@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4750: (2016-03-01 )
MSNPQYPTRLPCGSRVLDLARPHVMGILNVTPDSFSDGGRYDRLDDALRHAERMVLEGATLIDVGGESTRPGARSVSPTEELERVAPVVERIARELDVVISVDTSTPAVMRETARLGAGLINDVRSLQRDGALDAAVDSGLAVCLMHMRGEPQTMQDAPAYQDVVAEVGAFLQERVDACVAAGIDRERLLLDPGFGFAKTLEHNLVLFRHLQALHGLGLPLLVGVSRKSMIGKVLGREVDERLYGSLALAALALAKGARIIRVHDVAATVDVMRMISAVEMAD
Atome Classification :
(68 SA)
.........10-----..-......-20........30........40..-......50.....-----...60........70........80........90....-----....100.......110.......120......-.130.-....-..-140.......-------------------150..-..-.-..160.----------------------------.....--..170.......180.......190....---...200-........210..-----.-----.----------------...220.......230...---.------.------.-.240------.........250.......260.......270.......280.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNPQYPTRLP-----CG-
S
R
V
L
D
L-ARP
H
V
M
G
I
L
NVTPDSFSDGGRY
D
R
-
L
D
D
A
L
R
H
A
E
R
M
V
L-----EG
A
T
L
I
D
VGGESTRPGARSVS
P
T
E
E
L
E
R
V
A
P
V
V
E
R
I
A
R
E-----L
D
V
V
I
S
VDTS
T
P
A
V
M
R
E
T
A
R
L
G
A
G
L
I
N
D
V
R
S
L
Q
-RDGA
L
-
D
A
A
V
-
D
S
-
G
L
A
V
C
L
M
H
MR-------------------GEPQT-MQ-D-A
P
A
-
Y
Q
----------------------------
D
V
V
A
E
--
V
G
A
F
L
Q
E
R
V
D
A
C
V
A
AGIDR
E
R
L
LLDPGF
G
---
F
A
K
T
-
L
-
E
H
N
L
V
L
F
R
H
L
Q
A
L
-----H-----G----------------LG
L
P
L
L
VGV
S
R
K
S
M
I
G
K
V
L
---
G
------
R
------
E
-
V
D
--------
E
R
L
Y
G
S
L
A
L
A
A
L
A
L
AKG
A
R
I
I
R
V
H
D
V
A
A
T
V
D
V
M
R
M
I
S
A
V
EMAD
94
HHSearch
93.52
59%
-122
- C5 -
1AJ0
3
DHPS_ECOLI
A:
[5-274]
----------------
A
Q
-
G
T
S
L
D
L
-
S
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
-
E
P
G
A
L
-
E
A
A
A
-
E
T
-
G
L
P
V
C
L
M
H
M
Q
-------------------
G
N
P
K
T
-
M
Q
-
E
-
A
P
K
-
Y
D
----------------------------
D
V
F
A
E
--
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
-----
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---
N
------
V
------
G
-
P
S
--------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
--
22
PsiBlast_CBE
93.35
58%
-120
- C5 -
3TYZ
4
?
B:
[12-278]
---------------------
T
L
D
L
-
S
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
-
E
A
A
A
-
K
T
-
G
L
P
V
C
L
M
H
M
Q
-------------------
G
Q
P
K
N
-
M
Q
-
H
-
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
--
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
-----
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
------
V
------
P
-
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-
3
PsiBlast_PDB
92.55
60%
-123
- C5 -
1AJZ
2
DHPS_ECOLI
A:
[10-272]
----------------------
L
D
L
-
S
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
-
E
P
G
A
L
-
E
A
A
A
-
E
T
-
G
L
P
V
C
L
M
H
M
Q
-------------------
G
N
P
K
T
-
M
Q
-
E
-
A
P
K
-
Y
D
----------------------------
D
V
F
A
E
--
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
-----
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---
N
------
V
------
G
-
P
S
--------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
----
21
PsiBlast_CBE
92.29
58%
-118
- C5 -
3TZF
3
?
