@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4949: (2016-03-02 )
MTMTFQHDDLPLALYSAAQVRDLDARLIAAGTPGFELMQRAAHAAWRALRRRWPEAAALTVLAGHGNNAGDGYLIAALAQRAGWRVRVLAVAAPQRLAGDAAQAHAAALATGVVVEPWSECAVLEGVVVDALLGTGLAGAVREPFAQAIRLANAADLPVLAVDIPSGLSADTGAVLGEAIRADLTVTFIGLKIGLFTGEAPARVGELVFDELGSDAVVLQGLQPRAHRLARNALPSLAARPRTAHKGLFGHLLVVGGDTGMGGAVLLAAESALRCGAGLVSAATRVEHVPALLSRCPEVMAHGVASANQLLALAERASVLVLGPGLGQRAWGRSLLSAVRSRPLPQVWDADALNLLALEPVGAGPRTWILTPHPGEAARLLGRSTAEVQADRPAAALELARRYQAVVVLKGAGSLVAAPDGRLAVCSQGHPAMAGAGLGDVLSGITGALLAQRVEAFEAACLAVWLHAAAGERLGAQGRGLAATDLIPTVRQLLEECSPCLK
Atome Classification :
(30 SA)
.........10........20........-30........40........50...--.....60........70........80........90........100.......110.......--120...-....130.......140.......150.......160.......170.......180.......190..--.....200.......210.......220...--..-..230.......240.......250.......260.......270.......280.......290.......300-----......---------.-.310-.........320.......330......-.340........350.......360.......370.......380.......390.......400.......410.......420.....-..430.......440.......450.......460.......470.....-.-.480...---....-490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
M
T
F
QHDDL
P
L
A
L
Y
S
A
A
Q
VRDLD
A
R
L
I
A-AGTP
G
F
E
L
M
Q
R
A
A
H
A
A
W
R
A
L
R
R
RWP--EA
A
A
L
T
V
L
AGHGNNAG
D
G
Y
L
I
A
A
L
A
Q
RAG
W
R
V
R
V
L
A
VA
A
P
Q
R
LAG
D
A
A
Q
A
H
A
A
A
LAT
G
V
V
VEPW
S
--
E
C
A
V
L
E
-
G
V
V
V
D
A
L
L
GTG
L
A
G
A
V
R
E
P
F
A
Q
A
I
R
LANAADL
P
V
L
A
V
DIPSGLSA
D
T
G
A
V
L
G
E
A
I
RAD
L
T
V
T
F
I
G
L
K
I
G
--
L
FTGEA
P
A
R
V
G
E
L
V
F
D
E
LGS
D
A
V
VLQGL
Q
P
R
--
A
H
-
R
L
A
R
N
A
L
P
S
L
AARPRTAHKGL
F
G
H
L
L
V
V
GGDTGMG
G
A
V
L
L
A
A
E
S
A
L
RCG
A
G
L
V
S
A
A
T
R
V
E
H
V
P
A
L
L
S
R
C
P
E
V
M
A
------
H
G
V
A
S
A
---------
N
-
Q
L
---
L
A
L
A
ER
A
S
V
L
V
LGPGL
G
Q
R
A
W
G
R
S
L
L
S
A
-
V
RS-RPLPQVWDADA
L
N
L
L
A
LEPVGAGP
R
T
W
I
L
TPHP
G
E
A
A
R
L
LGRSTAEVQADR
P
A
A
A
L
E
L
A
R
R
Y
Q
A
V
V
V
LKGAG
S
L
V
AAPDG
R
L
A
V
CS-QGHPAMAGA
G
L
G
D
V
L
S
G
I
T
G
A
L
L
A
Q
R
V
E
A
F
E
A
A
C
L
A
V
W
L
H
A
AAGERLGAQ-G-RGL
A
A
T
D
---
L
I
P
T
-
V
R
Q
L
L
E
E
C
S
PCLK
29
HHSearch
93.83
30%
-112
* C3 *
3RSS
3
NNR_THEMA
A:
[11-501]
-----------------
H
H
M
K
E
I
D
E
L
T
I
K
E
Y
G
V
D
S
R
I
L
M
E
R
A
G
I
S
V
V
L
A
M
E
E
E
L
G
NL
S
D
Y
R
F
L
V
L
C
G
G
G
N
N
G
G
D
G
F
V
V
A
R
N
L
L
G
V
V
K
D
V
L
V
V
F
L
G
--
K
K
K
T
P
D
C
E
Y
N
Y
G
L
Y
K
K
F
G
G
K
V
V
E
Q
F
EP
S
I
L
N
E
F
-
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
--
H
I
L
F
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
--
N
--
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
------
V
P
I
D
T
E
KGFFSLQN
L
Q
-
E
C
---
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
-
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
-
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
-
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
---
L
L
R
L
-
I
P
E
A
I
R
R
L
K
----
3
PsiBlast_PDB
81.55
34%
-110
- C3 -
3RSF
3
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
14
PsiBlast_PDB
81.44
34%
-110
- C3 -
3RRB
4
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
20
PsiBlast_PDB
81.32
34%
-110
- C3 -
3RU2
4
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
17
PsiBlast_PDB
81.19
34%
-110
- C3 -
3RRJ
4
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
8
PsiBlast_PDB
81.18
34%
-107
- C3 -
3RTA
4
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
7
PsiBlast_PDB
81.02
34%
-107
- C3 -
3RT9
6
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
HI
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
12
PsiBlast_PDB
80.98
34%
-106
- C3 -
3RTG
7
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
15
PsiBlast_PDB
80.63
34%
-106
- C3 -
3RRE
6
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
16
PsiBlast_PDB
80.56
34%
-107
- C3 -
3RRF
6
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
9
PsiBlast_PDB
80.56
34%
-107
- C3 -
3RTC
6
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
6
PsiBlast_PDB
80.36
34%
-107
- C3 -
3RT7
7
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
2
PsiBlast_PDB
80.33
34%
-106
- C3 -
3RS9
6
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
18
PsiBlast_PDB
80.28
34%
-107
- C3 -
3RSG
6
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
19
PsiBlast_PDB
80.26
34%
-108
- C3 -
3RTB
4
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
1
PsiBlast_PDB
80.17
34%
-107
- C3 -
3RS8
7
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
4
PsiBlast_PDB
80.12
34%
-109
- C3 -
3RSQ
4
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
V
I
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
11
PsiBlast_PDB
79.97
34%
-107
- C3 -
3RTE
6
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
5
PsiBlast_PDB
79.74
34%
-107
- C3 -
3RSS
3
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
13
PsiBlast_PDB
79.51
34%
-105
- C3 -
3RU3
5
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
10
PsiBlast_PDB
79.04
34%
-106
- C3 -
3RTD
6
