@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4946: (2016-03-02 )
MSEAPRIQLLSPRLANQIAAGEVVERPASVAKELLENSLDAGSRRIDVEVEQGGIKLLRVRDDGRGIPADDLPLALARHATSKIRELEDLERVMSLGFRGEALASISSVARLTMTSRTADAGEAWQVETEGRDMQPRVQPAAHPVGTSVEVRDLFFNTPARRKFLRAEKTEFDHLQEVIKRLALARFDVAFHLRHNGKTIFALHEARDELARARRVGAVCGQAFLEQALPIEVERNGLHLWGWVGLPTFSRSQPDLQYFYVNGRMVRDKLVAHAVRQAYRDVLYNGRHPTFVLFFEVDPAVVDVNVHPTKHEVRFRDSRMVHDFLYGTLHRALGEVRPDDQLAPPGATSLTEPRPTGAAAGEFGPQGEMRLAESVLESPAARVGWSGGSSASGGSSGYSAYTRPEAPPSLAEAGGAYKAYFAPLPAGEAPAALPESAQDIPPLGYALAQLKGIYILAENAHGLVLVDMHAAHERITYERLKVAMASEGLRGQPLLVPESIAVSEREADCAEEHSSWFQRLGFELQRLGPESLAIRQIPALLKQAEATQLVRDVIADLLEYGTSDRIQAHLNELLGTMACHGAVRANRRLTLPEMNALLRDMEITERSGQCNHGRPTWTQLGLDELDKLFLRGR
Atome Classification :
(20 SA)
-.........10........20.-..---.....30........40........50........60........70......-..80........90---........100.......110.......120-........130----....-....140.......150.......160.-...-.-..170.......180..----.....190--......-----..200.......210.......220...------....230-----------------..------------.-..-----...240......--.--250-.-........260.......270.......280...-....290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480...-...-.490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MSEAP
R
I
Q
L
L
S
P
R
L
A
N
Q
IAA
G
E
-
V
V
---E
R
P
A
S
V
A
K
E
L
L
E
N
SLDAGS
R
R
I
D
V
E
V
EQG
G
I
K
L
L
R
VRDDGRGIPA
D
D
L
P
L
A
L
A
-
R
H
A
T
S
K
I
R
E
L
E
D
L
E
---
R
V
M
SLGFR
G
E
A
L
A
S
I
S
S
V
A
R
L
T
M
TSRTADA--G
E
A
W
Q
V
ETEG-----RDMQ-PRVQPAAHPVGT
S
V
E
V
R
D
LFFN
T
P
A
R
R
K
-
F
L
R
-A-EKT
E
F
D
H
L
Q
E
V
I
K
R
L
A
L
----
A
R
F
D
V
A
F
---
H
L
RHN
G
-----
K
T
I
F
A
L
H
E
A
R
D
E
L
A
R
A
R
R
V
G
A
V
C
G
Q
A
F
L
------
E
QAL
P
I
------------------
E
V
------------E-RN-----
G
L
H
L
W
G
WVGLPT--F--S---R-SQPD
L
Q
Y
F
Y
VNG
R
M
V
R
D
K
L
V
A
H
A
V
R
Q
A
Y
R
D
V
LYN-GRH
P
T
F
V
L
F
F
EVDP
A
V
V
D
V
NVHPTK
H
E
V
R
FR
D
S
R
M
V
H
D
F
L
Y
G
T
L
H
R
A
L
GEVRPDDQLAPPGATSLTEPRPTGAAAGEFGPQ
G
E
M
R
L
A
E
S
V
L
ES
P
A
A
RVGWSGGSSASGGSSGYSAYTRPEAPP
S
L
A
EAGGA
Y
K
A
Y
F
APLPAGEAPAALPESAQDIP
P
L
G
Y
A
L
A
QL
K
G
I
Y
I
L
AENAH
G
L
V
L
V
DMHA
A
H
E
R
I
T
Y
E
R
L
K
V
A
M
A-SEG-LRGQPLLVPESIAV
S
E
RE
A
D
C
A
E
E
H
S
S
W
F
Q
R
L
G
F
E
L
Q
RLGP
E
S
L
A
I
R
Q
I
P
A
L
L
K
Q
A
E
A
T
Q
L
V
R
D
V
I
A
D
L
L
EYGT
S
D
R
I
Q
A
H
L
N
E
L
L
G
T
M
A
CHGAVRANRRLT
L
P
E
M
N
A
L
L
R
D
M
EITERSGQCNHGRP
T
W
T
QL
G
L
D
E
L
D
K
L
F
LRGR
59
Fugue
93.82
62%
-100
- C1 -
1B63
4
MUTL_ECOLI
A:
[1-333]
---
S
H
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
-
E
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
-
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
--
Q
E
A
W
Q
A
Y
A
E
G
-----
R
D
M
N
V
-
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
--
R
