@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4997: (2016-03-03 )
MSDSPQNPGPSSLKIYFRLLGYVKPYIGMFLLSIVGFLIFASTQPMLAGILKYFVDGLSNPDAALFPNVQWPWLRDLHLVYAVPLLIILIAAWQGLGSFLGNFFLAKVSLGLVHDLRVALFNKLLVLPNRYFDTHSSGHLISRITFNVTMVTGAATDAIKVVIREGLTVVFLFLYLLWMNWKLTLVMLAILPVIAVMVTTASRKFRKQSKKIQVAMGDVTHVASETIQGYRVVRSFGGEAYEEKRFLDASQSNTDKQLRMTKTGAVYTPMLQLVIYVAMAILMFLVLWLRGDASAGDLVAYITAAGLLPKPIRQLSEVSSTVQRGVAGAESIFEQLDEAAEEDQGTVEKERVSGRLEVRNLSFRYPGTDKQVLDDISFIAEPGQMIALVGRSGSGKSTLANLVPRFYQHNDGKILLDGVEVEDYRLRNLRRHIALVTQQVTLFNDSVANNIAYGDLAGAPREEIERAAKAANAKEFIDNLPQGFDTEVGENGVLLSGGQRQRLAIARALLKDAPLLILDEATSALDTESERHIQAALDEVMKGRTTLVIAHRLSTIEKADLILVMDQGQIVERGSHAELLAQNGHYARLHAMGLDEQAPAPVG
Atome Classification :
(67 SA)
.........10........20.....-...30........40........50-.....-...60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280...--...----.--290.--......300.......310.......320.......330.....-..340-.--.---...------.---..--350........360...-..-.-.370.--.......380.......390.......400.......410-.........420...--....430......--.440.-......450..--....--.--460.......470----.......480.......490.......500.......510.......520.......530.......540-.--...--..-..550..-....-.560.......570.......580--.-......590.......600.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSDSPQNPGP
S
S
L
K
I
Y
F
R
L
L
G
Y
V
K
P
Y
-
I
G
M
F
L
L
S
I
V
G
F
L
I
FAST
Q
P
M
L
A
G
I
L
-
K
Y
F
VD-GLSNP
D
A
ALFPNVQ
W
P
W
L
R
D
L
H
L
V
Y
A
V
P
L
L
I
I
L
I
A
A
W
Q
G
L
G
S
F
L
G
N
F
F
L
A
K
V
S
L
G
L
V
H
D
L
R
V
A
L
F
N
K
L
L
VLPNRYFDTHSSG
H
L
I
S
R
I
T
F
N
V
T
M
V
TGA
A
T
D
A
I
K
V
V
I
RE
G
L
T
V
V
F
L
F
L
Y
L
L
W
MN
W
K
L
T
L
V
M
L
A
I
L
P
V
I
A
V
M
V
T
T
A
S
R
K
F
R
K
QS
K
K
I
Q
V
A
MG
D
V
T
H
V
A
S
E
T
I
Q
G
Y
R
V
V
R
S
FGG
E
A
Y
E
E
KRFLDASQSNTDK
Q
L
R
M
TKTG
A
V
Y
T
P
M
L
Q
L
V
I
Y
V
A
M
A
I
L
M
F
L
--
V
L
W
----L--RGDA--SA
G
D
L
V
A
Y
I
T
A
AGLL
P
K
P
I
R
Q
L
S
E
V
S
S
T
V
Q
RGVA
G
A
E
S
I
F
E
Q
L
D
-
E
A
A
E
--E--D---QG
T
------
V
---
E
K
--
E
R
-VSG
R
L
E
V
R
N
L
S
F
RY-PG-T-
D
K
-
Q
V
--
L
D
D
I
S
F
IAEPG
Q
M
I
A
L
V
GRSGS
G
K
S
T
L
A
N
L
V
P
R
F
Y
QHN---D
G
K
I
L
L
DGVEV
E
D
Y
R
--
L
R
N
L
R
R
H
I
A
L
V
T
Q
--
Q
V
T
LF-NDSVANNIAYG--DLAG--A--
P
R
E
E
I
E
R
A
A
K
AA
N
----
A
K
E
F
I
D
NLPQGFDTEVGEN
G
V
L
LSGG
Q
R
Q
R
L
A
I
A
R
A
L
LKDA
P
L
L
I
LDEATSALDT
E
S
E
R
H
I
Q
A
A
L
D
E
V
M--K--GR
T
--
T
L
-
V
I
A
HRLS-TIEK-A
D
L
I
L
V
MDQGQIVERGS
H
A
E
L
L
AQ--N-G
H
Y
A
R
L
H
AMGLDEQAPAPVG
103
HHSearch
84.91
41%
-109
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
-
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
-
K
P
L
L
D
-
D
G
F
G
K
T
D
R
S
-------------
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
--
A
S
F
PS--
V
--
M
D
S
L
--
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
E
Q
E
--
K
--
D
---
E
G
K
------
R
---
V
I
--
D
R
-
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
-
R
-
E
V
-
P
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
--
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
E
E
--
Y
--
S
R
E
Q
I
E
E
A
A
R
M
A
Y
----
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
--
S
L
-
V
I
A
H
R
L
S
-
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
--------
4
PsiBlast_PDB
84.13
40%
-109
- C2 -
3B60
2
MSBA_SALTY
A:
[10-578]
------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
-
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
-
K
P
L
L
D
D
G
F
G
K
T
D
R
S
V
L
L
-----
W
M
---------
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
--
A
S
F
PS--
V
--
M
D
S
L
--
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
E
Q
E
--
K
--
D
---
E
G
K
------
R
---
V
I
--
D
R
-
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
-
R
-
E
V
-
P
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
--
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
E
E
--
Y
--
S
R
E
Q
I
E
E
A
A
R
M
A
Y
----
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
--
S
L
-
V
I
A
H
R
L
S
-
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
-----------
23
PsiBlast_CBE
84.07
40%
-109
- C2 -
3B60
2
MSBA_SALTY
B:
[10-578]
------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
-
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
-
K
P
L
L
D
D
G
F
G
K
T
D
R
S
V
L
L
-----
W
M
---------
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
--
A
S
F
PS--
V
--
M
D
S
L
--
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
E
Q
E
--
K
--
D
---
E
G
K
------
R
---
V
I
--
D
R
-
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
-
R
-
E
V
-
P
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
--
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