NNR_THEMA
A:
[107-501]
------------------------------------------------------------------------------------------------------------------
G
K
V
V
E
Q
F
E
--
P
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
--
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
S
I
N
R
Y
VI
T
R
-
E
M
V
R
S
L
L
P
E
---
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
T
E
K
G
F
F
S
L
---------
Q
-
N
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
-
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
G
D
V
K
Y
N
Y
E
L
A
E
-
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
--
D
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
-
E
-
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
K
--------
36
HHSearch
68.03
30%
-104
- C3 -
3RPZ
3
NNRD_BACSU
A:
[10-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
E
H
V
R
A
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
------
W
R
D
G
W
K
---------
K
A
A
D
---
A
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
-
V
L
T
-
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
P
---
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
-
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
H
S
A
H
T
L
L
A
H
E
---
L
S
D
I
-
L
P
R
V
W
K
R
F
-----
22
PsiBlast_CBE
65.11
34%
-99
- C3 -
3RQQ
2
NNRD_BACSU
A:
[17-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
WR----
D
G
W
K
K
A
---------
A
-
D
A
----
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
-
V
L
T
-
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
-
P
K
R
E
G
P
V
--
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
-
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
------------------------------------
27
PsiBlast_CBE
64.55
34%
-100
- C3 -
3RPZ
3
NNRD_BACSU
A:
[17-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
WR----
D
G
W
K
K
A
---------
A
-
D
A
----
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
-
V
L
T
-
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
-
P
K
R
E
G
P
V
--
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
-
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
------------------------------------
23
PsiBlast_CBE
64.12
34%
-99
- C3 -
3RQH
3
NNRD_BACSU
A:
[17-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
WR----
D
G
W
K
K
A
---------
A
-
D
A
----
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
-
V
L
T
-
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
-
P
K
R
E
G
P
V
--
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
-
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
------------------------------------
25
PsiBlast_CBE
63.98
34%
-98
- C3 -
3RQ6
3
NNRD_BACSU
A:
[17-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
WR----
D
G
W
K
K
A
---------
A
-
D
A
----
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
-
V
L
T
-
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
-
P
K
R
E
G
P
V
--
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
-
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
------------------------------------
26
PsiBlast_CBE
63.97
34%
-99
- C3 -
3RQ2
3
NNRD_BACSU
A:
[17-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
WR----
D
G
W
K
K
A
---------
A
-
D
A
----
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
-
V
L
T
-
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
-
P
K
R
E
G
P
V
--
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
-
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
------------------------------------
28
PsiBlast_CBE
63.96
34%
-98
- C3 -
3RPH
4
NNRD_BACSU
A:
[17-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
WR----
D
G
W
K
K
A
---------
A
-
D
A
----
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
-
V
L
T
-
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
-
P
K
R
E
G
P
V
--
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
-
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
------------------------------------
21
PsiBlast_CBE
63.93
34%
-99
- C3 -
3RQX
5
NNRD_BACSU
A:
[17-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
WR----
D
G
W
K
K
A
---------
A
-
D
A
----
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
-
V
L
T
-
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
-
P
K
R
E
G
P
V
--
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
-
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
------------------------------------
24
PsiBlast_CBE
63.16
34%
-97
- C3 -
3RQ8
3
NNRD_BACSU
A:
[17-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
E
R
D
A
E
S
H
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
V
L
P
E
A
T
Y
WR----
D
G
W
K
K
A
---------
A
-
D
A
----
Q
L
E
E
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
-
V
L
T
-
A
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
-
P
K
R
E
G
P
V
--
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
K
R
A
E
Y
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
-
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
------------------------------------