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
----
A
R
F
D
V
T
I
---
N
L
S
H
N
-G----
K
I
V
R
Q
Y
R
A
V
P
E
G
G
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
------
E
Q
A
L
A
I
------------------
E
W
------------
Q
H
-
G
-----
D
L
T
L
R
G
W
V
A
D
P
N
------HTT
P
-
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
-
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
93.13
62%
-97
- C1 -
1B63
4
MUTL_ECOLI
A:
[1-333]
---
S
H
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
-
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
--
Q
E
A
W
Q
A
Y
A
E
G
-----
R
D
M
N
-
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
----
A
R
F
D
V
T
I
---
N
L
S
H
N
G
-----
K
I
V
R
Q
Y
R
A
V
P
E
G
G
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
------
E
Q
A
L
A
I
------------------
E
W
------------
Q
-
H
G
-----
D
L
T
L
R
G
W
V
A
D
P
N
--
H
T-
T
---
P
-
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
-
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.48
63%
-94
- C1 -
1NHI
5
MUTL_ECOLI
A:
[5-325]
-------
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
-
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
--
Q
E
A
W
Q
A
Y
A
E
G
-----
R
D
M
N
-
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
----
A
R
F
D
V
T
I
---
N
L
S
H
N
G
-----
K
I
V
R
Q
Y
R
A
V
P
E
G
G
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
------
E
Q
A
L
A
I
------------------
E
W
------------
Q
-
H
G
-----
D
L
T
L
R
G
W
V
A
D
P
N
--
H
--
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
-
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.27
63%
-91
- C1 -
1B63
4
MUTL_ECOLI
A:
[5-325]
-------
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
-
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
--
Q
E
A
W
Q
A
Y
A
E
G
-----
R
D
M
N
-
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
----
A
R
F
D
V
T
I
---
N
L
S
H
N
G
-----
K
I
V
R
Q
Y
R
A
V
P
E
G
G
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
------
E
Q
A
L
A
I
------------------
E
W
------------
Q
-
H
G
-----
D
L
T
L
R
G
W
V
A
D
P
N
--
H
--
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
-
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.94
63%
-95
- C1 -
1NHH
8
MUTL_ECOLI
A:
[5-325]
-------
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
-
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
--
Q
E
A
W
Q
A
Y
A
E
G
-----
R
D
M
N
-
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
----
A
R
F
D
V
T
I
---
N
L
S
H
N
G
-----
K
I
V
R
Q
Y
R
A
V
P
---
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
------
E
Q
A
L
A
I
------------------
E
W
------------
Q
-
H
G
-----
D
L
T
L
R
G
W
V
A
D
P
N
--
H
--
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
---
