@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4994: (2016-03-03 )
MYLETPKKFRSLANQAHQVAENYFRPISRKYDKAEHAYPKELDLLAALLDGMNSGSPEAVGATSASKRAGKQVEEGIKNGGNLSALLGVMELCWGDVGLLLAMPRQGLGNAAIAAVANEEQLQRFGGTWAAMAITEPGCGSDSAAIRTTATQDGDHYVLNGEKIFVTSGERADAVVVWATLNRNLGRAAIKSFVVEKGTPGMTVTRLEKKLGIKASDTASISFNDCRVPAANLLGNAEVDVQKGFAGVMETFDNTRPLVAGMAVGVAKAALDRTRELLKKAGCKFDYRKPLLTVSHAEATLYRLEAEWEAARLLTLKAAWMADNKLPNSKEASIAKAKAGRVANEITLKCVELAGALGYAEDELLEKWARDSKILDIFEGTQQIQLLIVARRLLGKSSSQLK
Atome Classification :
(38 SA)
.........10........20........30.-.......-----40------.........50--........60........70........80--.........90........100....--...110......-------.120...------.------...------130.......140.......150.--..-....160.......170.......-180-------.......190---..---......200.......210.......220.......230.......240.......250.......260.......270-----........280.......290.......300.......310.......320....-...330---.........340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MYLET
P
K
K
F
R
S
L
A
N
Q
A
H
Q
V
A
E
N
Y
F
R
P
I
S
R
KYD-KAEHAY
P
-----
K
-------
E
L
D
L
L
A
A
L
L
DG--MNSGSPEAVGAT
S
A
S
K
RA
G
K
Q
V
E
E
G
I
KNG---G
N
L
S
A
L
L
G
V
M
E
L
C
WGD
V
G
L
L
L
AMPRQ--GLGN
A
A
I
AAVA
N
-------
E
E
Q
L
Q
R
F------G------G
T
W
------
A
A
M
A
ITEPGCGSDS
A
A
I
R
T
TATQD--G
D
-
H
Y
V
LNG
E
K
I
F
V
TSGERA
D
A
V
V
V
W
A
-
T
LN-------RNL
G
R
A
A
I
K
----
S
F
---
V
VEKGTPG
M
T
V
T
R
L
E
K
K
LGIKASD
T
A
S
I
SFNDCRV
P
A
A
N
LLGN
A
E
V
D
V
Q
K
G
F
A
G
V
M
E
T
FDNTR
P
L
V
A
G
M
A
V
G
V
A
K
A
A
L
------
D
R
T
R
E
L
L
K
KAGCKFDYRKP
L
L
T
V
SHA
E
A
T
L
Y
R
L
EAEWE
A
A
R
L
L
T
L
K
A
A
WMADNKL-PNSK-----E
A
S
I
A
K
A
K
AGRVA
N
E
I
T
L
K
C
V
E
L
A
GALGY
A
E
D
E
L
L
E
K
W
ARDSK
I
L
D
I
FEG
T
Q
Q
I
Q
L
L
I
V
A
R
R
L
LGKSSSQLK
21
PsiBlast_CBE
91.76
34%
-75
- C2 -
1UKW
3
?
B:
[10-377]
---------
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
E
E
V
P
W
P
VIEKL
H
-------
E
V
G
L
L
N
A
I
I
---------
P
E
E
Y
G
G
M
------------
G
L
K
M
------
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
Y
T
I
P
M
A
S
--
D
L
G
I
T
P
V
L
L
A
G
T
-------
E
E
Q
K
E
R
F
LRPLTE
K
------
P
A
L
------
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
Q
--
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
-
T
V
N
-------
P
E
L
R
H
K
G
V
V
----
A
L
---
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
----
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
------
D
E
A
R
K
Y
A
K
E
---
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
-
P
H
A
H
-----
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
--------
1
PsiBlast_PDB
90.16
34%
-74
- C2 -
1UKW
2
?