E
E
--
Y
--
S
R
E
Q
I
E
E
A
A
R
M
A
Y
----
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
--
S
L
-
V
I
A
H
R
L
S
-
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
-----------
124
Fugue
83.96
40%
-107
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
-
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
-
K
P
L
L
D
-
D
G
F
G
K
-------------
T
D
R
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
--
A
S
F
PS--
V
--
M
D
S
L
--
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
E
Q
E
--
K
--
D
---
E
G
K
------
R
---
V
I
--
D
R
-
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
-
R
-
E
V
-
P
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
--
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
E
E
--
Y
--
S
R
E
Q
I
E
E
A
A
R
M
A
Y
----
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
--
S
L
-
V
I
A
H
R
L
S
-
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
--------
21
PsiBlast_CBE
83.81
40%
-109
- C2 -
3B60
2
MSBA_SALTY
D:
[10-578]
------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
-
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
-
K
P
L
L
D
D
G
F
G
K
T
D
R
S
V
L
L
-----
W
M
---------
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
--
A
S
F
PS--
V
--
M
D
S
L
--
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
E
Q
E
--
K
--
D
---
E
G
K
------
R
---
V
I
--
D
R
-
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
-
R
-
E
V
-
P
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
--
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
E
E
--
Y
--
S
R
E
Q
I
E
E
A
A
R
M
A
Y
----
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
--
S
L
-
V
I
A
H
R
L
S
-
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
-----------
22
PsiBlast_CBE
83.46
40%
-109
- C2 -
3B60
2
MSBA_SALTY
C:
[10-578]
------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
-
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
-
K
P
L
L
D
D
G
F
G
K
T
D
R
S
V
L
L
-----
W
M
---------
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
--
A
S
F
PS--
V
--
M
D
S
L
--
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
E
Q
E
--
K
--
D
---
E
G
K
------
R
---
V
I
--
D
R
-
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
-
R
-
E
V
-
P
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
--
L
A
S
L
R
N
Q
V
A
L
V
S
Q
--
N
V
H
L
F
-
N
D
T
V
A
N
N
I
A
Y
A
--
R
T
E
E
--
Y
--
S
R
E
Q
I
E
E
A
A
R
M
A
Y
----
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
--
S
L
-
V
I
A
H
R
L
S
-
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
-----------
9
PsiBlast_PDB
79.21
34%
-111
- C2 -
3QF4
1
Y288_THEMA
B:
[27-586]
-----------------
R
L
L
G
Y
L
R
P
H
-
T
----
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
-
G
V
L
-
S
P
Y
L
I
-
G
-
K
T
I
D
V
V
F
V
P
-------
R
R
F
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
--
G
G
W
----
L
A
L
K
D
I
I
--
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
--
D
--
D
---
P
D
A
------
V
---
E
L
--
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
-
K
K
-
P
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
--
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
G
--
N
-
P
G
--
A
--
T
D
E
E
I
K
E
A
A
K
L
T
H
----
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
--
S
I
-
I
I
A
H
R
L
N
-
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
--------------
7
PsiBlast_PDB
79.08
36%
-105
- C2 -
2ONJ
4
Y1866_STAAM
A:
[4-575]
-----------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
--
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
N
H
A
L
T
T
D
E
------
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
----
I
--
S
G
S
I
--
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
-
E
D
Y
D
--
I
--
K
---
N
G
V
------
G
---
A
Q
PI
E
I
-
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
-
N
-
E
A
-
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
--
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
--
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
G
--
R
-
P
T
--
A
--
T
D
E
E
V
V
E
A
A
K
M
A
N
----
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
--
T
L
-
I
V
A
H
R
L
S
-
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
-----------
31
PsiBlast_CBE
78.88
36%
-107
- C2 -
2HYD
3
Y1866_STAAM
B:
[4-575]
-----------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
--
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
N
H
A
L
T
T
D
E
------
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
GA
Y
L
A
----
I
--
S
G
S
I
--
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
-
E
D
Y
D
--