B:
[12-278]
---------------------
T
L
D
L
-
S
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
--
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
-
E
A
A
A
-
K
T
-
G
L
P
V
C
L
M
H
M
Q
-------------------
G
Q
P
K
N
-
M
Q
-
H
-
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
--
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
-----
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
------
V
------
P
-
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-
1
PsiBlast_PDB
91.97
60%
-122
- C5 -
1AJ0
3
DHPS_ECOLI
A:
[10-272]
----------------------
L
D
L
-
S
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
-
E
P
G
A
L
-
E
A
A
A
-
E
T
-
G
L
P
V
C
L
M
H
M
Q
-------------------
G
N
P
K
T
-
M
Q
-
E
-
A
P
K
-
Y
D
----------------------------
D
V
F
A
E
--
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
-----
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---
N
------
V
------
G
-
P
S
--------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
----
6
PsiBlast_PDB
91.82
58%
-117
- C5 -
3TZF
2
?
A:
[12-278]
---------------------
T
L
D
L
-
S
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
-
E
A
A
A
-
K
T
-
G
L
P
V
C
L
M
H
M
Q
-------------------
G
Q
P
K
N
-
M
Q
-
H
-
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
--
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
-----
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
------
V
------
P
-
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-
5
PsiBlast_PDB
91.38
58%
-116
- C5 -
3TYZ
4
?
A:
[12-278]
---------------------
T
L
D
L
-
S
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
-
E
A
A
A
-
K
T
-
G
L
P
V
C
L
M
H
M
Q
-------------------
G
Q
P
K
N
-
M
Q
-
H
-
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
--
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
-----
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
------
V
------
P
-
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-
2
PsiBlast_PDB
89.03
60%
-123
- C5 -
1AJ2
2
DHPS_ECOLI
A:
[10-272]
----------------------
L
D
L
-
S
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
-
E
P
G
A
L
-
E
A
A
A
-
E
T
-
G
L
P
V
C
L
M
H
M
Q
-------------------
G
N
P
K
T
-
M
Q
-
E
-
A
P
K
-
Y
D
----------------------------
D
V
F
A
E
--
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
-----
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---
N
------
V
------
G
-
P
S
--------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
----
4
PsiBlast_PDB
88.74
58%
-124
- C5 -
3TYU
1
?
A:
[12-278]
---------------------
T
L
D
L
-
S
R
P
Q
V
M
G
I
L
N
V
T
P
D
S
------
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
-
E
A
A
A
-
K
T
-
G
L
P
V
C
L
M
H
M
Q
-------------------
G
-----
M
Q
-
H
-
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
--
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
-----
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
------
V
------
P
-
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-
7
PsiBlast_PDB
87.95
58%
-142
- C5 -
3TZN
-
?
A:
[9-275]
---------------------
T
L
D
L
-
S
R
P
Q
V
M
G
I
L
-------------
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
--------------
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
-
E
A
A
A
-
K
T
-
G
L
P
V
C
L
M
H
M
Q
----------------------------
H
-
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
--
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
-----
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
------
V
------
P
-
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-
8
PsiBlast_PDB
85.46
51%
-132
- C5 -
2Y5J
4
?
A:
[8-290]
------
P
A
P
L
Q
-----
C
G
-
R
F
E
L
T
F
-
E
R
P
L
V
M
G
I
L
N
-------------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
--------
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
-
R
P
-----
L
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
-
Q
P
G
A
I
-
D
A
V
R
-
D
G
-
N
S
G
L
C
A
M
H
M
L
-------------------
G
E
P
Q
T
-
M
Q
V
G
-
E
P
D
-
Y
G
----------------------------
D
V
V
T
D
--
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
-
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
P
D
-----
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G--
G
------
K
------
P
-
P
L
--------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
-
9
PsiBlast_PDB
84.60
51%
-119
- C5 -
2Y5S
13
?
