@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4873: (2016-03-02 )
MNPSTAARALGIDFGTSNSTVGWWRPEVEPLIELEDGKITLPSVVFFNVEERRPVYGRQALGEYLEGYEGRLMRSLKSLLGSKLLKSETTVLGSALPFKDLLGLFIGQLKARGEAAAGQAFDAVVLGRPVFFVDDDPEADREAQDTLVQVANKLGFKEVSFQYEPIAAAFDYERCIQREELVLIVDIGGGTSDFSLVRLAPERRNLAERQDDILATGGVHIGGTDFDKQLSLEGVMPLFGYGSRMKSDAFMPTSYHLNLATWHTINAVYAQKSQLALKNMRYDIVDSTGIDRLFRLIEERAGHWLAMQVEDSKIRLTETERLHLSLERIEAGLGVELTRGLFENAVDGLLERVRNSVAQLLASAGVDPDRVDTVFFTGGSSGIPALRRSVSAMLPNARHVEGNLFGSIGSGLAIEAKKRYG
Atome Classification :
(20 SA)
.........10........20........30........40........50..--......60........70........80.......------------------------.------------------------90----.......------------------------.-------------------------100.......110.......120.......130.......140.......150.......160.......170-------....-------...180.......190.......200.......210..----..-.-.-.220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......------330------.--...--...340.......350.......360.......370.......380.......390....-...400-.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNP
S
T
A
A
R
A
L
G
I
D
FGTSNSTV
G
W
WRPEV
E
P
L
I
E
LEDG
K
I
T
L
P
S
V
V
F
F
NVEERR--PVY
G
R
Q
A
L
G
E
Y
L
E
GY
E
G
R
L
M
R
S
L
K
S
L
L
G
S
K
L
LKSE------------------------T------------------------TV----LGSAL
P
F
------------------------
K
-------------------------
D
L
L
G
L
F
I
G
Q
L
KARGEAAAGQ
A
F
D
A
V
V
LG
R
P
V
F
F
VDDDPEA
D
R
E
A
Q
D
T
L
V
Q
V
A
N
KLGF
K
E
V
S
F
Q
YEPI
A
A
AF
D
Y
-------
E
R
CI-------QRE
E
L
V
L
I
V
D
IGGGTSD
F
S
L
V
RL
A
P
E
R
R
N
L
A
E
R
QD
D
I
L
----AT-G-
G
-
V
H
IGGTD
F
D
K
QLSLEGVM
P
L
FGYGSRMKSDAFMP
T
S
Y
H
L
NLA
T
W
H
T
I
N
A
V
Y
A
Q
K
S
Q
L
A
L
K
NM
R
Y
DIVDST
G
I
D
R
L
F
R
L
I
E
ERAG
H
W
L
A
M
Q
VED
S
K
I
R
L
T
E
T
E
R
L
H
L
S
L
E
R
I
------EAG------L--G
V
E
--
L
T
R
G
L
F
E
N
A
V
D
G
L
L
E
R
V
R
N
S
V
A
Q
L
L
A
SAGVDPDR
V
D
T
V
F
FTGGSS
G
I
P
A
L
R
R
S
V
S
A
MLPN-ARHVEG-
N
L
FGSIGS
G
L
A
I
E
A
KKRYG
13
PsiBlast_PDB
91.93
22%
-79
- C1 -
3LDO
1
GRP78_HUMAN
A:
[3-379]
----
D
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
---
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
-
K
R
L
I
G
R
T
W
N
D
P
S
------------------------
V
------------------------
Q
Q
----
D
I
K
F
L
P
F
------------------------
K
V
V
E
K
KTKP
Y
I
Q
V
D
IGGG
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
T
I
A
---
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
GLD----
K
R
---------
E
G
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
-------
T
I
D
N
G
V
F
E
V
V
----
A
T
-
N
-
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
-
M
E
H
F
I
K
L
------------------------------
Y
K
K
K
T
G
---
K
D
V
R
K
D
---------------
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
------
Y
E
G
E
D
----
F
--
S
E
T
--
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
-----
28
HHSearch
91.69
22%
-72
- C1 -
3QFU
3
GRP78_YEAST
A:
[16-393]
----
N
Y
G
T
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
T
D
D
--
E
--
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
-
N
T
I
F
D
I
K
R
L
I
G
L
K
Y
N
D
R
S
V
Q
K
D
I
K
H
LP
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
V
------------------------
K
G
----
E
K
K
V
F
T
P
------------------------
E
-------------------------
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
-------
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
