@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4756: (2016-03-01 )
MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPAMADATYIEPIKWATVAKIIEKERPDALLPTMGGQTALNCALDLERHGVLEKFGVEMIGANADTIDKAEDRSRFDKAMKDIGLACPRSGIAHSMEEAYGVLEQVGFPCIIRPSFTMGGTGGGIAYNREEFEEICARGLDLSPTNELLIDESLIGWKEYEMEVVRDKKDNCIIVCSIENFDPMGVHTGDSITVAPAQTLTDKEYQIMRNASLAVLREIGVETGGSNVQFGICPNTGRMVVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDELQNDITGGRTPASFEPAIDYVVTKIPRFAFEKFPKADARLTTQMKSVGEVMAIGRTFQESVQKALRGLEVGATGFDPKLDLNDPEADSILKRELTVPSAERVWYVADAFRAGKSVEEVFELTRIDEWFLVQIEDLVKDEEKVKTLGLSSIDRELMYKLKRKGFSDARLAKLLGVTEKNLRSHRHKLKVLPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSSREKIMILGGGPNRIGQGIEFDYCCVHAALAMREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLEIVRVEQPKGVIVQYGGQTPLKLCRALEEAGVPIIGTSPDAIDRAEDRERFQQMVQRLNLRQPANATARSEDEALAASKAIGYPLVVRPSYVLGGRAMEIVYQEEELKRYMREAVQVSNDSPVLLDHFLNCAIEVDIDAVCDGEIVVIGAIMQHIEQAGVHSGDSACSLPPYSLPQHIQDEIREQVKKMALELGVVGLMNVQMAVQGEDIFVIEVNPRASRTVPFVSKCVGESLAKVAARVMAGKTLAEVGFTQEIIPPFFSVKEAVFPFAKFPGVDPILGPEMKSTGEVMGVGDSFAEAFAKAQLGASEILPTAGCAFISVREDDKPFAAQVAGDLVALGFEVVATAGTARVIEAAGLPVRRVNKVTEGRPHVVDMIKNDEVTLIINTTEGRQSIADSYSIRRNALQHKICCTTTIAGGQAICEALKFGPEKTVRRLQDLHAGIKA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.....-..560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPKRTDI
K
S
I
L
I
LGAG
P
I
V
I
GQACEFDYS
G
A
Q
A
C
K
A
L
R
EEG
Y
R
V
I
L
VNSNP
A
T
I
MTDPAMAD
A
T
Y
IEP
I
K
W
A
T
V
A
K
I
I
E
KERPDALLPTMGGQ
T
A
L
N
C
A
L
D
L
E
RH
G
V
L
E
K
F
G
V
E
M
IGANADTID
K
A
E
D
R
S
R
F
D
K
A
M
K
D
IGLACPRS
G
I
A
H
S
M
E
E
A
Y
G
V
L
E
QVGF
P
C
I
IRPSFTMGGTGGGIAY
N
R
E
E
F
E
E
I
C
ARGLDLSPTN
E
L
LIDESLI
G
W
K
E
Y
E
M
E
V
V
RDKKD
N
C
I
I
V
C
S
IENFDPMGVHTGD
S
I
T
VAPAQTLT
D
K
E
Y
Q
I
M
R
N
A
S
L
A
V
L
R
E
IGVETGGSN
V
Q
F
G
I
CPNTG
R
M
V
V
I
EMNPRVSR
S
S
ALASKATGF
P
I
A
K
I
A
A
K
L
AVG
Y
T
L
D
E
L
Q
N
DITGGRTPASFE
P
A
I
D
Y
V
V
T
K
I
P
R
F
A
F
E
KFPKA
D
A
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
F
Q
E
S
V
Q
K
A
L
RGLEVGATGFDPKLDLNDP
E
A
D
S
I
L
K
R
ELTVPSA
E
R
V
W
Y
V
A
D
A
F
RAG
K
S
V
E
E
V
F
E
L
T
RID
E
W
F
L
V
Q
I
E
D
L
VK
D
E
E
K
V
K
T
L
G
L
S
S
I
D
R
E
L
M
Y
K
L
K
RKGF
S
D
A
R
L
A
K
L
LGV
T
E
K
N
L
R
S
H
R
H
KLKVL
P
V
Y
K
R
V
D
T
C
A
A
E
FATD
T
A
Y
M
Y
S
T
Y
E
E
E
CEANPSS-R
E
K
I
M
I
LGG
G
P
N
RIGQGIE
F
D
Y
C
C
V
H
A
A
L
A
M
REDGY
E
T
I
M
V
NCNPETVSTDYDTSD
R
L
Y
FEPV
T
L
E
D
V
L
E
I
V
RVEQPK
G
V
I
V
QYGGQ
T
P
L
K
L
C
R
A
L
E
EAGV
P
I
IGTSPDAI
D
R
A
E
D
R
E
R
F
Q
Q
M
V
Q
RLNLRQPANATARSE
D
E
A
L
AASKAIG
Y
P
L
V
V
RPS
Y
V
LG
G
R
A
M
E
I
V
Y
Q
E
E
E
L
K
R
Y
M
R
E
A
V
QVSNDSP
V
L
L
D
H
FLN
C
A
I
E
V
D
I
DAVCDG
E
I
V
V
I
G
A
I
M
Q
H
I
E
Q
AGVHSGDSACSLPPYSL
P
Q
H
I
Q
D
E
I
R
E
Q
V
K
K
M
A
L
E
L
G
V
V
G
L
M
N
V
Q
M
A
V
QG
E
D
I
F
V
I
E
VNPRASR
T
V
P
F
V
S
K
C
V
G
E
S
L
A
K
V
A
A
R
V
MAG
K
T
L
A
EVGF
T
Q
E
IIP
P
F
F
S
V
K
E
A
V
FPFAKFPGVDPILGPEMKSTG
E
V
MGV
G
D
S
F
A
E
A
F
A
K
AQL
G
A
S
EILPTA
G
C
A
F
I
S
VREDDK
P
F
A
A
Q
V
A
G
D
L
V
A
L
G
F
E
V
VATAGT
A
R
V
I
EAAGL
P
V
R
R
V
N
K
VTEGRP
H
V
V
D
M
IKND
E
V
T
L
I
I
NTTEG
R
Q
S
I
A
D
S
Y
S
I
R
R
N
A
L
QHK
I
C
C
T
T
TIA
G
G
Q
A
I
C
E
A
L
KFG
P
E
K
T
V
R
R
L
Q
D
L
H
AGIKA
46
PsiBlast_CBE
89.46
76%
-83
- C1 -
1CE8
5
CARB_ECOLI
C:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
N
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
S
L
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
F
R
A
G
L
S
V
D
G
V
F
N
L
T
N
I
D
R
W
F
L
V
Q
I
E
E
L
V
R
L
E
E
K
V
A
E
V
G
I
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
E
E
C
E
A
N
P
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
K
E
V
I
P
P
Y
Y
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
40
PsiBlast_CBE
89.45
76%
-82
- C1 -
1BXR
7
CARB_ECOLI
C:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
S
L
D
D
P
E
A
L
T
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R
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L
K
D
A
G
A
D
R
I
W
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N
L
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N
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L
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K
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I
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A
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L
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Q
L
K
R
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G
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A
D
A
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A
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I
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Y
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A
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C
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D
G
Y
E
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Y
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I
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P
D
A
I
D
R
A
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D
R
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Q
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A
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L
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L
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Q
P
A
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A
T
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A
I
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M
A
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K
A
K
E
I
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Y
P
L
V
V
R
P
S
Y
V
L
G
G
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A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
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A
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V
S
N
D
A
P
V
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
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T
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M
R
Q
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L
A
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L
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N
V
Q
F
A
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N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
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L
A
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A
A
R
V
M
A
G
K
S
L
A
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T
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E
V
I
P
P
Y
Y
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K
E
V
V
L
P
F
N
K
F
P
G
V
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P
L
L
G
P
E
M
R
S
T
G
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M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
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A
L
L
S
V
R
E
G
D
K
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V
V
D
L
A
A
K
L
L
K
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A
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T
A
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A
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P
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L
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R
I
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N
G
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Y
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Y
I
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N
T
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A
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I
R
R
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A
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Q
Y
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T
T
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N
G
G
F
A
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A
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A
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N
A
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A
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E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
2
PsiBlast_PDB
88.98
76%
-82
- C1 -
1BXR
10
CARB_ECOLI
A:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
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F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
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G
Y
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V
I
L
V
N
S
N
P
A
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I
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P
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M
A
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A
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W
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I
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G
G
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N
C
A
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M
I
G
A
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A
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A
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A
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R
R
R
F
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A
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A
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A
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P
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F
T
M
G
G
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A
Y
N
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C
A
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W
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R
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A
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A
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A
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Y
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Y
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C
E
A
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P
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T
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V
L
G
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P
N
R
I
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C
V
H
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P
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D
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A
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K
A
K
E
I
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Y
P
L
V
V
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P
S
Y
V
L
G
G
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A
M
E
I
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E
A
D
L
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Q
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A
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S
V
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N
D
A
P
V
L
L
D
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F
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D
G
E
M
V
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I
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D
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M
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Q
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L
A
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E
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R
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N
V
Q
F
A
V
