@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4913: (2016-03-02 )
MSKKLFRKGILALAVSSVMGLSTHALADVVIGVAGPHTGANASFGEQYWRGASQAAEDINAAGGINGEKIKLVKADDACEPKQAVAVANRLVDQDKAIAVVGHFCSSSTIPASEVYDEAGIIAITPGSTNPQVTERGLSGMFRMCGRDDQQGVVAGDYIVNVLKAKKVAVIHDKDTYGQGLADATRAQLNKLGVKEVLYEGLTRGEKDFNALVTKIRASGAEVVYFGGLHPEAGPLVRQMREQGLTARFMSDDGVVTDELATTAGGPQYVKGVLMTFGADPRLIPDGKAVVEKFRAGGFEPEGYTLYSYASIQSLAAAFNGAGANDPAKAAEWLKSHPVQTVMGKKEWDKKGDLKVSDYVVYEWDDKGKYHQLP
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.-......310.......320..-.....330....-...340.......350.......360....--...370..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
K
K
L
F
R
K
G
I
L
A
L
A
V
S
S
V
MGL
S
T
H
A
L
A
D
V
V
I
GVAGPHTGAN
A
S
F
G
E
Q
Y
W
R
G
A
S
Q
A
A
E
D
I
N
AAGGING
E
K
I
K
L
V
KADDACE
P
K
Q
A
V
A
V
A
N
R
LVDQDK
A
I
A
V
V
G
HFCSSSTI
P
A
S
E
VYDEA
G
I
I
A
ITPGST
N
P
Q
V
T
E
R
G
L
S
G
M
F
R
MCGRDDQQ
G
V
V
A
G
D
Y
I
V
N
V
L
KA
K
K
V
A
V
I
HDKDTYGQG
L
A
D
A
T
R
A
Q
L
N
KL
G
V
K
E
V
L
Y
E
G
LTRG
E
K
D
F
N
A
L
V
T
K
I
RASGA
E
V
V
Y
FGGLHPE
A
G
P
L
V
R
Q
M
R
EQGL
T
A
R
FMSDDG
V
V
T
D
E
LATTAG
G
P
Q
Y
V
K
G
V
L
M
TFGADPRLIPD
G
K
A
V
V
E
K
F
RAGGFEPE
G
-
Y
T
L
Y
S
Y
A
S
I
Q
S
L
A
A
A
FNGAGA-N
D
P
A
K
A
A
E
W
L
K
S-H
P
V
Q
T
V
MGKKEWDKKG
D
L
K
V
S
D
Y
V
V
Y
EWDD--KGKYHQLP
40
HHSearch
95.28
55%
-72
* C1 *
3IPC
2
?
A:
[2-345]
---------------------------
D
V
V
I
A
V
G
A
P
L
T
G
P
N
A
A
F
G
A
Q
I
Q
K
G
A
E
Q
A
A
K
D
I
N
A
A
G
G
I
N
G
E
Q
I
K
I
V
L
G
D
D
V
S
D
P
K
Q
G
I
S
V
A
N
K
F
V
A
-
D
G
V
K
F
V
V
G
H
A
N
S
G
V
S
I
P
A
S
E
V
Y
A
E
N
G
I
L
E
I
T
P
A
A
T
N
P
V
F
T
E
R
G
L
W
N
T
F
R
T
C
G
R
D
D
Q
Q
G
G
I
A
G
K
Y
L
A
D
H
F
K
D
A
K
V
A
I
I
H
D
K
T
P
Y
G
Q
G
L
A
D
E
T
K
K
A
A
N
A
A
G
V
T
E
V
M
Y
E
G
V
N
V
G
D
K
D
F
S
A
L
I
S
K
M
K
E
A
G
V
S
I
I
Y
W
G
G
L
H
T
E
A
G
L
I
I
R
Q
A
A
D
Q
G
L
K
A
K
L
V
S
G
D
G
I
V
S
N
E
L
A
S
I
A
G
--
D
A
V
E
G
T
L
N
T
F
G
P
D
P
T
L
R
P
E
N
K
E
L
V
E
K
F
K
A
A
G
F
N
P
E
A
-
Y
T
L
Y
S
Y
A
A
M
Q
A
I
A
G
A
A
K
A
A
G
S
-
V
E
P
E
K
V
A
E
A
L
K
K
-
G
S
F
P
T
A
L
G
E
I
S
F
D
E
K
G
D
P
K
L
P
G
Y
V
M
Y
E
W
K
K
GP
D
G
K
F
T
Y
--
6
PsiBlast_PDB
94.15
55%
-74
- C1 -
3IPC
2
?