-------
G
L
D
K
S------
D
K
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
E
N
G
-------
V
F
E
V
Q
----
A
T
-
S
G
D
-
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
-
I
K
A
F
K
K
K
H
G
I
D
V
------------------------------------
S
D
N
------------
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
S
T
R
I
E
I
D
S
F
VD----
G
I
D
------
L
--
S
E
T
--
L
T
R
A
K
F
E
E
L
N
L
D
L
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
K
K
A
S
K
G
I
-
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
--
29
HHSearch
91.34
23%
-75
- C1 -
3I33
3
HSP72_HUMAN
A:
[23-401]
------
M
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
--
E
--
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
-
N
T
I
F
D
A
K
R
L
I
G
R
K
F
E
D
A
T
------------------------
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
Q
V
E
Y
K
G
----
E
T
K
T
F
F
P
------------------------
E
-------------------------
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
-------
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
-------
G
L
D
K
KGCA---
G
G
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
G
-------
I
F
E
V
K
----
S
T
-
A
G
D
-
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
-
A
E
E
F
K
R
K
H
K
K
D
----
I
G
--------------------------------
P
N
------------
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
YE----
G
V
D
------
F
--
Y
T
S
--
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
-
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
--
11
PsiBlast_PDB
91.31
22%
-80
- C1 -
3LDL
1
GRP78_HUMAN
A:
[3-379]
----
D
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
---
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
-
K
R
L
I
G
R
T
W
N
D
P
S
------------------------
V
------------------------
Q
Q
----
D
I
K
F
L
P
F
------------------------
K
V
V
E
K
KT
K
P
Y
I
Q
V
DIGGG
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
T
I
A
---
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
GLD----
K
R
---------
E
G
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
-------
T
I
D
N
G
V
F
E
V
V
----
A
T
-
N
-
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
-
M
E
H
F
I
K
L
------------------------------
Y
K
K
K
T
G
---
K
D
V
R
K
D
---------------
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
------
Y
E
G
E
D
----
F
--
S
E
T
--
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
-----
14
PsiBlast_PDB
91.04
22%
-80
- C1 -
3LDP
1
GRP78_HUMAN
A:
[3-379]
----
D
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
---
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
-
K
R
L
I
G
R
T
W
N
D
P
S
------------------------
V
------------------------
Q
Q
----
D
I
K
F
L
P
F
------------------------
K
V
V
E
K
KTKP
Y
I
Q
V
D
IGGG
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
T
I
A
---
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
GLD----
K
R
---------
E
G
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
-------
T
I
D
N
G
V
F
E
V
V
----
A
T
-
N
-
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
-
M
E
H
F
I
K
L
------------------------------
Y
K
K
K
T
G
---
K
D
V
R
K
D
---------------
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
------
Y
E
G
E
D
----
F
--
S
E
T
--
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
-----
26
HHSearch
90.90
22%
-78
- C1 -
3D2F
4
?
