@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4967: (2016-03-03 )
MATYNADAIEVLSGLDPVRKRPGMYTDTTRPNHLAQEVIDNSVDEALAGHAKSVQVILHQDNSLEVIDDGRGMPVDIHPEEGVPGVELILTKLHAGGKFSNKNYQFSGGLHGVGISVVNALSTRVEVRVKRDANEYRMTFADGFKDSDLEVIGTVGKRNTGTSVHFWPDPKYFDSAKFSVSRLKHVLKAKAVLCPGLSVVFEDKNTGERVEWHFEDGLRSYLTDAVAELPRLPDEPFCGNLEGSKEAVSWALLWLPEGGESVQESYVNLIPTAQGGTHVNGLRQGLLDAMREFCEFRNLLPRGVKLAPEDVWERIAFVLSMKMQEPQFSGQTKERLSSREAAAFVSGVVKDAFSLWLNEHAEIGLQLAELAISNAGRRLKAGKKVERKKITQGPALPGKLADCAGQEPMRAELFLVEGDSAGGSAKQARDKEFQAIMPLRGKILNTWEVDGGEVLASQEVHDIAVAIGVDPGASDLAQLRYGKICILADADSDGLHIATLLCALFVRHFRPLVEAGHVYVAMPPLYRIDLGKDIYYALDEAERDGILERLAAEKKRGKPQVTRFKGLGEMNPLQLRETTMDPNTRRLVQLTLEDATGTLEIMDMLLAKKRAGDRKSWLESKGNLAEVLV
Atome Classification :
(65 SA)
.........-10........20....----.----...---30----........40........50..----......60-........70........80........90........100......-------.110.......120.......130--.......140....-...150.....----..160.....-------..170.-.-.-....180.......190.......200.-------....-.--.210----------.-........---220.......230...------.--.-..240.......250.......260.-......270.......280.......290.......-300.-.-......310.......320....--...330.......340.......350.......360.......370.-----......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..-.....480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATYN
A
D
A
I
-
E
V
L
SGL
D
P
V
R
KRPGMY----T----DTT---R
P
----
N
H
L
A
Q
E
V
I
D
N
S
V
D
E
A
L
AGHA
K
S
----
V
Q
V
I
L
HQD-N
S
L
E
V
IDDGRG
M
P
V
D
IHPEEGV
P
G
V
E
L
I
L
T
K
LHAGGKFSNK
N
Y
Q
FSG-------GLH
G
V
G
I
S
V
V
N
A
LS
T
R
V
E
V
R
V
KRD--AN
E
Y
R
M
T
FADGFKD-SD
L
E
V
I
G
TVGK----RNTGT
S
V
H
FW-------PDPKYF-D-S-AK
F
S
V
S
R
L
K
H
V
L
K
A
K
A
VLCPG
L
S
V
V
F
ED-------KNTG-
E
--
R
V
------------
E
-
W
H
F
E
D
G
L
R
---
S
Y
L
T
D
A
V
A
ELPRLPDE------P--F-CGNLEGSKE
A
V
S
W
A
L
L
W
LPEG
G
E
S
V
Q
-
E
S
Y
V
N
L
IPTAQGG
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
F
R
N
L-LP-R-G-VKL
A
P
E
D
V
W
E
R
I
A
F
V
L
S
MKMQEP--QFS
G
Q
T
K
E
R
L
S
S
R
E
A
A
A
F
V
S
G
V
V
K
D
A
F
S
L
W
L
N
E
H
A
E
I
G
L
Q
L
A
E
L
A
I
S
-----NAGRRLKAGKK
V
E
R
K
KITQGPALP
G
K
L
A
DCAGQEP
M
R
A
E
L
F
L
V
EGDSAGGSAKQA
R
D
K
E
F
Q
A
I
MPLR
G
K
I
L
N
T
W
EVDG
G
E
V
L
ASQE
V
H
D
I
A
V
A
I
GVDP
G
A
S
-
D
L
A
Q
LRYG
K
I
C
I
L
A
DADSD
G
L
H
I
A
T
L
L
C
A
L
F
V
R
H
F
R
P
L
V
EAG
H
V
Y
V
AMP
P
L
Y
R
IDLGK
D
I
Y
Y
A
L
D
E
A
E
R
D
G
I
L
E
R
L
A
A
E
KKRGKPQ
V
T
RFKGLGEMN
P
L
Q
L
RETTMDPNT
R
R
L
V
Q
L
T
LEDAT
G
T
L
E
I
M
D
M
L
L
A
K
KRAG
D
R
K
S
W
L
E
SKGN
L
A
E
VLV
3
PsiBlast_PDB
83.99
41%
-93
- C3 -
4JUO
4
PARE_STRPN
C:
[47-657]
-----------------
A
V
R
K
R
P
G
M
Y
IGS-
T
----
D
G
A
---
G
L
----
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
---
D
R
----
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
---------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
--
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
T
L
K
K
I
G
T
A
P
K
----
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
-------
K
R
T
D
-
E
--
A
I
------------
E
-
F
H
Y
E
--
V
Q
DFV
S
Y
L
N
E
D
K
E
I
L
T
--
P
V
L
------
Y
--
F
-
E
G
E
D
N
G
F
Q
V
E
V
A
---
L
Q
Y
N
D
G
F
S
D
N
I
-
L
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
-
L
K
-
E
-
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
E
E
HL
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
ARDAR
E
A
A
R
K
A
R
-------------------
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
-
P
P
L
Y
K
-----------
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
--------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
-
V
E
P
R
R
K
W
I
E
----------
4
PsiBlast_PDB
83.47
41%
-88
- C3 -
4I3H
2
?