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N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
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V
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K
A
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V
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A
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A
A
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V
M
A
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A
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I
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P
Y
Y
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L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
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T
A
I
V
L
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A
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N
P
R
L
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K
V
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P
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D
R
I
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N
G
E
Y
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Y
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N
T
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R
A
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Y
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T
T
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N
G
G
F
A
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A
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N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
38
PsiBlast_CBE
88.94
76%
-82
- C1 -
1BXR
24
CARB_ECOLI
G:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
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D
Y
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A
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A
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A
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P
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Y
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W
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G
G
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A
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I
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A
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A
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R
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A
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A
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V
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F
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P
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T
M
G
G
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G
G
G
I
A
Y
N
R
E
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F
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C
A
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G
L
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P
T
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W
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V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
26
PsiBlast_CBE
88.90
76%
-83
- C1 -
1KEE
1
CARB_ECOLI
C:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
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D
R
R
R
F
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A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
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T
M
E
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A
L
A
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A
A
D
V
G
F
P
C
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I
R
P
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F
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M
G
G
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G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
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P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
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M
E
V
V
R
D
K
N
D
N
C
I
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C
S
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F
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A
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A
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L
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A
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A
L
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G
L
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G
A
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F
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A
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A
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A
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N
L
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R
W
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L
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I
E
E
L
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R
L
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V
A
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G
I
T
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L
N
A
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F
L
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L
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R
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A
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A
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L
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A
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I
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Q
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A
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Y
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C
E
A
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P
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I
M
V
L
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G
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N
R
I
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F
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Y
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C
V
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Q
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L
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A
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A
A
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P
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A
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A
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A
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L
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L
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A
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A
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T
A
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E
M
A
V
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K
A
K
E
I
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Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
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L
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M
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L
A
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N
V
Q
F
A
V
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N
N
E
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Y
L
I
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P
R
A
A
R
T
V
P
F
V
S
K
A
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L
A
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A
A
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V
M
A
G
K
S
L
A
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G
V
T
K
E
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I
P
P
Y
Y
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V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
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A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
29
PsiBlast_CBE
88.82
76%
-83
- C1 -
1CS0
32
CARB_ECOLI
G:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
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Y
I
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I
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W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
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P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
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R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
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A
R
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G
I
A
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T
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E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
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C
S
I
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F
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A
M
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A
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N
A
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A
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V
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V
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A
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K
N
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A
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V
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F
N
F
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K
F
A
G
A
N
D
R
L
T
T
Q
M
K
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V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
S
L
D
D
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A
L
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K
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R
E
L
K
D
A
G
A
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Y
I
A
D
A
F
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A
G
L
S
V
D
G
V
F
N
L
T
N
I
D
R
W
F
L
V
Q
I
E
E
L
V
R
L
E
E
K
V
A
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V
G
I
T
G
L
N
A
D
F
L
R
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L
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R
K
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F
A
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A
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A
K
L
A
G
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R
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A
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I
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K
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Q
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D
L
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P
V
Y
K
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D
T
C
A
A
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A
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M
Y
S
T
Y
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E
E
C
E
A
N
P
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T
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K
I
M
V
L
G
G
G
P
N
R
I
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F
