@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4761: (2016-03-01 )
MGKIIGIDLGTTNSCVAILENGNVKVIENAEGARTTPSIIAYTNDGETLVGQPAKRQAVTNPQNTLYAVKRLIGRRFEENVVQKDIQMVPYSIVKADNGDAWVEVKGQKMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGLDKAKGDHTVIVYDLGGGTFDVSVIEIAEVDGEHQFEVLATNGDTFLGGEDFDIRLIDYLVDEFKKESGINLKGDPLAMQRLKEAAEKAKIELSSTQQTDVNLPYVTADASGPKHLNVKVSRAKLESLVEDLVQRTIEPCRTALKDAGLDVSDIHEVILVGGQTRMPLVQKTVAEFFGKEARKDVNPDEAVAVGAAIQGAVLAGDVKDVLLLDVTPLTLGIETLGGVMTGLIEKNTTIPTKKSQVFSTADDNQGAVTIHVLQGERKQAAQNKSLGKFDLADIPPAPRGVPQIEVTFDIDANGILHVSAKDKATGKQQSIVIKASSGLSEDEIQQMVRDAEANAEEDRKFEELAAARNQGDALVHATRKMITEAGDKATAEDKATIEKALGELEAAVKGDDKAEIEAKMNALSQASTPLAQKMYAEQAQQGEDAPQGEQAKAADDVVDAEFEEVKDNK
Atome Classification :
(91 SA)
.........10........20........30........40........50........60........70........80........90...-.-....100--...----.--.---.--.--110-........120.......130.......140.......150.......160.......170.......180-.---.------..-...190.......200.....-..210.......220.......230.......240...-....250.......260.......270.--......280..--.....290.......300.......310.-......320.......330.........340.......350.....-.-.360--........370.......380...----....390.......400...----....410.......420.......430......-.440.......450.......460.....-..470.......480.......----490.......500..-..-...510.......520.......530.......540.......550-.......560.......570.......----580.......590.......600.......610.......620.......630.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
K
I
I
G
I
D
LGTTN
S
C
V
A
I
LENG
N
V
K
V
I
ENAEGARTT
P
S
I
I
A
YTNDGETLVGQPAKRQAVTNP
Q
N
T
L
Y
A
V
K
R
L
I
G
R
R
F
E
E
N
V
V
Q
K
D
I
Q
MV
P
Y
S
I
V
-K-ADNG
D
A
W
--
V
E
V----K--G---Q--K--MA--P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
YLGEPVT
E
A
V
I
T
V
P
A
YFND
S
Q
R
Q
A
T
KDAGRIAG
L
D
V
K
R
I
INEP
T
A
A
A
L
A
YGLD-K---A------KG-D
H
T
V
I
V
Y
DLGG
G
T
F
D
V
S
V
I
E
I
-
A
EVDGE
H
Q
F
E
V
L
ATNGDTFLGGEDFD
I
R
L
I
D
Y
L
V
D
E
F
K
-KESGINLKG
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L--SSTQQTDVNL
P
--
Y
V
TADASGP
K
H
L
N
V
K
V
S
R
A
K
L
E
S
L
V
E
D
L
V
-
Q
R
T
I
E
P
C
R
T
A
L
K
DAGL
D
--
V
S
D
I
H
E
V
I
LVGGQTRM
P
L
V
Q
K
T
V
A
E
F
F
-
G
-
K
E
A
---RKDV
N
P
D
E
A
V
A
V
G
A
A
IQ
G
A
V
LAGD----V
K
D
V
L
L
L
DVT
P
L
T
L
G
I
E
T
L
G
----
G
V
M
T
G
L
IEKNTTIPTKKS
Q
V
F
STADDNQ
G
A
V
T
I
-
H
V
LQG
E
R
K
Q
A
AQNKSLGKFDLADIPPAPR-GV
P
Q
I
E
V
T
F
DIDAN
G
I
L
H
V
SAK----DKATGKQ
Q
S
I
V
I
K
AS-SG-L
S
E
D
E
I
Q
Q
M
V
R
DAEAN
A
E
E
D
R
K
F
E
E
L
A
A
ARNQG
D
A
L
V
H
A
T
R
K
M
I
T
E-AGDKATA
E
D
K
A
T
I
E
K
A
L
G
E
L
E
A
AVKGD----
D
K
A
E
I
E
A
K
M
N
A
L
S
QAST
P
L
A
Q
K
M
Y
A
E
Q
A
QQGEDAPQGEQAKAADDVV
D
A
E
F
E
E
VKDNK
4
PsiBlast_PDB
97.76
77%
-75
- C4 -
4B9Q
1
DNAK_ECOLI
A:
[2-600]
-
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
-
A
-
A
D
N
G
D
A
W
--
V
E
V
----
K
--
G
---
Q
--
K
--
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
---
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
-
D
E
V
D
G
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
-
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
D
V
N
L
P
--
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
--
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
---
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
----
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
-------------------------------------
22
PsiBlast_CBE
96.50
78%
-73
- C4 -
4JN4
12
DNAK_ECOLI
B:
[2-596]
-
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
-
A
-
A
D
N
G
D
A
W
--
V
E
V
----
K
--
G
---
Q
--
K
--
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
---
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
-
D
E
V
D
G
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
-
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
D
V
N
L
P
--
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
--
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
---
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
----
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
-------------------------------------
3
PsiBlast_PDB
96.44
78%
-71
- C4 -
4JNE
12
DNAK_ECOLI
A:
[2-596]
-
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
-
A
-
A
D
N
G
D
A
W
--
V
E
V
----
K
--
G
---
Q
--
K
--
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
---
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
-
D
E
V
D
G
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
-
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
D
V
N
L
P
--
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
--
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
---
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
----
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
-------------------------------------
2
PsiBlast_PDB
96.27
78%
-73
- C4 -
4JN4
12
DNAK_ECOLI
A:
[2-596]
-
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
-
A
-
A
D
N
G
D
A
W
--
V
E
V
----
K
--
G
---
Q
--
K
--
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
---
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
-
D
E
V
D
G
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
-
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
D
V
N
L
P
--
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
--
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
---
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
----
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
-------------------------------------
21
PsiBlast_CBE
96.07
78%
-72
- C4 -
4JNE
11
DNAK_ECOLI
B:
[2-596]
-
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
-
A
-
A
D
N
G
D
A
W
--
V
E
V
----
K
--
G
---
Q
--
K
--
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
---
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