A:
[24-642]
-----------------
A
V
R
K
R
P
G
M
Y
IGS-
T
----
D
G
A
---
G
L
----
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
---
D
R
----
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
---------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
--
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
T
L
K
K
I
G
T
A
P
K
----
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
-------
K
R
T
D
-
E
--
A
I
------------
E
-
F
H
Y
E
N
G
V
Q
D
F
V
S
Y
L
N
E
D
K
E
I
L
T
--
P
V
L
------
Y
--
F
-
E
G
E
D
N
G
F
Q
V
E
V
A
---
L
Q
Y
N
D
G
F
S
D
N
I
-
L
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
-
L
K
-
E
-
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
E
E
H
L
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
-----------------
G
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
S
K
G
-------
A
Y
A
W
-
D
G
E
L
E
E
L
R
---------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
-
V
E
P
R
R
K
W
I
E
----------
21
PsiBlast_CBE
83.40
74%
-84
- C2 -
1S16
4
PARE_ECOLI
B:
[4-383]
--
T
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
----
T
----
D
T
T
---
R
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
R
----
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
--
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
-
Q
D
L
Q
V
V
G
T
C
G
K
----
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
-------
E
I
N
N
-
T
--
E
Q
------------
R
-
W
C
Y
Q
D
G
L
N
---
D
Y
L
A
E
A
V
N
G
L
P
T
L
P
E
K
------
P
--
F
-
I
G
N
F
A
G
D
T
E
A
V
D
W
A
L
L
W
L
P
E
G
G
E
L
L
T
-
E
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
-
L
P
-
R
-
G
-
V
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
-----
S
A
Q
R
R
M
R
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
83.13
74%
-84
- C2 -
1S16
4
PARE_ECOLI
A:
[4-383]
--
T
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
----
T
----
D
T
T
---
R
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
R
----
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
--
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
-
Q
D
L
Q
V
V
G
T
C
G
K
----
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
-------
E
I
N
N
-
T
--
E
Q
------------
R
-
W
C
Y
Q
D
G
L
N
---
D
Y
L
A
E
A
V
N
G
L
P
T
L
P
E
K
------
P
--
F
-
I
G
N
F
A
G
D
T
E
A
V
D
W
A
L
L
W
L
P
E
G
G
E
L
L
T
-
E
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
-
L
P
-
R
-
G
-
V
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
-----
S
A
Q
R
R
M
R
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.13
74%
-84
- C2 -
1S16
4
PARE_ECOLI
A:
[4-383]
--
T
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
----
T
----
D
T
T
---
R
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
R
----
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
--
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
-
Q
D
L
Q
V
V
G
T
C
G
K
----
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
-------
E
I
N
N
-
T
--
E
Q
------------
R
-
W
C
Y
Q
D
G
L
N
---
D
Y
L
A
E
A
V
N
G
L
P
T
L
P
E
K
------
P
--
F
-
I
G
N
F
A
G
D
T
E
A
V
D
W
A
L
L
W
L
P
E
G
G
E
L
L
T
-
E
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
-
L
P
-
R
-
G
-
V
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
-----
S
A
Q
R
R
M
R
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
81.26
68%
-93
- C2 -
3LNU
-
?
A:
[59-422]
--------------
G
L
D
P
V
K
R
R
P
G
M
Y
----
T
----
D
T
A
---
R
P
----
N
H
L
A
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
Q
----
I
E
V
T
L
Y
K
D
-
G
S
C
E
V
S
D
D
G
R
G
M
P
V
D
I
H
P
E
E
K
I
P
G
V
E
L
I
L
T
R
L
---------------------------
G
V
S
V
V
N
A
L
S
T
K
V
E
L
F
I
K
R
E
--
G
S
E
H
R
M
E
F
R
D
G
N
A
A
-
S
K
L
E
V
V
G
T
V
G
K
----
K
N
T
G
T
R
L
R
F
W
-------
A
D
P
K
Y
F
-
D
-
T
-
P
K
F
N
V
R
A
L
R
H
L
L
R
A
K
A
V
L
C
P
G
L
T
V
K
L
H
D
-------
E
A
T
G
-
E
--
Q
D
------------
S
-
W
Y
F
E
N
G
L
R
---
D
Y
L
K
G
E
M
A
E
H
E
M
L
P
A
D
------
L
--
F
-
V
G
S
L
K
K
D
T
E
I
V
D
W
A
A
G
W
V
-
P
E
G
E
L
V
Q
-
E
S
Y
V
N
L
I
P
T
A
Q
H
G
T
H
V
N
G
L
R
S
G
L
T
D
A
L
R
E
F
C
D
F
R
N
L
-
L
P
-
R
-
G
-
V
K
L
A
P
E
D
V
W
D
R
V
T
F
V
L
S
L
K
M
T
D
P
--
Q
F
S
G
Q
T
K
E
R
L
S
S
R
Q
A
A
G
F
I
E
G
A
A
H
D
A
F
S
L
Y
L
N
Q
N
V
E
I
G
E
K
I
A
Q
I
A
I
D
-----
R
A
S
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.02
68%
-94
- C2 -
3LNU
-
?