A:
[2-335]
---------------------------
D
V
V
I
A
V
G
A
P
L
T
G
P
N
A
A
F
G
A
Q
I
Q
K
G
A
E
Q
A
A
K
D
I
N
A
A
G
G
I
N
G
E
Q
I
K
I
V
L
G
D
D
V
S
D
P
K
Q
G
I
S
V
A
N
K
F
V
-
A
D
G
V
K
F
V
V
G
H
A
N
S
G
V
S
I
P
A
S
E
V
Y
A
E
N
G
I
L
E
I
T
P
A
A
T
N
P
V
F
T
E
R
G
L
W
N
T
F
R
T
C
G
R
D
D
Q
Q
G
G
I
A
G
K
Y
L
A
D
H
F
K
D
A
K
V
A
I
I
H
D
K
T
P
Y
G
Q
G
L
A
D
E
T
K
K
A
A
N
A
A
G
V
T
E
V
M
Y
E
G
V
N
V
G
D
K
D
F
S
A
L
I
S
K
M
K
E
A
G
V
S
I
I
Y
W
G
G
L
H
T
E
A
G
L
I
I
R
Q
A
A
D
Q
G
L
K
A
K
L
V
S
G
D
G
I
V
S
N
E
L
A
S
I
A
G
--
D
A
V
E
G
T
L
N
T
F
G
P
D
P
T
L
R
P
E
N
K
E
L
V
E
K
F
K
A
A
G
F
N
P
E
A
-
Y
T
L
Y
S
Y
A
A
M
Q
A
I
A
G
A
A
K
A
A
G
S
-
V
E
P
E
K
V
A
E
A
L
K
K
-
G
S
F
P
T
A
L
G
E
I
S
F
D
E
K
G
D
P
K
L
P
G
Y
V
M
Y
E
W
------------
4
PsiBlast_PDB
93.76
55%
-76
- C1 -
3IP9
2
?
A:
[2-335]
---------------------------
D
V
V
I
A
V
G
A
P
L
T
G
P
N
A
A
F
G
A
Q
I
Q
K
G
A
E
Q
A
A
K
D
I
N
A
A
G
G
I
N
G
E
Q
I
K
I
V
L
G
D
D
V
S
D
P
K
Q
G
I
S
V
A
N
K
F
V
-
A
D
G
V
K
F
V
V
G
H
F
N
S
G
V
S
I
P
A
S
E
V
Y
A
E
N
G
I
L
E
I
T
P
A
A
T
N
P
V
F
T
E
R
G
L
W
N
T
F
R
T
C
G
R
D
D
Q
Q
G
G
I
A
G
K
Y
L
A
D
H
F
K
D
A
K
V
A
I
I
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D
K
T
P
Y
G
Q
G
L
A
D
E
T
K
K
A
A
N
A
A
G
V
T
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V
M
Y
E
G
V
N
V
G
D
K
D
F
S
A
L
I
S
K
M
K
E
A
G
V
S
I
I
Y
W
G
G
L
H
T
E
A
G
L
I
I
R
Q
A
A
D
Q
G
L
K
A
K
L
V
S
G
D
G
I
V
S
N
E
L
A
S
I
A
G
--
D
A
V
E
G
T
L
N
T
F
G
P
D
P
T
L
R
P
E
N
K
E
L
V
E
K
F
K
A
A
G
F
N
P
E
A
-
Y
T
L
Y
S
Y
A
A
M
Q
A
I
A
G
A
A
K
A
A
G
S
-
V
E
P
E
K
V
A
E
A
L
K
K
-
G
S
F
P
T
A
L
G
E
I
S
F
D
E
K
G
D
P
K
L
P
G
Y
V
M
Y
E
W
------------
2
PsiBlast_PDB
93.72
55%
-75
- C1 -
3IP6
2
?
A:
[2-335]
---------------------------
D
V
V
I
A
V
G
A
P
L
T
G
P
N
A
A
F
G
A
Q
I
Q
K
G
A
E
Q
A
A
K
D
I
N
A
A
G
G
I
N
G
E
Q
I
K
I
V
L
G
D
D
V
S
D
P
K
Q
G
I
S
V
A
N
K
F
V
-
A
D
G
V
K
F
V
V
G
H
F
N
S
G
V
S
I
P
A
S
E
V
Y
A
E
N
G
I
L
E
I
T
P
A
A
T
N
P
V
F
T
E
R
G
L
W
N
T
F
R
T
C
G
R
D
D
Q
Q
G
G
I
A
G
K
Y
L
A
D
H
F
K
D
A
K
V
A
I
I
H
D
K
T
P
Y
G
Q
G
L
A
D
E
T
K
K
A
A
N
A
A
G
V
T
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M
Y
E
G
V
N
V
G
D
K
D
F
S
A
L
I
S
K
M
K
E
A
G
V
S
I
I
Y
W
G
G
L
H
T
E
A
G
L
I
I
R
Q
A
A
D
Q
G
L
K
A
K
L
V
S
G
D
G
I
V
S
N
E
L
A
S
I
A
G
--
D
A
V
E
G
T
L
N
T
F
G
P
D
P
T
L
R
P
E
N
K
E
L
V
E
K
F
K
A
A
G
F
N
P
E
A
-
Y
T
L
Y
S
Y
A
A
M
Q
A
I
A
G
A
A
K
A
A
G
S
-
V
E
P
E
K
V
A
E
A
L
K
K
-
G
S
F
P
T
A
L
G
E
I
S
F
D
E
K
G
D
P
K
L
P
G
Y
V
M
Y
E
W
------------
1
PsiBlast_PDB
93.57
55%
-75
- C1 -
3IP5
2
?