-
D
E
V
D
G
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
-
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
D
V
N
L
P
--
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
--
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
---
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
----
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
-------------------------------------
1
PsiBlast_PDB
95.64
79%
-78
- C5 -
2KHO
-
DNAK_ECOLI
A:
[4-600]
---
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
-
A
-
A
D
N
G
D
A
W
--
V
E
V
----
K
--
G
---
Q
--
K
--
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
---
G
------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
-
D
E
V
D
G
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
-
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
D
V
N
L
P
--
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
--
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
---
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
D
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
----
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
-------------------------------------
112
HHSearch
85.09
67%
-72
- C4 -
2V7Y
2
DNAK_GEOKA
A:
[1-504]
M
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
K
V
----------------------------
E
I
----
E
--
G
---
K
--
Q
--
Y
T
--
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
---
E
-------
E
-
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
-
G
----
D
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
-
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
--
S
G
V
T
Q
T
Q
I
S
L
P
--
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
--
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
---
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
----
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
-
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
-----------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.35
63%
-76
- C4 -
2V7Y
2
DNAK_GEOKA
A:
[1-504]
M
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
--------------------------
D
Y
K
--
V
E
I
----
E
--
G
---
K
--
Q
--
Y
T
--
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
---
E
------
E
--
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
-----
G
D
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
-
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
--
S
G
V
T
Q
T
Q
I
S
L
P
--
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
--
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
---
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
----
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
-
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
-----------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.29
63%
-75
- C5 -
4ANI
-
DNAK_GEOKA
C:
[1-509]
M
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
--------------------------
D
Y
K
--
V
E
I
----
E
--
G
---
K
--
Q
--
Y
T
--
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
---
E
------
E
--
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
-----
G
D
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
-
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
--
S
G
V
T
Q
T
Q
I
S
L
P
--
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
--
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
---
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
----
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
-
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.77
53%
-68
- C4 -
1YUW
-
HSP7C_BOVIN
A:
[4-540]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
----
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
-
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
----
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
-
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
---------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.55
53%
-72
- C4 -
3C7N
9
HSP7C_BOVIN
B:
[4-540]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-----
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
----
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
-
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
----
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
-
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
---------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.72
81%
-84
- C4 -
1DKG
-
DNAK_ECOLI
D:
[3-382]
--
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
-
A
-
A
D
N
G
D
A
W
--
V
E
V
----
K
--
G
---
Q
--
K
--
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
----------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
-
D
----
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
-
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
D
V
N
L
P
--
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
L
S
--
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
---
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Fugue
75.13
80%
-80
- C4 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
--
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
-
A
-
A
D
N
G
D
A
W
--
V
E
V
-----KG----
Q
--
K
--
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
-
K
----------
T
G
-
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
-
D
E
-
K
T
F
E
V
L
A
---
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
-
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
SS--
A
Q
Q
T
D
V
N
L
P
--
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N-
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
--LS
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
----KEP
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
74.61
25%
-59
- C4 -
3D2F
4
?