A:
[10-377]
---------
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
E
E
V
P
W
P
V
I
E
K
L
H
-------
E
V
G
L
L
N
A
I
I
---------
P
E
E
Y
G
G
M
------------
G
L
K
M
------
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
Y
T
I
P
M
A
S
--
D
L
G
I
T
P
V
L
L
A
G
T
-------
E
E
Q
K
E
R
F
L
R
PLTE
K
------
P
A
L
------
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
Q
--
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
-
T
V
N
-------
P
E
L
R
H
K
G
V
V
----
A
L
---
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
----
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
------
D
E
A
R
K
Y
A
K
E
---
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
-
P
H
A
H
-----
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
--------
29
PsiBlast_CBE
90.08
34%
-68
- C2 -
1EGE
3
ACADM_HUMAN
D:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
39
PsiBlast_CBE
89.24
33%
-66
- C2 -
1EGC
5
ACADM_HUMAN
C:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
4
PsiBlast_PDB
88.88
34%
-68
- C2 -
1EGE
3
ACADM_HUMAN
A:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
31
PsiBlast_CBE
88.61
34%
-66
- C2 -
1EGE
3
ACADM_HUMAN
B:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
36
PsiBlast_CBE
88.28
33%
-65
- C2 -
1EGD
3
ACADM_HUMAN
C:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
34
PsiBlast_CBE
88.13
34%
-63
- C2 -
2A1T
3
ACADM_HUMAN
B:
[41-418]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
103
HHSearch
88.10
34%
-63
- C2 -
1UKW
2
?
A:
[1-378]
I
D
F
S
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
-
E
K
E
E
V
P
W
-----
P
-------
V
I
E
K
L
H
E
------
V
G
L
L
N
A
I
I
P
------------
E
E
Y
G
G
M
G
L
---
K
M
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
Y
T
I
P
M
A
S
--
D
L
G
I
T
P
V
L
L
A
G
T
-------
E
E
Q
K
E
R
F
------
L
R
PLTEK
P
A
L
------
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
Q
--
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
-
T
V
N
-------
P
E
L
R
H
K
G
V
V
----
A
L
---
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
-
E
---
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
------
D
E
A
R
K
Y
A
---
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
-
P
H
A
H
-----
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
A
-------
22
PsiBlast_CBE
87.36
34%
-64
- C2 -
4P13
3
ACADM_HUMAN
D:
[7-384]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
E
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
28
PsiBlast_CBE
87.29
34%
-65
- C2 -
1T9G
3
ACADM_HUMAN
B:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
38
PsiBlast_CBE
87.23
33%
-66
- C2 -
1EGC
5
ACADM_HUMAN
D:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
37
PsiBlast_CBE
87.22
33%
-64
- C2 -
1EGD
3
ACADM_HUMAN
B:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
40
PsiBlast_CBE
87.12
33%
-64
- C2 -
1EGC
5
ACADM_HUMAN
B:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
2
PsiBlast_PDB
87.08
34%
-63
- C2 -
4P13
3
ACADM_HUMAN
A:
[7-384]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
E
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
33
PsiBlast_CBE
86.79
34%
-65
- C2 -
2A1T
4
ACADM_HUMAN
C:
[41-418]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
26
PsiBlast_CBE
86.74
34%
-63
- C2 -
1T9G
3
ACADM_HUMAN
D:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
112
Fugue
86.50
34%
-70
- C2 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
M
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
-
H
K
G
I
-
Y
D
--------------
K
E
L
I
D
E
L
L
S
L
GI
T
G
A
Y
F
E
E
K
Y
G
G
------------
S
G
D
D
G
G
---
D
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
-
S
L
C
A
N
P
I
W
Q
F
G
T
-------
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
------
T
K
L
------
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
--
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
-
M
T
D
KS-------
K
G
N
H
G
I
T
----
A
F
---
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
----
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
------
A
D
A
V
E
Y
S
K
Q
---
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
-
P
F
T
V
-----
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
-------
30
PsiBlast_CBE
86.47
34%
-64
- C2 -
1EGE
3
ACADM_HUMAN
C:
[16-393]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
K
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
24
PsiBlast_CBE
86.39
34%
-64
- C2 -
4P13
3
ACADM_HUMAN
B:
[7-384]
-
F
T
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
-
Y
P
-----
V
-------
P
L
I
R
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
N
C
G
G
L
G
L
------------------