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.64
63%
-93
- C1 -
1NHJ
3
MUTL_ECOLI
A:
[5-325]
-------
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
-
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
P
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
--
Q
E
A
W
Q
A
Y
A
E
G
-----
R
D
M
N
-
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
----
A
R
F
D
V
T
I
---
N
L
S
H
N
G
-----
K
I
V
R
Q
Y
R
A
V
P
E
G
G
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
------
E
Q
A
L
A
I
------------------
E
W
------------
Q
-
H
G
-----
D
L
T
L
R
G
W
V
A
D
P
N
--
H
--
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
-
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.48
63%
-81
- C- -
1B62
2
MUTL_ECOLI
A:
[9-329]
-------
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
-
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
--
Q
E
A
W
Q
A
Y
A
E
G
-----
R
D
M
N
-
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
----
A
R
F
D
V
T
I
---
N
L
S
H
N
G
-----
K
I
V
R
Q
Y
R
A
V
P
E
G
G
Q
K
E
R
R
L
G
A
I
C
G
T
A
F
L
------
E
Q
A
L
A
I
------------------
E
W
------------
Q
-
H
G
-----
D
L
T
L
R
G
W
V
A
D
P
N
--
H
--
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
-
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
-
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
72.24
25%
-86
* C1 *
3H4L
2
PMS1_YEAST
A:
[13-363]
--------------
D
V
H
R
I
T
S
G
Q
-
V
I
---
T
D
L
T
T
A
V
K
E
L
V
D
N
S
I
D
A
N
A
N
Q
I
E
I
I
F
K
D
Y
G
L
E
S
I
E
C
S
D
N
G
D
G
I
D
P
S
N
Y
E
F
L
A
L
-
K
H
Y
T
---------
A
---
K
V
Q
T
L
G
F
R
G
E
A
L
S
S
L
C
G
I
A
K
L
S
V
I
T
T
T
S
P
---
P
K
A
D
K
L
E
Y
D
M
-----
V
G
H
I
-
T
S
K
T
T
T
S
R
N
K
G
T
T
V
L
V
S
Q
L
F
H
N
L
P
V
R
Q
K
-
E
F
S
K
T
-
F
K
R
Q
F
T
K
C
L
T
V
I
Q
G
Y
A
I
----
I
N
A
A
I
K
F
---
S
V
W
N
I
T
PK
G
K
K
N
L
I
L
S
T
M
R
N
S
---
S
M
R
K
N
I
S
S
V
F
G
A
G
G
M
------
R
G
L
E
E
V
------------------
D
L
V
L
D
LNPFKNRML--
D
Y
-----
K
I
R
V
K
G
Y
I
S
Q
N
S
--
F
GC
G
---
R
-
N
S
K
D
R
Q
F
I
Y
V
N
K
R
P
V
E
Y
S
T
L
L
K
C
C
N
E
V
Y
K
T
F
-
N
N
-
V
Q
F
P
A
V
F
L
N
L
E
L
P
M
S
L
I
D
V
N
V
T
P
D
K
R
V
I
L
L
H
N
E
R
A
V
I
D
I
F
K
T
T
L
S
D
Y
Y
N
R
Q
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.44
28%
-97
- C1 -
1H7U
2
PMS2_HUMAN
A:
[31-359]
------------------------
V
V
---
L
S
L
S
T
A
V
K
E
L
V
E
N
S
L
D
A
G
A
T
N
I
D
L
K
L
K
D
Y
G
V
D
L
I
E
V
S
D
N
G
C
G
V
E
E
E
N
F
E
G
L
T
L
-
K
------------------------
G
E
A
L
S
S
L
C
A
L
S
D
V
T
I
S
T
C
H
A
S
A
K
V
G
T
R
L
M
F
D
H
N
G
-----
K
I
I
Q
-
K
--
T
P
Y
P
R
P
R
G
T
T
V
S
V
Q
Q
L
F
S
T
L
P
V
R
H
K
E
F
Q
R
-
N
-
I
K
K
E
Y
A
K
M
V
Q
V
L
H
A
Y
C
I
I
SAG
I
R
V
S
C
T
N
---
Q
L
G
Q
G
K
-----
R
Q
P
V
V
C
T
G
G
S
P
S
I
--
K
E
N
I
G
S
V
F
G
Q
K
Q
L
------
Q
S
L
I
P
F
V
Q
L
P
PS
D
S
V
C
E
E
Y
GLSCS
D
