@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4786: (2016-03-01 )
MTDRYIAFANSPVGRRLVGAVGLPSPLRLERWQAGRVRPVDGPLVIGGSGALAEAVLPFAGKLTDAVFAAVDGQFELPRWTAEHSPRAKAVLFDASGLTRFEQLVALRDFFQPVLKGLDKCPKVVVLGRPPESLKDPVTASVQRSLEGFTRSLGKEIRRGGNVQLLYVGKGAEDQLEGALRFFLSPKSAYVSGQVIRLAANSAQVHDWSKPLAGQRALVTGAARGIGAAIAETLARDGAEVVLLDVPPAREALEGLAARLGGRAVALDICAADAGQQLVEALPEGVDIVVHNAGITRDKTLAKMSSDFWNSVINVNLNAPQVLTQALLDGGKLHDNGRVVLLASISGIAGNLGQSNYAVSKAGLIGLAQAWAPALGKRGITINAVAPGFIETQMTAAIPLTIREAGRRMNSMSQGGLPQDVAETVAWFAQPSSGAVSGQVLRVCGQSLLGA
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160......---.170---.---......180.......190......-.200.....-...210.......220.......230.......240--..---...--..--250.......-260-...--...--..270...---------....280--..----.---.----..---..290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400..-------.....410.......420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTD
R
Y
I
A
FANSPV
G
R
R
L
V
GAVGLPSP
L
R
L
E
RWQAGRVRPVDG
P
L
V
IGG
S
G
A
L
A
E
A
V
L
P
F
A
G
K
L
T
D
A
V
F
A
AVDGQFELPRWTAEHSPR
A
K
A
V
L
FDAS
G
L
T
R
F
E
Q
L
V
A
L
R
D
F
F
Q
P
V
L
K
G
L
D
KC
P
K
V
V
V
LGRP
P
E
S
LKD
P
V
T
A
S
V
Q
R
S
L
E
G
F
T
R
S
L
G
K
E
I
RRGG
N
V
Q
L
L
Y
V---GKG
A
---
E
---
D
Q
L
E
G
A
L
R
F
FLSPKSAYVS
G
Q
V
I
R
L
-AAN-SAQVH-DWSKPLAGQ
R
A
L
V
T
G
AAR
G
I
G
A
A
I
A
E
T
L
ARDG
A
E
V
V
--
L
L
---DVP--
P
A
--
R
E
A
L
E
G
L
A
A
R
-LG--G
R
A
--
V
A
L
--
D
I
CA
A
D
A
G
---------
Q
Q
L
V
E
A---LP----E---G----
V
D
---
I
V
V
HNAGITR
D
K
T
L
A
K
M
S
S
D
F
W
N
S
V
I
N
VNLN
A
P
Q
V
L
T
Q
A
L
LDGGKLHDN
G
R
V
V
L
L
A
SISGIAGNLGQSNYAV
S
K
A
G
L
I
G
L
A
Q
A
W
A
P
A
LGKR
G
I
T
I
NAVAP
G
F
I
ETQMTAA
I
P
L
T
I
R
E
-------
A
G
R
RMNSMSQGGL
P
Q
D
V
A
E
T
V
A
W
FAQPSSGAV
S
G
Q
V
L
R
V
C
G
Q
S
LLGA
5
PsiBlast_PDB
90.79
50%
-94
- C2 -
4FW8
2
?
A:
[20-454]
--------------
S
F
L
A
R
Q
L
G
V
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
-------------
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
A
A
I
P
L
A
T
R
E
-------
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
1
PsiBlast_PDB
90.37
50%
-95
- C2 -
3U0B
1
?