A:
[8-290]
------
P
A
P
L
Q
-----
C
G
-
R
F
E
L
T
F
-
E
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
-
R
P
-----
L
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
-
Q
P
G
A
I
-
D
A
V
R
-
D
G
-
N
S
G
L
C
A
M
H
M
L
-------------------
G
E
P
Q
T
-
M
Q
V
G
-
E
P
D
-
Y
G
----------------------------
D
V
V
T
D
--
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
-
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
P
D
-----
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G--
G
------
K
------
P
-
P
L
--------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
-
24
PsiBlast_CBE
84.10
51%
-119
- C5 -
2Y5S
9
?
B:
[8-290]
------
P
A
P
L
Q
-----
C
G
-
R
F
E
L
T
F
-
E
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
-
R
P
-----
L
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
-
Q
P
G
A
I
-
D
A
V
R
-
D
G
-
N
S
G
L
C
A
M
H
M
L
-------------------
G
E
P
Q
T
-
M
Q
V
G
-
E
P
D
-
Y
G
----------------------------
D
V
V
T
D
--
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
-
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
P
D
-----
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G--
G
------
K
------
P
-
P
L
--------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
-
23
PsiBlast_CBE
83.84
58%
-146
- C5 -
3TYU
1
?
B:
[12-278]
---------------------
T
L
D
L
-
S
R
P
Q
V
M
G
I
L
N
------------
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
---------------
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
-
E
A
A
A
-
K
T
-
G
L
P
V
C
L
M
H
M
Q
----------------------------------------------------------------
D
L
M
T
D
--
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
-
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
-----
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---
N
------
V
------
P
-
P
Q
--------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-
93
HHSearch
83.80
52%
-117
- C5 -
2Y5S
13
?
A:
[5-290]
---
T
F
L
P
A
P
L
Q
-----
C
G
-
R
F
E
L
T
F
-
E
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
------
L
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
-
Q
P
G
A
I
-
D
A
V
R
-
D
G
-
N
S
G
L
C
A
M
H
M
L
-------------------
G
E
P
Q
T
-
M
Q
-
V
G
E
P
D
-
Y
G
----------------------------
D
V
V
T
D
--
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
-
V
V
D
D
N
Y
A
L
L
A
A
L
P
D
T
-----
A
P
A
R
PD
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
---
G
------
G
K-----
P
-
P
L
--------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
-
92
HHSearch
83.53
46%
-134
* C5 *
2DQW
-
?
A:
[17-287]
---------
L
W
-----
L
R
-
D
R
A
L
D
L
-
D
R
V
R
L
L
G
V
L
N
L
T
P
--------------
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
I
L
D
L
G
A
E
-----------
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
S
L
------
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
-
D
E
R
M
V
-
A
L
A
A
-
R
H
-
G
V
A
A
V
V
M
H
M
P
V------------------
P
D
P
A
T
-
M
M
-
A
-
H
A
R
-
Y
R
----------------------------
D
V
V
A
E
--
V
K
A
F
L
E
A
Q
A
R
R
A
L
S
A
G
V
P
--
Q
V
V
L
D
P
G
F
G
---
F
G
K
L
-
L
-
E
H
N
L
A
L
L
R
R
L
D
E
I
-----
V
-----
A
----------------
L
G
H
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
---
G
------
V
------
E
D
P
A
--------
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
Y
G
--
38
PsiBlast_CBE
83.23
41%
-129
- C5 -
4D9P
6
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
-----
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
47
PsiBlast_CBE
83.08
41%
-124
- C5 -
3TYD
8
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
59
PsiBlast_CBE
82.94
41%
-131
- C5 -
3H2E
6
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
----
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
44
PsiBlast_CBE
82.80
41%
-131
- C5 -
3TYE
7
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
-------
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
64
PsiBlast_CBE
82.74
41%
-129
- C5 -
1TX2
6
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
50
PsiBlast_CBE
82.66
41%
-126
- C5 -
3TYB
5
?