A:
[2-335]
---------------------------
D
V
V
I
A
V
G
A
P
L
T
G
P
N
A
A
F
G
A
Q
I
Q
K
G
A
E
Q
A
A
K
D
I
N
A
A
G
G
I
N
G
E
Q
I
K
I
V
L
G
D
D
V
S
D
P
K
Q
G
I
S
V
A
N
K
F
V
-
A
D
G
V
K
F
V
V
G
H
F
N
S
G
V
S
I
P
A
S
E
V
Y
A
E
N
G
I
L
E
I
T
P
A
A
T
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P
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F
T
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G
L
W
N
T
F
R
T
C
G
R
D
D
Q
Q
G
G
I
A
G
K
Y
L
A
D
H
F
K
D
A
K
V
A
I
I
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D
K
T
P
Y
G
Q
G
L
A
D
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K
K
A
A
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A
A
G
V
T
E
V
M
Y
E
G
V
N
V
G
D
K
D
F
S
A
L
I
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K
M
K
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A
G
V
S
I
I
Y
W
G
G
L
H
T
E
A
G
L
I
I
R
Q
A
A
D
Q
G
L
K
A
K
L
V
S
G
D
G
I
V
S
N
E
L
A
S
I
A
G
--
D
A
V
E
G
T
L
N
T
F
G
P
D
P
T
L
R
P
E
N
K
E
L
V
E
K
F
K
A
A
G
F
N
P
E
A
-
Y
T
L
Y
S
Y
A
A
M
Q
A
I
A
G
A
A
K
A
A
G
S
-
V
E
P
E
K
V
A
E
A
L
K
K
-
G
S
F
P
T
A
L
G
E
I
S
F
D
E
K
G
D
P
K
L
P
G
Y
V
M
Y
E
W
------------
5
PsiBlast_PDB
93.49
55%
-75
- C1 -
3IPA
3
?
A:
[2-335]
---------------------------
D
V
V
I
A
V
G
A
P
L
T
G
P
N
A
A
F
G
A
Q
I
Q
K
G
A
E
Q
A
A
K
D
I
N
A
A
G
G
I
N
G
E
Q
I
K
I
V
L
G
D
D
V
S
D
P
K
Q
G
I
S
V
A
N
K
F
V
-
A
D
G
V
K
F
V
V
G
H
F
N
S
G
V
S
I
P
A
S
E
V
Y
A
E
N
G
I
L
E
I
T
P
A
A
T
N
P
V
F
T
E
R
G
L
W
N
T
F
R
T
C
G
R
D
D
Q
Q
G
G
I
A
G
K
Y
L
A
D
H
F
K
D
A
K
V
A
I
I
H
D
K
T
P
Y
G
Q
G
L
A
D
E
T
K
K
A
A
N
A
A
G
V
T
E
V
M
Y
E
G
V
N
V
G
D
K
D
F
S
A
L
I
S
K
M
K
E
A
G
V
S
I
I
Y
W
G
G
L
H
T
E
A
G
L
I
I
R
Q
A
A
D
Q
G
L
K
A
K
L
V
S
G
D
G
I
V
S
N
E
L
A
S
I
A
G
--
D
A
V
E
G
T
L
N
T
F
G
P
D
P
T
L
R
P
E
N
K
E
L
V
E
K
F
K
A
A
G
F
N
P
E
A
-
Y
T
L
Y
S
Y
A
A
M
Q
A
I
A
G
A
A
K
A
A
G
S
-
V
E
P
E
K
V
A
E
A
L
K
K
-
G
S
F
P
T
A
L
G
E
I
S
F
D
E
K
G
D
P
K
L
P
G
Y
V
M
Y
E
W
------------
3
PsiBlast_PDB
93.39
55%
-76
- C1 -
3IP7
3
?
A:
[2-335]
---------------------------
D
V
V
I
A
V
G
A
P
L
T
G
P
N
A
A
F
G
A
Q
I
Q
K
G
A
E
Q
A
A
K
D
I
N
A
A
G
G
I
N
G
E
Q
I
K
I
V
L
G
D
D
V
S
D
P
K
Q
G
I
S
V
A
N
K
F
V
-
A
D
G
V
K
F
V
V
G
H
F
N
S
G
V
S
I
P
A
S
E
V
Y
A
E
N
G
I
L
E
I
T
P
A
A
T
N
P
V
F
T
E
R
G
L
W
N
T
F
R
T
C
G
R
D
D
Q
Q
G
G
I
A
G
K
Y
L
A
D
H
F
K
D
A
K
V
A
I
I
H
D