A:
[59-422]
--------------
G
L
D
P
V
K
R
R
P
G
M
Y
----
T
----
D
T
A
---
R
P
----
N
H
L
A
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
Q
----
I
E
V
T
L
Y
K
D
-
G
S
C
E
V
S
D
D
G
R
G
M
P
V
D
I
H
P
E
E
K
I
P
G
V
E
L
I
L
T
R
L
---------------------------
G
V
S
V
V
N
A
L
S
T
K
V
E
L
F
I
K
R
E
--
G
S
E
H
R
M
E
F
R
D
G
N
A
A
-
S
K
L
E
V
V
G
T
V
G
K
----
K
N
T
G
T
R
L
R
F
W
-------
A
D
P
K
Y
F
-
D
-
T
-
P
K
F
N
V
R
A
L
R
H
L
L
R
A
K
A
V
L
C
P
G
L
T
V
K
L
H
D
-------
E
A
T
G
-
E
--
Q
D
------------
S
-
W
Y
F
E
N
G
L
R
---
D
Y
L
K
G
E
M
A
E
H
E
M
L
P
A
D
------
L
--
F
-
V
G
S
L
K
K
D
T
E
I
V
D
W
A
A
G
W
V
P
E
-
G
E
L
V
Q
-
E
S
Y
V
N
L
I
P
T
A
Q
H
G
T
H
V
N
G
L
R
S
G
L
T
D
A
L
R
E
F
C
D
F
R
N
L
-
L
P
-
R
-
G
-
V
K
L
A
P
E
D
V
W
D
R
V
T
F
V
L
S
L
K
M
T
D
P
--
Q
F
S
G
Q
T
K
E
R
L
S
S
R
Q
A
A
G
F
I
E
G
A
A
H
D
A
F
S
L
Y
L
N
Q
N
V
E
I
G
E
K
I
A
Q
I
A
I
D
-----
R
A
S
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.24
51%
-93
- C2 -
4HXZ
1
?
A:
[8-381]
-------
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
----
T
----
N
I
E
---
N
P
----
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
S
K
----
I
N
I
T
L
Y
E
D
-
N
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
-----------------
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
--
G
N
V
Y
H
I
V
F
E
D
G
F
K
T
-
K
D
L
E
I
I
D
N
V
G
K
----
K
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
-
D
-
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
-------
E
I
K
K
-
E
--
K
L
------------
T
-
W
H
F
E
T
G
L
K
---
G
Y
L
-
D
H
K
L
E
A
E
T
L
P
A
E
------
P
--
F
I
I
D
N
F
S
N
G
D
S
Y
L
D
A
V
F
C
W
C
E
D
P
S
E
S
I
K
-
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
E
K
N
S
L
-
S
V
-
K
-
N
-
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
-----
V
A
Q
K
R
I
N
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.52
51%
-91
- C2 -
4KQV
7
?
A:
[7-380]
------
K
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
----
T
----
N
I
E
---
N
P
----
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
S
K
----
I
N
I
T
L
Y
E
D
-
N
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
N
-----------------
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
--
G
N
V
Y
H
I
V
F
E
D
G
F
K
T
-
K
D
L
E
I
I
D
N
V
G
K
----
K
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
-
D
-
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
-------
E
I
K
K
-
E
--
K
L
------------
T
-
W
H
F
E
T
G
L
K
---
G
Y
L
-
D
H
K
-----
L
P
A
E
------
P
--
F
I
I
D
N
F
S
N
G
D
S
Y
L
D
A
V
F
C
W
C
----
E
S
I
K
-
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
E
K
N
S
L
-
S
V
-
K
-
N
-
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
-----
V
A
Q
K
R
I
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.21
51%
-89
- C2 -
4HYM
1
?
