@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4852: (2016-03-02 )
MSVVRIGPYTLPNRLILAPMAGVTDRPFRQLCRRLGAGMVVSEMVTSDVRLWNSRKSRLRLIHDGEDEPRSVQIAGGDPAMLAEAAQRNVELGAQIIDINMGCPAKKVCNKAAGSALLRDEALVAEILDAVVRAVDVPVTLKIRTGWDRDNRNGVTVAKLAEQAGIQALAVHGRTRADLYTGEAEYETIAAIKQAVSIPVFANGDIDSPEKARKVIEQTGVDALLIGRAAQGRPWIFREIDHYLRTGEHLPAAPLPEVQSILLEHLAELHLFYGEEMGVRIARKHVGWYLATLPGAREFRAQFNRLQDTDAQCASVRQFFAERQNNGTGVAA
Atome Classification :
(21 SA)
.........10........-20.--------.......30....--.-...-40-..-......50.---------.-..--.---------------...60-.-.......70-------......-----------------------..----------------------80........90........100.---------..-....110.......120.......130...--....140....------..--.150-....--....160.......170..-------.....180--..--.-.-.....190....-...200........210......----.220.......230.......240.......250.......260.......270.......280-.......290.......300.-......310...-....320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
V
V
R
IGPYTLPN
R
L
I
LAP-MAG--------VTD
R
P
F
R
Q
L
C
R
RL--G-A
G
M
-
V
V
-
S
E
-
M
V
T
S
D
V
R
L
W
---------N-SR--K---------------
S
R
L
R
L
-
I
-HDGEDEP
R
S
-------
V
Q
IAGG-----------------------
D
P
----------------------
A
M
L
A
E
A
A
Q
R
N
V
ELG
A
Q
I
I
D
INMGC---------
P
A
-
K
K
V
C
N
K
A
AG
S
A
L
L
R
D
E
A
L
V
A
E
I
L
D
A
V
V
R
AV--DV
P
V
T
L
K
I
RTG------WD--RDN--RNG
V
--
T
V
A
K
L
A
E
Q
AG
I
Q
A
L
A
VHGR-------TRA
D
L
Y----TG--E-
A
-
E
Y
E
T
I
A
A
I
K
Q
A
V-SI
P
V
F
-ANGDID
S
P
E
K
A
R
K
V
I
E
Q
----TGV
D
A
L
L
IGRAAQGRP
W
I
F
R
E
I
D
H
Y
L
RTGEHLPAAP
L
P
E
V
Q
S
I
L
L
E
H
L
A
E
L
H
L
F
Y
G
EE
M
G
V
R
I
A
-
R
K
HV
G
W
Y
L
ATLP
G
A
R
E
F
R
A
Q
F
-
N
RLQDTD
A
Q
C
A
S
-
V
R
Q
F
F
A
E
RQNNGTGVAA
123
HHSearch
96.96
34%
-92
- C2 -
1VHN
4
?
A:
[5-309]
------------
V
K
V
G
L
A
P
-
M
A
G
--------
Y
T
D
S
A
F
R
T
L
A
F
E
W
--
G
-
A
D
F
-
A
F
-
S
E
-
M
V
S
A
K
G
F
L
M
---------
N
-
S
Q
--
K
---------------
T
E
E
L
L
---
P
Q
P
H
E
R
N
V
A
-------
V
Q
I
F
G
S
-----------------------
E
P
----------------------
N
E
L
S
E
A
A
R
I
L
S
E
-
K
Y
K
W
I
D
L
N
A
G
C
---------
P
V
-
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
G
K
F
S
V
K
T
R
L
G
------
W
E
--
K
N
----
E
V
E
--
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
-------
T
V
V
Q
S
F
----
T
G
--
R
-
A
-
E
W
K
A
L
S
V
L
E
K
---
R
I
P
T
F
-
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
----
S
G
C
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
D
F
L
R
S
G
K
Y
-
S
E
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
E
M
-
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
-
M
K
I
E
E
V
Q
I
L
K
E
M
-
F
Y
N
F
I
K
E
V
E
--------
1
PsiBlast_PDB
95.16
32%
-94
- C2 -
1VHN
4
?