K
T
P
Y
G
Q
G
L
A
D
E
T
K
K
A
A
N
A
A
G
V
T
E
V
M
Y
E
G
V
N
V
G
D
K
D
F
S
A
L
I
S
K
M
K
E
A
G
V
S
I
I
Y
W
G
G
L
H
T
E
A
G
L
I
I
R
Q
A
A
D
Q
G
L
K
A
K
L
V
S
G
D
G
I
V
S
N
E
L
A
S
I
A
G
--
D
A
V
E
G
T
L
N
T
F
G
P
D
P
T
L
R
P
E
N
K
E
L
V
E
K
F
K
A
A
G
F
N
P
E
A
-
Y
T
L
Y
S
Y
A
A
M
Q
A
I
A
G
A
A
K
A
A
G
S
-
V
E
P
E
K
V
A
E
A
L
K
K
-
G
S
F
P
T
A
L
G
E
I
S
F
D
E
K
G
D
P
K
L
P
G
Y
V
M
Y
E
W
------------
11
PsiBlast_PDB
89.51
42%
-83
- C1 -
2LIV
-
LIVJ_ECOLI
A:
[2-338]
---------------------------
D
I
K
V
A
V
V
G
A
M
S
G
P
V
A
Q
Y
G
D
Q
E
F
T
G
A
E
Q
A
V
A
D
I
N
A
K
G
G
I
K
G
N
K
L
Q
I
A
K
Y
D
D
A
C
D
P
K
Q
A
V
A
V
A
N
K
V
V
N
-
D
G
I
K
Y
V
I
G
H
L
C
S
S
S
T
Q
P
A
S
D
I
Y
E
D
E
G
I
L
M
I
T
P
A
A
T
A
P
E
L
T
A
R
G
Y
Q
L
I
L
R
T
T
G
L
D
S
D
Q
G
P
T
A
A
K
Y
I
L
E
K
V
K
P
Q
R
I
A
I
V
H
D
K
Q
Q
Y
G
E
G
L
A
R
A
V
Q
D
G
L
K
K
G
N
A
N
V
V
F
F
D
G
I
T
A
G
E
K
D
F
S
T
L
V
A
R
L
K
K
E
N
I
D
F
V
Y
Y
G
G
Y
H
P
E
M
G
Q
I
L
R
Q
A
R
A
A
G
L
K
T
Q
F
M
G
P
E
G
V
A
N
V
S
L
S
N
I
A
G
--
E
S
A
E
G
L
L
V
T
K
P
K
N
Y
D
Q
V
P
A
N
K
P
I
V
D
A
I
K
A
K
K
Q
D
P
S
G
A
F
V
W
T
T
Y
A
A
L
Q
S
L
Q
A
G
L
N
--
Q
S
-
D
D
P
A
E
I
A
K
Y
L
K
A
-
N
S
V
D
T
V
M
G
P
L
T
W
D
E
K
G
D
L
K
G
F
E
F
G
V
F
D
W
H
A
--
N
G
------
26
PsiBlast_CBE
88.79
42%
-73
- C1 -
4N0Q
1
LIVB3_BRUME
C:
[10-347]
---------------------------
D
I
T
I
G
V
I
A
P
L
T
G
P
V
A
A
F
G
D
Q
V
K
K
G
A
E
T
A
V
E
V
I
N
K
A
G
G
I
K
G
E
K
V
V
L
K
F
A
D
D
A
G
E
P
K
Q
G
V
S
A
A
N
Q
I
V
G
-
D
G
I
K
F
V
V
G
L
V
T
T
G
V
A
V
P
V
S
D
V
L
S
E
N
G
V
L
M
V
T
P
T
A
T
G
P
D
L
T
A
R
G
L
E
N
V
F
R
T
C
G
R
D
G
Q
Q
A
E
V
M
A
D
Y
V
L
K
N
M
K
D
K
K
V
A
V
I
H
D
K
G
A
Y
G
K
G
L
A
D
A
F
K
A
A
I
N
K
G
G
I
T
E
V
H
Y
D
S
V
T
P
G
D
K
D
F
S
A
L
V
T
K
L
K
S
A
G
A
E
V
V
Y
F
G
G
Y
H
A
E
G
G
L
L
S
R
Q
L
H
D
A
G
M
Q
A
L
V
L
G
G
E
G
L
S
N
T
E
Y
W
A
I
G
G
--
T
N
A
Q
G
T
L
F
T
N
A
K
D
A
T
K
N
P
A
A
K
D
A
I
Q
A
L
K
A
K
N
I
P
A
E
A
-
F
T
M
N
A
Y
A
A
V
E
V
I
K
A
G
I
E
R
A
G
S
T
D
D
S
A
A
V
A
K
A
L
H
D
G
K
P
I
E
T
A
I
G
T
L
T
Y
S
E
T
G
D
L
S
S
P
S
F
D
I
F
K
W
D
D
----------
7
PsiBlast_PDB
88.68
42%
-80
- C1 -
1Z15
-
LIVJ_ECOLI
A:
[2-338]
---------------------------
D
I
K
V
A
V
V
G
A
M
S
G
P
V
A
Q
Y
G
D
Q
E
F
T
G
A
E
Q
A
V
A
D
I
N
A
K
G
G
I
K
G
N
K
L
Q
I
V
K
Y
D
D
A
C
D
P
K
Q
A
V
A
V
A
N
K
V
V
N
-
D
G
I
K
Y
V
I
G
H
L
C
S
S
S
T
Q
P
A
S
D
I
Y
E
D
E
G
I
L
M
I
T
P
A
A
T
A
P
E
L
T