A:
[7-377]
------
K
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
----
T
----
N
I
E
---
N
P
----
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
S
K
----
I
N
I
T
L
Y
E
D
-
N
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
N
------
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
--
G
N
V
Y
H
I
V
F
E
D
G
F
K
T
-
K
D
L
E
I
I
D
N
V
G
K
----
K
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
-
D
-
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
-------
E
I
K
K
-
E
--
K
L
------------
T
-
W
H
F
E
T
G
L
K
---
G
Y
L
-
D
H
K
L
E
A
E
T
L
P
A
E
------
P
--
F
I
I
D
N
F
S
N
G
D
S
Y
L
D
A
V
F
C
W
C
E
D
P
S
E
S
I
K
-
N
S
Y
V
N
L
I
P
T
P
Q
D
G
T
H
V
T
G
L
K
N
G
I
Y
D
A
I
K
A
Y
I
E
K
N
S
-------
N
-
I
K
I
T
A
N
D
S
F
A
Q
L
N
Y
V
I
S
V
K
I
T
N
P
--
Q
F
A
G
Q
T
K
E
K
L
S
N
K
D
V
T
N
F
V
A
T
A
V
K
D
L
L
T
I
W
L
N
Q
N
P
D
E
A
R
Q
I
V
E
N
I
S
K
-----
V
A
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
67.60
35%
-79
- C2 -
3ZKB
3
GYRB_MYCTU
D:
[17-427]
---
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
G
E
R
G
L
-
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
T
----
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
--
G
Y
E
W
S
Q
V
Y
E
---
K
S
-
E
P
L
G
L
K
Q
G
A
P
T
----
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
ERVTQ------------STAPHK
V
K
S
R
--
T
-
F
H
Y
P
G
G
-------
L
V
D
F
V
K
H
I
N
R
T
K
N
A
IHSS
I
V
D
--
F
-
S
G
--
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
S
E
S
V
H
--
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
-
L
K
D
K
-
D
-
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
-----
S
A
Q
A
R
I
A
A
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
66.67
35%
-74
- C2 -
3ZKB
4
GYRB_MYCTU
C:
[17-430]
---
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
G
E
R
G
L
-
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
T
----
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
--
G
Y
E
W
S
Q
V
Y
E
---
K
S
-
E
P
L
G
L
K
Q
G
A
P
T
----
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
ERV--------------A
P
H
K
V
K
S
R
----
T
-
F
H
Y
P
G
G
-------
L
V
D
F
V
K
H
I
N
R
T
K
N
A
IHSSI
V
D
--
F
-
S
G
--
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
S
E
S
V
H
--
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
-
L
K
D
K
-
D
-
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
-----
S
A
Q
A
R
I
A
A
R
K
A
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
66.63
35%
-87
- C2 -
3ZM7
2
GYRB_MYCTU
C:
[36-436]
--------------
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
G
E
R
G
L
-
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
T
----
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
--------------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
--
G
Y
E
W
S
Q
V
Y
E
---
K
S
-
E
P
L
G
L
K
Q
G
A
P
T
----
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
ER---------------KV
K
S
R
-------
T
-
F
H
Y
P
G
G
-------
L
V
D
F
V
K
H
I
N
R
T
K
N
A
IHS
S
I
V
D
--
F
-
S
G
--
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
S
E
S
V
H
--
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
-
L
K
D----
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
--
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
-----
S
A
Q
A
R
I
A
A
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
66.52
35%
-80
- C2 -
3ZKD
3
GYRB_MYCTU
C:
[17-426]
---
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
G
E
R
G
L
-
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
T
----
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
--
G
Y
E
W
S
Q
V
Y
E
---
K
S
-
E
P
L
G
L
K
Q
G
A
P
T
----
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
ERVTQDE--------
R
A
A
E
S
T
APHK
V
K
S
R
T
-
F
H
Y
P
G
G
-------
L
V
D
F
V
K
H
I
N
R
T
K
N
A
IHS
S
I
V
D
--
F
-
S
G
--
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
S
E
S
V
H
--
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
-
L
K
D----
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
-----
S
A
Q
A
R
I
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Fugue
66.25
38%
-80
- C2 -
1KIJ
3
?
A:
[7-390]
-------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
IGGT
G
-----
V
E
---
G
Y
----
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
E
----
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
--
G
K
H
H
R
I
A
F
S
R
G
E
V
T
-
E
P
L
R
V
V
G
E
A
P
R
----
G
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
G
N
---
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
-------
R
Q
H
G
-
K
--
E
E
------------
V
-
F
L
D
K
G
G
V
A
---
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
E
K
------
P
--
F
-
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
N
A
E
I
L
--
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
-
N
K
-
E
K
G
-
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
A
L
R
-----
A
A
Q
A
R
E
A
A
R
K
A
R
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Fugue
66.12
36%
-73
- C2 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
----
G
D
T
---
D
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
G
G
I
K
---
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
------
I
--
F
-
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
Q
E
N
I
Y
--
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-
S
K
-
K
A
K
-
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
-----
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
66.12
35%
-81
- C2 -
3ZKD
3
GYRB_MYCTU
G:
[17-425]
---
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
G
E
R
G
L
-
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
T
----
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
--
G
Y
E
W
S
Q
V
Y
E
---
K
S
-
E
P
L
G
L
K
Q
G
A
P
T
----
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
ERV--------------PHK
V
K
S
R
-----
T
-
F
H
Y
P
G
G
-------
L
V
D
F
V
K
H
I
N
R
T
K
N
A
IHS
S
I
V
D
--
F
-
S
G
--
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
S
E
S
V
H
--
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
-
L
------
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
-----
S
A
Q
A
R
I
A
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
65.94
35%
-75
- C2 -
3ZKB
4
GYRB_MYCTU
B:
[17-429]
---
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
G
E
R
G
L
-
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
T
----
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
--
G
Y
E
W
S
Q
V
Y
E
---
K
S
-
E
P
L
G
L
K
Q
G
A
P
T
----
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
ER---------------VK
S
R
--------
T
-
F
H
Y
P
G
G
-------
L
V
D
F
V
K
H
I
N
R
T
K
N
A
IHSS
I
V
D
--
F
-
S
G
--
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
S
E
S
V
H
--
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
-
L
K
D
K
-
D
-
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
-----
S
A
Q
A
R
I
A
A
R
K
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
65.94
35%
-76
- C2 -
3ZKD
3
GYRB_MYCTU
H:
[17-426]
---
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
G
E
R
G
L
-
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
T
----
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
T
H
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
--
G
Y
E
W
S
Q
V
Y
E
---
K
S
-
E
P
L
G
L
K
Q
G
A
P
T
----
K
K
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
ERVTQ------------K
V
K
S
R
-------
T
-
F
H
Y
P
G
G
-------
L
V
D
F
V
K
H
I
N
R
T
K
N
A
IHSSI
V
D
--
F
-
S
G
--
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
S
E
S
V
H
--
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
-
L
----
D
-
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
-----
S
A
Q
A
R
I
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
65.58
38%
-81
- C2 -
1KIJ
3
?