A:
[30-454]
------------------------
Q
P
E
T
L
R
R
Y
R
P
G
D
-
P
P
L
A
G
S
L
L
I
G
G
S
G
R
V
A
E
P
L
R
T
A
L
A
D
D
Y
N
L
V
S
N
N
I
G
G
-----
R
W
A
D
S
F
G
----
G
V
V
F
D
A
T
G
I
T
E
A
E
G
L
K
E
L
Y
T
F
F
T
P
L
L
R
N
L
A
P
C
A
R
V
V
V
V
G
T
T
P
A
E
A
G
S
V
H
A
Q
V
V
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
V
S
L
V
Y
L
---
S
A
D
A
---
K
PGA
T
G
L
E
S
T
M
R
F
I
L
S
A
K
S
A
Y
V
D
G
Q
V
F
R
V
G
A
A
D
-
S
T
P
P
A
-
D
W
D
K
P
L
D
G
K
V
A
V
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
T
V
V
--
A
I
---
D
V
D
--
G
A
--
A
E
D
L
K
R
V
A
D
K
-
V
G
--
G
T
A
--
L
T
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
T
A
H
---
V
T
----
E
---
H
HGGK
V
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
E
K
R
W
D
A
V
I
A
V
N
L
L
A
P
Q
R
L
T
E
G
L
V
G
N
G
T
I
G
E
G
G
R
V
I
G
L
S
S
M
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
L
A
E
A
L
A
P
V
L
A
D
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
----------
R
E
-------
V
G
R
R
L
N
S
L
F
Q
G
G
Q
P
V
D
V
A
E
L
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
T
I
R
V
C
G
Q
A
M
L
G
A
26
PsiBlast_CBE
89.55
50%
-94
- C2 -
3Q6I
1
?
C:
[21-446]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
N
N
--------
R
W
A
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
-----
A
I
P
L
A
T
R
E
-------
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
22
PsiBlast_CBE
89.32
50%
-96
- C2 -
4FW8
1
?
D:
[29-454]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
-------------
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
-----
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
-----
I
P
L
A
T
R
E
--------
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
6
PsiBlast_PDB
88.17
50%
-93
- C2 -
3Q6I
2
?
A:
[12-446]
--------------
S
F
L
A
R
Q
L
G
V
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
-------------
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
A
A
I
P
L
A
T
R
E
-------
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
24
PsiBlast_CBE
87.96
50%
-93
- C2 -
4FW8
2
?
B:
[20-454]
--------------
S
F
L
A
R
Q
L
G
-
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
-------------
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
SPD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
-
A
I
P
L
A
T
R
E
-------
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
25
PsiBlast_CBE
87.91
50%
-94
- C2 -
3Q6I
1
?
D:
[21-446]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
-------------
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
-----
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
-----
I
P
L
A
T
R
E
--------
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
4
PsiBlast_PDB
87.50
50%
-94
- C2 -
3V1U
3
?
A:
[37-462]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
------------
A
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
---
I
P
L
A
T
R
E
-------
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
27
PsiBlast_CBE
87.22
50%
-95
- C2 -
3Q6I
2
?
B:
[12-446]
--------------
S
F
L
A
R
Q
L
G
-
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
-------------
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
SPD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
Q
M
T
-
A
I
P
L
A
T
R
E
-------
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
3
PsiBlast_PDB
87.17
50%
-92
- C2 -
3V1T
-
?
C:
[29-454]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
--------------
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
SPD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
----------
R
E
-------
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
23
PsiBlast_CBE
86.83
50%
-92
- C2 -
4FW8
1
?
C:
[29-454]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
N
N
--------
R
W
A
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
-----
A
I
P
L
A
T
R
E
-------
V
G
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
126
Fugue
84.44
51%
-101
- C2 -
3LLS
8
?
A:
[50-475]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
----------------
G
N
D
S
F
G
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
---
S
P
D
A
---
K
PAA
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
R
R
L
N
----------------------
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
21
PsiBlast_CBE
83.95
50%
-101
- C2 -
3LLS
7
?
B:
[52-475]
-------------------------
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
------------
A
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
----------------------
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
104
HHSearch
83.80
51%
-86
- C2 -
3U0B
1
?