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Y
C
C
V
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A
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L
E
I
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P
K
G
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Q
Y
G
G
Q
T
P
L
K
L
A
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A
L
E
A
A
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V
P
V
I
G
T
S
P
D
A
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D
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A
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D
R
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F
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H
A
V
E
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L
K
L
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Q
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A
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A
T
V
T
A
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E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
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I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
K
E
V
I
P
P
Y
Y
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
5
PsiBlast_PDB
88.81
76%
-82
- C1 -
1CS0
15
CARB_ECOLI
A:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
T
Y
I
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I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
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F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
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A
M
K
K
I
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L
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A
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G
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A
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E
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A
L
A
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A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
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F
D
A
M
G
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A
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A
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N
A
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M
A
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I
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V
E
T
G
G
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N
V
Q
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A
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N
P
K
N
G
R
L
I
V
I
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A
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A
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A
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A
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A
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Y
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N
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F
A
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A
N
D
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L
T
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M
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M
A
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G
R
T
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Q
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L
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A
L
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L
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G
A
T
G
F
D
P
K
V
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L
D
D
P
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A
L
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K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
F
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A
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L
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V
D
G
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F
N
L
T
N
I
D
R
W
F
L
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I
E
E
L
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R
L
E
E
K
V
A
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V
G
I
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
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P
V
Y
K
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C
A
A
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A
T
D
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Y
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C
E
A
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P
S
T
D
R
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K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
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A
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E
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I
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P
L
K
L
A
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A
L
E
A
A
G
V
P
V
I
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P
D
A
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A
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D
R
E
R
F
Q
H
A
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L
K
L
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Q
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A
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A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
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Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
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Q
E
I
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M
R
Q
Q
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L
A
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L
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N
V
Q
F
A
V
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N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
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K
A
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P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
K
E
V
I
P
P
Y
Y
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V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
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F
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L
D
A
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G
T
A
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V
L
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A
G
I
N
P
R
L
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N
K
V
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R
P
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D
R
I
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N
G
E
Y
T
Y
I
I
N
T
T
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G
R
R
A
I
E
D
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V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
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A
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A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
37
PsiBlast_CBE
88.80
76%
-84
- C1 -
1C30
3
CARB_ECOLI
C:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
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A
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Y
I
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P
I
H
W
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V
V
R
K
I
I
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K
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P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
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L
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R
Q
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V
L
E
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F
G
V
T
M
I
G
A
T
A
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A
I
D
K
A
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R
R
R
F
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A
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K
K
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L
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A
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G
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A
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T
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A
L
A
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A
A
D
V
G
F
P
C
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I
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P
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F
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G
G
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G
G
G
I
A
Y
N
R
E
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F
E
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I
C
A
R
G
L
D
L
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P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
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E
V
V
R
D
K
N
D
N
C
I
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S
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A
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V
M
A
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R
T
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L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
S
L
D
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A
L
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L
K
D
A
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A
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A
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A
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A
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L
S
V
D
G
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F
N
L
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N
I
D
R
W
F
L
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I
E
E
L
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R
L
E
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V
A
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G
I
T
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L
N
A
D
F
L
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L
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R
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A
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A
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L
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Y
D
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Y
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C
A
A
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A
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M
Y
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Y
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E
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C
E
A
N
P
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T
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R
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K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
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L
A
L
R
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Y
E
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I
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V
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C