A:
[2-389]
------
S
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
N
R
G
I
D
I
V
V
N
E
V
S
N
R
S
T
P
S
V
V
G
F
G
P
K
--
N
--
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
-
N
T
V
A
N
L
K
R
I
I
G
L
D
Y
H
H
P
D
F
E
Q
E
S
K
H
FT
S
K
L
V
E
L
DDK
K
T
G
---
A
------------------------
E
V
R
F
AG
E
K
H
V
F
S
A
------------------------
T
-------------------------
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
-------
Y
N
I
A
D
A
A
R
I
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
-------
G
I
F
K
TDLPEGE
E
K
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
K
G
-------
Q
L
K
V
L
----
G
T
-
A
-
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
-
A
D
E
F
K
T
K
Y
K
I
D
------------------------------
I
------
R
E
N
------------
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
A
N
T
N
A
P
F
S
V
E
S
V
MN----
D
V
D
------
V
--
S
S
Q
--
L
S
R
E
E
L
E
E
L
V
K
P
L
L
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
K
-
P
L
S
T
T
L
-
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
--
12
PsiBlast_PDB
90.24
22%
-80
- C1 -
3LDN
-
GRP78_HUMAN
A:
[26-402]
----
D
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
---
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
-
K
R
L
I
G
R
T
W
N
D
P
S
------------------------
V
------------------------
Q
Q
----
D
I
K
F
L
P
F
------------------------
K
V
V
E
K
KT
K
P
Y
I
Q
V
DIGGG
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
T
I
A
---
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
GLD----
K
R
---------
E
G
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
-------
T
I
D
N
G
V
F
E
V
V
----
A
T
-
N
-
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
-
M
E
H
F
I
K
L
------------------------------
Y
K
K
K
T
G
---
K
D
V
R
K
D
---------------
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
------
Y
E
G
E
D
----
F
--
S
E
T
--
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
-----
18
PsiBlast_PDB
90.07
22%
-77
- C1 -
3IUC
2
GRP78_HUMAN
A:
[29-400]
---------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
--
L
I
-
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
-
K
R
L
I
G
R
T
W
N
D
P
S
------------------------
V
------------------------
Q
Q
----
D
I
K
F
L
P
F
------------------------
K
V
V
E
K
KT
K
P
Y
I
Q
V
D
IGGG
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
-------
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
GLD----
K
R
---------
E
G
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
-------
T
I
D
N
G
V
F
E
V
V
----
A
T
-
N
-
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
-
M
E
H
F
I
K
L
------------------------------
Y
K
K
K
T
G
---
K
D
V
R
K
D
---------------
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
------
Y
E
G
E
D
----
F
--
S
E
T
--
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
-----
17
PsiBlast_PDB
89.68
21%
-75
- C1 -
3QFU
3
GRP78_YEAST
A:
[21-390]
---------
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
T
D
D
E
R
----
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
-
D
I
K
R
L
I
G
L
K
Y
N
D
R
S
------------------------
V
------------------------
Q
K
----
D
I
K
H
L
P
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
V
KG
E
K
K
V
F
T
P
E
-------------------------
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
T
I
A
---
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
GL-----
D
K
S
--------
D
K
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
---
E
N
G
V
F
E
V
Q
---
A
----
T
S
-
G
-
D
-
T
H
L
G
G
E
D
F
D
Y
K
I
------------
V
R
Q
L
I
K
A
F
K
--------------------------
K
K
H
G
I
D
V
S
D
N
N
-----------
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
S
T
R
I
E
I
D
S
F
------
V
D
G
------
I
--
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
-
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
-----
16
PsiBlast_PDB
89.46
21%
-76
- C1 -
3QML
4
GRP78_YEAST
A:
[17-386]
---------
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
T
D
D
E
R
----
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
-
D
I
K
R
L
I
G
L
K
Y
N
D
R
S
------------------------
V
------------------------
Q
K
----
D
I
K
H
L
P
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
VKG
E
K
K
V
F
T
P
E
-------------------------
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
T
I
A
---
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
GL-----
D
K
S
--------
D
K
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
---
E
N
G
V
F
E
V
Q
---
A
----
T
S
-
G
-
D
-
T
H
L
G
G
E
D
F
D
Y
K
I
------------
V
R
Q
L
I
K
A
F
K
--------------------------
K
K
H
G
I
D
V
S
D
N
N
-----------
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
S
T
R
I
E
I
D
S
F
------
V
D
G
------
I
--
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
-
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
-----
27
HHSearch
89.04
27%
-72
- C1 -
2V7Y
2
DNAK_GEOKA
A:
[2-351]
------
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