A:
[5-307]
------------
V
K
V
G
L
A
P
-
M
A
G
--------
Y
T
D
S
A
F
R
T
L
A
F
E
W
--
G
-
A
D
F
-
A
F
-
S
E
-
M
V
S
A
K
G
F
L
M
---------
N
-
S
Q
--
K
---------------
T
E
-
E
L
-
L
-
P
Q
P
H
E
R
N
V
A
-------
V
Q
I
F
G
S
-----------------------
E
P
----------------------
N
E
L
S
E
A
A
-
R
I
L
S
E
K
Y
K
W
I
D
L
N
A
G
C
---------
P
V
-
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
G
K
F
S
V
K
T
R
L
G
------
W
E
--
K
N
E
--
V
E
----
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
-------
T
V
V
Q
S
F
----
T
G
--
R
-
A
-
E
W
K
A
L
S
V
L
E
K
---
R
I
P
T
F
-
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
----
S
G
C
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
D
F
L
R
S
G
K
Y
S
E
P
S
R
-
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
E
M
-
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
-
M
K
I
E
E
V
Q
I
L
K
E
M
-
F
Y
N
F
I
K
E
----------
113
Fugue
91.08
31%
-97
- C2 -
1VHN
4
?
A:
[5-309]
------------
V
K
V
G
L
A
P
M
A
-
G
--------
Y
T
D
S
A
F
R
T
L
A
F
E
W
--
G
-
A
D
F
-
A
F
-
S
E
M
V
S
A
K
G
F
L
------------
M
N
S
--
Q
---------------
K
T
E
E
L
-
L
-
P
Q
P
H
E
R
N
V
A
-------
V
Q
I
F
G
S
-----------------------
E
P
----------------------
N
E
L
S
E
A
A
R
I
-
L
S
E
K
Y
K
W
I
D
L
N
A
G
C
---------
P
V
-
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
G
K
F
S
V
K
T
R
L
G
------
W
E
--
K
N
E
----
V
E
--
E
I
Y
R
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
-------
T
V
V
Q
S
F
----
T
G
--
R
-
A
-
E
W
K
A
L
S
V
L
E
K
---
R
I
P
T
F
-
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
----
S
G
C
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
D
F
L
R
S
G
K
-
Y
S
E
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
-
E
M
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
M
K
--
I
E
E
V
Q
I
L
K
E
M
F
Y
N
F
I
K
E
V
E
--------
115
Fugue
87.38
30%
-89
- C2 -
4BFA
6
DUSC_ECOLI
A:
[22-338]
----------
A
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
S
L
V
R
E
L
L
T
E
V
N
-
D
-
Y
D
L
-
C
I
-
T
E
-
F
V
R
V
V
D
Q
L
----------
L
-
P
V
--
K
---------------
V
F
H
R
I
-
C
-
P
E
L
Q
N
A
S
R
T
PS
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
C
---------
P
S
-
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
------
W
D
--
S
G
E
--
K
-
K
F
--
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
E
Q
G
Y
----
R
A
--
E
-
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
-
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
----
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
------
N
E
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
L
Y
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
D
I
E
K
L
--------
2
PsiBlast_PDB
83.42
33%
-94
- C2 -
4BFA
5
DUSC_ECOLI
A:
[22-279]
----------
A
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
S
L
V
R
E
L
L
T
E
V
--
N
D
Y
D
L
-
C
I
-
T
E
-
F
V
R
V
V
D
Q
L
L
-----------
P
V
--
K
---------------
V
F
H
R
I
-
C
-
P
E
L
Q
N
A
S
R
T
PS
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
C
---------
P
S
-
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
------
W
D
--
S
G
E
--
K
K
-
F
--
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
E
Q
G
Y
----
R
A
--
E
H
I
-
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
-
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
----
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
------
N
E
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
----------------------------------------------------------------------
3
PsiBlast_PDB
83.10
33%
-107
- C2 -
3W9Z
1
DUSC_ECOLI
A:
[2-267]
-------------
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
S
L
V
R
E
L
L
T
E
V
--
N
D
Y
D
L
-
C
I
-
T
E
-
F
V
R
V
V
D
Q
L
L
-----------
P
V
--
K
---------------
V
F
H
R
I
-
C
-
P
E
L
Q
N
A
S
R
T
PS
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
C
-----------------------
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
------
W
D
--
S
G
E
--
K
K
-
F
--
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
E
Q
G
Y
----
R
A
--
E
H
I
-
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
-
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
----
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