N
P
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Y
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L
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P
K
G
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I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
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D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
K
E
V
I
P
P
Y
Y
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
6
PsiBlast_PDB
88.70
76%
-83
- C1 -
1KEE
15
CARB_ECOLI
A:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
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Y
I
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P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
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G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
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N
D
N
C
I
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C
S
I
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F
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A
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A
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A
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A
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A
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V
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A
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P
K
N
G
R
L
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A
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R
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A
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A
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A
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A
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D
G
V
F
N
L
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L
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L
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G
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Q
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L
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L
A
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A
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A
A
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T
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P
D
A
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A
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A
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A
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A
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G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
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F
L
D
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A
V
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V
D
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A
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N
N
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Y
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A
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A
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L
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M
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V
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A
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A
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M
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K
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A
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L
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A
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A
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R
P
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D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
24
PsiBlast_CBE
88.63
76%
-84
- C1 -
1KEE
31
CARB_ECOLI
G:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
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N
F
D
A
M
G
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D
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A
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A
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N
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L
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V
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K
N
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L
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A
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F
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A
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A
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R
L
T
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A
I
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L
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A
L
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G
L
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G
A
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F
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A
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A
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A
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A
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N
L
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D
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W
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L
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E
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L
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R
L
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V
A
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G
I
T
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L
N
A
D
F
L
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L
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R
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A
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A
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A
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L
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A
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I
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Y
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Y
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F
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C
C
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Y
G
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Q
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P
L
K
L
A
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A
L
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A
A
G
V
P
V
I
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T
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P
D
A
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A
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R
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A
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L
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L
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A
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A
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T
A
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E
M
A
V
E
K
A
K
E
I
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Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
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M
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L
A
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L
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L
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N
V
Q
F
A
V
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N
N
E
V
Y
L
I
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V
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P
R
A
A
R
T
V
P
F
V
S
K
A
T
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V
P
L
A
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A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
K
E
V
I
P
P
Y
Y
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
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G
F
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L
D
A
T
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G
T
A
I
V
L
G
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A
G
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N
P
R
L
V
N
K
V
H
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G
R
P
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I
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D
R
I
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N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
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A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
8
PsiBlast_PDB
88.62
76%
-83
- C1 -
1CE8
12
CARB_ECOLI
A:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
N
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
T
Y
I
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I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
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T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
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C
S
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A
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A
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K
N
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A
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A
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A
A
K
L
A
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Y
T
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T
P
A
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F
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P
S
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Y
V
V
T
K
I
P
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F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
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V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
S
L
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
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Y
I
A
D
A
F
R
A
G
L
S
V
D
G
V
F
N
L
T
N
I
D
R
W
F
L
V
Q
I
E
E
L
V
R
L
E
E
K
V
A
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V
G
I
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
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A
R
L
A
K
L
A
G
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R
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A
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I
R
K
L
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D
Q
Y
D
L
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P
V
Y
K
R
V
D
T
C
A
A
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F
A
T
D
T
A
Y
M
Y
S
T
Y
E
E
E
C
E
A
N
P
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
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Y
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I
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C
N
P
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Y
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V
L
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I
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P
K
G
