@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4829: (2016-03-01 )
MMESYDVIVIGAGPGGYNAAIRAGQLGLKVACVEGRETLGGTCLNVGCMPSKALLHASELYAAASGGEFARLGIRVSPELDLAQMMKQKDESVAALTRGVEFLFRKHKVQWIKGWARLQGEGRVGVALADGGHAQLEARDIVIATGSEPAPLPGVPVDNQRILDSTGALELVEVPRHLVVIGAGVIGLELGSVWRRLGAQVTVLEYLERICPGLDGETARTLQRALTRQGMRFRLGTRVVAARSGEQGVELDLQPAAGGATESLQADYVLVAIGRRPYTEGLGLETVGLASDRRGMLENQGQRSAAPGVWVIGDVTSGPMLAHKAEEEAIVCIERIAGHAAEMNAEVIPSVIYTQPEVASVGLGEEQLQAARREYKVGRFPFSANSRAKINHESEGFIKILSDARSDQVLGVHMIGPGVSEMIGEACVAMEFSASAEDLALTCHPHPTRSEALRQAAMDVHGRAMQN
Atome Classification :
(47 SA)
.........10........20........30...------..------...40........50........-60----.....-...-.70.....--.-.--.80-.........90.......-.100.......110.......120.......----------130--------....------...-.140.......150....--.--..160.......170-.-......180.......190.......200.......210........220......-.230.......240.....-.--.250.......260-........270.......280.......290.......-.300-.......310.....-.-.320.......330...-....340-..----......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMESY
D
V
I
V
I
GAGPGGY
N
A
A
I
RAGQL
G
L
K
V
A
CVE------GR------ETLG
G
T
C
LNVGCM
P
S
K
A
L
L
H
A
S
E
-
L
-----
Y
AAAS-GG
E
-
F
A
R
L
G
I
R
V--S-P--EL--
D
L
A
Q
M
M
K
QK
D
E
S
V
A
A
L
T
R
-
G
V
E
F
L
F
R
K
H
K
V
Q
W
I
K
G
W
A
RLQGE
G
R
V
G
V
A
L
A----------DG---------GH
A
Q
------
L
E
A
-
R
D
I
V
I
ATGSEPAPLPGVP--V--DNQRILDSTG
A
L
E
L
V
-E-VPR
H
L
V
V
I
GA
G
V
I
G
L
E
L
G
S
V
W
R
R
LGAQ
V
T
V
L
E
Y
L
E
R
IC-PGLD
G
E
T
A
R
T
L
Q
R
A
L
T
R-QG
M
R
F
R
LG
T
R
V
V
A
ARSGEQ-
G
--
V
E
L
D
L
QPAAGGAT--ESLQA
D
Y
V
L
V
A
IGRRPYTEGLG
L
E
T
VGLA-S
D
R
R
G
M
L
E-NQGQ-RSAAP
G
V
W
V
I
G
DVTS-G-PMLAHKAEE
E
A
I
V
C
I
E
R
-IAG
H
A
A
--EM----
N
A
E
VI
P
S
V
IYTQP
E
V
ASVGL
G
E
E
Q
L
Q
A
A
R
R
EYKVGRFPFSANS
R
A
K
INHESE
G
F
I
K
I
L
S
DARS
D
Q
V
L
G
V
H
MIGP
G
V
S
E
M
I
G
E
A
C
V
A
M
EFSASAE
D
L
A
L
T
CHPHP
T
R
S
E
A
L
R
Q
A
A
M
D
VHGRAMQN
103
HHSearch
95.51
53%
-104
- C1 -
3URH
3
?
A:
[26-486]
----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
------
K
R
------
S
T
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
-
M
-----
F
H
Q
A
Q
-
H
G
--
L
E
A
L
G
V
E
V
A
-
N
-
P
--
K
L
--
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
-
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
K
V
S
V
T
N
E
----------
K
G
---------
E
E
Q
V
------
L
E
A
-
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
V
A
F
--
D
E
K
T
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
-
G
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
S
G
D
-
G
--
A
K
V
T
F
E
P
V
K
G
G
E
A
--
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
-
L
D
S
R
G
R
V
E
I
D
R
H
F
-
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
-
I
A
G
Q
A
G
--
H
V
----
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
-----
7
PsiBlast_PDB
95.41
51%
-107
- C1 -
3URH
3
?