A
------------
L
-
H
N
-----
L
F
Y
I
S
G
F
I
S
Q
C
T
HG
V
--
G
---
R
-
S
S
T
D
R
Q
F
F
F
I
N
R
R
P
C
D
P
A
K
V
C
R
L
V
N
E
V
Y
H
--
M
Y
N
R
H
Q
Y
P
F
V
V
L
N
I
S
V
D
S
E
C
V
D
I
N
------
Q
I
L
L
Q
E
E
K
L
L
L
A
V
L
K
T
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.11
26%
-79
- C1 -
3H4L
2
PMS1_YEAST
A:
[16-354]
-----------------
R
I
T
S
G
Q
-
V
I
---
T
D
L
T
T
A
V
K
E
L
V
D
N
S
I
D
A
N
A
N
Q
I
E
I
I
F
K
D
Y
G
L
E
S
I
E
C
S
D
N
G
D
G
I
D
P
S
N
Y
E
F
L
A
L
-
K
H
Y
T
---------
A
---
K
V
Q
T
L
G
F
R
G
E
A
L
S
S
L
C
G
I
A
K
L
S
V
I
T
T
T
S
-
P
--
P
K
A
D
K
L
E
Y
D
M
-----
V
G
H
I
-
T
S
K
T
T
T
S
R
N
K
G
T
T
V
L
V
S
Q
L
F
H
N
L
P
V
R
Q
K
E
F
S
K
-
T
-
F
K
R
Q
F
T
K
C
L
T
V
I
Q
G
Y
A
I
----
I
N
A
A
I
K
F
S
V
W
N
I
T
P
K
G
-----
K
K
N
L
I
L
S
T
M
R
N
S
S
M
R
-
K
N
I
S
S
V
F
G
A
G
G
M
RG
L
E
E
V
D
L
V
L
D
L
------------------
N
P
------------
F
-
K
N
RMLDY
K
I
R
V
K
G
Y
I
S
Q
N
S
--
F
GC
G
---
R
-
N
S
K
D
R
Q
F
I
Y
V
N
K
R
P
V
E
Y
S
T
L
L
K
C
C
N
E
V
Y
K
-
T
F
N
N
-
V
Q
F
P
A
V
F
L
N
L
E
L
P
M
S
L
I
D
V
N
V
T
P
D
K
R
V
I
L
L
H
N
E
R
A
V
I
D
I
F
K
T
T
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
67.01
66%
-58
- C1 -
1B63
4
MUTL_ECOLI
A:
[3-218]
-----
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
-
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
--
Q
E
A
W
Q
A
Y
A
E
G
-----
R
D
M
N
-
V
T
V
K
P
A
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
----
A
R
F
D
V
T
I
---
N
L
S
H
N
G
-----
K
I
V
R
Q
Y
R
A
V
P
E
G
G
Q
K
E
R
R
L
G
A
I
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
64.96
65%
-48
- C1 -
1B63
4
MUTL_ECOLI
A:
[1-204]
S
H
M
P
I
Q
---
V
L
P
P
Q
L
A
N
Q
I
A
A
G
----
E
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
-A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
II---
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
--
Q
E
A
W
Q
A
Y
A
E
G
RDM
N
V
T
-
V
K
-
P
A
-
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-R
T
-
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
----
A
R
F
D
V
T
I
---
N
L
S
H
N
G
-----
K
I
V
R
Q
Y
R
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.35
28%
-94
- C1 -
1EA6
2
PMS2_HUMAN
A:
[27-359]
-------------------
C
S
G
Q
-
V
V
---
L
S
L
S
T
A
V
K
E
L
V
E
N
S
L
D
A
G
A
T
N
I
D
L
K
L
K
D
Y
G
V
D
L
I
E
V
S
D
N
G
C
G
V
E
E
E
N
F
E
G
L
T
L
---------------------------
E
A
L
S
S
L
C
A
L
S
D
V
T
I
S
T
C
H
A
S
A
K
V
G
T
R
L
M
F
D
H
N
G
-----
K
I
I
Q
-
K
--
T
P
Y
P
R
P
R
G
T
T
V
S
V
Q
Q
L
F
S
T
L
P
V
R
H
K
E
F
Q
R
-
N
-
I
K
K
E
Y
A
K
M
V
Q
V
L
H
A
Y
C
I
I
SAG
I
R
V
S
C
T
N
---
Q
L
G
Q
G
K
-----
R
Q
P
V
V
C
T
G
G
S
P
S
I
--
K
E
N
I
G
S
V
F
G
Q
K
Q
L
------
Q
S
L
I
P
F
V
Q
L
PPS
D
S
V
C
E
E
Y
GLSCS
D
A
------------
L
-
H
N
-----
L
F
Y
I
S
G
F
I
S
Q
C
T
HG
V
--
G
---
R
-
S
S
T
D
R
Q
F
F
F
I
N