A:
[21-291]
---
M
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
51
PsiBlast_CBE
82.37
41%
-128
- C5 -
3TYA
7
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
40
PsiBlast_CBE
82.35
41%
-127
- C5 -
4D8Z
6
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
20
PsiBlast_PDB
82.30
41%
-128
- C5 -
3H2A
4
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
39
PsiBlast_CBE
82.23
41%
-124
- C5 -
4D9P
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
54
PsiBlast_CBE
82.22
41%
-125
- C5 -
3H2N
5
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
46
PsiBlast_CBE
82.15
41%
-128
- C5 -
3TYD
8
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
63
PsiBlast_CBE
81.90
41%
-129
- C5 -
3H21
4
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
-------
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
14
PsiBlast_PDB
81.90
41%
-117
- C5 -
1TX2
6
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
65
PsiBlast_CBE
81.79
41%
-129
- C5 -
1TX0
6
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
56
PsiBlast_CBE
81.69
41%
-129
- C5 -
3H2M
7
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
66
PsiBlast_CBE
81.41
41%
-125
- C5 -
1TWZ
5
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
62
PsiBlast_CBE
81.40
41%
-128
- C5 -
3H24
8
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
------
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
19
PsiBlast_PDB
81.39
41%
-125
- C5 -
3H26
4
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
43
PsiBlast_CBE
81.34
41%
-126
- C5 -
4D8A
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
37
PsiBlast_CBE
81.25
41%
-137
- C5 -
4DAF
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
----------
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
45
PsiBlast_CBE
81.24
41%
-124
- C5 -
3TYE
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
------
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
16
PsiBlast_PDB
81.23
41%
-129
- C5 -
3H22
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
--
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
42
PsiBlast_CBE
81.18
41%
-134
- C5 -
4D8A
6
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
----------
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
57
PsiBlast_CBE
81.07
41%
-119
- C5 -
3H2M
5
?
A:
[21-291]
---
M
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
48
PsiBlast_CBE
81.02
41%
-123
- C5 -
3TYC
7
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
52
PsiBlast_CBE
80.97
41%
-127
- C5 -
3TYA
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
----
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
41
PsiBlast_CBE
80.93
41%
-124
- C5 -
4D8Z
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
-
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
55
PsiBlast_CBE
80.71
41%
-126
- C5 -
3H2N
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
---
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
-----
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
13
PsiBlast_PDB
80.70
41%
-124
- C5 -
1TX0
6
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
--------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
12
PsiBlast_PDB
80.60
41%
-122
- C5 -
1TWZ
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
70
PsiBlast_CBE
80.56
44%
-137
- C5 -
2DZB
1
?
B:
[15-286]
-----------RTLW-
L
R
-
D
R
A
L
D
L
-
D
R
V
R
L
L
G
V
L
N
L
T
P
D
-----------
P
E
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
I
L
D
L
G
A
E
S
T
-------
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
-
S
-----
L
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
-
D
E
R
M
V
-
A
L
A
A
-
R
H
-
G
V
A
A
V
V
M
H
M
P
----------------------------
A
-
H
A
R
-
Y
R
----------------------------
D
V
V
A
E
--
V
K
A
F
L
E
A
Q
A
R
R
A
L
S
A
G
V
--
P
Q
V
V
L
D
P
G
F
G
---
F
G
K
L
-
L
-
E
H
N
L
A
L
L
R
R
L
D
E
I
-----
V
-----
A
----------------
L
G
H
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
---
G
------
V
------
E
D
P
A
--------
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
Y
---
36
PsiBlast_CBE
80.51
41%
-131
- C5 -
4DAF
5
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
----------
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
11
PsiBlast_PDB
80.44
41%
-121
- C5 -
1TWW
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
71
PsiBlast_CBE
80.41
44%
-133
- C5 -
2DZB
1
?
A:
[14-287]
-----------V
R
T
L
W
L
R
-
D
R
A
L
D
L
-
D
R
V
R
L
L
G
V
L
N
L
T
P
--------------
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
I
L
D
L
G
A
E
S
----------
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
-
S
-----
L
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
-
D
E
R
M
V
-
A
L
A
A
-
R
H
-
G
V
A
A
V
V
M
H
M
P
V------------------
P
D
P
A
T
-
M
M
-
A
-
H
A
R
-
Y
R
----------------------------
D
V
V
A
E
--
V
K
A
F
L
E
A
Q
A
R
R
A
L
S
A
G
V
--
P
Q
V
V
L
D
P
G
F
G
---
F
G
K
L
-
L
-
E
H
N
L
A
L
L
R
R
L
D
E
I
-----
V
-----
A
----------------
L
G
H
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
---
G
------
V
------
E
D
P
A
--------
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
Y
G
--
58
PsiBlast_CBE
80.38
41%
-120
- C5 -
3H2F
4
?