A:
[26-482]
----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
------
K
R
------
S
T
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
-
M
-----
F
H
Q
A
Q
-
H
G
--
L
E
A
L
G
V
E
V
A
-
N
-
P
--
K
L
--
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
-
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
K
V
S
V
T
N
E
----------
K
G
---------
E
E
Q
V
------
L
E
A
-
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
--
V
A
F
D
E
K
T
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
-
G
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
S
G
D
-
G
--
A
K
V
T
F
E
P
V
K
G
G
E
A
--
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
-
L
D
S
R
G
R
V
E
I
D
R
H
F
-
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
-
I
A
G
Q
A
G
--
H
V
----
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
---------
106
HHSearch
93.53
48%
-97
- C1 -
1V59
4
DLDH_YEAST
A:
[2-475]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
------
K
R
------
G
K
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
L
-----
F
H
Q
M
H
-
T
E
--
A
Q
K
R
G
I
D
V
N
G
D
-
I
--
K
I
--
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
-
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
K
I
R
V
T
P
V
----------
D
G
LEGTVK---
E
D
H
I
------
L
D
V
-
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
-
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
K
N
V
-
V
E
I
V
V
E
D
T
K
T
N
K
Q
--
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
-
V
D
K
R
G
R
L
V
I
D
D
Q
F
-
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
-
L
K
T
G
H
G
--
H
V
----
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
---
104
HHSearch
93.37
50%
-101
- C1 -
1ZMD
3
DLDH_HUMAN
A:
[3-468]
Q
P
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
------
K
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
Y
-----
Y
H
M
A
H
-
G
T
D
-
F
A
S
R
G
I
E
M
S-
E
-
V
--
R
L
--
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
-
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
----------
D
G
---------
G
T
Q
V
------
I
D
T
-
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
G
K
--
I
D
V
S
I
E
A
A
S
G
G
K
A
--
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
D
P
R
G
R
I
P
V
N
T
R
F
-
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
-
M
A
G
G
A
V
--
H
I
----
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
-----
9
PsiBlast_PDB
93.24
47%
-95
- C1 -
1V59
4
DLDH_YEAST
A:
[2-477]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
------
K
R
------
G
K
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
L
-----
F
H
Q
M
H
-
T
-
E
-
A
Q
K
R
G
I
D
V
--
N
-
G
--
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
-
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
K
I
R
V
T
P
V
----------
D
G
---------
L
E
G
T
VK
E
D
H
I
L
D
V
-
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
-
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
-
K
N
V
V
E
I
V
V
E
D
T
K
T
N
K
Q
--
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
-
V
D
K
R
G
R
L
V
-
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
-
L
K
T
G
H
G
--
H
V
----
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
4
PsiBlast_PDB
93.16
50%
-103
- C1 -
1ZMD
3
DLDH_HUMAN
A:
[8-464]
-----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
------
K
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
Y
-----
Y
H
M
A
H
-
G
T
D
-
F
A
S
R
G
I
E
M
--
S
-
E
V
-
R
L
--
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
-
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
----------
D
G
---------
G
T
Q
V
------
I
D
T
-
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
-
G
K
-
I
D
V
S
I
E
A
A
S
G
G
K
A
--
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
D
P
R
G
R
I
P
V
N
T
R
F
-
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
-
M
A
G
G
A
V
--
H
I
----
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
---------
105
HHSearch
93.14
49%
-101
* C1 *
2QAE
2
DLDH_TRYCR
A:
[1-465]
--
N
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
------
K
R
------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
-
L
-----
Y
H
D
A
H
-
A
-
N
-
F
A
R
Y
G
L
M
G
GE
G
-
V
--
T
M
--
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
-
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
S
I
R
V
N
G
L
----------
D
G
---------
K
Q
E
M
------
L
E
T
-
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
L
P-
F
--
D
E
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
-
P
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
G
D
-
S
--
V
S
L
E
V
E
----
G
K
R
--
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
-
K
N
E
R
G
F
V
K
I
G
D
H
F
-
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
-
K
G
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
-
L
A
G
K
P
G
--
H
V
----
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
---
2
PsiBlast_PDB
92.48
50%
-101
- C1 -
3RNM
4
DLDH_HUMAN
A:
[29-485]
-----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
------
K
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
Y
-----
Y
H
M
A
H
-
G
K
D
-
F
A
S
R
G
I
E
M
--
S
-
E
V
-
R
L
--
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
-
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
----------
D
G
---------
G
T
Q
V
------
I
D
T
-
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
-
G
K
-
I
D
V
S
I
E
A
A
S
G
G
K
A
--
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
D
P
R
G
R
I
P
V
N
T
R
F
-
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
-
M
A
G
G
A
V
--
H
I
----
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
---------
57
PsiBlast_CBE
92.30
47%
-97
- C1 -
1V59
3
DLDH_YEAST
B:
[2-477]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
------
K
R
------
G
K
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
L
-----
F
H
Q
M
H
-
T
-
E
-
A
Q
K
R
G
I
D
V
--
N
-
G
--
D
I
KI
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
-
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
K
I
R
V
T
P
V
----------
D
G
---------
L
E
G
T
VKEDHI
L
D
V
-
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
-
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
-
K
NV
V
E
I
V
V
E
D
T
K
T
N
K
Q
--
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
-
V
D
K
R
G
R
L
V
-
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
-
L
K
T
G
H
G
--
H
V
----
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
28
PsiBlast_CBE
92.22
50%
-102
- C1 -
1ZY8
2
DLDH_HUMAN
C:
[8-464]
-----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
------
K
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
Y
-----
Y
H
M
A
H
-
G
K
D
-
F
A
S
R
G
I
E
M
--
S
-
E
V-
R
L
--
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
-
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
----------
D
G
---------
G
T
Q
V
------
I
D
T
-
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
-
G
K-
I
D
V
S
I
E
A
A
S
G
G
K
A
--
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
D
P
R
G
R
I
P
V
N
T
R
F
-
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
-
M
A
G
G
A
V
--
H
I
----
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
---------
59
PsiBlast_CBE
92.21
50%
-107
- C1 -
2YQU
6
?