A:
[2-635]
-
S
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
N
R
G
I
D
I
V
V
N
E
V
S
N
R
S
T
P
S
V
V
G
F
G
P
-
K
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
T
V
A
N
L
K
R
I
I
G
L
D
Y
H
H
P
D
F
E
Q
E
S
K
H
F
T
S
K
L
V
-
E
-
L
D
D
K
K
T
G
--
A
E
V
R
F
AG
E
--
K
---
H
--
V
--
F
S
--
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
-
K
---
T
DLPEGE
E
K
-
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
-
K
----
K
G
Q
L
K
V
L
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
-
T
K
Y
K
I
D
I
R
E
N
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
--
S
A
N
T
N
A
P
F
S
V
E
--
S
V
M
N
----
D
V
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
K
P
L
L
-
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
--
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
-
G
-
K
P
L
---
S
T
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
P
T
LR--
V
R
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
D
K
QVED
E
D
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
T
D
I
T
Q
L
P
---
P
N
T
P
E
Q
I
A
N
W
E
I
T
G
V
Q
L
P
E
G
Q
D
S
V
P
V
K
L
K
L
R
C
D
P
S
G
L
H
T
I
E
E
A
Y
T
I
E
D
T
K
T
V
K
K
D
D
L
T
I
V
A
H
T
F
G
-
L
D
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
E
E
Y
A
P
F
A
S
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
D
E
GFDS
I
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
------------------------
13
PsiBlast_PDB
73.50
52%
-79
- C4 -
3A8Y
1
HS71A_HUMAN
A:
[11-387]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
E
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
------
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
73.49
52%
-79
- C4 -
4IO8
1
HS71A_HUMAN
A:
[7-379]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
D
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
------
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
73.32
50%
-79
- C4 -
3L6Q
5
?
A:
[19-398]
-
G
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
E
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
K
F
D
D
Q
A
V
Q
S
D
M
T
H
W
P
F
K
V
V
-
R
-
G
P
K
D
K
P
I
--
I
S
V
----
N
Y
L
G
---
E
--
K
K
E
F
H
--
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
---
G
------
T
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
-
E
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
Q
D
F
K
R
K
N
R
G
M
D
L
T
T
N
A
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
T
I
E
L
D
SL
Y
E
G
I
D
Y
S
------
V
A
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
-
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
--
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
A
L
I
Q
E
F
F
N
G
-
K
E
P
---
C
K
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
73.27
52%
-78
- C4 -
3FE1
4
HSP76_HUMAN
B:
[27-403]
----
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
R
K
F
A
D
T
T
V
Q
S
D
M
K
H
W
P
F
R
V
V
---
S
E
G
G
K
P
K
--
V
R
V
C
Y
RG
E
--
D
---
K
--
T
--
F
Y
--
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
R
---
G
------
A
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
D
A
G
V
-----
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
-
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
T
L
E
I
D
--
S
L
F
E
G
V
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
73.22
52%
-77
- C4 -
1HJO
2
HS71A_HUMAN
A:
[5-380]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
E
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
------
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
73.14
50%
-82
- C4 -
3FZH
1
HSP7C_HUMAN
A:
[5-381]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.03
52%
-75
- C4 -
3ATU
4
HS71A_HUMAN
A:
[11-386]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
E
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
------
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
72.98
50%
-83
- C4 -
3LDQ
1
HSP7C_HUMAN
A:
[5-381]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
72.91
50%
-76
- C4 -
2QWP
7
HSP7C_BOVIN
A:
[4-389]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
72.84
51%
-75
- C4 -
2QWM
5
HSP7C_BOVIN
B:
[4-384]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
TK
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
72.83
50%
-73
- C4 -
1ATR
3
HSP7C_BOVIN
A:
[4-383]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
V
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
72.78
50%
-80
- C4 -
3FZM
1
HSP7C_HUMAN
A:
[5-381]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
72.78
51%
-73
- C4 -
4H5R
10
HSP7C_HUMAN
A:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.78
51%
-79
- C4 -
3QFU
3
GRP78_YEAST
A:
[18-394]
-
G
T
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
T
D
D
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
D
I
K
R
L
I
G
L
K
Y
N
D
R
S
V
Q
K
D
I
K
H
L
P
F
N
V
V
-
N
-
K
D
G
K
P
A
V
E
-
V
S
V
----
K
--
G
---
E
--
K
K
V
F
T
--
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
S
------
D
K
-
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
-
E
----
N
G
V
F
E
V
Q
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
-
K
K
H
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
--
S
S
Q
M
S
T
R
I
E
I
D
--
S
F
V
D
G
I
D
----
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
--
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
-
K
K
A
---
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
72.77
51%
-77
- C4 -
1HPM
6
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
72.74
52%
-78
* C4 *
3QFU
3
GRP78_YEAST
A:
[18-393]
-
G
T
