB
72.44
30%
-114
- C3 -
3LWP
1
TRUB_PYRFU
A:
[47-272]
------------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
-----
H
G
D
-------------
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
----
G
--
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
I
T
L
H
D
L
----
V
D
Y
Y
Y
F
W
K
E
----
D
----
G
------
I
------
E
--
E
Y
F
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--------------------------------------------------------------------
19
PsiBlast_PDB
71.84
30%
-109
- C3 -
3HJW
2
TRUB_PYRFU
A:
[40-265]
------------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
-----
H
G
D
-------------
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
-----------------
R
R
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
----
G
--
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
I
T
L
H
D
L
----
V
D
Y
Y
Y
F
W
K
E
----
D
----
G
------
I
------
E
--
E
Y
F
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--------------------------------------------------------------------
12
PsiBlast_PDB
71.12
30%
-104
- C3 -
3HAY
1
TRUB_PYRFU
A:
[47-272]
------------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
-----
H
G
D
-------------
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
-----------------
R
R
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
----
G
--
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
I
T
L
H
D
L
----
V
D
Y
Y
Y
F
W
K
E
----
D
----
G
------
I
------
E
--
E
Y
F
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--------------------------------------------------------------------
17
PsiBlast_PDB
71.00
30%
-113
- C3 -
3LWV
1
TRUB_PYRFU
A:
[47-272]
------------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
-----
H
G
D
-------------
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
----
G
--
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
I
T
L
H
D
L
----
V
D
Y
Y
Y
F
W
K
E
----
D
----
G
------
I
------
E
--
E
Y
F
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--------------------------------------------------------------------
15
PsiBlast_PDB
70.84
30%
-110
- C3 -
3LWQ
1
TRUB_PYRFU
A:
[47-272]
------------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
-----
H
G
D
-------------
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
---------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
----
G
--
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
I
T
L
H
D
L
----
V
D
Y
Y
Y
F
W
K
E
----
D
----
G
------
I
------
E
--
E
Y
F
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--------------------------------------------------------------------
20
PsiBlast_PDB
70.79
30%
-117
- C3 -
3HJY
3
TRUB_PYRFU
A:
[40-265]
------------
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
-----
H
G
D
-------------
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
------------------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
----
G
--
R
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
E
D
-
E
T
L
I
T
L
H
D
L
----
V
D
Y
Y
Y
F
W
K
E
----
D
----
G
------
I
------
E
--
E
Y
F
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
L
A
V
P
--------------------------------------------------------------------