------
N
E
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
----------------------------------------------------------------------
22
PsiBlast_CBE
82.58
32%
-96
- C2 -
4YCO
1
DUSC_ECOLI
C:
[6-262]
-----------
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
S
L
V
R
E
L
L
T
E
V
--
N
D
Y
D
L
-
C
I
-
T
E
-
F
V
R
V
V
D
Q
L
L
-----------
P
V
--
K
---------------
V
F
H
R
I
-
C
-
P
E
L
Q
N
A
S
R
T
PSGTLVR
V
Q
L
L
G
Q
-----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
A
---------
P
S
-----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
------
W
D
--
S
G
E
--
K
K
-
F
--
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
E
Q
G
Y
----
R
A
--
E
H
I
-
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
-
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
----
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
------
N
E
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
----------------------------------------------------------------------
4
PsiBlast_PDB
82.51
32%
-96
- C2 -
4YCO
1
DUSC_ECOLI
A:
[6-262]
-----------
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
S
L
V
R
E
L
L
T
E
V
--
N
D
Y
D
L
-
C
I
-
T
E
-
F
V
R
V
V
D
Q
L
L
-----------
P
V
--
K
---------------
V
F
H
R
I
-
C
-
P
E
L
Q
N
A
S
R
T
PS
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
A
---------
P
S
-----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
------
W
D
--
S
G
E
--
K
K
-
F
--
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
E
Q
G
Y
----
R
A
--
E
H
I
-
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
-
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
----
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
------
N
E
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
----------------------------------------------------------------------
21
PsiBlast_CBE
82.00
33%
-96
- C2 -
4BFA
6
DUSC_ECOLI
B:
[22-279]
----------
A
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
S
L
V
R
E
L
L
T
E
V
--
N
D
Y
D
L
-
C
I
-
T
E
-
F
V
R
V
V
D
Q
L
L
-----------
P
V
--
K
---------------
V
F
H
R
I
-
C
-
P
E
L
Q
N
A
S
R
T
PS
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
--------------------
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
------
W
D
--
S
G
E
--
K
K
-
F
--
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
E
Q
G
Y
----
R
A
--
E
H
I
-
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
-
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
----
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
------
N
E
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
----------------------------------------------------------------------
5
PsiBlast_PDB
81.62
32%
-95
- C2 -
4YCP
2
DUSC_ECOLI
A:
[7-262]
------------
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
S
L
V
R
E
L
L
T
E
V
--
N
D
Y
D
L
-
C
I
-
T
E
-
F
V
R
V
V
D
Q
L
L
-----------
P
V
--
K
---------------
V
F
H
R
I
-
C
-
P
E
L
Q
N
A
S
R
T
PS
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
A
---------
P
--------
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
------
W
D
--
S
G
E
--
K
K
-
F
--
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
E
Q
G
Y
----
R
A
--
E
H
I
-
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
-
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
----
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
------
N
E
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
----------------------------------------------------------------------
6
PsiBlast_PDB
81.54
32%
-94
- C2 -
4BF9
1
DUSC_ECOLI
A:
[21-279]
---------
M
A
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
S
L
V
R
E
L
L
T
E
V
--
N
D
Y
D
L
-
C
I
-
T
E
-
F
V
R
V
V
D
Q
L
L
-----------
P
V
--
K
---------------
V
F
H
R
I
-
C
-
P
E
L
Q
N
A
S
R
T
PS
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
C
---------
P
S
-
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
------
W
D
--
S
G
E
--
K
K
-
F
--
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
E
Q
G
Y
----
R
A
--
E
H
I
-
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
-
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
----
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