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
T
D
-
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
D
I
K
R
L
I
G
L
K
Y
N
D
R
S
V
Q
K
D
I
K
H
L
P
F
N
V
V
-
N
-
K
-
D
G
K
P
A
V
E
V
S
V
KG--
E
--
K
---
K
--
V
--
F
T
--
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
S
------
D
K
-
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
-
E
----
N
G
V
F
E
V
Q
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
-
K
K
H
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
--
S
S
Q
M
S
T
R
I
E
I
D
--
S
F
V
D
----
G
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
--
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
-
D
G
K
K
A
---
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
72.74
50%
-75
- C4 -
1NGF
1
HSP7C_BOVIN
A:
[4-383]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
N
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
72.73
50%
-75
- C4 -
1NGB
2
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
Q
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.71
52%
-75
- C4 -
3JXU
2
HS71A_HUMAN
A:
[29-403]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
E
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
------
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
72.70
50%
-81
- C4 -
3L4I
3
?
A:
[19-399]
-
G
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
E
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
K
F
D
D
Q
A
V
Q
S
D
M
T
H
W
P
F
K
V
V
-
R
-
G
P
K
D
K
P
I
--
I
S
V
----
N
Y
L
G
---
E
--
K
K
E
F
H
--
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
---
G
------
T
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
-
E
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
Q
D
F
K
R
K
N
R
G
M
D
L
T
T
N
A
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
T
I
E
L
D
SL
Y
E
G
I
D
Y
S
------
V
A
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
-
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
--
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
A
L
I
Q
E
F
F
N
G
-
K
E
P
---
C
K
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
72.69
50%
-80
- C4 -
3FZK
3
HSP7C_HUMAN
A:
[5-381]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.65
52%
-74
- C4 -
3ATV
3
HS71A_HUMAN
A:
[11-386]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
E
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
------
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
72.62
51%
-76
- C4 -
4H5T
3
HSP7C_HUMAN
A:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.60
51%
-76
- C4 -
2QWL
4
HSP7C_BOVIN
A:
[4-384]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
72.57
50%
-74
- C4 -
1QQM
5
HSP7C_BOVIN
A:
[1-378]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
A
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
A
------
V
G
A
E
R
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
A
H
A
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
72.52
50%
-76
- C4 -
1QQO
4
HSP7C_BOVIN
A:
[1-378]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
A
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
72.52
50%
-76
- C4 -
2QWR
4
HSP7C_BOVIN
A:
[4-386]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
72.47
50%
-76
- C4 -
1BA1
4
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
K
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
72.47
50%
-76
- C4 -
1BUP
6
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
S
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
72.43
50%
-81
- C4 -
3FZF
1
HSP7C_HUMAN
A:
[5-381]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
72.43
50%
-75
- C4 -
1ATS
2
HSP7C_BOVIN
A:
[4-383]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
E
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.42
51%
-75
- C4 -
2QWM
5
HSP7C_BOVIN
A:
[4-384]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.41
51%
-75
- C4 -
2QWL
4
HSP7C_BOVIN
B:
[4-384]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
TK
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
72.35
50%
-72
- C4 -
2QWO
7
HSP7C_BOVIN
A:
[4-390]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
72.33
50%
-76
- C4 -
1NGH
1
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
N
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
72.29
51%
-72
- C4 -
4H5W
5
HSP7C_HUMAN
A:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
72.28
50%
-76
- C4 -
1NGE
1
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
72.28
52%
-78
- C4 -
4J8F
14
F10A1_RAT (first)
A:
[14-389]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
E
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
------
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
72.26
51%
-72
- C4 -
4H5N
9
HSP7C_HUMAN
A:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.25
51%
-74
- C4 -
1NGJ
2
HSP7C_BOVIN
A:
[4-383]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
72.25
52%
-76
- C4 -
1S3X
5
HS71A_HUMAN
A:
[7-382]
----
I
G
I
D
L
G
T
T
Y
S
C
I
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
E
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
------
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
72.23
52%
-74
- C4 -
2E8A
2
HS71A_HUMAN
A:
[10-385]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
E
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
------
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.17
50%
-76
- C4 -
2QWN
5
HSP7C_BOVIN
A:
[4-385]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.14
52%
-81
- C4 -
3FE1
2
HSP76_HUMAN
A:
[27-403]
----