N
G
--
E
--
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
--
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
---
K
------------------------
V
------------------------
E
I
----
E
G
K
Q
Y
T
P
------------------------
Q
-------------------------
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
-------
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
-------
G
L
D
K
-------
E
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
G
D
G
-------
V
F
E
V
K
----
A
T
A
G
-
D
-
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
-
V
N
Q
F
K
Q
E
H
G
I
D
----
L
S
--------------------------------
K
D
------------
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
I
S
L
P
F
I
SANEN
G
P
L
H
------
L
--
E
M
T
--
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
K
-
E
P
H
K
G
V
-
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
--
8
PsiBlast_PDB
88.68
20%
-79
- C1 -
4JN4
9
DNAK_ECOLI
A:
[1-378]
-----
S
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
-
T
Q
D
G
E
--
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
-
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
------------------------
V
------------------------
Q
R
----
D
V
S
I
M
P
F
------------------------
K
I
I
A
A
DNG
D
A
W
V
E
V
KG
Q
K
M
A
P
P
----
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
R
I
A
---
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
LDKGTG
N
R
T
I
-------------
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
---
G
E
K
T
F
E
V
L
----
A
T
-
N
-
G
D
T
H
L
G
G
E
D
F
D
S
R
L
--------------------------
I
N
Y
L
V
E
E
-----
F
K
K
D
Q
G
I
D
L
R
N
------
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
------------
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
------
T
A
D
AT
G
P
K
H
M
--
N
I
K
--
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G
K
-
E
P
R
K
D
V
-
N
P
D
E
A
V
A
I
G
A
A
V
Q
------
9
PsiBlast_PDB
87.67
20%
-77
- C1 -
4JNE
9
DNAK_ECOLI
A:
[1-378]
-----
S
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
-
T
Q
D
G
E
--
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
-
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
------------------------
V
------------------------
Q
R
----
D
V
S
I
M
P
F
------------------------
K
I
I
A
A
DNG
D
A
W
V
E
V
KG
Q
K
M
A
P
P
----
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
R
I
A
---
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
LDKGTG
N
R
T
I
-------------
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
---
G
E
K
T
F
E
V
L
----
A
T
-
N
-
G
D
T
H
L
G
G
E
D
F
D
S
R
L
--------------------------
I
N
Y
L
V
E
E
-----
F
K
K
D
Q
G
I
D
L
R
N
------
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
------------
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
------
T
A
D
AT
G
P
K
H
M
--
N
I
K
--
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G
K
-
E
P
R
K
D
V
-
N
P
D
E
A
V
A
I
G
A
A
V
Q
------
4
PsiBlast_PDB
87.27
24%
-81
- C1 -
3L4I
3
?
A:
[21-364]
--------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
E
R
----
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
-
K
R
L
I
G
R
K
F
D
D
Q
A
------------------------
V
------------------------
Q
S
----
D
M
T
H
W
P
F
------------------------
K
V
V
R
G
P
KD
K
P
I
I
S
V
N
Y
LG
E
K
K
E
F
H
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-------
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
GL-----
D
K
K
G
-------
T
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----------
E
D
G
I
F
EVK
A
T
A
-
G
-
D
-
T
H
L
G
G
E
D
F
D
N
R
L
-
V
E
F
C
V
Q
D
F
K
R
K
N
R
-----------
G
M
D
L
T
T
----
N
A
--------------------------------
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
T
I
E
L
D
S
L
------
Y
E
G
------
I
D
Y
S
V
A
--
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
------------------------------------
7
PsiBlast_PDB
87.21
21%
-83
- C1 -
2KHO
-
DNAK_ECOLI
A:
[4-378]
--------
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
-
T
Q
D
G
E
--
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
-
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
------------------------
V
------------------------
Q
R
----
D
V
S
I
M
P
F
------------------------
K
I
I
A
A
DNG
D
A
W
V
E
V
KG
Q
K
M
A
P
P
----
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
R
I
A
---
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
GLDKGTG
N
R
T
I
-------------
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
E
V
D
---
G
E
K
T
F
E
V
L
----
A
T
-
N
-
G
D
T
H
L
G
G
E
D
F
D
S
R
L
--------------------------
I
N
Y
L
V
E
E
-----
F
K
K
D
Q
G
I
D
L
R
N
------
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
------------
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
------
T
A
D
AT
G
P
K
H
M
--
N
I
K
--
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G
K
-
E
P
R
K
D
V
-
N
P
D
E
A
V
A
I
G
A
A
V
Q
------
3
PsiBlast_PDB
86.51
24%
-79
- C1 -
3KVG
4
?