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
G
N
--
S
L
G
Q
M
P
I
I
I
A
G
N
-------
D
Q
Q
K
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
PDP----
K
A
P
A
N
K
A
F
T
----
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
E
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
------
52
PsiBlast_CBE
85.54
33%
-63
- C2 -
3MDE
4
ACADM_PIG
B:
[8-383]
---
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
R
T
G
E
-
Y
P
-----
V
-------
P
L
L
K
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
S
F
G
G
L
G
L
------------------
G
I
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
--
T
L
G
Q
V
P
L
I
I
G
G
N
-------
Y
Q
Q
Q
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
-------
P
D
P
K
A
P
A
S
K
----
A
F
TGF
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
----
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
------
12
PsiBlast_PDB
84.79
33%
-63
- C2 -
3MDD
2
ACADM_PIG
A:
[8-383]
---
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
R
T
G
E
-
Y
P
-----
V
-------
P
L
L
K
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
S
F
G
G
L
G
L
------------------
G
I
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
--
T
L
G
Q
V
P
L
I
I
G
G
N
-------
Y
Q
Q
Q
K
K
Y
------
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
-------
P
D
P
K
A
P
A
S
K
----
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
----
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
------
13
PsiBlast_PDB
84.13
33%
-64
- C2 -
3MDE
3
ACADM_PIG
A:
[8-383]
---
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
R
T
G
E
-
Y
P
-----
V
-------
P
L
L
K
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
S
F
G
G
L
G
L
------------------
G
I
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
--
T
L
G
Q
V
P
L
I
I
G
G
N
-------
Y
Q
Q
Q
K
K
Y
------
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
-------
P
D
P
K
A
P
A
S
K
----
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
----
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
------
53
PsiBlast_CBE
82.94
33%
-60
- C2 -
3MDD
2
ACADM_PIG
B:
[8-383]
---
E
Q
Q
K
E
F
Q
A
T
A
---
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
R
T
G
E
-
Y
P
-----
V
-------
P
L
L
K
R
A
W
E
L
G
L
--
M
N
T
H
I
P
E
S
F
G
G
L
G
L
------------------
G
I
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
V
Q
T
A
I
E
A
N
--
T
L
G
Q
V
P
L
I
I
G
G
N
-------
Y
Q
Q
Q
K
K
Y
------
L
------
G
R
M
TEEPLM
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
--
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
-
R
S
D
-------
P
D
P
K
A
P
A
S
K
----
A
F
TGF
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
----
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
------
D
---
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
-
R
N
T
Y
-----
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
------
108
HHSearch
81.58
33%
-63
- C2 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
M
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
-
H
K
G
I
Y
D
K
-----
E
-------
L
I
D
E
L
L
S
------
L
G
I
T
G
A
Y
F
E
------------
E
K
Y
G
G
S
G
D
DGG
D
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
S
A
T
V
-
S
L
C
A
N
P
I
W
Q
F
G
T
-------
E
A
Q
K
E
K
F
------
L
V
P
L
V
E
G
T
K
L
------
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
D-
D
G
-
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
-
M
T
D
-------
K
S
K
G
N
H
G
I
T
----
A
F
---
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
-
E
---
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
------
A
D
A
V
E
Y
S
---
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
-
P
F
T
V
-----
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
-------
41
PsiBlast_CBE
79.41
32%
-71
- C2 -
4L1F
5
?
B:
[12-378]
-----------
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
-
K
A
-
H
I
W
D
-----
R
-------
K
L
------
I
D
K
--
M
--
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
----------
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V-
S
L
C
A
T
P
I
Y
M
F
G
T
-------
E
E
Q
K
Q
K
Y
LAPIAE
G
------
T
H
V
------
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
--
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
-
M
T
D
-------
K
S
Q
G
V
H
G
I
S
----
A
F
---
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
----
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
AAAVKY
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
---------
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
-
P
Y
S
E
-----
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
--------
9
PsiBlast_PDB
78.44
32%
-71
- C2 -
4L1F
6
?