B:
[2-446]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
------
K
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-----
Y
E
A
K
K
-
G
-----
L
L
G
A
K
V
--
K
G
V
--
E
L
--
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
-
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
---
L
V
----------
E
E
---------
T
G
E
E
------
L
E
A
-
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
-
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
-
G
--
A
R
V
E
L
E
---
G
G
----
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
-
T
D
E
R
G
R
I
P
V
D
E
H
L
-
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
-
M
V
R
G
F
G
--
H
V
----
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
---------
11
PsiBlast_PDB
92.06
50%
-107
- C1 -
2YQU
4
?
A:
[2-446]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
------
K
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-----
Y
E
A
K
K
-
G
-----
L
L
G
A
K
V
--
K
G
V
--
E
L
--
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
-
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
---
L
V
----------
E
E
---------
T
G
E
E
------
L
E
A
-
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
-
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
-
G
--
A
R
V
E
L
E
---
G
G
----
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
-
T
D
E
R
G
R
I
P
V
D
E
H
L
-
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
-
M
V
R
G
F
G
--
H
V
----
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
---------
31
PsiBlast_CBE
91.88
50%
-101
- C1 -
2F5Z
18
DLDH_HUMAN
J:
[8-464]
-----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
------
K
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
Y
-----
Y
H
M
A
H
-
G
T
D
-
F
A
S
R
G
I
E
M
--
S
-
E
V-
R
L
--
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
-
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
----------
D
G
---------
G
T
Q
V
------
I
D
T
-
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
-
G
K-
I
D
V
S
I
E
A
A
S
G
G
K
A
--
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
D
P
R
G
R
I
P
V
N
T
R
F
-
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
-
M
A
G
G
A
V
--
H
I
----
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
---------
58
PsiBlast_CBE
91.81
47%
-96
- C1 -
1JEH
2
DLDH_YEAST
B:
[2-477]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
------
K
R
------
G
K
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
L
-----
F
H
Q
M
H
-
T
-
E
-
A
Q
K
R
G
I
D
V
--
N
-
G
--
D
I
KI
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
-
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
K
I
R
V
T
P
V
----------
D
G
---------
L
E
G
T
VKEDHI
L
D
V
-
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
-
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
-
K
NV
V
E
I
V
V
E
D
T
K
T
N
K
Q
--
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
-
V
D
K
R
G
R
L
V
-
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
-
L
K
T
G
H
G
--
H
V
----
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
38
PsiBlast_CBE
91.75
50%
-101
- C1 -
2F5Z
4
DLDH_HUMAN
C:
[8-464]
-----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
------
K
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
Y
-----
Y
H
M
A
H
-
G
T
D
-
F
A
S
R
G
I
E
M
--
S
-
E
V
-
R
L
--
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
-
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
----------
D
G
---------
G
T
Q
V
------
I
D
T
-
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
-
G
K
-
I
D
V
S
I
E
A
A
S
G
G
K
A
--
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
D
P
R
G
R
I
P
V
N
T
R
F
-
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
-
M
A
G
G
A
V
--
H
I
----
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
---------
24
PsiBlast_CBE
91.72
50%
-104
- C1 -
1ZY8
2
DLDH_HUMAN
G:
[8-464]
-----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
------
K
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
Y
-----
Y
H
M
A
H
-
G
K
D
-
F
A
S
R
G
I
E
M
--
S
-
E
V-
R
L
--
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
-
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
----------
D
G
---------
G
T
Q
V
------
I
D
T
-
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
-
G
K-
I
D
V
S
I
E
A
A
S
G
G
K
A
--
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
D
P
R
G
R
I
P
V
N
T
R
F
-
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
-
M
A
G
G
A
V
--
H
I
----
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
---------
8
PsiBlast_PDB
91.67
47%
-97
- C1 -
1JEH
2
DLDH_YEAST
A:
[2-477]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
------
K
R
------
G
K
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
L
-----
F
H
Q
M
H
-
T
-
E
-
A
Q
K
R
G
I
D
V
--
N
-
G
--
D
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
-
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
K
I
R
V
T
P
V
----------
D
G
---------
L
E
G
T
VK
E
D
H
I
L
D
V
-
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
-
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
-
K
NV
V
E
I
V
V
E
D
T
K
T
N
K
Q
--
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
-
V
D
K
R
G
R
L
V
-
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
-
L
K
T
G
H
G
--
H
V
----
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
-
37
PsiBlast_CBE
91.59
50%
-99
- C1 -
2F5Z
1
DLDH_HUMAN
D:
[8-464]
-----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
------
K