A:
[7-371]
-------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
IGG-
T
----
G
V
E
---
G
Y
----
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
E
----
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
--
G
K
H
H
R
I
A
F
S
R
G
E
V
T
-
E
P
L
R
V
V
G
E
A
P
R
----
G
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
-
N
-
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
-------
R
Q
H
G
-
K
--
E
E
------------
V
-
F
L
D
K
G
G
V
A
---
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
E
K
------
P
--
F
-
L
--
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
N
A
E
I
L
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
-
K
-
G
-
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
65.19
39%
-77
- C2 -
1KIJ
3
?
A:
[7-385]
-------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
----
I
----
G
G
T
G
V
E
G
Y
----
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
E
----
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
--
G
K
H
H
R
I
A
F
S
R
G
E
V
T
-
E
P
L
R
V
V
G
E
A
P
R
----
G
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
-
N
-
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
-------
R
Q
H
G
-
K
--
E
E
------------
V
-
F
L
D
K
G
G
V
A
---
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
E
K
------
P
--
F
-
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
-
Q
G
Y
N
A
E
I
-
L
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
-
N
K
E
K
-
G
-
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
A
L
R
-----
A
A
Q
A
R
E
A
A
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
64.11
38%
-80
- C2 -
1KIJ
3
?
B:
[7-371]
-------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
IGG-
T
----
G
V
E
---
G
Y
----
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
E
----
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
--
G
K
H
H
R
I
A
F
S
R
G
E
V
T
-
E
P
L
R
V
V
G
E
A
P
R
----
G
K
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
-
N
-
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
-------
R
Q
H
G
-
K
--
E
E
------------
V
-
F
L
D
K
G
G
V
A
---
S
F
A
K
A
L
A
E
G
E
D
L
L
Y
E
K
------
P
--
F
-
L
--
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
N
A
E
I
L
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
-
K
-
G
-
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.78
37%
-68
- C2 -
4WUB
5
GYRB_ECOLI
A:
[3-363]
--
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
-
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
G
G
I
K
---
A
F
V
--
E
Y
L
N
K
N
K
T
P
I
H
------
P
NI
F
-
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
-
N
D
G
F
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-
S
-------
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
62.57
37%
-79
- C2 -
4ZVI
3
?
A:
[1-349]
---------------
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
--------------------------
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
---
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
G
G
I
K
---
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
------
I
--
F
-
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
-
N
D
G
F
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-
S
K
-
K
-
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
62.29
37%
-68
- C2 -
4WUC
5
GYRB_ECOLI
A:
[3-363]
--
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
-
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
G
G
I
K
---
A
F
V
--
E
Y
L
N
K
N
K
T
P
I
H
------
P
N
I
F
-
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
-
N
D
G
F
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-
S
-------
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.98
37%
-67
- C2 -
4XTJ
5
GYRB_ECOLI
A:
[3-363]
--
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
-
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
G
G
I
K
---
A
F
V
--
E
Y
L
N
K
N
K
T
P
I
H
------
P
NI
F
-
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
-
N
D
G
F
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-
S
-------
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
61.51
37%
-68
- C2 -
1EI1
5
GYRB_ECOLI
A:
[9-363]
--------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
G
G
I
K
---
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
------
I
--
F
-
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
-
N
D
G
F
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-
S
K
-
K
-
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.18
37%
-68
- C2 -
4WUD
4
GYRB_ECOLI
A:
[3-363]
--
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
-
N
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
G
G
I
K
---
A
F
V
--
E
Y
L
N
K
N
K
T
P
I
H
------
P
N
I
F
-
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
-
N
D
G
F
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-
S
-------
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
61.14
37%
-66
- C2 -
1EI1
6
GYRB_ECOLI
B:
[9-363]
--------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
G
G
I
K
---
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
------
I
--
F
-
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
-
N
D
G
F
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-
S
K
-
K
-
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
59.60
37%
-64
- C2 -
4PRV
2
GYRB_ECOLI
A:
[16-370]
--------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
G
G
I
K
---
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
------
I
--
F
-
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
-
N
D
G
F
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
----------------
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
59.11
37%
-65
- C2 -
4PU9
3
GYRB_ECOLI
A:
[16-370]
--------
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
G
G
I
K
---
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
P
N
------
I
--
F
-
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
-
N
D
G
F
Q
E
N
I
-
Y
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
-
S
K
-------------
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
55.81
51%
-72
- C2 -
4HY1
1
?