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
R
K
F
A
D
T
T
V
Q
S
D
M
K
H
W
P
F
R
V
V
---
S
E
G
G
K
P
K
--
V
R
V
C
Y
RG
E
--
D
---
K
--
T
--
F
Y
--
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
R
---
G
------
A
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
D
A
G
V
-----
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
-
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
T
L
E
I
D
--
S
L
F
E
G
V
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
72.13
50%
-78
- C4 -
1KAZ
6
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
E
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
72.09
50%
-74
- C4 -
1NGA
2
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
72.09
51%
-73
- C4 -
4H5R
8
HSP7C_HUMAN
B:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
TK
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
72.07
51%
-78
- C4 -
3GDQ
3
HS71L_HUMAN
A:
[28-406]
-
G
I
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
N
D
P
V
V
Q
A
D
M
K
L
W
P
F
Q
V
I
N
E
-
G
G
K
P
K
V
L
--
V
S
Y
----
K
--
G
---
E
--
N
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
L
K
E
T
A
E
A
F
L
G
H
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
-----------
G
-
E
R
H
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
S
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
N
L
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
M
D
--
K
A
K
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
R
L
L
Q
D
Y
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
72.05
50%
-76
- C4 -
2QWQ
5
HSP7C_BOVIN
A:
[4-386]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
72.03
50%
-79
- C4 -
3M3Z
1
HSP7C_HUMAN
A:
[5-381]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
72.00
51%
-72
- C4 -
3LDL
1
GRP78_HUMAN
A:
[4-383]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
-
K
T
K
P
Y
I
Q
--
V
D
I
----
G
--
G
G
Q
T
K
--
T
--
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
-----
D
N
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
-
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
R
I
E
I
E
SF
Y
E
G
E
D
F
S
E
------
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
--
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
---
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
71.95
50%
-81
- C4 -
3FZL
2
HSP7C_HUMAN
A:
[5-381]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
71.91
51%
-74
- C4 -
4H5W
4
HSP7C_HUMAN
B:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
TK
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
71.91
51%
-74
- C4 -
3HSC
5
HSP7C_BOVIN
A:
[4-383]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
71.90
50%
-77
- C4 -
2BUP
6
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
G
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
71.87
51%
-79
- C4 -
3I33
3
HSP72_HUMAN
A:
[26-402]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
K
R
L
I
G
R
K
F
E
D
A
T
V
Q
S
D
M
K
H
W
P
F
R
V
V
S
E
-
G
G
K
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
--
T
K
T
F
F
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
KGC
A
------
G
G
-
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
-
R
K
H
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
V
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
71.87
50%
-75
- C4 -
1NGG
1
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
S
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.87
52%
-80
- C4 -
3FE1
2
HSP76_HUMAN
C:
[27-402]
----
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
R
K
F
A
D
T
T
V
Q
S
D
M
K
H
W
P
F
R
V
V
---
S
E
G
G
K
P
K
--
V
R
V
C
Y
RG
E
--
D
---
K
--
T
--
F
Y
--
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
R
---
G
------
A
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
D
A
G
V
-----
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
-
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
T
L
E
I
D
--
S
L
F
E
G
V
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.86
52%
-74
- C4 -
3AY9
5
HS71A_HUMAN
A:
[11-386]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
E
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
------
K
G
-
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
71.84
50%
-75
- C4 -
1NGD
3
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
N
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
71.82
50%
-81
- C4 -
1HX1
1
HSP7C_BOVIN
A:
[24-400]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.82
50%
-78
- C4 -
1BA0
5
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
K
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
71.77
51%
-76
- C4 -
1NGI
2
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
71.74
50%
-78
- C4 -
1KAY
6
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
A
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
71.71
51%
-81
- C4 -
3I33
3
HSP72_HUMAN
A:
[23-402]
-
M
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
K
R
L
I
G
R
K
F
E
D
A
T
V
Q
S
D
M
K
H
W
P
F
R
V
V
-
S
-
E
-
G
G
K
P
K
--
V
Q
V
E
Y
KG
E
--
T
---
K
--
T
--
F
F
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
GCA---
G
G
-
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
----
D
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
-
R
K
H
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
----
G
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
G
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
71.69
51%
-74
- C4 -
3LDP
1
GRP78_HUMAN
A:
[4-383]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
-
K
T
K
P
Y
I
Q