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
Y
-----
Y
H
M
A
H
-
G
T
D
-
F
A
S
R
G
I
E
M
--
S
-
E
V-
R
L
--
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
-
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
----------
D
G
---------
G
T
Q
V
------
I
D
T
-
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
-
G
K-
I
D
V
S
I
E
A
A
S
G
G
K
A
--
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
D
P
R
G
R
I
P
V
N
T
R
F
-
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
-
M
A
G
G
A
V
--
H
I
----
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
---------
26
PsiBlast_CBE
91.49
50%
-103
- C1 -
1ZY8
2
DLDH_HUMAN
E:
[8-464]
-----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
------
K
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
Y
-----
Y
H
M
A
H
-
G
K
D
-
F
A
S
R
G
I
E
M
--
S
-
E
V-
R
L
--
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
-
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
----------
D
G
---------
G
T
Q
V
------
I
D
T
-
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
-
G
K-
I
D
V
S
I
E
A
A
S
G
G
K
A
--
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
D
P
R
G
R
I
P
V
N
T
R
F
-
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
-
M
A
G
G
A
V
--
H
I
----
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
---------
40
PsiBlast_CBE
91.48
50%
-100
- C1 -
1ZMD
20
DLDH_HUMAN
H:
[8-464]
-----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
------
K
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
-
Y
-----
Y
H
M
A
H
-
G
T
D
-
F
A
S
R
G
I
E
M
--
S
-
E
V-
R
L
--
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
-
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
Q
V
T
A
T
K
A
----------
D
G
---------
G
T
Q
V
------
I
D
T
-
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
-
G
K-
I
D
V
S
I
E
A
A
S
G
G
K
A
--
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
D
P
R
G
R
I
P
V
N
T
R
F
-
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
-
M
A
G
G
A
V
--
H
I
----
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
---------
117
HHSearch
90.89
50%
-105
- C1 -
2YQU
4
?
A:
[1-451]
---
M
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
------
K
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
-
R
-----
I
Y
E
A
K
-
K
G
L
--
L
G
A
K
V
K
---
G
-
V
--
E
L
--
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
-
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
L
V
E
E
-----------
T
-----------
G
E
E
------
L
E
A
-
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q-
V
--
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
-
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
-
G
--
A
R
V
E
L
-----
E
G
G
--
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
-
T
D
E
R
G
R
I
P
V
D
E
H
L
-
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
-
M
V
R
G
F
G
--
H
V
----
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
----
60
PsiBlast_CBE
90.83
50%
-106
- C1 -
2EQ7
3
?
B:
[2-446]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
------
K
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-----
Y
E
A
K
K
-
G
-----
L
L
G
A
K
V
--
K
G
V
--
E
L
--
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
-
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
---
L
V
----------
E
E
---------
T
G
E
E
------
L
E
A
-
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
-
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
-
G
--
A
R
V
E
L
E
---
G
G
----
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
-
T
D
E
R
G
R
I
P
V
D
E
H
L
-
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
-
M
V
R
G
F
G
--
H
V
----
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
---------
10
PsiBlast_PDB
90.51
50%
-106
- C1 -
2EQ7
3
?
A:
[2-446]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
------
K
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-----
Y
E
A
K
K
-
G
-----
L
L
G
A
K
V
--
K
G
V
--
E
L
--
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
-
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
---
L
V
----------
E
E
---------
T
G
E
E
------
L
E
A
-
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
-
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
-
G
--
A
R
V
E
L
E
---
G
G
----
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
-
T
D
E
R
G
R
I
P
V
D
E
H
L
-
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
-
M
V
R
G
F
G
--
H
V
----
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
---------
13
PsiBlast_PDB
89.00
47%
-101
- C1 -
1LPF
2
DLDH_PSEFL
A:
[2-470]
--
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKE
G
K
------
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
-
K
-----
Y
H
E
A
K
-
E
A
--
F
K
V
H
G
I
E
A
--
K
G
V
--
T
I
--
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
-
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
----------
D
G
---------
K
T
Q
V
------
L
E
A
-
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
S
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
-
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
-
Q
--
V
T
V
T
F
T
D
A
N
G
E
Q
K
--
E
T
F
--
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
-
L
D
E
R
G
F
I
Y
V
D
D
H
C
-
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
-
G
-
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
-
I
A
G
H
K
A
--
Q
M
----
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
-
109
HHSearch
88.71
47%
-98
- C1 -
2EQ6
2
?