B:
[8-271]
-------
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
----
T
----
N
I
E
---
N
P
----
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
S
K
----
I
N
I
T
L
Y
E
D
-
N
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
F
S
-------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
--
G
N
V
Y
H
I
V
F
E
D
G
F
K
T
-
K
D
L
E
I
I
D
N
V
G
K
----
K
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
-
D
-
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
-------
E
I
K
K
-
E
--
K
L
------------
T
-
W
H
F
E
T
G
L
K
---
G
Y
L
-
D
H
K
L
-
A
E
T
L
P
A
E
-------------------------------
P
S
E
S
I
K
-
N
S
Y
V
N
L
I
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
54.23
75%
-59
- C2 -
4HZ0
2
PARE_ECOLI
B:
[3-205]
-------------
T
G
L
E
P
V
R
R
R
P
G
M
Y
----
T
----
D
T
T
---
R
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
R
----
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
--
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
--
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
-
Q
D
L
Q
V
V
G
T
C
G
K
----
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
-------
E
I
N
N
-
T
--
E
Q
------------
R
-
W
C
Y
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
54.05
75%
-57
- C2 -
4HZ0
2
PARE_ECOLI
A:
[3-205]
-------------
T
G
L
E
P
V
R
R
R
P
G
M
Y
----
T
----
D
T
T
---
R
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
R
----
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
--
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
--
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
-
Q
D
L
Q
V
V
G
T
C
G
K
----
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
-------
E
I
N
N
-
T
--
E
Q
------------
R
-
W
C
Y
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
53.81
76%
-68
- C2 -
3FV5
1
PARE_ECOLI
A:
[1-201]
--------------
G
L
E
P
V
R
R
R
P
G
M
Y
----
T
----
D
T
T
---
R
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
R
----
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
----------------------------
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
--
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
-
Q
D
L
Q
V
V
G
T
C
G
K
----
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
-------
E
I
N
N
-
T
--
E
Q
------------
R
-
W
C
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
53.73
76%
-68
- C2 -
3FV5
1
PARE_ECOLI
A:
[1-201]
--------------
G
L
E
P
V
R
R
R
P
G
M
Y
----
T
----
D
T
T
---
R
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
R
----
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
----------------------------
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
--
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
-
Q
D
L
Q
V
V
G
T
C
G
K
----
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
-------
E
I
N
N
-
T
--
E
Q
------------
R
-
W
C
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
52.09
76%
-62
- C2 -
3FV5
1
PARE_ECOLI
B:
[1-201]
--------------
G
L
E
P
V
R
R
R
P
G
M
Y
----
T
----
D
T
T
---
R
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
R
----
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
---------------------------
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
--
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
-
Q
D
L
Q
V
V
G
T
C
G
K
----
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
-------
E
I
N
N
-
T
--
E
Q
------------
R
-
W
C
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
50.30
47%
-67
- C2 -
4MOT
1
?
A:
[17-226]
----------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
IGS-
T
----
D
G
A
---
G
L
----
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
R
----
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
--
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
T
L
K
K
I
G
T
A
L
K
----
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
-------
K
R
T
D
-
E
--
A
I
------------
E
-
F
H
Y
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
50.00
66%
-51
- C2 -
1S14
1
PARE_ECOLI
B:
[17-194]
----------------
E
P
V
R
R
R
P
G
M
Y
----
T
----
D
T
T
---
R
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
R
----
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
------------------------------
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
--
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
-
Q
D
L
Q
V
V
G
T
C
G
K
----
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
-------
E
I
N
N
-
T
--
E
Q
------------
R
-
W
C
Y
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
49.95
47%
-68
- C2 -
4MBC
1
?
A:
[17-226]
----------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
IGS-
T
----
D
G
A
---
G
L
----
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
R
----
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
--
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
T
L
K
K
I
G
T
A
L
K
----
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
-------
K
R
T
D
-
E
--
A
I
------------
E
-
F
H
Y
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
49.67
47%
-65
- C2 -
4EM7
1
?
A:
[17-226]
----------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
IGS-
T
----
D
G
A
---
G
L
----
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
R
----
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
--
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
T
L
K
K
I
G
T
A
L
K
----
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
-------
K
R
T
D
-
E
--
A
I
------------
E
-
F
H
Y
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
49.58
47%
-65
- C2 -
5BOD
1
?