A:
[30-454]
------------------------
Q
P
E
T
L
R
R
Y
R
P
G
D
P
P
L
A
G
S
L
L
I
-
G
G
S
G
R
V
A
E
P
L
R
T
A
L
A
D
D
Y
N
L
V
S
N
-
N
-
I
G
-
G
R
---
W
A
D
---
S
F
G
G
V
V
F
D
A
T
G
I
T
E
A
E
G
L
K
E
L
Y
T
F
F
T
P
L
L
R
N
L
A
P
C
A
R
V
V
V
V
G
T
T
P
A
E
A
G
S
V
H
A
Q
V
V
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
V
S
L
V
Y
L
---
S
A
D
A
KPG
A
---
T
G
L
E
S
T
M
R
F
I
L
S
A
K
S
A
Y
V
D
G
Q
V
F
R
V
-
G
A
A
-
D
S
T
P
P
A
D
W
D
K
P
L
D
G
K
V
A
V
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
T
V
V
--
A
I
---
D
V
D
--
G
A
--
A
E
D
L
K
R
V
A
D
K
-
V
G
--
G
T
A
--
L
T
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
T
A
H
---
V
T
E
HHG
G
---
K
----
V
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
E
K
R
W
D
A
V
I
A
V
N
L
L
A
P
Q
R
L
T
E
G
L
V
G
N
G
T
I
G
E
G
G
R
V
I
G
L
S
S
M
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
L
A
E
A
L
A
P
V
L
A
D
K
G
I
T
I
N
A
V
A
P
G
F
I
E
T
----------
R
E
-------
V
G
R
R
L
N
S
L
F
Q
G
G
Q
P
V
D
V
A
E
L
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
T
I
R
V
C
G
Q
A
M
L
G
A
2
PsiBlast_PDB
83.53
50%
-100
- C2 -
3LLS
8
?
A:
[50-475]
-----------------------
P
Q
P
E
T
L
R
R
Y
R
A
G
E
-
P
P
L
T
G
S
L
L
I
G
G
A
G
R
V
V
E
P
L
R
A
A
L
E
K
D
Y
D
L
V
G
N
------------
D
S
F
G
----
G
L
V
F
D
A
T
G
I
T
E
P
A
G
L
K
G
L
H
E
F
F
T
P
V
L
R
N
L
G
R
C
G
R
V
V
V
V
G
G
T
P
E
A
A
A
S
T
N
E
R
I
A
Q
R
A
L
E
G
F
T
R
S
L
G
K
E
L
R
R
G
A
T
T
A
L
V
Y
L
S
PD
A
K
P
A
---
A
---
T
G
L
E
S
T
M
R
F
L
L
S
A
K
S
A
Y
V
D
G
Q
V
F
S
V
-
G
A
D
D
S
T
P
P
A
-
D
W
E
K
P
L
D
G
K
V
A
I
V
T
G
A
A
R
G
I
G
A
T
I
A
E
V
F
A
R
D
G
A
H
V
V
--
A
I
---
D
V
E
--
S
A
--
A
E
N
L
A
E
T
A
S
K
-
V
G
--
G
T
A
--
L
W
L
--
D
V
T
A
D
D
A
V
---------
D
K
I
S
E
H
---
L
R
----
D
---
H
HGGK
A
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
L
A
N
M
D
D
A
R
W
D
A
V
L
A
V
N
L
L
A
P
L
R
L
T
E
G
L
V
G
N
G
S
I
G
E
G
G
R
V
I
G
L
S
S
I
A
G
I
A
G
N
R
G
Q
T
N
Y
A
T
T
K
A
G
M
I
G
I
T
Q
A
L
A
P
G
L
A
A
K
G
I
T
I
N
A
V
A
P
G
F
I
E
----------------------
R
R
L
N
S
L
L
Q
G
G
Q
P
V
D
V
A
E
A
I
A
Y
F
A
S
P
A
S
N
A
V
T
G
N
V
I
R
V
C
G
Q
A
M
I
G
A
49
PsiBlast_CBE
58.42
37%
-91
- C2 -
2PNF
3
FABG_AQUAE
B:
[4-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
--
I
T
---
G
T
S
GE
R
A
--
K
A
V
A
E
E
I
A
N
K
-
Y
G
--
V
K
A
HG
V
E
M
--
N
L
L
S
E
E
S
I
---------
N
K
A
F
E
E
IYN
L
V
----
D
---
G
----
I
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
M
S
L
L
D
W
E
E
V
L
K
V
N
L
T
G
T
F
L
V
T
Q
N
S
L
R
K
M
I
K
Q
R
W
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
L
A
P
R
N
V
L
V
N
A
V
A
P
G
F
I
E
T
D
M
T
A
V
L
S
E
E
I
K
Q
-------
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
------
14
PsiBlast_PDB
58.15
40%
-94
- C2 -
2UVD
-
?