A:
[4-458]
-
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
------
A
G
-------
E
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
-----
L
H
H
L
K
-
V
A
E
---
G
F
G
L
K
A
--
K
-
P
--
E
L
--
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
-
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
E
V
E
V
G
------------------------
G
E
R
------
Y
G
A
-
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
---
G
E
D
V
W
D
S
T
R
A
L
K
V
E
E
G
-
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
-
P
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
-
G
--
L
H
V
R
L
E
P
A
E
G
G
E
G
--
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
-
V
D
E
R
G
F
I
R
V
N
A
R
M
-
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
-
A
A
G
K
D
S
--
A
F
----
D
Y
-
Q
V
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
---
12
PsiBlast_PDB
87.99
48%
-99
- C1 -
2QAE
2
DLDH_TRYCR
A:
[17-467]
------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
------
K
R
------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
-
L
-----
Y
H
D
A
H
-
A
-
N
-
F
A
R
Y
G
L
M
G
--
G
-
E
GV
T
M
--
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
-
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
S
I
R
V
N
G
L
----------
D
G
---------
K
Q
E
M
------
L
E
T
-
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
P
--
F
--
D
E
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
-
P
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
G
D
-
S
--
V
S
L
E
V
E
-
G
---
K
R
--
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
-
K
N
E
R
G
F
V
K
I
G
D
H
F
-
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
-
L
A
G
K
P
G
--
H
V
----
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
-
63
PsiBlast_CBE
87.93
45%
-105
- C1 -
3LAD
2
DLDH_AZOVI
B:
[2-470]
--
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
KYKGKE
G
K
------
T
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
-
K
-----
F
H
E
A
H
-
E
-
S
-
F
K
L
H
G
I
S
T
--
G
-
E
V-
A
I
--
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
-
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
K
K
V
E
V
T
A
A
----------
D
G
---------
S
S
Q
V
------
L
D
T
-
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
--
V
--
D
Q
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
-
P
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
N
K
-
Q
--
V
T
V
K
F
V
D
A
E
G
E
K
S
--
Q
A
F
--
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
-
L
D
E
R
G
F
I
Y
V
D
D
Y
C
-
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
-
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
-
I
A
G
H
K
A
--
Q
M
----
N
Y
D
L
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
-
61
PsiBlast_CBE
87.93
48%
-98
- C1 -
2QAE
2
DLDH_TRYCR
B:
[17-467]
------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
------
K
R
------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
-
L
-----
Y
H
D
A
H
-
A
-
N
-
F
A
R
Y
G
L
M
G
--
G
-
E
GV
T
M
--
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
-
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
S
I
R
V
N
G
L
----------
D
G
---------
K
Q
E
M
------
L
E
T
-
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
P
--
F
--
D
E
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
-
P
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
G
D
-
S
--
V
S
L
E
V
E
-
G
---
K
R
--
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
-
K
N
E
R
G
F
V
K
I
G
D
H
F
-
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
-
L
A
G
K
P
G
--
H
V
----
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
-
62
PsiBlast_CBE
87.88
47%
-100
- C1 -
1LPF
2
DLDH_PSEFL
B:
[2-470]
--
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
KYIGKE
G
K
------
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
-
K
-----
Y
H
E
A
K
-
E
A
--
F
K
V
H
G
I
E
A
--
K
G
V
--
T
I
--
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
-
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
----------
D
G
---------
K
T
Q
V
------
L
E
A
-
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
S
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
-
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
-
Q
--
V
T
V
T
F
T
D
A
N
G
E
Q
K
--
E
T
F
--
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
-
L
D
E
R
G
F
I
Y
V
D
D
H
C
-
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
-
G
-
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
-
I
A
G
H
K
A
--
Q
M
----
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
-
14
PsiBlast_PDB
87.16
45%
-105
- C1 -
3LAD
2
DLDH_AZOVI
A:
[2-470]
--
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
KYKGKE
G
K
------
T
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
-
K
-----
F
H
E
A
H
-
E
-
S
-
F
K
L
H
G
I
S
T
--
G
-
E
V
-
A
I
--
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
-
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
K
K
V
E
V
T
A
A
----------
D
G
---------
S
S
Q
V
------
L
D
T
-
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
--
V
--
D
Q
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
-
P
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
N
K
-
Q
--
V
T
V
K
F
V
D
A
E
G
E
K
S
--
Q
A
F
--
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
-
L
D
E
R
G
F
I
Y
V
D
D
Y
C
-
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
-
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
-
I
A
G
H
K
A
--
Q
M
----
N
Y
D
L
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
-
15
PsiBlast_PDB
86.91
46%
-95
- C1 -
2EQ6
2
?
A:
[4-460]
-
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
------
A
G
------
E
-
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
-----
L
H
H
L
K
-
V
A
E
---
G
F
G
L
K
A
--
K
-
P
--
E
L
--
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
-
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
E
V
E
V
------------------------
G
G
E
R
------
Y
G
A
-
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
---
G
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
-
P
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
-
G
--
L
H
V
R
L
E
P
A
E
G
G
E
G
--
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
-
V
D
E
R
G
F
I
R
V
N
A
R
M
-
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
-
A
A
G
K
D
S
--
A
F
----
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
-
74
PsiBlast_CBE
86.86
46%
-96
- C1 -
2EQ6
2
?