A:
[17-226]
----------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
IGS-
T
----
D
G
A
---
G
L
----
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
R
----
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
G
-------------------------
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
--
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
T
L
K
K
I
G
T
A
L
K
----
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
-------
K
R
T
D
-
E
--
A
I
------------
E
-
F
H
Y
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.80
66%
-54
- C2 -
1S14
1
PARE_ECOLI
A:
[27-194]
------------------------------
T
----
D
T
T
---
R
P
----
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
R
----
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
I
H
P
E
E
G
V
P
A
V
E
L
I
L
C
------------------------------
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
--
G
Q
V
Y
N
I
A
F
E
N
G
E
K
V
-
Q
D
L
Q
V
V
G
T
C
G
K
----
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
-------
E
I
N
N
-
T
--
E
Q
------------
R
-
W
C
Y
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
48.61
47%
-64
- C2 -
4MB9
2
?
A:
[17-226]
----------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
IGS-
T
----
D
G
A
---
G
L
----
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
R
----
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
G
-------------------
G
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
--
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
T
L
K
K
I
G
T
A
L
K
----
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
-------
K
R
T
D
-
E
--
A
I
------------
E
-
F
H
Y
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
48.54
47%
-67
- C2 -
4LPB
1
?
A:
[17-226]
----------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
IGS-
T
----
D
G
A
---
G
L
----
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
R
----
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
M
H
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
--
G
A
V
Y
K
Q
R
F
E
N
G
G
K
P
V
T
T
L
K
K
I
G
T
A
L
K
----
S
K
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
-------
K
R
T
D
-
E
--
A
I
------------
E
-
F
H
Y
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
48.45
44%
-67
- C2 -
4BAE
2
GYRB_MYCSM
B:
[4-203]
--------------
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
G
E
R
G
L
-
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
F
A
T
R
----
V
D
V
K
I
H
A
D
-
G
S
V
E
V
R
D
D
G
R
G
I
P
V
E
M
H
A
T
-
G
M
P
T
I
D
V
V
M
T
Q
L
-------------------------
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
T
V
L
R
D
--
G
Y
E
W
-------
F
Q
Y
-
Y
D
R
S
V
P
G
K
L
K
Q
GGET
K
E
T
G
T
T
I
R
F
W
-------
A
D
P
E
I
F
-
E
-
T
-
T
D
Y
N
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
E
L
T
D
-------
E
R
D
G
-
K
--
H
R
------------
V
-
F
H
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
47.74
46%
-52
- C2 -
4DUH
1
GYRB_ECOLI
A:
[15-217]
--------------
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
---------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
47.72
51%
-59
- C2 -
4KQV
2
?
B:
[8-217]
-------
S
I
-
E
V
L
T
G
L
D
P
V
K
K
R
P
G
M
Y
----
T
----
N
I
E
---
N
P
----
N
H
L
I
Q
E
I
I
D
N
S
V
D
E
V
L
A
G
F
A
S
K
----
I
N
I
T
L
Y
E
D
-
N
S
I
E
V
A
D
D
G
R
G
M
P
V
D
I
H
P
E
H
K
M
S
G
I
E
L
I
M
T
K
L
H
S
G
G
K
---------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
E
I
K
R
D
--
G
N
V
Y
H
I
V
F
E
D
G
F
K
T
-
K
D
L
E
I
I
D
N
V
G
K
----
K
N
T
G
T
K
I
R
F
W
-------
P
N
K
K
Y
F
-
D
-
D
-
I
K
V
N
F
K
A
L
K
N
L
L
E
A
K
A
I
L
C
K
A
L
T
I
K
Y
S
N
-------
E
I
K
K
-
E
--
K
L
------------
T
-
W
H
F
E
T
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
46.81
48%
-55
- C2 -
4K4O
2
?
A:
[1-206]
--------------
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
S
G
E
G
L
-
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
K
S
----
I
Q
V
I
I
E
P
D
-
D
S
I
T
V
I
D
D
G
R
G
I
P
V
G
I
Q
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
---------------------------
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
K
D
--
G
K
V
Y
Y
Q
E
Y
R
R
G
A
V
V
-
D
D
L
K
V
I
E
E
T
D
R
----
H
--
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
T
E
-
T
-
T
V
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
-------
R
R
E
G
-
Q
E
D
K
K
------------
E
-
Y
H
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
46.80
48%
-61
* C2 *
4HXW
2
?
A:
[1-206]
--------------
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
S
G
E
G
L
-
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
K
S
----
I
Q
V
I
I
E
P
D
-
D
S
I
T
V
I
D
D
G
R
G
I
P
V
G
I
Q
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
--------------------------
V
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
K
D
--
G
K
V
Y
Y
Q
E
Y
R
R
G
A
V
V
-
D
D
L
K
V
I
E
E
T
D
R
----
H
--
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
T
E
-
T
-
T
V
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
-------
R
R
E
G
-
Q
E
D
K
K
------------
E
-
Y
H
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
46.54
46%
-59
- C2 -
1AJ6
1
GYRB_ECOLI
A:
[11-216]
-----------
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-------
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
H
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
46.49
46%
-56
- C2 -
4DUH
1
GYRB_ECOLI
B:
[12-217]
-----------
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-------------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
46.43
47%
-61
- C2 -
4HYP
2
GYRB_ECOLI
A:
[2-205]
--------------
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
46.06
47%
-57
- C2 -
4KFG
3
GYRB_ECOLI
A:
[2-206]
--------------
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
-----------
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
45.89
47%
-62
- C2 -
4HYP
2
GYRB_ECOLI
C:
[2-205]
--------------
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
45.73
47%
-63
- C2 -
4HYP
2
GYRB_ECOLI
B:
[2-205]
--------------
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
45.62
47%
-48
- C2 -
3G7E
1
GYRB_ECOLI
A:
[1-203]
--------------
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
45.34
47%
-60
- C2 -
4HYP
2
GYRB_ECOLI
D:
[2-205]
--------------
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
I
-----
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-----
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
45.33
48%
-56
- C2 -
4KSG
2
?