A:
[21-364]
--------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
E
R
----
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
-
K
R
L
I
G
R
K
F
D
D
Q
A
------------------------
V
------------------------
Q
S
----
D
M
T
H
W
P
F
------------------------
K
V
V
R
G
P
KD
K
P
I
I
S
V
N
Y
LG
E
K
K
E
F
H
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-------
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
GL-----
D
K
K
G
-------
T
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----------
E
D
G
I
F
EVK
A
T
A
-
G
-
D
-
T
H
L
G
G
E
D
F
D
N
R
L
-
V
E
F
C
V
Q
D
F
K
R
K
N
R
-----------
G
M
D
L
T
T
----
N
A
--------------------------------
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
T
I
E
L
D
S
L
------
Y
E
G
------
I
D
Y
S
V
A
--
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
------------------------------------
15
PsiBlast_PDB
86.28
21%
-73
- C1 -
3QFP
1
GRP78_YEAST
A:
[17-386]
---------
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
---
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
T
D
D
E
R
----
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
-
D
I
K
R
L
I
G
L
K
Y
N
D
R
S
------------------------
V
------------------------
Q
K
----
D
I
--
L
P
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
V
KG
E
K
K
V
F
T
P
E
-------------------------
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
T
I
A
---
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
GL-----
D
K
----------
K
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
---
E
N
G
V
F
E
V
Q
---
A
----
T
S
-
G
-
D
-
T
H
L
G
G
E
D
F
D
Y
K
I
------------
V
R
Q
L
I
K
-----------------------------
K
K
H
G
I
D
V
S
D
N
N
-----------
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
M
S
T
R
I
E
I
D
S
F
------
V
D
G
------
I
--
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
-
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
-----
5
PsiBlast_PDB
86.24
24%
-79
- C1 -
3L6Q
5
?
A:
[21-364]
--------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
E
R
----
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
-
K
R
L
I
G
R
K
F
D
D
Q
A
------------------------
V
------------------------
Q
S
----
D
M
T
H
W
P
F
------------------------
K
V
V
R
G
P
KD
K
P
I
I
S
V
N
Y
LG
E
K
K
E
F
H
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-------
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
GL-----
D
K
K
G
-------
T
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----------
E
D
G
I
F
EVK
A
T
A
-
G
-
D
-
T
H
L
G
G
E
D
F
D
N
R
L
-
V
E
F
C
V
Q
D
F
K
R
K
N
R
-----------
G
M
D
L
T
T
----
N
A
--------------------------------
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
T
I
E
L
D
S
L
------
Y
E
G
------
I
D
Y
S
V
A
--
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
------------------------------------
1
PsiBlast_PDB
85.70
25%
-75
* C1 *
2V7Y
2
DNAK_GEOKA
A:
[2-347]
------
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
------
T
N
P
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
---
K
------------------------
V
------------------------
E
I
----
E
G
K
Q
Y
T
P
------------------------
Q
-------------------------
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
----
A
Q
R
Q
A
T
K
D
A
G
R
I
A
---
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
-------
G
L
D
K
-------
E
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
-------
L
G
D
G
V
F
E
V
K
----
A
T
-
A
-
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
----------------------
I
D
Y
L
V
N
--
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
---------
D
A
A
E
K
A
K
K
E
L
S
G
-
V
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
-----------------------
T
--
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
K
-
E
P
H
K
G
V
-
N
P
D
E
V
V
A
I
G
A
A
I
Q
------
20
PsiBlast_PDB
85.19
22%
-71
- C1 -
3I33
3
HSP72_HUMAN
A:
[25-369]
--------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
E
R
----
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
-
K
R
L
I
G
R
K
F
E
D
A
T
------------------------
V
------------------------
Q
S
----
D
M
K
H
W
P
F
------------------------
R
V
V
S
E
GG
K
P
K
V
Q
V
E
Y
KGET
K
T
F
F
P
E
-
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
-------
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
GLDK---
K
G
C
A
-------
G
G
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----------
E
D
G
I
F
EVK
S
T
A
-
G
-
D
-
T
H
L
G
G
E
D
F
D
---------------
N
R
M
V
S
--------
H
L
---------------
A
E
E
F
K
R
K
H
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
----
I
E
I
D
S
L
Y
E
G
V
D
-----------------
F
--
Y
T
S
--
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
-----------------------------------