A:
[2-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
K
V
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
I
D
L
A
K
Q
G
A
N
V
V
--
V
N
Y
AG
N
E
Q
--
K
A
--
N
E
V
V
D
E
I
K
-
K
-
L
G
--
S
D
A
--
I
A
V
R
A
D
V
A
N
A
E
D
V
---------
T
N
M
V
K
Q
---
T
V
----
D
V
FG
Q
----
V
D
---
I
L
V
N
N
A
G
V
T
K
D
N
L
L
M
R
M
K
E
E
E
W
D
T
V
I
N
T
N
L
K
G
V
F
L
C
T
K
A
V
S
R
F
M
M
R
Q
R
H
G
R
I
V
N
I
A
S
V
V
G
V
T
G
N
P
G
Q
A
N
Y
V
A
A
K
A
G
V
I
G
L
T
K
T
S
A
K
E
L
A
S
R
N
I
T
V
N
A
I
A
P
G
F
I
A
T
D
M
T
D
V
L
D
E
N
I
K
A
-------
E
M
L
K
L
I
P
A
A
Q
F
G
E
A
Q
D
I
A
N
A
V
T
F
F
A
S
D
Q
S
K
Y
I
T
G
Q
T
L
N
V
D
G
------
102
PsiBlast_CBE
56.64
38%
-96
- C2 -
4BNV
1
FABG_PSEAE
B:
[23-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
L
Q
G
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
I
G
T
A
T
---
S
A
S
--
G
A
--
E
K
I
A
E
T
L
K
A
N
G
V
E
--
G
A
G
--
L
V
L
--
D
V
S
S
D
E
S
V
---------
A
A
T
L
E
H
---
I
Q
----
Q
---
H
----
L
G
QPL
I
V
V
N
N
A
G
I
------------
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
R
G
M
T
K
A
R
W
G
R
I
I
N
I
G
S
V
V
G
-----
G
Q
T
N
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
-------
A
L
L
G
Q
I
P
L
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
------
39
PsiBlast_CBE
55.29
38%
-106
- C2 -
3TZC
5
?