I
--
K
---
N
G
V
------
G
---
A
Q
PI
E
I
-
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
-
N
-
E
A
-
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
--
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
--
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
G
--
R
-
P
T
--
A
--
T
D
E
E
V
V
E
A
A
K
M
A
N
----
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
--
T
L
-
I
V
A
H
R
L
S
-
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
-----------
6
PsiBlast_PDB
78.73
36%
-106
- C2 -
2HYD
3
Y1866_STAAM
A:
[4-575]
-----------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
--
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
N
H
A
L
T
T
D
E
------
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
----
I
--
S
G
S
I
--
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
-
E
D
Y
D
--
I
--
K
---
N
G
V
------
G
---
A
Q
PI
E
I
-
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
-
N
-
E
A
-
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
--
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
--
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
G
--
R
-
P
T
--
A
--
T
D
E
E
V
V
E
A
A
K
M
A
N
----
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
--
T
L
-
I
V
A
H
R
L
S
-
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
-----------
30
PsiBlast_CBE
78.61
36%
-106
- C2 -
2ONJ
4
Y1866_STAAM
B:
[4-575]
-----------------
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
--
P
M
L
I
P
L
L
I
K
Y
A
I
D
-
G
V
I
N
N
H
A
L
T
T
D
E
------
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
GA
Y
L
A
----
I
--
S
G
S
I
--
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
-
E
D
Y
D
--
I
--
K
---
N
G
V
------
G
---
A
Q
PI
E
I
-
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
-
N
-
E
A
-
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
--
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
--
D
N
I
L
F
-
S
D
T
V
K
E
N
I
L
L
G
--
R
-
P
T
--
A
--
T
D
E
E
V
V
E
A
A
K
M
A
N
----
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
--
T
L
-
I
V
A
H
R
L
S
-
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
-----------
10
PsiBlast_PDB
78.40
34%
-112
- C2 -
4Q4A
1
Y288_THEMA
B:
[27-586]
-----------------
R
L
L
G
Y
L
R
P
H
-
T
----
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
-
G
V
L
-
S
P
Y
L
I
-
G
-
K
T
I
D
V
V
F
V
P
-------
R
R
F
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
--
G
G
W
----
L
A
L
K
D
I
I
--
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
--
D
--
D
---
P
D
A
------
V
---
E
L
--
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
-
K
K
-
P
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
--
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
G
--
N
-
P
G
--
A
--
T
D
E
E
I
K
E
A
A
K
L
T
H
----
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
--
S
I
-
I
I
A
H
R
L
N
-
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
--------------
11
PsiBlast_PDB
77.97
34%
-107
- C2 -
4Q4H
-
Y288_THEMA
B:
[27-586]
-----------------
R
L
L
G
Y
L
R
P
H
-
T
----
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
-
G
V
L
-
S
P
Y
L
I
-
G
-
K
T
I
D
V
V
F
V
P
-------
R
R
F
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
--
G
G
W
----
L
A
L
K
D
I
I
--
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
--
D
--
D
---
P
D
A
------
V
---
E
L
--
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
-
K
K
-
P
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
--
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
G
--
N
-
P
G
--
A
--
T
D
E
E
I
K
E
A
A
K
L
T
H
----
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
--
S
I
-
I
I
A
H
R
L
N
-
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
--------------
12
PsiBlast_PDB
77.55
34%
-111
- C2 -
4Q4J
-
Y288_THEMA
B:
[27-586]
-----------------
R
L
L
G
Y
L
R
P
H
-
T
----
F
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
-
G
V
L
-
S
P
Y
L
I
-
G
-
K
T
I
D
V
V
F
V
P
-------
R
R
F
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
--
G
G
W
----
L
A
L
K
D
I
I
--
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
--
D
--
D
---
P
D
A
------
V
---
E
L
--
R
E
-
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
-
K
K
-
P
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
--
R
S
S
L
R
S
S
I
G
I
V
L
Q
--
D
T
I
L
F
-
S
T
T
V
K
E
N
L
K
Y
G
--
N
-
P
G
--
A
--
T
D
E
E
I
K
E
A
A
K
L
T
H
----
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
--
S
I
-
I
I
A
H
R
L
N
-
T
I
K
N
-
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
--------------
106
HHSearch
77.06
31%
-105
- C2 -
3WMG
5
?