B:
[4-460]
-
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
------
A
G
------
E
-
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
-----
L
H
H
L
K
-
V
A
E
---
G
F
G
L
K
A
--
K
-
P
--
E
L
--
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
-
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
E
V
E
V
------------------------
G
G
E
R
------
Y
G
A
-
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
---
G
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
-
P
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
-
G
--
L
H
V
R
L
E
P
A
E
G
G
E
G
--
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
-
V
D
E
R
G
F
I
R
V
N
A
R
M
-
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
-
A
A
G
K
D
S
--
A
F
----
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
-
110
HHSearch
86.56
46%
-101
- C1 -
3LAD
2
DLDH_AZOVI
A:
[1-468]
-
S
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
------
K
Y
KGKEGK
T
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
-
K
-----
F
H
E
A
H
-
E
S
F
--
K
L
H
G
I
S
T
G-
E
-
V
--
A
I
--
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
-
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
K
K
V
E
V
T
A
A
----------
D
G
---------
S
S
Q
V
------
L
D
T
-
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
--
V
--
D
Q
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
-
P
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
N
K
-
Q
--
V
T
V
K
F
V
D
--
A
E
G
E
--
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
-
L
D
E
R
G
F
I
Y
V
D
D
Y
C
-
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
-
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
-
I
A
G
H
K
A
--
Q
M
----
N
Y
D
L
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
---
75
PsiBlast_CBE
86.00
42%
-100
- C1 -
1EBD
2
DLDH1_GEOSE
B:
[5-451]
-----
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
-------
K
------
G
N
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
-
R
-----
Y
E
Q
A
K
-
H
S
E
---
E
M
G
I
K
A
E-
N
-
V
--
T
I
--
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
-
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
T
V
R
V
V
N
G
----------
D
S
---------
A
Q
T
-------
Y
T
F
-
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
N
-
R
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
-
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
D
-
G
--
V
T
V
T
Y
E
--
A
N
G
E
T
--
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
-
M
T
N
R
G
L
I
E
V
D
Q
Q
C
-
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
-
I
A
G
H
P
S
--
A
V
----
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
----------
107
HHSearch
84.15
39%
-94
- C1 -
1OJT
1
?
A:
[3-475]
A
D
A
E
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
------
R
Y
------
K
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
A
-
V
-----
I
D
E
V
R
-
H
L
A
---
A
N
G
I
K
Y
P-
E
-
P
--
E
L
--
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
-
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
Q
F
L
D
P
H
H
L
E
V
S
L
T
A
G
DAYE
Q
A
A
P
T
G
---------
E
K
K
I
------
V
A
F
-
K
N
C
I
I
A
A
G
S
R
V
T
K
L
P
F
I
P
-----
E
D
P
R
I
I
D
S
S
G
A
L
A
L
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
-
Q
G
A
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
V
A
V
E
P
K
E
D
-
G
--
V
Y
V
T
F
E
G
A
-
N
A
P
K
--
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
-
V
T
D
R
G
F
I
E
V
D
K
Q
M
-
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
-
Q
-
P
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
-
C
A
G
H
K
A
--
Y
F
----
D
A
R
V
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
T
L
G
E
S
I
G
M
A
A
E
V
A
L
G
T
C
T
--
19
PsiBlast_PDB
83.82
37%
-104
- C1 -
4JDR
9
DLDH_ECOLI
A:
[9-456]
------
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
------
R
Y
------
N
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
-
V
-----
I
E
E
A
K
-
A
---
L
A
E
H
G
I
V
F
G-
E
-
P
--
K
T
--
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
-
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
K
F
T
G
A
N
T
L
E
V
E
-
G
----------
E
N
---------
G
K
T
V
------
I
N
F
-
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
P
--
H
--
E
D
P
R
I
W
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
-
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
-
K
-
F
N
L
M
L
E
T
K
V
T
A
V
E
A
K
E
D
-
G
--
I
Y
V
T
M
E
G
K
K
A
P
A
---
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
-
V
D
D
R
G
F
I
R
-
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
-
Q
-
P
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
-
I
A
G
K
K
H
--
Y
F
----
D
P
K
V
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
----------
81
PsiBlast_CBE
83.62
37%
-104
- C1 -
4JDR
5
DLDH_ECOLI
B:
[9-456]
------
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
------
R
Y
------
N
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
-
V
-----
I
E
E
A
K
-
A
---
L
A
E
H
G
I
V
F
G-
E
-
P
--
K
T
--
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
-
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
K
F
T
G
A
N
T
L
E
V
E
-
G
----------
E
N
---------
G
K
T
V
------
I
N
F
-
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
P
--
H
--
E
D
P
R
I
W
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
-
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
-
K
-
F
N
L
M
L
E
T
K
V
T
A
V
E
A
K
E
D
-
G
--
I
Y
V
T
M
E
G
K
K
A
P
A
---
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
-
V
D
D
R
G
F
I
R
-
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
-
Q
-
P
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
-
I
A
G
K
K
H
--
Y
F
----
D
P
K
V
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
----------
118
HHSearch
83.38
42%
-100
- C1 -
1EBD
2
DLDH1_GEOSE
A:
[2-455]
--
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
------
K
G
-------
N
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
-
R
-----
Y
E
Q
A
K
-
H
S
E
---
E
M
G
I
K
A
E
-
N
-
V
--
T
I
--
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
-
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
T
V
R
V
V
N
G
----------
D
----------
S
A
Q
T
------
Y
T
F
-
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
-
N
R
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
-
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
D
-
G
--
V
T
V
T
Y
E
A
--
N
G
E
T
--
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
-
M
T
N
R
G
L
I
E
V
D
Q
Q
C
-
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
-
I
A
G
H
P
S
--
A
V
----
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
------
18
PsiBlast_PDB
83.17
42%
-100
- C1 -
1EBD
2
DLDH1_GEOSE
A:
[5-451]
-----
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
-------
K
------
G
N
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
-
R
-----
Y
E
Q
A
K
-
H
S
E
---
E
M
G
I
K
A
E
-
N
-
V
--
T
I
--
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
-
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
T
V
R
V
V
N
G
----------
D
S
---------
A
Q
T
-------
Y
T
F
-
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
N
-
R
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
-
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
E
D
-
G
--
V
T
V
T
Y
E
--
A
N
G
E
T
--
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
-
M
T
N
R
G
L
I
E
V
D
Q
Q
C
-
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
-
I
A
G
H
P
S
--
A
V
----
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
----------
89
PsiBlast_CBE
82.37
39%
-93
- C1 -
1OJT
1
?