--
V
D
I
----
G
--
G
G
Q
T
K
--
T
--
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
-----
D
N
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
-
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
R
I
E
I
E
SF
Y
E
G
E
D
F
S
E
------
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
--
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
---
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
71.68
50%
-77
- C4 -
1KAX
6
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
M
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
71.54
50%
-76
- C4 -
1QQN
6
HSP7C_BOVIN
A:
[1-378]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
A
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
A
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
A
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
A
H
A
K
D
I
S
E
N
K
R
A
V
R
R
L
A
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
71.43
51%
-73
- C4 -
4H5V
9
HSP7C_HUMAN
A:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
71.34
51%
-73
- C4 -
3LDO
1
GRP78_HUMAN
A:
[4-384]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
-
K
T
K
P
Y
I
Q
--
V
D
I
----
G
--
G
G
Q
T
K
--
T
--
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
-----
D
N
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
-
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
R
I
E
I
E
SF
Y
E
G
E
D
F
S
E
------
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
--
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
---
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
71.34
52%
-78
- C4 -
3A8Y
1
HS71A_HUMAN
B:
[11-385]
----
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
-
N
D
G
D
K
P
K
V
Q
--
V
S
Y
----
K
--
G
---
E
--
T
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
R
T--
G
---------
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
-
D
--
D
G
--
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
-
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
--
S
L
F
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
--
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
71.32
51%
-73
- C4 -
3LDO
1
GRP78_HUMAN
B:
[4-383]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
-
K
T
K
P
Y
I
Q
--
V
D
I
----
G
--
G
GQT
K
--
T
--
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
-----
D
N
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
-
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
R
I
E
I
E
SF
Y
E
G
E
D
F
S
E
------
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
--
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
---
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
71.18
50%
-74
- C4 -
1NGC
2
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
-
N
D
A
G
R
P
K
V
Q
--
V
E
Y
----
K
--
G
---
E
T
K
S
--
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
K
------
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
-
E
--
D
G
--
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
-
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
I
E
I
D
--
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
---
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.11
51%
-75
- C4 -
3IUC
2
GRP78_HUMAN
A:
[26-404]
-
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
-
K
T
K
P
Y
I
Q
--
V
D
I
----
G
--
G
G
Q
T
K
--
T
--
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
-----
D
N
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
-
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
R
I
E
I
E
SF
Y
E
G
E
D
F
S
E
T
------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
--
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
---
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
70.89
51%
-74
- C4 -
3LDL
2
GRP78_HUMAN
B:
[4-383]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
-
K
T
K
P
Y
I
Q
--
V
D
I
----
G
--
G
GQT
K
--
T
--
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
-----
D
N
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
-
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
R
I
E
I
E
SF
Y
E
G
E
D
F
S
E
------
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
--
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
---
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
70.86
51%
-76
- C4 -
3IUC
3
GRP78_HUMAN
C:
[25-406]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
-
K
T
K
P
Y
I
Q
--
V
D
I
----
G
--
G
GQT
K
--
T
--
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
-----------
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
-----
D
N
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
-
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
R
I
E
I
E
SF
Y
E
G
E
D
F
S
E
T
------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
--
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
---
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
70.21
51%
-70
- C4 -
3LDP
1
GRP78_HUMAN
B:
[4-383]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
-
K
T
K
P
Y
I
Q
--
V
D
I
----
G
--
G
GQT
K
--
T
--
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
-
K
---
R
------
E
G
-
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
-----
D
N
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
-
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
R
I
E
I
E
SF
Y
E
G
E
D
F
S
E
------
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
--
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
---
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------