A:
[29-598]
------------------------------
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
-
G
R
M
F
Q
-
V
F
T
K
S
K
S
Q
I
-----------
E
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
-
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
--
G
G
Q
L
I
--
A
--
R
G
S
L
--
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
-
R
V
P
Q
--
Y
--
R
---
R
P
D
PG
A
E
V
V
T
---
Q
P
--
L
V
-
L
K
Q
G
I
V
F
E
N
V
H
F
R
Y
-
P
T
-
R
M
N
V
-
E
V
--
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
--
F
H
A
L
R
S
Q
I
G
L
V
S
Q
--
E
P
V
L
F
-
S
G
T
I
R
D
N
I
L
Y
G
--
K
R
D
---
A
--
T
D
E
E
V
I
Q
A
L
R
E
A
N
----
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
--
S
V
-
V
I
A
H
R
L
S
-
T
V
A
R
-
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
-
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
-------
105
HHSearch
75.85
31%
-108
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[5-572]
-------------
P
E
A
R
K
L
L
G
L
A
Y
P
E
-
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
-
G
K
I
I
D
-
V
I
Y
T
N
P
T
V
D
-------
Y
S
---
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
--
G
G
L
L
M
--
G
--
S
A
H
M
--
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
-
R
E
P
K
--
L
--
P
---
F
N
E
------
G
V
I
L
N
E
--
K
S
-
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
-
R
P
E
V
-
P
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
--
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
--
A
D
D
P
SS
V
--
T
A
E
E
I
Q
R
V
A
E
V
A
N
----
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
--
V
L
-
V
I
A
H
R
L
S
-
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P-----------------------
15
PsiBlast_PDB
75.38
36%
-105
- C2 -
4AYX
5
ABCBA_HUMAN
A:
[93-574]
------------------------------------------------------------------------------------------------------------------
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
--
V
L
Y
K
G
G
L
L
--
M
G
S
A
HM
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
-
R
E
P
K
LP
F
--
N
---
E
G
V
------
I
---
L
N
--
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
-
R
-
P
E
V
P
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
--
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
AD
D
P
S
S
--
V
--
T
A
E
E
I
Q
R
V
A
E
V
A
N
----
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
--
V
L
-
V
I
A
H
R
L
S
-
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P-
N
-
G
-------------------
34
PsiBlast_CBE
74.72
35%
-101
- C2 -
4M1M
3
MDR1A_MOUSE
B:
[140-682]
-------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
----
I
--
S
K
E
Y
--
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
-
N
K
P
S
--
I
--
D
SFS
K
S
G
------
H
---
K
P
--
D
N
-
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
-
P
S
-
R
-
K
E
V
Q
I
--
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
--
V
R
Y
L
R
E
I
I
G
V
V
S
Q
--
E
P
V
L
F
-
A
T
T
I
A
E
N
I
R
Y
G
--
R
-
E
D
--
V
--
T
M
D
E
I
E
K
A
V
K
E
A
N
----
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
--
G
R
T
--
T
I
-
V
I
A
H
R
L
S
-
T
V
R
N
-
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
--
K
-
G
I
Y
F
K
L
--------------
18
PsiBlast_PDB
74.71
35%
-103
- C2 -
4M2S
1
MDR1A_MOUSE
A:
[140-675]
-------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
----
I
--
S
K
E
Y
--
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
-
N
K
P
S
--
I
--
D
SFS
K
S
G
------
H
---
K
P
--
D
N
-
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
-
P
S
-
R
-
K
E
V
Q
I
--
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
--
V
R
Y
L
R
E
I
I
G
V
V
S
Q
--
E
P
V
L
F
-
A
T
T
I
A