R
R
P
C
D
P
A
K
V
C
R
L
V
N
E
V
Y
H
--
M
Y
N
R
H
Q
Y
P
F
V
V
L
N
I
S
V
D
S
E
C
V
-----------
L
L
Q
E
E
K
L
L
L
A
V
L
K
T
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
56.80
51%
-89
- C2 -
3NCV
-
MUTL_NEIG1
A:
[463-654]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
P
L
G
F
A
I
A
Q
L
L
G
I
Y
I
L
A
Q
A
E
D
S
L
L
L
I
D
M
H
A
A
A
E
R
V
N
Y
E
K
M
K
R
Q
R
Q
-
E
N
G
N
L
Q
S
Q
H
L
L
I
P
V
T
F
A
A
S
H
E
E
C
A
A
L
A
D
H
A
E
T
L
A
G
F
G
L
E
L
S
D
M
G
G
N
T
L
A
V
R
A
A
P
V
M
L
G
K
S
D
V
V
S
L
A
R
D
V
L
G
E
L
A
Q
V
G
-----
A
S
H
E
N
R
I
L
A
T
M
S
C
H
G
S
I
R
A
G
R
R
L
T
L
P
E
M
N
A
L
L
R
D
M
E
N
T
P
R
S
N
Q
C
N
H
G
R
P
T
W
V
K
L
T
L
K
E
L
D
T
L
F
----
64
Fugue
56.06
54%
-123
- C1 -
1B63
3
MUTL_ECOLI
A:
[219-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
F
L
------
E
Q
A
L
A
I
------------------
E
W
------------
Q
-
H
G
-----
D
L
T
L
R
G
W
V
A
D
P
N
--
H
--
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
-
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
55.46
51%
-89
- C2 -
3NCV
-
MUTL_NEIG1
A:
[463-654]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
P
L
G
F
A
I
A
Q
L
L
G
I
Y
I
L
A
Q
A
E
D
S
L
L
L
I
D
M
H
A
A
A
E
R
V
N
Y
E
K
M
K
R
Q
R
Q
E
N
G
N
-
L
Q
S
Q
H
L
L
I
P
V
T
F
A
A
S
H
E
E
C
A
A
L
A
D
H
A
E
T
L
A
G
F
G
L
E
L
S
D
M
G
G
N
T
L
A
V
R
A
A
P
V
M
L
G
K
S
D
V
V
S
L
A
R
D
V
L
G
E
L
A
Q
V
G
-----
A
S
H
E
N
R
I
L
A
T
M
S
C
H
G
S
I
R
A
G
R
R
L
T
L
P
E
M
N
A
L
L
R
D
M
E
N
T
P
R
S
N
Q
C
N
H
G
R
P
T
W
V
K
L
T
L
K
E
L
D
T
L
F
----
66
Fugue
53.40
46%
-103
- C1 -
1B63
3
MUTL_ECOLI
A:
[219-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
F
L
E
Q
A
L
A
I
E
W
Q
H
-------------------------------------------------------
G
-----
D
L
T
L
R
G
W
V
A
D
P
N
---HT
T
---
P
-
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
-
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
52.32
33%
-75
- C2 -
3KDG
-
MUTL_BACSU
A:
[433-625]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
-
E
V
E
-
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
-
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
G
----
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
R
--
60
Fugue
52.10
33%
-74
* C2 *
3KDG
-
MUTL_BACSU
A:
[433-627]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
-
E
V
E
-
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
-
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
G
----
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
R
V
M
11
PsiBlast_PDB
52.05
33%
-79
- C2 -
3GAB
-
MUTL_BACSU
A:
[435-624]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
-
E
---
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
-
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
-----
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
---