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I
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Q
Y
G
G
Q
T
P
L
K
L
A
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A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
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D
R
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F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
K
E
V
I
P
P
Y
Y
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
43
PsiBlast_CBE
88.61
76%
-84
- C1 -
1M6V
3
CARB_ECOLI
C:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
N
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
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T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
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T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
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L
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E
I
G
V
E
T
G
G
S
N
V
Q
F
A
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N
P
K
N
G
R
L
I
V
I
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S
R
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A
L
A
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A
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A
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F
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F
A
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A
N
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L
T
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M
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M
A
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R
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Q
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L
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A
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L
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A
T
G
F
D
P
K
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S
L
D
D
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E
A
L
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R
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L
K
D
A
G
A
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Y
I
A
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A
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A
G
L
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D
G
V
F
N
L
T
N
I
D
R
W
F
L
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Q
I
E
E
L
V
R
L
E
E
K
V
A
E
V
G
I
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
E
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C
E
A
N
P
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
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L
A
L
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D
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Y
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I
M
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C
N
P
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Y
D
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L
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T
L
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L
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I
V
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I
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K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
S
------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
K
E
V
I
P
P
Y
Y
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
41
PsiBlast_CBE
88.54
76%
-82
- C1 -
1M6V
30
CARB_ECOLI
G:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
N
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
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R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
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G
L
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T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
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C
S
I
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F
D
A
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K
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A
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A
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F
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K
F
A
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A
N
D
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L
T
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M
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G
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V
M
A
I
G
R
T
Q
Q
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L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
S
L
D
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A
L
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K
I
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R
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L
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A
G
A
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A
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A
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A
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L
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V
D
G
V
F
N
L
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D
R
W
F
L
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I
E
E
L
V
R
L
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V
A
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G
I
T
G
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N
A
D
F
L
R
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L
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A
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A
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A
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L
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L
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Y
D
L
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Y
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A
A
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Y
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Y
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C
E
A
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I
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V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
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L
A
L
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Y
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C
N
P
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Y
D
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D
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L
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L
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L
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I
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I
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P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
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D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
S
------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
K
E
V
I
P
P
Y
Y
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
H
I
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D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
3
PsiBlast_PDB
88.47
76%
-82
- C1 -
1C30
14
CARB_ECOLI
A:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
T
Y
I
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P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
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A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
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F
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A
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A
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A
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A
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V
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A
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P
K
N
G
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L
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A
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A
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R
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A
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L
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A
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D
P
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A
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A
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D
G
V
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N
L
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L
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E
E
L
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R
L
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L
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G
G
Q
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L
K
L
A
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A
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A
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V
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T
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P
D
A
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A
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L
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A
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A
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K
A
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G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
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--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
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A
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D
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A
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N
N
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Y
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A
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A
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G
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M
G
V
G
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A
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A
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A
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L
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M
K
K
H
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A
L
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V
D
L
A
A
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L
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A
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G
T
A
I
V
L
G
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A
G
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N
P
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L
V
N
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V
H
E
G
R
P
H
I
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D
R
I
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N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
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D