E
N
I
R
Y
G
--
R
-
E
D
--
V
--
T
M
D
E
I
E
K
A
V
K
E
A
N
----
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
--
G
R
T
--
T
I
-
V
I
A
H
R
L
S
-
T
V
R
N
-
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
--
K
-
G
I
Y
F
K
L
--------------
35
PsiBlast_CBE
74.69
35%
-105
- C2 -
4M1M
3
MDR1A_MOUSE
A:
[140-675]
-------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
----
I
--
S
K
E
Y
--
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
-
N
K
P
S
--
I
--
D
SFS
K
S
G
------
H
---
K
P
--
D
N
-
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
-
P
S
-
R
-
K
E
V
Q
I
--
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
---
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
--
V
R
Y
L
R
E
I
I
G
V
V
S
Q
--
E
P
V
L
F
-
A
T
T
I
A
E
N
I
R
Y
G
--
R
-
E
D
--
V
--
T
M
D
E
I
E
K
A
V
K
E
A
N
----
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
--
G
R
T
--
T
I
-
V
I
A
H
R
L
S
-
T
V
R
N
-
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
--
K
-
G
I
Y
F
K
L
--------------
14
PsiBlast_PDB
73.42
36%
-104
- C2 -
4AYT
6
ABCBA_HUMAN
A:
[93-567]
------------------------------------------------------------------------------------------------------------------
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
--
V
L
Y
K
G
G
L
L
--
M
G
S
A
HM
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
-
R
E
P
K
LP
F
--
N
---
E
G
V
------
I
---
L
N
--
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
-
R
-
P
E
V
P
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
--
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
AD
D
P
S
S
--
V
--
T
A
E
E
I
Q
R
V
A
E
V
A
N
----
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
--
V
L
-
V
I
A
H
R
L
S
-
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
----------------------------
17
PsiBlast_PDB
70.25
36%
-108
- C2 -
4AYW
2
ABCBA_HUMAN
A:
[124-598]
------------------------------------------------------------------------------------------------------------------
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
--
V
L
Y
K
G
G
L
L
--
M
G
S
A
HM
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
-
R
E
P
K
--
L
PF
N
---
E
G
V
------
I
---
L
N
--
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
-
R
-
P
E
V
P
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
--
P
V
W
L
R
S
K
I
G
T
V
S
Q
--
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
G
AD
D
P
S
S
--
V
--
T
A
E
E
I
Q
R
V
A
E
V
A
N
----
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
--
V
L
-
V
I
A
H
H
L
S
-
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
----------------------------
53
PsiBlast_CBE
54.61
49%
-99
- C2 -
3NH9
3
A:
[52-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
E
F
E
N
V
H
F
S
Y
--
A
-
D
-
G
R
-
E
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
--
Q
A
S
L
R
S
H
I
G
V
V
P
Q
--
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
T
---
A
--
G
N
D
E
V
E
A
A
A
Q
A
A
G
----
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
--
T
I
-
V
V
A
H
R
L
S
-
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
--------------
54
PsiBlast_CBE
53.69
49%
-96
- C2 -
3NH6
2
A:
[52-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
E
F
E
N
V
H
F
S
Y
--
A
-
D
-
G
R
-
E
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
--
Q
A
S
L
R
S
H
I
G
V
V
P
Q
--
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
T
---
A
--
G
N
D
E
V
E
A
A
A
Q
A
A
G
----
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
--
T
I
-
V
V
A
H
R
L
S
-
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
--------------
44
PsiBlast_CBE
53.64
52%
-92
- C2 -
5DGX
1
?