------
N
E
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
----------------------------------------------------------------------
23
PsiBlast_CBE
80.70
32%
-95
- C2 -
4YCO
1
DUSC_ECOLI
B:
[6-262]
-----------
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
L
D
S
L
V
R
E
L
L
T
E
V
--
N
D
Y
D
L
-
C
I
-
T
E
-
F
V
R
V
V
D
Q
L
L
-----------
P
V
--
K
---------------
V
F
H
R
I
-
C
-
P
E
L
Q
N
A
S
R
T
PSGTLVR
V
Q
L
L
G
Q
-----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
W
G
V
D
L
N
C
G
A
---------
P
S
-----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
------
W
D
--
S
G
E
--
K
K
-
F
--
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
E
Q
G
Y
----
R
A
--
E
H
I
-
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
-
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
----
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
------
N
E
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
----------------------------------------------------------------------
124
HHSearch
79.09
29%
-84
- C2 -
3B0P
1
DUSAL_THET8
A:
[2-318]
----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
R
H
F
R
F
L
V
R
Q
V
--
S
-
L
G
V
R
L
Y
-
T
E
-
M
T
V
D
Q
A
V
L
R
---------
G
-
N
R
--
E
-----------------
R
L
L
-
A
-
F
R
P
E
E
H
P
I
A
-------
L
Q
L
A
G
S
-----------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
C
---------
P
S
-
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
------
L
E
--
G
K
E
T
Y
R
G
L
A
--
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
-------
S
A
L
---------IP
P
-
L
-
R
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
-
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
-
K
-----
R
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
--
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
---
T
P
P
W
A
V
-
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
R
S
L
Q
A
L
D
R
A
-
L
R
L
M
E
E
E
V
G
E
-------
114
Fugue
78.57
29%
-87
- C2 -
3B0P
1
DUSAL_THET8
A:
[2-318]
----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
R
H
F
R
F
L
V
R
Q
V
--
S
-
L
G
V
-
R
L
Y
T
E
-
M
T
V
D
Q
A
V
L
R
---------
G
-
N
R
--
E
---------------
R
L
L
A
F
----
R
P
E
E
H
P
I
A
-------
L
Q
L
A
G
S
-----------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
C
---------
P
S
-
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
------
L
E
GK
E
T
Y
--
R
G
L
A
--
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
-------
S
---
A
L
----
I
P
--
P
-
L
-
R
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
-
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
R
------
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
V
-----
F
G
L
P
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
A
V
-
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
R
S
L
Q
A
L
D
R
A
-
L
R
L
M
E
E
E
V
G
E
-------
127
HHSearch
77.08
21%
-87
- C2 -
3HGJ
2
?
A:
[5-336]
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
-
M
C
Q
YSATLEGE
V
T
D
W
H
L
L
H
Y
P
T
R
A
L
G
G
-
V
G
L
-
I
L
-
V
E
-
A
T
A
V
E
P
L
G
R
ISPYDLGIW
S
-
E
D
H
L
P
---------------
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
-------
I
Q
L
A
H
A
GRKAGTARPWEGGKPLGWRVVGP
S
P
IPFDEGYPVPEPLD
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
GY
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
-
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
V
PR
E
L
P
L
F
V
R
V
S
A
T
DWGEGG
W
S
--
L
----
E
D
T
L
--
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
-------
G
V
V
L
R
V
RIPL
A
P
--
G
-
F
-
Q
V
P
F
A
D
A
V
R
K
R
V
-
G
L
R
T
G
-
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
----
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
Y
F
P
L
R
A
A
K
A
L
G
------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.97
34%
-92
- C2 -
3B0V
1
DUSAL_THET8
C:
[22-260]
---------
M
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
R
H
F
R
F
L
V
R
Q
V
--
S
-
L
G
V
-
R
L
-
Y
T
-
E
M
T
V
D
Q
A
V
L
---------
R
-
G
N
--
R
---------------
E
R
L
-
L
-
A
-
F
R
P
E
E
H
P
I
A
-------
L
Q
L
A
G
S
-----------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
C
---------
P
S
-
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
------
L
E
G-
K