A:
[12-378]
-----------
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
-
K
A
-
H
I
W
D
-----
R
-------
K
L
------
I
D
K
--
M
--
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
----------
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V-
S
L
C
A
T
P
I
Y
M
F
G
T
-------
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
------
T
H
V
------
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
--
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
-
M
T
D
-------
K
S
Q
G
V
H
G
I
S
----
A
F
---
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
----
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
---------
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
-
P
Y
S
E
-----
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
--------
54
PsiBlast_CBE
70.64
35%
-82
- C2 -
1BUC
3
ACDS_MEGEL
B:
[70-382]
----------------------------------------------------------------------------------------------------
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
--------
S
A
T
V
S
L
C
A
N
PIWQFGT
E
A
Q
K
E
K
F
LVPLVE
G
------
T
K
L
------
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
--
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
-
M
T
D
-------
K
S
K
G
N
H
G
I
T
----
A
F
---
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
----
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
------
A
D
A
V
E
Y
S
K
Q
---
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
-
P
F
T
V
-----
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
--------
14
PsiBlast_PDB
70.31
35%
-78
- C2 -
1BUC
3
ACDS_MEGEL
A:
[70-382]
----------------------------------------------------------------------------------------------------
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
A
I
T
L
--------
S
A
T
V
S
L
C
A
N
P
I
W
Q
FGT
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
------
T
K
L
------
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
--
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
-
M
T
D
-------
K
S
K
G
N
H
G
I
T
----
A
F
---
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
----
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
------
A
D
A
V
E
Y
S
K
Q
---
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
-
P
F
T
V
-----
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
--------
105
HHSearch
70.27
30%
-55
- C2 -
3P4T
3
?
A:
[23-399]
-
S
I
W
T
T
A
E
R
E
A
L
R
K
T
V
R
A
F
A
E
R
E
V
L
P
H
A
H
E
W
E
-
R
A
G
E
I
P
R
-----
E
-------
L
H
R
K
A
A
E
------
L
G
L
L
G
A
G
F
P
------------
E
D
A
G
G
S
G
G
---
D
G
A
D
P
V
V
I
C
E
E
M
H
Y
A
G
S
P
G
G
V
Y
A
S
L
F
TC
G
I
A
V
P
H
M
I
A
S
G
D
-------
Q
R
L
I
D
T
Y
------
V
R
P
T
L
R
G
E
K
I
------
G
A
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
D
--
G
D
-
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
-
R
T
G
-------
G
-
P
G
A
G
G
V
S
----
L
I
---
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
-
E
---
N
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
------
D
L
T
V
E
W
C
---
R
N
R
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
V
A
R
V
Y
T
R
H
V
V
E
R
Q
L
A
G
E
T
N
L
I
A
-----
E
V
C
F
A
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
L
T
S
L
A
A
K
T
L
---------
3
PsiBlast_PDB
69.00
33%
-49
- C2 -
1JQI
4
ACADS_RAT
A:
[8-383]
--
V
E
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
-
K
-
E
H
L
F
P
-----
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
--
E
L
S
G
A
G
L
D
Y
L
A
Y
S
I
---
A
L
E
E
I
S
R
G
C
A
S
T
---
G
V
I
M
S
V
N
N
S
L
Y
L
-----
G
P
I
L
K
F
G
S
S
--
Q
Q
K
Q
Q
W
I
T
P
F
T
N
-------
G
D
K
I
G
C
F
-------------------------
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
--
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
-
S
T
D
-------
R
S
R
Q
N
K
G
I
S
----
A
F
---
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
----
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
------
D
C
A
---
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
-
P
F
T
K
-----
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
--------
25
PsiBlast_CBE
68.70
33%
-49
- C2 -
1JQI
4
ACADS_RAT
B:
[8-383]
--
V
E
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
-
K
-
E
H
L
F
P
-----
T
SQVKKMG
E
L
G
L
L
A
M
D
V
P
E
--
E
L
S
G
A
G
L
D
Y
L
A
Y
S
I
---
A
L
E
E
I
S
R
G
C
A
S
T
---
G
V
I
M
S
V
N
N
S
L
Y
L
-----
G
P
I
L
K
F
G
S
S
--
Q
Q
K
Q
Q
W
I
T
P
F