A:
[21-291]
---
M
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
-----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
97
HHSearch
80.23
43%
-121
- C5 -
1EYE
2
DHPS1_MYCTU
A:
[5-274]
---------------------------
P
V
Q
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
A
A
------
Q
G
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
-
P
L
L
A
-
E
A
-
D
V
P
W
V
L
M
H
W
R
-------------------
A
V
S
A
D
T
P
H
-
V
-
P
V
R
-
Y
G
----------------------------
N
V
V
A
E
--
V
R
A
D
L
L
A
S
V
A
D
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
---
F
A
K
T
-
A
-
Q
H
N
W
A
I
L
H
A
L
P
E
L
-----
V
-----
A
----------------
T
G
I
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
---
A
------
G
PDGVMR
P
-
T
D
--------
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
A
E
15
PsiBlast_PDB
80.21
41%
-124
- C5 -
3H21
4
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
49
PsiBlast_CBE
80.08
41%
-123
- C5 -
3TYB
7
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
61
PsiBlast_CBE
80.06
41%
-128
- C5 -
3H2C
6
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
---------
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-
E
S
T
R
------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
99
HHSearch
79.79
42%
-109
- C5 -
3TR9
4
?
A:
[12-293]
------
S
F
H
L
R
-----
L
R
D
D
K
R
I
V
F
-
S
E
P
A
V
M
G
I
I
N
V
S
P
N
S
F
Y
H
P
H
--
L
D
-
L
N
S
A
L
R
T
A
E
K
M
V
D
-----
E
G
A
D
I
L
D
I
G
G
E
A
T
N
P
F
V
-
S
P
S
T
Q
I
E
L
D
R
L
L
P
V
I
D
A
I
K
K
R
-----
F
P
Q
L
I
S
V
D
T
S
R
P
R
V
M
R
E
A
V
N
T
G
A
D
M
I
N
D
Q
R
A
L
Q
-
L
D
D
A
L
-
T
T
V
S
-
A
L
-
K
T
P
V
C
L
M
H
F
P
-------------------
S
E
T
R
K
-
P
G
-
S
--
T
T
-
H
F
----------------------------
Y
F
L
Q
S
--
V
K
K
E
L
Q
E
S
I
Q
R
C
K
K
A
G
I
S
E
D
R
I
I
I
D
P
G
F
G
Q
GN
Y
G
K
N
-
V
-
S
E
N
F
Y
L
L
N
K
L
P
E
F
-----
V
-----
A
----------------
M
G
L
P
V
L
S
G
W
S
R
K
S
M
I
G
D
V
L
---
N
------
Q
------
P
-
P
E
--------
N
R
L
F
G
S
I
A
A
D
V
L
A
V
Y
H
G
A
S
I
I
R
T
H
D
V
K
A
T
R
E
A
I
K
I
A
T
Y
T
R
S
V
D
34
PsiBlast_CBE
79.76
41%
-128
- C5 -
4DAI
6
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
32
PsiBlast_CBE
79.56
41%
-130
- C5 -
4DB7
6
?
B:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
-------
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
18
PsiBlast_PDB
79.39
41%
-119
- C5 -
3H24
6
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
35
PsiBlast_CBE
79.37
41%
-124
- C5 -
4DAI
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
33
PsiBlast_CBE
79.32
41%
-126
- C5 -
4DB7
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
---
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
72
PsiBlast_CBE
78.86
44%
-127
- C5 -
2DZA
1
?