A
R
G
Y
Q
L
I
L
R
T
T
G
L
D
S
D
Q
G
P
T
A
A
K
Y
I
L
E
K
V
K
P
Q
R
I
A
I
V
H
D
K
Q
Q
Y
G
E
G
L
A
R
A
V
Q
D
G
L
K
K
G
N
A
N
V
V
F
F
D
G
I
T
A
G
E
K
D
F
S
T
L
V
A
R
L
K
K
E
N
I
D
F
V
Y
Y
G
G
Y
H
P
E
M
G
Q
I
L
R
Q
A
R
A
A
G
L
K
T
Q
F
M
G
P
E
G
V
A
N
V
S
L
S
N
I
A
G
--
E
S
A
E
G
L
L
V
T
K
P
K
N
Y
D
Q
V
P
A
N
K
P
I
V
D
A
I
K
A
K
K
Q
D
P
S
G
A
F
V
W
T
T
Y
A
A
L
Q
S
L
Q
A
G
L
N
--
Q
S
-
D
D
P
A
E
I
A
K
Y
L
K
A
-
N
S
V
D
T
V
M
G
P
L
T
W
D
E
K
G
D
L
K
G
F
E
F
G
V
F
D
W
H
A
--
N
G
------
8
PsiBlast_PDB
88.20
42%
-72
- C1 -
1Z16
2
LIVJ_ECOLI
A:
[2-338]
---------------------------
D
I
K
V
A
V
V
G
A
M
S
G
P
V
A
Q
Y
G
D
Q
E
F
T
G
A
E
Q
A
V
A
D
I
N
A
K
G
G
I
K
G
N
K
L
Q
I
V
K
Y
D
D
A
C
D
P
K
Q
A
V
A
V
A
N
K
V
V
N
-
D
G
I
K
Y
V
I
G
H
L
C
S
S
S
T
Q
P
A
S
D
I
Y
E
D
E
G
I
L
M
I
T
P
A
A
T
A
P
E
L
T
A
R
G
Y
Q
L
I
L
R
T
T
G
L
D
S
D
Q
G
P
T
A
A
K
Y
I
L
E
K
V
K
P
Q
R
I
A
I
V
H
D
K
Q
Q
Y
G
E
G
L
A
R
A
V
Q
D
G
L
K
K
G
N
A
N
V
V
F
F
D
G
I
T
A
G
E
K
D
F
S
T
L
V
A
R
L
K
K
E
N
I
D
F
V
Y
Y
G
G
Y
H
P
E
M
G
Q
I
L
R
Q
A
R
A
A
G
L
K
T
Q
F
M
G
P
E
G
V
A
N
V
S
L
S
N
I
A
G
--
E
S
A
E
G
L
L
V
T
K
P
K
N
Y
D
Q
V
P
A
N
K
P
I
V
D
A
I
K
A
K
K
Q
D
P
S
G
A
F
V
W
T
T
Y
A
A
L
Q
S
L
Q
A
G
L
N
--
Q
S
-
D
D
P
A
E
I
A
K
Y
L
K
A
-
N
S
V
D
T
V
M
G
P
L
T
W
D
E
K
G
D
L
K
G
F
E
F
G
V
F
D
W
H
A
--
N
G
------
9
PsiBlast_PDB
88.14
42%
-73
- C1 -
1Z17
2
LIVJ_ECOLI
A:
[2-338]
---------------------------
D
I
K
V
A
V
V
G
A
M
S
G
P
V
A
Q
Y
G
D
Q
E
F
T
G
A
E
Q
A
V
A
D
I
N
A
K
G
G
I
K
G
N
K
L
Q
I
V
K
Y
D
D
A
C
D
P
K
Q
A
V
A
V
A
N
K
V
V
N
-
D
G
I
K
Y
V
I
G
H
L
C
S
S
S
T
Q
P
A
S
D
I
Y
E
D
E
G
I
L
M
I
T
P
A
A
T
A
P
E
L
T
A
R
G
Y
Q
L
I
L
R
T
T
G
L
D
S
D
Q
G
P
T
A
A
K
Y
I
L
E
K
V
K
P
Q
R
I
A
I
V
H
D
K
Q
Q
Y
G
E
G
L
A
R
A
V
Q
D
G
L
K
K
G
N
A
N
V
V
F
F
D
G
I
T
A
G
E
K
D
F
S
T
L
V
A
R
L
K
K
E
N
I
D
F
V
Y
Y
G
G
Y
H
P
E
M
G
Q
I
L
R
Q
A
R
A
A
G
L
K
T
Q
F
M
G
P
E
G
V
A
N
V
S
L
S
N
I
A
G
--
E
S
A
E
G
L
L
V
T
K
P
K
N
Y
D
Q
V
P
A
N
K
P
I
V
D
A
I
K
A
K
K
Q
D
P
S
G
A
F
V
W
T
T
Y
A
A
L
Q
S
L
Q
A
G
L
N
--
Q
S
-
D
D
P
A
E
I
A
K
Y
L
K
A
-
N
S
V
D
T
V
M
G
P
L
T
W
D
E
K
G
D
L
K
G
F
E
F
G
V
F
D
W
H
A
--
N
G
------
15
PsiBlast_PDB
88.13
42%
-71
- C1 -
4N0Q
1
LIVB3_BRUME
A:
[10-347]
---------------------------
D
I
T
I
G
V
I
A
P
L
T
G
P
V
A
A
F
G
D
Q
V
K
K
G
A
E
T
A
V
E
V
I
N
K
A
G
G
I
K
G
E
K
V
V
L
K
F
A
D
D
A
G
E
P
K
Q
G
V
S
A
A
N
Q
I
V
G