A:
[5-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
E
---
T
G
S
------
K
---
E
L
--
A
K
-
V
D
G
N
V
T
I
K
D
L
S
F
A
F
-
G
----
E
H
-
K
V
--
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
---
E
G
E
I
L
L
D
G
V
D
T
R
E
L
T
--
L
E
N
L
R
S
H
L
S
I
V
S
Q
--
N
V
H
L
F
-
D
D
T
V
Y
N
N
I
A
F
G
-----
E
--
V
--
S
E
E
E
V
I
D
A
L
K
R
A
N
----
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
----------------
L
E
S
L
T
--
K
--
S
C
T
--
T
I
-
V
I
A
H
R
L
S
-
T
V
E
N
-
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
--
G
-
G
L
Y
T
R
L
Y
Q
S
G
L
---------
52
PsiBlast_CBE
53.49
49%
-96
- C2 -
3NHA
4
A:
[52-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
E
F
E
N
V
H
F
S
Y
--
A
-
D
--
R
-
E
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
--
Q
A
S
L
R
S
H
I
G
V
V
P
Q
--
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
T
---
A
--
G
N
D
E
V
E
A
A
A
Q
A
A
G
----
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
--
T
I
-
V
V
A
H
R
L
S
-
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
--------------
107
HHSearch
53.48
44%
-85
- C2 -
3NH6
2
A:
[19-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
F
I
D
M
E
N
M
F
D
L
L
K
-
E
E
T
E
--
V
--
K
---
D
L
P
GA----
G
---
P
L
--
R
F
-
Q
K
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
-
G
--
R
-
E
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
--
Q
A
S
L
R
S
H
I
G
V
V
P
Q
--
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
T
---
A
--
G
N
D
E
V
E
A
A
A
Q
A
A
G
----
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
--
T
I
-
V
V
A
H
R
L
S
-
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
-------
51
PsiBlast_CBE
52.85
49%
-98
- C2 -
3NHB
3
A:
[52-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
I
E
F
E
N
V
H
F
S
Y
--
A
-
D
--
R
-
E
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
--
Q
A
S
L
R
S
H
I
G
V
V
P
Q
--
D
T
V
L
F
-
N
D
T
I
A
D
N
I
R
Y
G
--
R
V
T
---
A
--
G
N
D
E
V
E
A
A
A
Q
A
A
G
----
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
--
T
I
-
V
V
A
H
R
L
S
-
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
--------------
113
HHSearch
52.46
45%
-95
- C2 -
2FF7
1
A:
[5-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
P
G
---
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
H
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
----------
85
PsiBlast_CBE
51.77
43%
-80
- C2 -
2IXF
4
TAP1_RAT
C:
[6-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
------
L
---
A
P
--
L
N
-
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
-
N
V
-
Q
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
--
L
T
R
T
--
P
--
T
M
E
E
I
T
A
V
A
M
E
S
G
----
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
W
A
S
R
T
--
V
L
-
L
I
T
H
Q
L
S
-
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
-----------------
89
PsiBlast_CBE
51.35
42%
-83
- C2 -
2IXE
3
D:
[6-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
------
L
---
A
P
--
L
N
-
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
-
N
V
-
Q
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
----
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
--
L
T
R
T
--
P
--
T
M
E
E
I
T
A
V
A
M
E
S
G
----
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
-----
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
--
V
L
-
L
I
T
Q
Q
L
S
-
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
-----------------
87
PsiBlast_CBE
51.09
43%
-79
- C2 -
2IXF
5
TAP1_RAT
A:
[6-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
------
L
---
A
P
--
L
N
-
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
-
N
V
-
Q
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
--
L
T
R
T
--
P
--
T
M
E
E
I
T
A
V
A
M
E
S
G
----
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
--
V
L
-
L
I
T
H
Q
L
S
-
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
-----------------
110
HHSearch
50.85
42%
-85
- C2 -
2IXE
4
TAP1_RAT
A:
[13-256]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
-
H
P
N
V
-
Q
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
--
L
T
R
T
--
P
--
T
M
E
E
I
T
A
V
A
M
E
S
G
----
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
--
S
R
T
--
V
L
-
L
I
T
Q
Q
L
S
-
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
E
A
-----------
86
PsiBlast_CBE
50.79
43%
-77
- C2 -
2IXF
4
TAP1_RAT
B:
[6-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
------
L
---
A
P
--
L
N
-
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
-
N
V
-
Q
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
--
L
T
R
T
--
P
--
T
M
E
E
I
T
A
V
A
M
E
S
G
----
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
--
V
L
-
L
I
T
H
Q
L
S
-
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
-----------------
88
PsiBlast_CBE
50.61
43%
-85
- C2 -
1JJ7
2
A:
[10-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
L
E
G
L
V
Q
F
Q
D
V
S
F
A
Y
-
P
N
R
P
-
D
V
-
L
V
--
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
P
L
P
Q
Y
E
--
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
--
E
P
Q
V
F
-
G
R
S
L
Q
E
N
I
A
Y
G
--
L
T
Q
K
--
P
--
T
M
E
E
I
T
A
A
A
V
K
S
G
----
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
P
--
E
RY
S