E
T
--
Y
R
G
L
AQ
S
V
E
A
M
A
E
-
A
G
V
K
V
F
V
V
H
A
R
SALLALS
T
K
A
N
R
E
----
I
P
--
P
-
L
-
R
H
D
W
V
H
R
L
K
G
D
F
-
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
--
L
F
H
L
----
K
R
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
----------------------------------------------------------------------------------------------
24
PsiBlast_CBE
75.68
34%
-85
* C2 *
3B0U
2
DUSAL_THET8
Y:
[2-239]
----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
R
H
F
R
F
L
V
R
Q
V
--
S
-
L
G
V
-
R
L
-
Y
T
-
E
M
T
V
D
Q
A
V
L
---------
R
-
G
N
--
R
---------------
E
R
L
-
L
-
A
-
F
R
P
E
E
H
P
I
A
-------
L
Q
L
A
G
S
-----------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
C
---------
P
S
-
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
------
L
E
G-
K
E
T
--
Y
R
G
L
AQ
S
V
E
A
M
A
E
-
A
G
V
K
V
F
V
V
H
A
R
SALLALS
T
K
A
N
R
E
----
I
P
--
P
-
L
-
R
H
D
W
V
H
R
L
K
G
D
F
-
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
--
L
F
H
L
----
K
R
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.38
34%
-88
- C2 -
3B0U
3
DUSAL_THET8
X:
[2-239]
----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
R
H
F
R
F
L
V
R
Q
V
--
S
-
L
G
V
-
R
L
-
Y
T
-
E
M
T
V
D
Q
A
V
L
---------
R
-
G
N
--
R
---------------
E
R
L
-
L
-
A
-
F
R
P
E
E
H
P
I
A
-------
L
Q
L
A
G
S
-----------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
C
---------
P
S
-
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
------
L
E
G-
K
E
T
--
Y
R
G
L
AQ
S
V
E
A
M
A
E
-
A
G
V
K
V
F
V
V
H
A
R
SALLALS
T
K
A
N
R
E
----
I
P
--
P
-
L
-
R
H
D
W
V
H
R
L
K
G
D
F
-
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
--
L
F
H
L
----
K
R
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
----------------------------------------------------------------------------------------------
25
PsiBlast_CBE
75.16
34%
-89
- C2 -
3B0P
1
DUSAL_THET8
B:
[2-239]
----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
R
H
F
R
F
L
V
R
Q
V
--
S
-
L
G
V
-
R
L
-
Y
T
-
E
M
T
V
D
Q
A
V
L
---------
R
-
G
N
--
R
---------------
E
R
L
-
L
-
A
-
F
R
P
E
E
H
P
I
A
-------
L
Q
L
A
G
S
-----------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
C
---------
P
S
-
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
------
L
E
G-
K
E
T
--
Y
R
G
L
AQ
S
V
E
A
M
A
E
-
A
G
V
K
V
F
V
V
H
A
R
SAL--------------
I
P
--
P
-
L
-
R
H
D
W
V
H
R
L
K
G
D
F
-
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
--
L
F
H
L
----
K
R
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
----------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.53
34%
-87
- C2 -
3B0P
1
DUSAL_THET8
A:
[2-239]
----------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
T
D
R
H
F
R
F
L
V
R
Q
V
--
S
-
L
G
V
-
R
L
-
Y
T
-
E
M
T
V
D
Q
A
V
L
---------
R
-
G
N
--
R
---------------
E
R
L
-
L
-
A
-
F
R
P
E
E
H
P
I
A
-------
L
Q
L
A
G
S
-----------------------
D
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
D
E
I
N
L
N
L
G
C
---------
P
S
-
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
------
L
E
G-
K
E
T
--
Y
R
G
L
A
Q
S
V
E
A
M
A
E
-
A
G
V
K
V
F
V
V
H
A
R
SAL--------------
I
P
--
P
-
L
-
R
H
D
W
V
H
R
L
K
G
D
F
-
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
--
L
F
H
L
----
K
R
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
----------------------------------------------------------------------------------------------
10
PsiBlast_PDB
50.44
31%
-38
- C2 -
4XP7
1
DUS2L_HUMAN
A:
[18-258]
------------
N
K
L
I
L
A
P
-
M
V
R
--------
V
G
T
L
P
M
R
L
L
A
L
D
Y
--
G
-
A
D
I
-
V
Y
-
C
E
-
E
L
I
-
D
L
K
M
I
---------
Q
-
C
K
--
R
VVNEVLSTVDFVAPD
D
R
V
V
F
-
R
-
T
C
E
R
E
Q
N
R
V
-------
V
F
Q
M
G
T
-----------------------
S
D
----------------------
A
E
R
A
L
A
V
A
R
L
V
E
N
D
V
A
G
I
D
V
N
M
G
C
---------
P
K
-
Q
---------
A
L
L
S
D
P
D
K
I
E
K
I
L
S
T
L
V
K
G
T
--
R
R
P
V
T
C
K
I
R
I
L
------
P
S
--
L
E
----
D
T
L
--
S
L
V
K
R
I
E
R
T
G
I
A
A
I
A
V
H
G
R
-------
K
R
E
E
R
P
----
Q
H
--
P
-
V
-
S
C
E
V
I
K
A
I
A
D
T
L
-
S
I
P
V
I
-
A
N
G
G
S
H
D
H
I
Q
Q
Y
S
D
I
E
D
F
R
Q
A
T
A
A
S
S
V
M
V
A
R
A
A
M
W
N
P
S
I
F
--------------------------------------------------------------------------------------------------