A:
[1-206]
--------------
G
L
E
A
V
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
S
G
E
G
L
-
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
K
S
----
I
Q
V
I
I
E
P
D
-
D
S
I
T
V
I
D
D
G
R
G
I
P
V
G
I
Q
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
---------------------------
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
K
D
--
G
K
V
Y
Y
Q
E
Y
R
R
G
A
V
V
-
D
D
L
K
V
I
E
E
T
D
R
----
H
--
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
T
E
-
T
-
T
V
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
-------
R
R
E
G
-
Q
E
D
K
K
------------
E
-
Y
H
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Fugue
45.02
47%
-64
- C2 -
1KIJ
2
?
A:
[7-218]
-------
A
I
R
-
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
----
I
----
G
G
T
G
V
E
G
Y
----
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
----YAT
E
I
L
V
R
L
N
E
-D
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
-------G
A
Y
K
V
S
G
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
--
R
G
E
V
T
-
E
P
L
R
V
V
G
E
A
P
R
----
G
K
T
G
T
R
V
T
F
K
P
DPEIFG-------
N
---
L
R
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R------
Q
H
---
G
--
K
E
------------
E
-
V
F
L
D
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
44.80
47%
-56
- C2 -
4KFG
3
GYRB_ECOLI
B:
[2-205]
--------------
G
L
D
A
V
R
K
R
P
G
M
Y
----
I
GDTD
D
G
T
---
G
L
----
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
E
----
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
------
G
V
S
A
A
E
V
I
M
T
V
L
-------
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
-
A
P
L
A
V
T
G
E
T
E
K
------
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
T
N
-
V
-
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
-------
K
R
D
G
-
K
--
E
D
------------
H
-
F
H
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
43.52
43%
-65
- C2 -
4URO
2
GYRB_STAAU
D:
[25-230]
---------------
L
E
A
A
R
K
R
P
G
M
Y
----
I
----
G
S
T
---
S
E
R
G
L
-
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
Q
----
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
I
------
P
A
V
E
V
I
L
T
V
---------------------------
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
--
E
T
I
Y
H
Q
A
Y
K
K
G
V
P
Q
-
F
D
L
K
E
V
G
T
T
D
K
------
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
T
E
-
T
-
T
V
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
-------
E
R
D
E
-
E
--
N
V
R
E
D
---------
S
-
Y
H
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
43.45
45%
-55
- C2 -
4URN
1
?
A:
[17-223]
------------
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
GS-
T
----
D
K
R
---
G
L
----
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
N
E
----
I
D
V
T
I
N
K
D
-
G
S
I
S
I
E
D
N
G
R
G
M
P
T
G
I
H
-
K
S
G
K
P
T
V
E
V
I
F
T
V
L
--------------------------
V
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
--
G
N
I
Y
H
Q
S
F
K
N
G
G
S
P
-
S
S
-
G
L
V
K
K
G
K
T
----
K
K
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
-
K
A
S
-
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
-------
L
R
S
G
K
E
--
R
Q
------------
E
H
Y
H
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
42.85
45%
-56
- C2 -
4URN
2
?
B:
[32-223]
--------------------------GS--
T
----
D
K
R
---
G
L
----
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
N
E
----
I
D
V
T
I
N
K
D
-
G
S
I
S
I
E
D
N
G
R
G
M
P
T
G
I
H
-
K
S
G
K
P
T
V
E
V
I
F
T
V
L
-------------------------
G
V
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
--
G
N
I
Y
H
Q
S
F
K
N
G
G
S
P
-
S
S
-
G
L
V
K
K
G
K
T
----
K
K
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
-
K
A
S
-
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
-------
L
R
S
G
K
E
--
R
Q
------------
E
H
Y
H
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
42.36
45%
-53
- C2 -
4URN
1
?
C:
[19-224]
--------------
G
L
E
A
V
R
K
R
P
G
M
Y
IGS-
T
----
D
K
R
---
G
L
----
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
N
E
----
I
D
V
T
I
N
K
D
-
G
S
I
S
I
E
D
N
G
R
G
M
P
T
G
I
H
-
K
S
G
K
P
T
V
E
V
I
F
T
V
L
---------------------------
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
--
G
N
I
Y
H
Q
S
F
K
N
G
G
S
P
-
S
S
-
G
L
V
K
K
G
K
T
----
K
K
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
-
K
A
S
-
T
S
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
-------
L
R
S
G
K
E
--
R
Q
------------
E
H
Y
H
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------