D:
[10-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
S
G
A
Q
A
I
S
D
Y
-
L
G
DN
G
K
G
--
M
A
L
--
N
V
T
N
P
E
S
I
---------
E
A
V
L
K
A
---
I
T
----
D
E
FG
G
----
V
D
---
I
L
V
N
N
A
--------------
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
--------
A
N
F
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
--
N
D
E
Q
R
T
-------
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
20
PsiBlast_PDB
55.15
37%
-88
- C2 -
2P68
-
FABG_AQUAE
A:
[4-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
--
I
T
---
G
T
S
G
E
R
A
--
K
A
V
A
E
E
I
A
N
K
-
Y
G
--
V
K
A
H
G
V
E
M
--
N
L
L
S
E
E
S
I
---------
N
K
A
F
E
E
I
Y
N
L
V
----
D
---
G
----
I
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
M
S
L
L
D
W
E
E
V
L
K
V
N
L
T
G
T
F
L
V
T
Q
N
S
L
R
K
M
I
K
Q
R
W
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
L
A
P
R
N
V
L
V
N
A
V
A
P
G
F
I
E
T
D
M
T
A
V
L
S
E
E
I
K
Q
-------
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
------
12
PsiBlast_PDB
54.26
38%
-90
- C2 -
4I08
6
FABG_VIBCH
A:
[10-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
S
G
A
Q
A
I
S
D
Y
-
L
G
DN
G
K
G
--
M
A
L
--
N
V
T
N
P
E
S
I
---------
E
A
V
L
K
A
---
I
T
----
D
E
FG
G
----
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
----
N
D
E
Q
R
T
-------
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
19
PsiBlast_PDB
54.11
37%
-90
- C2 -
2PNF
3
FABG_AQUAE
A:
[4-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
--
I
T
---
G
T
S
G
E
R
A
--
K
A
V
A
E
E
I
A
N
K
-
Y
G
--
V
K
A
H
G
V
E
M
--
N
L
L
S
E
E
S
I
---------
N
K
A
F
E
E
I
Y
N
L
V
----
D
---
G
----
I
D
---
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
M
S
L
L
D
W
E
E
V
L
K
V
N
L
T
G
T
F
L
V
T
Q
N
S
L
R
K
M
I
K
Q
R
W
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
L
A
P
R
N
V
L
V
N
A
V
A
P
G
F
I
E
T
D
M
T
A
V
L
S
E
E
I
K
Q
-------
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
------
36
PsiBlast_CBE
53.64
38%
-86
- C2 -
4I08
9
FABG_VIBCH
B:
[10-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
S
G
A
Q
A
I
S
D
Y
-
L
G
DN
G
K
G
--
M
A
L
--
N
V
T
N
P
E
S
I
---------
E
A
V
L
K
A
---
I
T
----
D
E
FG
G
----
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
--
T
K
A
L
N
D
E
Q
R
T
-------
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
33
PsiBlast_CBE
53.17
39%
-93
- C2 -
4WK6
1
?
B:
[10-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
S
G
A
Q
A
I
S
D
Y
-
L
G
DN
G
K
G
--
M
A
L
--
N
V
T
N
P
E
S
I
---------
E
A
V
L
K
A
---
I
T
----
D
E
FG
G
----
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
A
S
V
V
G
T
M
----
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
-------
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
11
PsiBlast_PDB
52.85
38%
-87
- C2 -
3RRO
11
FABG_VIBCH
A:
[10-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
S
G
A
Q
A
I
S
D
Y
-
L
G
DN
G
K
G
--
M
A
L
--
N
V
T
N
P
E
S
I
---------
E
A
V
L
K
A
---
I
T
----
D
E
FG
G
----
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
-------
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
37
PsiBlast_CBE
52.43
38%
-86
- C2 -
3RSH
12
FABG_VIBCH
B:
[10-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
S
G
A
Q
A
I
S
D
Y
-
L
G
DN
G
K
G
--
M
A
L
--
N
V
T
N
P
E
S
I
---------
E
A
V
L
K
A
---
I
T
----
D
E
FG
G
----
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
-
L
N
D
E
Q
R
T
-------
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
10
PsiBlast_PDB
52.40
38%
-88
- C2 -
3RSH
11
FABG_VIBCH
A:
[10-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
S
G
A
Q
A
I
S
D
Y
-
L
G
DN
G
K
G
--
M
A
L
--
N
V
T
N
P
E
S
I
---------
E
A
V
L
K
A
---
I
T
----
D
E
FG
G
----
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
---
D
E
Q
R
T
-------
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
30
PsiBlast_CBE
51.20
39%
-85
- C2 -
4NBU
2
?