A:
[7-467]
----
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
------
R
Y
------
K
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
A
-
V
I
D
E
V
R
H
L
A
A
N
-
G
I
K
-
Y
P
E
---------
P
--
E
L
--
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
-
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
Q
F
L
D
P
H
H
L
E
V
S
L
T
----------
A
G
DAYE
Q
A
A
P
T
G
E
K
K
------
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
K
L
P
F
I
P
--
E
--
D
-
P
R
I
I
D
S
S
G
A
L
A
L
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
-
Q
G
A
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
V
A
V
E
P
K
E
D
-
G
--
V
Y
V
T
F
E
-
G
A
N
A
P
K
--
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
-
V
T
D
R
G
F
I
E
-
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
-
Q
-
P
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
-
C
A
G
H
K
A
--
Y
F
----
D
A
R
V
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
T
L
G
E
S
I
G
M
A
A
----------
102
HHSearch
82.34
41%
-100
- C1 -
1LVL
2
DLDH1_PSEPU
A:
[2-455]
Q
T
I
Q
T
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
------
G
-------
Q
A
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
V
A
E
-
Q
-----
F
H
Q
A
S
-
R
F
T
E
P
S
P
L
G
I
S
V
A
-
S
-
P
--
R
L
--
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
-
G
V
A
A
L
L
K
K
H
G
V
K
V
V
H
G
W
A
K
V
L
D
G
K
Q
V
E
V
D
------------------------
G
Q
R
------
I
Q
C
-
E
H
L
L
L
A
T
G
S
S
S
V
E
L
P
M
L
P
--
L
--
G
-
G
P
V
I
S
S
T
E
A
L
A
P
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
-
P
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
-
L
G
I
A
L
H
L
G
H
S
V
E
G
Y
E
N
G
C
-------
L
L
A
N
D
-
G
K
G
G
Q
--
L
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
-
M
N
-
G
A
A
I
A
I
D
E
R
C
-
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
G
-
E
-
P
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
-
I
A
G
K
A
R
--
R
F
----
E
P
A
A
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
---
90
PsiBlast_CBE
81.41
39%
-92
- C1 -
1BHY
1
?
A:
[7-467]
----
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
------
R
Y
------
K
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
A
-
V
I
D
E
V
R
H
L
A
A
N
-
G
I
K
-
Y
P
E
---------
P
--
E
L
--
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
-
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
Q
F
L
D
P
H
H
L
E
V
S
L
T
----------
A
G
DAYE
Q
A
A
P
T
G
E
K
K
------
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
K
L
P
F
I
P
--
E
--
D
-
P
R
I
I
D
S
S
G
A
L
A
L
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
-
Q
G
A
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
V
A
V
E
P
K
E
D
-
G
--
V
Y
V
T
F
E
-
G
A
N
A
P
K
--
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
-
V
T
D
R
G
F
I
E
-
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
-
Q
-
P
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
-
C
A
G
H
K
A
--
Y
F
----
D
A
R
V
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
G
G
D
M
I
G
E
V
Y
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
T
L
G
E
S
I
G
M
A
A
----------
82
PsiBlast_CBE
79.46
40%
-96
- C1 -
1LVL
2
DLDH1_PSEPU
A:
[8-457]
------
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
------
G
-------
Q
A
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
V
A
E
-
Q
-----
F
H
Q
A
S
R
F
T
E
-
P
S
P
L
G
I
S
V
A
-
S
-
P
--
R
L
--
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
-
G
V
A
A
L
L
K
K
H
G
V
K
V
V
H
G
W
A
K
V
L
D
G
K
Q
V
E
V
-------------
D
G
---------
Q
R
I
Q
------
C
E
---
H
L
L
L
A
T
G
S
S
S
V
E
L
P
M
L
P
--
L
--
G
G
P
-
V
I
S
S
T
E
A
L
A
P
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
-
P
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
-
L
G
I
A
L
H
L
G
H
S
V
E
G
Y
E
N
G
--------
C
L
L
A
N
D
G
K
G
G
Q
--
L
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
-
M
N
G
A
A
I
A
I
-
D
E
R
C
-
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
G
-
E
-
P
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
-
I
A
G
K
A
R
--
R
F
----
E
P
A
A