S
R
V
I
R
R
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A
L
Q
Y
K
V
H
Y
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T
T
L
N
G
G
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A
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A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
34
PsiBlast_CBE
88.46
76%
-85
- C1 -
1C3O
3
CARB_ECOLI
C:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
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A
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Y
I
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I
H
W
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V
V
R
K
I
I
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K
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P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
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R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
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A
I
D
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A
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R
R
R
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A
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K
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L
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A
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A
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A
L
A
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A
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V
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G
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F
E
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C
A
R
G
L
D
L
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P
T
K
E
L
L
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D
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S
L
I
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W
K
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Y
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E
V
V
R
D
K
N
D
N
C
I
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A
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L
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A
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A
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C
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A
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P
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A
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A
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A
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L
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A
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A
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T
A
I
E
M
A
V
E
K
A
K
E
I
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Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
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H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
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M
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L
A
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V
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F
A
V
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N
N
E
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Y
L
I
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V
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P
R
A
A
R
T
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P
F
V
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K
A
T
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L
A
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A
A
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V
M
A
G
K
S
L
A
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T
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P
Y
Y
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V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
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A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
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D
R
I
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G
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Y
T
Y
I
I
N
T
T
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G
R
R
A
I
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D
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R
V
I
R
R
S
A
L
Q
Y
K
V
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Y
D
T
T
L
N
G
G
F
A
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A
M
A
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N
A
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A
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E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
10
PsiBlast_PDB
88.46
76%
-83
- C1 -
1A9X
-
CARB_ECOLI
A:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
N
V
N
S
N
P
A
T
I
M
T
D
P
E
M
A
D
A
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Y
I
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I
H
W
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V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
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R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
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D
R
R
R
F
D
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A
M
K
K
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L
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A
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A
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E
E
A
L
A
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A
A
D
V
G
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I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
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D
E
S
L
I
G
W
K
E
Y
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E
V
V
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N
D
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C
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C
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F
A
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A
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L
T
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A
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R
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L
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A
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F
D
P
K
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A
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A
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A
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D
G
V
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N
L
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L
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E
L
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R
L
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A
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F
L
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A
A
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Y
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C
E
A
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P
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A
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A
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L
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A
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A
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A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
A
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
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G
I
M
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I
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G
D
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L
P
A
Y
T
L
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M
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K
L
A
F
E
L
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N
V
Q
F
A
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N
N
E
V
Y
L
I
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P
R
A
A
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T
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V
S
K
A
T
G
V
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L
A
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A
A
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A
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S
L
A
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G
V
T
K
E
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I
P
P
Y
Y
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K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
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G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
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A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
4
PsiBlast_PDB
88.40
76%
-83
- C1 -
1C3O
14
CARB_ECOLI
A:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
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N
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P
A
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I
M
T
D
P
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M
A
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A
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Y
I
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I
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W
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V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
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A
L
N
C
A
L
E
L
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Q
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F
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M
I
G
A
T
A
D
A
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A
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R
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A
M
K
K
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L
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A
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A
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A
A
D
V
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P
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P
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F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
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F
E
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I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
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D
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L
I
G
W
K
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Y
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M
E
V
V
R
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N
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C
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C
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F
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A
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A
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N
L
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L
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C