T
N
-------
G
D
K
I
G
C
F
-------------------------
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
--
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
-
S
T
D
-------
R
S
R
Q
N
K
G
I
S
----
A
F
---
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
----
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
------
D
C
A
---
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
-
P
F
T
K
-----
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
--------
77
PsiBlast_CBE
55.94
31%
-58
- C2 -
3B96
2
ACADV_HUMAN
A:
[95-438]
----------------------------------------------------------------------------------------------------
L
V
E
I
V
G
M
H
D
L
---
G
V
G
I
T
L
G
-
A
H
Q
--
S
I
G
F
K
G
I
L
L
F
G
T
-------
K
A
Q
K
E
K
Y
L
P
K
L
A
S
G
------
E
T
V
------
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
S
I
R
T
S
A
V
P
S
PC
G
K
-
Y
Y
T
L
N
G
S
K
L
W
I
S
N
G
G
L
A
D
I
F
T
V
F
A
K
T
P
V
-------
T
D
P
A
T
G
A
V
K
E
K
I
T
A
F
---
V
V
E
R
G
F
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
V
L
G
----
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
-------
F
G
M
A
A
A
L
A
------
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
A
N
M
-
D
Q
G
A
TDF
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
------------
17
PsiBlast_PDB
55.79
35%
-56
- C2 -
4N5F
10
?
A:
[125-385]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
------
R
V
I
------
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
E
L
R
--
D
G
-
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
-
M
T
D
-------
P
E
A
G
K
R
G
I
S
----
A
F
---
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
----
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
------
D
K
A
R
---
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
-
P
C
L
S
-----
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------
78
PsiBlast_CBE
53.89
32%
-58
- C2 -
2UXW
3
ACADV_HUMAN
A:
[126-445]
------------------------------------------------------------------------------------------------------------------
V
G
I
T
L
G
-
A
H
Q
--
S
I
G
F
K
G
I
L
L
F
G
T
-------
K
A
Q
K
E
K
Y
L
P
K
L
A
S
G
------
E
T
V
------
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
S
I
R
T
S
A
V
P
S
PC
G
K
-
Y
Y
T
L
N
G
S
K
L
W
I
S
N
G
G
L
A
D
I
F
T
V
F
A
K
T
P
V
-------
T
D
P
A
T
G
A
V
K
E
K
I
T
A
F
---
V
V
E
R
G
F
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
V
L
G
----
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
-------
F
G
M
A
A
A
L
A
------
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
A
N
M
-
D
Q
G
A
TDF
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
------------
61
PsiBlast_CBE
51.23
35%
-56
- C2 -
4N5F
10
?
B:
[125-385]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
------
R
V
I
------
G
A
F
C
L
T
E
P
H
-------
L
R
T
R
A
E
L
R
--
D
---
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
-
M
T
D
-------
P
E
A
G
K
R
G
I
S
----
A
F
---
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
----
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
------
D
K
A
R
---
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
-
P
C
L
S
-----
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------
80
PsiBlast_CBE
50.19
36%
-60
- C2 -
2D29
2
?
A:
[123-384]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
W
------
G
---
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
--
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
-
R
T
D
PPPSPER
K
H
Q
G
I
S
A
F
A
----
F
F
---
R
P
E
R
G
---
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
----
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
------
D
Y
A
L
A
Y
A
K
---
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
-
P
F
T
L
-----
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
L
--------
79
PsiBlast_CBE
49.14
36%
-63
- C2 -
2D29
2
?
B:
[123-384]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
W
------
G
---
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
--
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
-
R
T
D
PPPSPER
K
H
Q
G
I
S
A
F
A
----
F
F
---
R
P
E
R
G
---
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
----
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
------
D
Y
A
L
A
Y
A
K
---
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
-
P
F
T
L
-----
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
L
--------