B:
[15-286]
-----------RTLW-
L
R
-
D
R
A
L
D
L
-
D
R
V
R
L
L
G
V
L
N
L
T
P
D
S
-------------
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
I
L
D
L
G
A
E
S
T
R
P
---
P
V
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
-
S
-----
L
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
-
D
E
R
M
V
-
A
L
A
A
-
R
H
-
G
V
A
A
V
V
M
H
M
P
V------------------
P
D
P
A
T
-
M
M
-
A
-
H
A
R
-
Y
R
----------------------------
D
V
V
A
E
--
V
K
A
F
L
E
A
Q
A
R
R
A
L
S
A
G
V
--
P
Q
V
V
L
D
P
G
F
G
---
F
G
K
L
-
L
-
E
H
N
L
A
L
L
R
R
L
D
E
I
-----
V
-----
A
----------------
L
G
H
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
---
G
------
V
------
E
D
P
A
--------
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
Y
---
17
PsiBlast_PDB
78.58
41%
-116
- C5 -
3H23
5
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
53
PsiBlast_CBE
78.55
41%
-123
- C5 -
3H2O
3
?
A:
[22-291]
----
K
W
D
Y
D
L
R
-----
C
G
-
E
Y
T
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
-
A
E
P
K
I
A
E
V
A
A
-
H
Y
-
D
V
P
I
I
L
M
H
N
R
----------------------------
D
-
N
M
N
-
Y
R
----------------------------
N
L
M
A
D
--
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
-
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
-----
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---
D
------
L
------
P
-
V
E
--------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
----
73
PsiBlast_CBE
77.34
43%
-118
- C5 -
1EYE
2
DHPS1_MYCTU
A:
[7-269]
-----------------------------
Q
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
A
A
Q
------
G
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
-
A
D
P
A
M
-
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
W
R
-------------------
A
V
S
A
D
-
T
P
-
H
-
V
P
V
R
Y
G
----------------------------
N
V
V
A
E
--
V
R
A
D
L
L
A
S
V
A
D
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
---
F
A
K
T
-
A
-
Q
H
N
W
A
I
L
H
A
L
P
E
L
-----
V
-----
A
----------------
T
G
I
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
---
A
GPDGVM
R
------
P
-
T
D
--------
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
-----
74
PsiBlast_CBE
73.54
35%
-119
- C5 -
2VEG
2
DHPS_STRR6
A:
[8-303]
--------------------------
A
K
T
V
I
C
G
I
I
N
V
T
P
---------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
-----
E
G
A
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
R
K
E
-----
S
D
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
T
G
L
M
-
G
D
E
K
M
-
P
H
V
V
-
A
E
-
A
R
A
Q
V
V
I
M
F
N
P
V
M
A
R
P
QHPSSLIFPHFGF--
A
F
T
----
E
-
L
A
D
-
F
E
----------------------------
T
L
P
I
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
---
F
G
L
T
-
K
-
K
E
N
L
L
L
L
R
D
L
D
K
L
-----
H
-----
Q
----------------
K
G
Y
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
N
G
------
F
------
E
-
V
N
PET
E
L
G
F
R
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
H
R
M
A
V
E
I
A
S
A
I
R
L
A
D
96
HHSearch
68.87
31%
-102
- C5 -
2BMB
1
FOL1_YEAST
A:
[222-543]
------------------------
V
-
S
P
T
Y
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
A
L
YL
H
E
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
R
E
S
TELPQ
D
K
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
S
G
G
L
F
D
S
N
M
F
-
A
V
I
A
-
E
N
P
E
I
C
Y
I
L
S
H
T
R
-------------------
G
D
I
S
T
-
M
N
-
R
-
L
A
H
-
Y
E
NFALGDSIQ
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
L
I
R
N
--
V
G
Q
E
I
G
E
R
Y
I
K
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
---
F
A
K
T
-
W
-
K
Q
N
L
Q
I
I
R
H
I
P
I
L
-----
K
-----
N
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
L
R
N
M
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
---
K
------
D
V-----
D
-
A
K
--------
Q
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
G
S
D
M
V
R
V
H
D
V
K
N
C
S
K
S
I
K
L
A
D
A
I
Y
K
G
-