R
S
--
V
L
-
L
I
T
Q
H
L
S
-
L
V
E
Q
-
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
E
K
--
K
-
G
C
Y
-----------------
84
PsiBlast_CBE
50.05
43%
-77
- C2 -
2IXF
4
D:
[6-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
------
L
---
A
P
--
L
N
-
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
-
N
V
-
Q
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
----
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
--
L
T
R
T
--
P
--
T
M
E
E
I
T
A
V
A
M
E
S
G
----
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
--
V
L
-
L
I
T
H
Q
L
S
-
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
-----------------
90
PsiBlast_CBE
49.79
42%
-80
- C2 -
2IXE
4
TAP1_RAT
A:
[6-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
------
L
---
A
P
--
L
N
-
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
-
N
V
-
Q
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
--
L
T
R
T
--
P
--
T
M
E
E
I
T
A
V
A
M
E
S
G
----
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
W
A
S
R
T
--
V
L
-
L
I
T
Q
Q
L
S
-
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
-----------------
73
PsiBlast_CBE
49.50
47%
-95
- C2 -
2FGJ
2
D:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
A
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
91
PsiBlast_CBE
49.40
42%
-83
- C2 -
4K8O
4
A:
[6-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
------
L
---
A
P
--
L
N
-
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
-
N
V
-
Q
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
--
L
T
R
T
--
P
--
T
M
E
E
I
T
A
V
A
M
E
S
G
----
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
A
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
--
V
L
-
L
I
T
Q
Q
L
S
-
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
-----------------
92
PsiBlast_CBE
49.24
42%
-79
- C2 -
2IXG
2
A:
[6-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
------
L
---
A
P
--
L
N
-
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
P
-
N
V
-
Q
V
--
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
--
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
E
P
L
L
F
-
G
R
S
F
R
E
N
I
A
Y
G
--
L
T
R
T
--
P
--
T
M
E
E
I
T
A
V
A
M
E
S
G
----
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
--
V
L
-
L
I
T
Q
Q
L
S
-
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
-----------------
69
PsiBlast_CBE
48.79
47%
-90
- C2 -
2FGK
2
HLYBP_ECOLX
B:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
H
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
79
PsiBlast_CBE
48.78
47%
-94
- C2 -
1XEF
3
HLYBP_ECOLX
C:
[5-227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
A
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
70
PsiBlast_CBE
48.64
47%
-88
- C2 -
2FGK
2
HLYBP_ECOLX
A:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
H
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
82
PsiBlast_CBE
48.59
42%
-87
- C2 -
3VX4
3
?
D:
[28-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
S
F
-
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
--
G
-
F
-
G
R
-
D
T
--
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
--
K
T
A
L
R
R
H
I
S
Y
L
P
Q
--
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
V
L
G
--
A
K
E
G
--
T
--
S
Q
E
D
I
I
R
A
C
E
I
A
E
----
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
-
M
--
T
--
E
K
T
--
I
I
-
F
V
A
H
R
L
S
-
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
-
G
F
Y
Y
N
L
--------------
68
PsiBlast_CBE
48.40
47%
-87
- C2 -
2FGK
2
HLYBP_ECOLX
C:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
H
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
66
PsiBlast_CBE
48.38
48%
-90
- C2 -
2PMK
1
A:
[7-229]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
H
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
81
PsiBlast_CBE
48.37
47%
-91
- C2 -
1XEF
3
HLYBP_ECOLX
A:
[5-227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
A
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
67
PsiBlast_CBE
48.32
47%
-91
- C2 -
2FGK
2
D:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
H
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
78
PsiBlast_CBE
48.14
47%
-91
- C2 -
1XEF
3
D:
[5-227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
A
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
80
PsiBlast_CBE
48.09
47%
-94
- C2 -
1XEF
3
HLYBP_ECOLX
B:
[5-227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
A
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
76
PsiBlast_CBE
48.04
47%
-86
- C2 -
2FGJ
2
HLYBP_ECOLX
A:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
A
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
64
PsiBlast_CBE
48.02
48%
-89
- C2 -
2FF7
1
A:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
H
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
71
PsiBlast_CBE
47.96
47%
-89
- C2 -
2FFB
1
A:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
H
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
74
PsiBlast_CBE
47.46
47%
-87
- C2 -
2FGJ
2
HLYBP_ECOLX
C:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
A
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
83
PsiBlast_CBE
47.24
42%
-88
- C2 -
3VX4
3
?