-
D
G
I
K
F
V
V
G
L
V
T
T
G
V
A
V
P
V
S
D
V
L
S
E
N
G
V
L
M
V
T
P
T
A
T
G
P
D
L
T
A
R
G
L
E
N
V
F
R
T
C
G
R
D
G
Q
Q
A
E
V
M
A
D
Y
V
L
K
N
M
K
D
K
K
V
A
V
I
H
D
K
G
A
Y
G
K
G
L
A
D
A
F
K
A
A
I
N
K
G
G
I
T
E
V
H
Y
D
S
V
T
P
G
D
K
D
F
S
A
L
V
T
K
L
K
S
A
G
A
E
V
V
Y
F
G
G
Y
H
A
E
G
G
L
L
S
R
Q
L
H
D
A
G
M
Q
A
L
V
L
G
G
E
G
L
S
N
T
E
Y
W
A
I
G
G
--
T
N
A
Q
G
T
L
F
T
N
A
K
D
A
T
K
N
P
A
A
K
D
A
I
Q
A
L
K
A
K
N
I
P
A
E
A
-
F
T
M
N
A
Y
A
A
V
E
V
I
K
A
G
I
E
R
A
G
S
T
D
D
S
A
A
V
A
K
A
L
H
D
G
K
P
I
E
T
A
I
G
T
L
T
Y
S
E
T
G
D
L
S
S
P
S
F
D
I
F
K
W
D
D
----------
27
PsiBlast_CBE
88.06
42%
-70
- C1 -
4N0Q
1
LIVB3_BRUME
B:
[9-347]
--------------------------
A
D
I
T
I
G
V
I
A
P
L
T
G
P
V
A
A
F
G
D
Q
V
K
K
G
A
E
T
A
V
E
V
I
N
K
A
G
G
I
K
G
E
K
V
V
L
K
F
A
D
D
A
G
E
P
K
Q
G
V
S
A
A
N
Q
I
V
G
-
D
G
I
K
F
V
V
G
L
V
T
T
G
V
A
V
P
V
S
D
V
L
S
E
N
G
V
L
M
V
T
P
T
A
T
G
P
D
L
T
A
R
G
L
E
N
V
F
R
T
C
G
R
D
G
Q
Q
A
E
V
M
A
D
Y
V
L
K
N
M
K
D
K
K
V
A
V
I
H
D
K
G
A
Y
G
K
G
L
A
D
A
F
K
A
A
I
N
K
G
G
I
T
E
V
H
Y
D
S
V
T
P
G
D
K
D
F
S
A
L
V
T
K
L
K
S
A
G
A
E
V
V
Y
F
G
G
Y
H
A
E
G
G
L
L
S
R
Q
L
H
D
A
G
M
Q
A
L
V
L
G
G
E
G
L
S
N
T
E
Y
W
A
I
G
G
--
T
N
A
Q
G
T
L
F
T
N
A
K
D
A
T
K
N
P
A
A
K
D
A
I
Q
A
L
K
A
K
N
I
P
A
E
A
-
F
T
M
N
A
Y
A
A
V
E
V
I
K
A
G
I
E
R
A
G
S
T
D
D
S
A
A
V
A
K
A
L
H
D
G
K
P
I
E
T
A
I
G
T
L
T
Y
S
E
T
G
D
L
S
S
P
S
F
D
I
F
K
W
D
D
----------
21
PsiBlast_CBE
87.90
41%
-75
- C1 -
1USK
1
LIVK_ECOLI
D:
[2-336]
---------------------------
D
I
K
V
A
V
V
G
A
M
S
G
P
I
A
Q
W
G
D
M
E
F
N
G
A
R
Q
A
I
K
D
I
N
A
K
G
G
I
K
G
D
K
L
V
G
V
E
Y
D
D
A
C
D
P
K
Q
A
V
A
V
A
N
K
I
V
N
-
D
G
I
K
Y
V
I
G
H
L
C
S
S
S
T
Q
P
A
S
D
I
Y
E
D
E
G
I
L
M
I
S
P
G
A
T
N
P
E
L
T
Q
R
G
Y
Q
H
I
M
R
T
A
G
L
D
S
S
Q
G
P
T
A
A
K
Y
I
L
E
T
V
K
P
Q
R
I
A
I
I
H
D
K
Q
Q
Y
G
E
G
L
A
R
S
V
Q
D
G
L
K
A
A
N
A
N
V
V
F
F
D
G
I
T
A
G
E
K
D
F
S
A
L
I
A
R
L
K
K
E
N
I
D
F
V
Y
Y
G
G
Y
Y
P
E
M
G
Q
M
L
R
Q
A
R
S
V
G
L
K
T
Q
F
M
G
P
E
G
V
G
N
A
S
L
S
N
I
A
G
--
D
A
A
E
G
M
L
V
T
M
P
K
R
Y
D
Q
D
P
A
N
Q
G
I
V
D
A
L
K
A
D
K
K
D
P
S
G
P
Y
V
W
I
T
Y
A
A
V
Q
S
L
A
T
A
L
E
R
T
G
S
-
D
E
P
L
A
L
V
K
D
L
K
A
-
N
G
A
N
T
V
I
G
P
L
N
W
D
E
K
G
D
L
K
G
F
D
F
G
V
F
Q
W
------------
14
PsiBlast_PDB
87.68
41%
-74
- C1 -
1USI
1
LIVK_ECOLI
A:
[2-336]
---------------------------
D
I
K
V
A
V
V
G
A
M
S
G
P
I
A
Q
W
G
D
M
E
F
N
G
A
R
Q