B:
[11-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
--
I
A
---
D
F
N
--
E
A
A
G
K
E
A
V
E
---
A
N
-
P
G
--
V
V
F
--
I
R
V
--
D
V
S
D
R
E
S
V
---------
H
R
L
V
E
N
---
V
A
----
E
R
FG
K
----
I
D
---
I
L
I
N
N
A
G
I
T
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
G
K
G
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
A
E
V
P
E
K
V
I
E
-------
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
--
38
PsiBlast_CBE
50.84
38%
-86
- C2 -
3RRO
13
FABG_VIBCH
B:
[10-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
S
G
A
Q
A
I
S
D
Y
-
L
G
DN
G
K
G
--
M
A
L
--
N
V
T
N
P
E
S
I
---------
E
A
V
L
K
A
---
I
T
----
D
EFG
G
----
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
-------
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
55
PsiBlast_CBE
49.00
37%
-86
- C2 -
4JRO
1
?
C:
[26-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
G
K
V
A
V
V
T
G
G
S
R
G
I
G
R
D
I
A
I
N
L
A
K
E
G
A
N
I
---
F
F
---
N
Y
N
--
G
S
--
P
E
A
A
E
E
T
A
K
L
-
V
A
--
E
H
G
--
V
E
V
--
E
A
M
K
A
N
V
A
IAEDVDAFF
K
Q
A
I
E
R
---
F
G
----
R
--------
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
D
E
W
D
D
V
I
N
I
N
L
K
G
T
F
L
C
T
K
A
V
S
R
T
M
M
K
Q
R
A
G
K
I
I
N
M
A
S
V
V
G
L
I
G
N
A
G
Q
A
N
Y
V
A
S
K
A
G
V
I
G
L
T
K
T
T
A
R
E
L
A
P
R
G
I
N
V
N
A
V
A
P
G
F
I
T
T
D
M
T
D
K
L
D
E
K
T
K
E
-------
A
M
L
A
Q
I
P
L
G
A
Y
G
T
T
E
D
I
A
N
A
V
L
F
L
A
S
D
A
S
K
Y
I
T
G
Q
T
L
S
V
D
G
------
52
PsiBlast_CBE
48.43
38%
-84
- C2 -
1Q7B
4
FABG_ECOLI
B:
[5-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
E
T
L
A
A
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
N
G
A
Q
A
I
S
D
Y
-
L
G
AN
G
K
G
--
L
M
L
--
N
V
T
D
P
A
S
I
---------
E
S
V
L
E
K
---
I
R
----
A
---
E
FGE-
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
D
E
E
W
N
D
I
I
E
T
N
L
S
S
V
F
R
L
S
K
A
V
M
R
A
M
M
K
K
R
H
G
R
I
I
T
I
G
S
V
V
G
T
M
G
N
G
G
Q
A
N
Y
A
A
A
K
A
G
L
I
G
F
S
K
S
L
A
R
E
V
A
S
R
G
I
T
V
N
V
V
A
P
G
F
I
E
T
D
M
T
R
--
S
D
D
Q
R
A
G
I
L
A
Q
VP
A
G
R
L
-------
G
G
A
Q
E
I
A
N
A
V
A
F
L
A
S
D
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
53
PsiBlast_CBE
47.47
38%
-82
- C2 -
1Q7B
4
FABG_ECOLI
A:
[5-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
E
T
L
A
A
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
N
G
A
Q
A
I
S
D
Y
-
L
G
AN
G
K
G
--
L
M
L
--
N
V
T
D
P
A
S
I
---------
E
S
V
L
E
K
---