A
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M
Y
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C
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A
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P
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M
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L
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P
N
R
I
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Q
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F
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Y
C
C
V
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A
L
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A
A
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V
P
V
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P
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A
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A
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D
R
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F
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A
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L
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L
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A
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T
A
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A
V
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A
K
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Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
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A
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N
N
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Y
L
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P
R
A
A
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T
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P
F
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A
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L
A
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A
A
R
V
M
A
G
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L
A
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I
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Y
Y
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E
V
V
L
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F
N
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F
P
G
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P
L
L
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P
E
M
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M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
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N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
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L
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A
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L
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A
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Y
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I
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T
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G
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N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
44
PsiBlast_CBE
88.37
76%
-83
- C1 -
1CE8
32
CARB_ECOLI
G:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
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A
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A
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A
C
K
A
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A
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C
A
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G
A
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R
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C
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A
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A
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A
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A
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A
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A
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Y
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L
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V
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P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
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I
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A
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G
D
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N
N
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Y
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A
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A
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A
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Y
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F
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P
L
L
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P
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M
R
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T
G
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M
G
V
G
R
T
F
A
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A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
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L
D
A
T
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G
T
A
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V
L
G
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A
G
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N
P
R
L
V
N
K
V
H
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P
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Y
T
Y
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T
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A
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I
R
R
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A
L
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Y
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T
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G
F
A
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A
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A
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A
D
A
T
E
K
V
I
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V
Q
E
M
H
A
Q
I
K
-
47
PsiBlast_CBE
88.35
76%
-84
- C1 -
1A9X
49
CARB_ECOLI
G:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
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V
N
S
N
P
A
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A
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V
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I
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M
G
G
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A
L
N
C
A
L
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L
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Q
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M
I
G
A
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A
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A
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R
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A
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A
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A
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A
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G
G
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G
G
G
I
A
Y
N
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F
E
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I
C
A
R
G
L
D
L
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P
T
K
E
L
L
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L
I
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W
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V
V
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N
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C
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A
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D
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M
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R
T
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L
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A
L
R
G
L
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V
G
A
T
G
F
D
P
K
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L
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A
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L
K
D
A
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A
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A
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A
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L
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V
D
G
V
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N
L
T
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R
W
F
L
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E
E
L
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L
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I
T
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L
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A
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F
L
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L
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A
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A
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E
A
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L
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G
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F
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Y
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C
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G
G
Q
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P
L
K
L
A
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A
L
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A
A
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V
P
V
I
G
T
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P
D
A
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A
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D
R
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A
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E
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L
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L
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Q
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A
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A
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V
T
A
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E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
A
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
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I
Q
D
V
M
R
Q
Q
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Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
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L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
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G
V
T
K
E
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I
P
P
Y
Y
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
E
G
R
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
I
K
-
1
PsiBlast_PDB
88.35
76%
-84
- C1 -
1JDB
17
CARB_ECOLI
B:
[1-1073]
M
P
K
R
T
D
I
K
S
I
L
I
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