A
I
K
D
I
N
A
K
G
G
I
K
G
D
K
L
V
G
V
E
Y
D
D
A
C
D
P
K
Q
A
V
A
V
A
N
K
I
V
N
-
D
G
I
K
Y
V
I
G
H
L
C
S
S
S
T
Q
P
A
S
D
I
Y
E
D
E
G
I
L
M
I
S
P
G
A
T
N
P
E
L
T
Q
R
G
Y
Q
H
I
M
R
T
A
G
L
D
S
S
Q
G
P
T
A
A
K
Y
I
L
E
T
V
K
P
Q
R
I
A
I
I
H
D
K
Q
Q
Y
G
E
G
L
A
R
S
V
Q
D
G
L
K
A
A
N
A
N
V
V
F
F
D
G
I
T
A
G
E
K
D
F
S
A
L
I
A
R
L
K
K
E
N
I
D
F
V
Y
Y
G
G
Y
Y
P
E
M
G
Q
M
L
R
Q
A
R
S
V
G
L
K
T
Q
F
M
G
P
E
G
V
G
N
A
S
L
S
N
I
A
G
--
D
A
A
E
G
M
L
V
T
M
P
K
R
Y
D
Q
D
P
A
N
Q
G
I
V
D
A
L
K
A
D
K
K
D
P
S
G
P
Y
V
W
I
T
Y
A
A
V
Q
S
L
A
T
A
L
E
R
T
G
S
-
D
E
P
L
A
L
V
K
D
L
K
A
-
N
G
A
N
T
V
I
G
P
L
N
W
D
E
K
G
D
L
K
G
F
D
F
G
V
F
Q
W
------------
25
PsiBlast_CBE
87.58
42%
-74
- C1 -
4N0Q
1
LIVB3_BRUME
D:
[10-347]
---------------------------
D
I
T
I
G
V
I
A
P
L
T
G
P
V
A
A
F
G
D
Q
V
K
K
G
A
E
T
A
V
E
V
I
N
K
A
G
G
I
K
G
E
K
V
V
L
K
F
A
D
D
A
G
E
P
K
Q
G
V
S
A
A
N
Q
I
V
G
-
D
G
I
K
F
V
V
G
L
V
T
T
G
V
A
V
P
V
S
D
V
L
S
E
N
G
V
L
M
V
T
P
T
A
T
G
P
D
L
T
A
R
G
L
E
N
V
F
R
T
C
G
R
D
G
Q
Q
A
E
V
M
A
D
Y
V
L
K
N
M
K
D
K
K
V
A
V
I
H
D
K
G
A
Y
G
K
G
L
A
D
A
F
K
A
A
I
N
K
G
G
I
T
E
V
H
Y
D
S
V
T
P
G
D
K
D
F
S
A
L
V
T
K
L
K
S
A
G
A
E
V
V
Y
F
G
G
Y
H
A
E
G
G
L
L
S
R
Q
L
H
D
A
G
M
Q
A
L
V
L
G
G
E
G
L
S
N
T
E
Y
W
A
I
G
G
--
T
N
A
Q
G
T
L
F
T
N
A
K
D
A
T
K
N
P
A
A
K
D
A
I
Q
A
L
K
A
K
N
I
P
A
E
A
-
F
T
M
N
A
Y
A
A
V
E
V
I
K
A
G
I
E
R
A
G
S
T
D
D
S
A
A
V
A
K
A
L
H
D
G
K
P
I
E
T
A
I
G
T
L
T
Y
S
E
T
G
D
L
S
S
P
S
F
D
I
F
K
W
D
D
----------
22
PsiBlast_CBE
87.58
41%
-74
- C1 -
1USK
1
LIVK_ECOLI
C:
[2-336]
---------------------------
D
I
K
V
A
V
V
G
A
M
S
G
P
I
A
Q
W
G
D
M
E
F
N
G
A
R
Q
A
I
K
D
I
N
A
K
G
G
I
K
G
D
K
L
V
G
V
E
Y
D
D
A
C
D
P
K
Q
A
V
A
V
A
N
K
I
V
N
-
D
G
I
K
Y
V
I
G
H
L
C
S
S
S
T
Q
P
A
S
D
I
Y
E
D
E
G
I
L
M
I
S
P
G
A
T
N
P
E
L
T
Q
R
G
Y
Q
H
I
M
R
T
A
G
L
D
S
S
Q
G
P
T
A
A
K
Y
I
L
E
T
V
K
P
Q
R
I
A
I
I
H
D
K
Q
Q
Y
G
E
G
L
A
R
S
V
Q
D
G
L
K
A
A
N
A
N
V
V
F
F
D
G
I
T
A
G
E
K
D
F
S
A
L
I
A
R
L
K
K
E
N
I
D
F
V
Y
Y
G
G
Y
Y
P
E
M
G
Q
M
L
R
Q
A
R
S
V
G
L
K
T
Q
F
M
G
P
E
G
V
G
N
A
S
L
S
N
I
A
G
--
D
A
A
E
G
M
L
V
T
M
P
K
R
Y
D
Q
D
P
A
N
Q
G
I
V
D
A
L
K
A
D
K
K
D
P
S
G
P
Y
V
W
I
T
Y
A
A
V
Q
S
L
A
T
A
L
E
R
T
G
S
-
D
E
P
L
A
L
V
K
D
L
K
A
-
N
G
A
N
T
V
I
G
P
L
N
W
D
E
K
G
D
L
K
G
F
D
F
G
V
F
Q
W
------------
13
PsiBlast_PDB
87.58
41%
-73
- C1 -
1USK
1
LIVK_ECOLI
A:
[2-336]