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
-
114
HHSearch
77.12
35%
-95
- C1 -
2A8X
3
DLDH_MYCTU
A:
[1-461]
-
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
------
P
-------
K
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
-
L
-----
V
H
I
F
T
-
K
D
--
A
K
A
F
G
I
S
G
--
E
-
V
--
T
F
--
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
-
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
T
L
L
V
D
L
N
----------
D
G
---------
G
T
E
S
------
V
T
F
-
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
--
S
-
A
N
V
V
T
Y
E
E
Q
I
L
S
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
-
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
G
S
-
Q
--
V
T
V
T
V
T
----
K
D
G
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
-
L
T
D
R
K
A
I
G
V
D
D
Y
M
-
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
-
L
-
L
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
-
I
A
G
A
E
T
L
T
L
G
----
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
---
87
PsiBlast_CBE
76.34
35%
-90
- C1 -
3II4
3
DLDH_MYCTU
B:
[3-454]
-
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
------
P
K
-------
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
-
L
-----
V
H
I
F
T
-
K
D
A
-
K
A
-
F
G
I
S
G
--
E
-
V
--
T
F
--
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
-
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
T
L
L
V
D
L
N
----------
D
G
---------
G
T
E
S
------
V
T
F
-
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
--
S
A
N
V
V
T
Y
E
E
Q
I
L
S
R
--
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
-
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
---
G
--
S
Q
V
T
V
T
V
T
K
D
G
V
A
--
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
-
D
D
Y
M
-
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
-
L
-
L
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
-
I
A
G
--
A
--
E
T
L
T
LG
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
------------
88
PsiBlast_CBE
74.69
35%
-92
- C1 -
3II4
3
DLDH_MYCTU
A:
[4-454]
--
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
------
P
K
-------
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
-
L
-----
V
H
I
F
T
-
K
D
A
-
K
A
-
F
G
I
S
G
--
E
-
V
--
T
F
--
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
-
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
T
L
L
V
D
L
N
----------
D
G
---------
G
T
E
S
------
V
T
F
-
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
--
S
A
N
V
V
T
Y
E
E
Q
I
L
S
R
--
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
-
P
N
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
G
---
G
--
S
Q
V
T
V
T
V
T
K
D
G
V
A
--
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
D
R
K
A
I
G
V
-
D
D
Y
M
-
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
-
L
-
L
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
-
I
A
G
--
A
--
E
T
L
T
LG
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
------------
91
PsiBlast_CBE
74.07
31%
-96
- C1 -
4YWO
6
?
A:
[16-449]
----
H
K
L
A
I
I
G
Y
G
A
A
G
F
A
A
M
I
K
A
N
E
L
G
V
K
P
V
L
I
-------
G
K
------
G
E
I
G
G
T
C
V
N
V
G
C
V
P
S
K
R
M
L
Y
I
A
E
-
I
-----
Y
K
K
A
R
------
E
V
T
G
S
E
V
--
Y
-
P
--
P
F
--
S
S
F
Q
---
E
K
D
G
L
V
Q
E
M
R
K
T
K
Y
E
D
L
L
S
Y
Y
D
V
E
L
I
Q
G
E
A
R
F
I
S
P
H
A
V
K
V
--------------
N
---------
G
Q
V
-------
I
E
A
-
E
K
F
V
I
A
T
G
S
S
P
L
-
I
P
R
I
P
G-
L
--
D
K
V
G
F
W
T
N
R
E
A
L
S
P
D
-
R
-
R
I
D
S
L
A
V
I
G
G
R
A
L
A
L
E
F
A
Q
M
Y
S
R
M
K
V
E
V
A
I
L
Q
R
S
P
V
L
I
-
P
D
W
E
P
E
A
S
V
E
A
R
R
I
M
E
N
-
D
G
V
A
V
V
T
G
V
N
V
K
E
V
R
K
G
A
G
-
K
--
I
V
I
T
D
K
G
---------
E
V
E
A
D
E
I
L
L
A
T
G
R
K
P
N
V
D
-
L
G
L
E
N
A
G
V
R
-
L
N
E
R
G
G
I
K
-
V
D
D
E
L
R
T
D
N
P
H
I
Y
A
A
G
D
V
L
G
-
G
-
K
M
L
E
A
L
A
G
R
Q
G
S
I
A
T
E
N
A
L
T
G
S
H
K
--
R
V
----
D
E
N
A
V
P
Q
V
I
F
T
Q
P
N
L
A
R
V
G
L
T
E
A
E
A
R
A
K
E
G
E
V
E
A
R
V
L
P
M
S
S
V
A
K
A
E
I
I
N
S
R
L
G
F
V
K
M
V
T
--
M
N
G
R
I
V
G
V
H
A
V
G
E
N
V
A
E
M
I
G
E
A
A
L
A
I
R
F
G
A
T
V
H
D
L
I
D
T
V
H
M
F
P
T
I
A
E
S
L
R
L
V
A
L
---------