I
R
----
A
---
E
FGE-
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
D
E
E
W
N
D
I
I
E
T
N
L
S
S
V
F
R
L
S
K
A
V
M
R
A
M
M
K
K
R
H
G
R
I
I
T
I
G
S
V
V
G
T
M
G
N
G
G
Q
A
N
Y
A
A
A
K
A
G
L
I
G
F
S
K
S
L
A
R
E
V
A
S
R
G
I
T
V
N
V
V
A
P
G
F
I
E
T
D
M
T
R
A
L
S
D
D
Q
R
A
G
I
L
A
Q
VP
A
G
R
L
-------
G
G
A
Q
E
I
A
N
A
V
A
F
L
A
S
D
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
51
PsiBlast_CBE
46.69
38%
-82
- C2 -
1Q7B
3
FABG_ECOLI
C:
[5-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
E
T
L
A
A
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
N
G
A
Q
A
I
S
D
Y
-
L
G
AN
G
K
G
--
L
M
L
--
N
V
T
D
P
A
S
I
---------
E
S
V
L
E
K
---
I
R
----
A
---
E
FGE-
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
D
E
E
W
N
D
I
I
E
T
N
L
S
S
V
F
R
L
S
K
A
V
M
R
A
M
M
K
K
R
H
G
R
I
I
T
I
G
S
V
V
G
T
M
G
N
G
G
Q
A
N
Y
A
A
A
K
A
G
L
I
G
F
S
K
S
L
A
R
E
V
A
S
R
G
I
T
V
N
V
V
A
P
G
F
I
E
T
D
M
T
R
A
L
S
D
D
Q
R
A
GILAQVP
A
G
R
L
-------
G
G
A
Q
E
I
A
N
A
V
A
F
L
A
S
D
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
50
PsiBlast_CBE
46.56
38%
-82
- C2 -
1Q7B
3
FABG_ECOLI
D:
[5-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
E
T
L
A
A
R
G
A
K
V
I
-------
G
T
A
--
T
S
--
E
N
G
A
Q
A
I
S
D
Y
-
L
G
AN
G
K
G
--
L
M
L
--
N
V
T
D
P
A
S
I
---------
E
S
V
L
E
K
---
I
R
----
A
---
E
FGE-
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
D
E
E
W
N
D
I
I
E
T
N
L
S
S
V
F
R
L
S
K
A
V
M
R
A
M
M
K
K
R
H
G
R
I
I
T
I
G
S
V
V
G
T
M
G
N
G
G
Q
A
N
Y
A
A
A
K
A
G
L
I
G
F
S
K
S
L
A
R
E
V
A
S
R
G
I
T
V
N
V
V
A
P
G
F
I
E
T
D
M
T
R
A
L
S
D
D
Q
R
A
GILAQVP
A
G
R
L
-------
G
G
A
Q
E
I
A
N
A
V
A
F
L
A
S
D
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
------
54
PsiBlast_CBE
46.45
37%
-84
- C2 -
4JRO
1
?
D:
[26-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
G
K
V
A
V
V
T
G
G
S
R
G
I
G
R
D
I
A
I
N
L
A
K
E
G
A
N
I
---
F
F
---
N
Y
N
--
G
S
--
P
E
A
A
E
E
T
A
K
L
-
V
A
--
E
H
G
--
V
E
V
--
E
A
M
K
A
N
V
A
IAEDVDAFF
K
Q
A
I
E
R
---
F
G
----
R
--------
V
D
---
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
D
E
W
D
D
V
I
N
I
N
L
K
G
T
F
L
C
T
K
A
V
S
R
T
M
M
K
Q
R
A
G
K
I
I
N
M
A
S
V
V
G
L
I
G
N
A
G
Q
A
N
Y
V
A
S
K
A
G
V
I
G
L
T
K
T
T
A
R
E
L
A
P
R
G
I
N
V
N
A
V
A
P
G
F
I
T
T
D
M
T
---
D
E
K
T
K
E
-------
A
M
L
A
Q
I
P
L
G
A
Y
G
T
T
E
D
I
A
N
A
V
L
F
L
A
S
D
A
S
K
Y
I
T
G
Q
T
L
S
V
D
G
------