---------------------------
D
I
K
V
A
V
V
G
A
M
S
G
P
I
A
Q
W
G
D
M
E
F
N
G
A
R
Q
A
I
K
D
I
N
A
K
G
G
I
K
G
D
K
L
V
G
V
E
Y
D
D
A
C
D
P
K
Q
A
V
A
V
A
N
K
I
V
N
-
D
G
I
K
Y
V
I
G
H
L
C
S
S
S
T
Q
P
A
S
D
I
Y
E
D
E
G
I
L
M
I
S
P
G
A
T
N
P
E
L
T
Q
R
G
Y
Q
H
I
M
R
T
A
G
L
D
S
S
Q
G
P
T
A
A
K
Y
I
L
E
T
V
K
P
Q
R
I
A
I
I
H
D
K
Q
Q
Y
G
E
G
L
A
R
S
V
Q
D
G
L
K
A
A
N
A
N
V
V
F
F
D
G
I
T
A
G
E
K
D
F
S
A
L
I
A
R
L
K
K
E
N
I
D
F
V
Y
Y
G
G
Y
Y
P
E
M
G
Q
M
L
R
Q
A
R
S
V
G
L
K
T
Q
F
M
G
P
E
G
V
G
N
A
S
L
S
N
I
A
G
--
D
A
A
E
G
M
L
V
T
M
P
K
R
Y
D
Q
D
P
A
N
Q
G
I
V
D
A
L
K
A
D
K
K
D
P
S
G
P
Y
V
W
I
T
Y
A
A
V
Q
S
L
A
T
A
L
E
R
T
G
S
-
D
E
P
L
A
L
V
K
D
L
K
A
-
N
G
A
N
T
V
I
G
P
L
N
W
D
E
K
G
D
L
K
G
F
D
F
G
V
F
Q
W
------------
24
PsiBlast_CBE
87.33
41%
-74
- C1 -
1USI
1
LIVK_ECOLI
C:
[2-336]
---------------------------
D
I
K
V
A
V
V
G
A
M
S
G
P
I
A
Q
W
G
D
M
E
F
N
G
A
R
Q
A
I
K
D
I
N
A
K
G
G
I
K
G
D
K
L
V
G
V
E
Y
D
D
A
C
D
P
K
Q
A
V
A
V
A
N
K
I
V
N
-
D
G
I
K
Y
V
I
G
H
L
C
S
S
S
T
Q
P
A
S
D
I
Y
E
D
E
G
I
L
M
I
S
P
G
A
T
N
P
E
L
T
Q
R
G
Y
Q
H
I
M
R
T
A
G
L
D
S
S
Q
G
P
T
A
A
K
Y
I
L
E
T
V
K
P
Q
R
I
A
I
I
H
D
K
Q
Q
Y
G
E
G
L
A
R
S
V
Q
D
G
L
K
A
A
N
A
N
V
V
F
F
D
G
I
T
A
G
E
K
D
F
S
A
L
I
A
R
L
K
K
E
N
I
D
F
V
Y
Y
G
G
Y
Y
P
E
M
G
Q
M
L
R
Q
A
R
S
V
G
L
K
T
Q
F
M
G
P
E
G
V
G
N
A
S
L
S
N
I
A
G
--
D
A
A
E
G
M
L
V
T
M
P
K
R
Y
D
Q
D
P
A
N
Q
G
I
V
D
A
L
K
A
D
K
K
D
P
S
G
P
Y
V
W
I
T
Y
A
A
V
Q
S
L
A
T
A
L
E
R
T
G
S
-
D
E
P
L
A
L
V
K
D
L
K
A
-
N
G
A
N
T
V
I
G
P
L
N
W
D
E
K
G
D
L
K
G
F
D
F
G
V
F
Q
W
------------
10
PsiBlast_PDB
86.56
42%
-69
- C1 -
1Z18
4
LIVJ_ECOLI
A:
[2-338]
---------------------------
D
I
K
V
A
V
V
G
A
M
S
G
P
V
A
Q
Y
G
D
Q
E
F
T
G
A
E
Q
A
V
A
D
I
N
A
K
G
G
I
K
G
N
K
L
Q
I
V
K
Y
D
D
A
C
D
P
K
Q
A
V
A
V
A
N
K
V
V
N
-
D
G
I
K
Y
V
I
G
H
L
C
S
S
S
T
Q
P
A
S
D
I
Y
E
D
E
G
I
L
M
I
T
P
A
A
T
A
P
E
L
T
A
R
G
Y
Q
L
I
L
R
T
T
G
L
D
S
D
Q
G
P
T
A
A
K
Y
I
L
E
K
V
K
P
Q
R
I
A
I
V
H
D
K
Q
Q
Y
G
E
G
L
A
R
A
V
Q
D
G
L
K
K
G
N
A
N
V
V
F
F
D
G
I
T
A
G
E
K
D
F
S
T
L
V
A
R
L
K
K
E
N
I
D
F
V
Y
Y
G
G
Y
H
P
E
M
G
Q
I
L
R
Q
A
R
A
A
G
L
K
T
Q
F
M
G
P
E
G
V
A
N
V
S
L
S
N
I
A
G
--
E
S
A
E
G
L
L
V
T
K
P
K
N
Y
D
Q
V
P
A
N
K
P
I
V
D
A
I
K
A
K
K
Q
D
P
S
G
A
F
V
W
T
T
Y
A
A
L
Q
S
L
Q
A
G
L
N
--
Q
S
-
D
D
P
A
E
I
A
K
Y
L
K
A
-
N
S
V
D
T
V
M
G
P
L
T
W
D
E
K
G
D
L
K
G
F
E
F
G
V
F
D
W
H
A
--
N
G
------