A:
[29-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
-
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
--
G
-
F
-
G
R
-
D
T
--
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
--
K
T
A
L
R
R
H
I
S
Y
L
P
Q
--
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
V
L
G
--
A
K
E
G
--
T
--
S
Q
E
D
I
I
R
A
C
E
I
A
E
----
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
-
M
--
T
--
E
K
T
--
I
I
-
F
V
A
H
R
L
S
-
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
-
G
F
Y
Y
N
L
--------------
75
PsiBlast_CBE
47.09
47%
-88
- C2 -
2FGJ
2
HLYBP_ECOLX
B:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
A
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
77
PsiBlast_CBE
47.04
47%
-87
- C2 -
2FFA
2
A:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
A
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
109
HHSearch
46.78
39%
-87
- C2 -
3VX4
3
?
A:
[29-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
-
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
F
-
G
--
R
-
D
T
--
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
--
K
T
A
L
R
R
H
I
S
Y
L
P
Q
--
Q
A
Y
V
F
-
S
G
S
I
M
D
N
L
V
L
G
--
A
K
E
G
--
T
--
S
Q
E
D
I
I
R
A
C
E
I
A
E
----
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
---
T
--
E
K
T
--
I
I
-
F
V
A
H
R
L
S
-
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
-
G
F
Y
Y
N
L
F
N
------------
57
PsiBlast_CBE
46.30
47%
-89
- C2 -
1MV5
3
LMRA_LACLA
C:
[2-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
-
S
-
E
--
Q
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
--
L
E
N
W
R
S
Q
I
G
F
V
S
Q
--
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
G
D
--
Y
--
T
D
E
D
L
W
Q
V
L
D
L
A
F
----
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
--
T
L
-
V
I
A
H
R
L
S
-
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
---------------
112
HHSearch
45.34
47%
-88
- C2 -
1MV5
3
LMRA_LACLA
A:
[2-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
-
S
--
E
-
Q
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
--
L
E
N
W
R
S
Q
I
G
F
V
S
Q
--
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
G
D
--
Y
--
T
D
E
D
L
W
Q
V
L
D
L
A
F
----
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
--
T
L
-
V
I
A
H
R
L
S
-
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
L
---------
72
PsiBlast_CBE
45.02
47%
-90
- C2 -
3B5J
1
A:
[7-229]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
R
F
R
Y
-
K
P
-
D
-
S
P
-
V
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
--
P
N
W
L
R
R
Q
V
G
V
V
L
Q
--
D
N
V
L
L
-
N
R
S
I
I
D
N
I
S
L
A
--
N
-
P
G
--
M
--
S
V
E
K
V
I
Y
A
A
K
L
A
G
----
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
--
V
I
-
I
I
A
H
R
L
S
-
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
------------------------
59
PsiBlast_CBE
44.65
47%
-87
- C2 -
1MV5
3
LMRA_LACLA
A:
[2-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
-
S
-
E
--
Q
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
--
L
E
N
W
R
S
Q
I
G
F
V
S
Q
--
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
G
D
--
Y
--
T
D
E
D
L
W
Q
V
L
D
L
A
F
----
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
--
T
L
-
V
I
A
H
R
L
S
-
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
---------------
56
PsiBlast_CBE
43.25
47%
-85
- C2 -
1MV5
3
D:
[2-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
-
S
-
E
--
Q
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
--
L
E
N
W
R
S
Q
I
G
F
V
S
Q
--
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
G
D
--
Y
--
T
D
E
D
L
W
Q
V
L
D
L
A
F
----
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
--
T
L
-
V
I
A
H
R
L
S
-
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
---------------
58
PsiBlast_CBE
43.03
47%
-83
- C2 -
1MV5
2
LMRA_LACLA
B:
[2-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
-
S
-
E
--
Q
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
--
L
E
N
W
R
S
Q
I
G
F
V
S
Q
--
D
S
A
I
M
-
A
G
T
I
R
E
N
L
T
Y
G
--
L
E
G
D
--
Y
--
T
D
E
D
L
W
Q
V
L
D
L
A
F
----
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
--
T
L
-
V
I
A
H
R
L
S
-
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
---------------
102
PsiBlast_CBE
42.07
31%
-98
- C2 -
4MKI
4
ECFA2_CALS4
A:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
V
E
N
V
S
F
I
Y
N
E
G
-
T
-
P
Y
-
A
T
VA
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
---
K
G
K
I
Y
I
N
G
I
D
I
T
D
K
K
VS
L
K
D
I
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
-
E
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
L
--
S
--
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
GI
S
K
E
L
A
D
K
S
P
--
F
E
---------
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
--
D
--
K
Y
K
M
I
T
I
-
L
V
S
H
N
M
E
-
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
------
A
E
R
L
E
K
I
G
L
---------
99
PsiBlast_CBE
39.95
34%
-80
- C2 -
4U00
3
?
A:
[18-228]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
---
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
A-
L
R
E
I
R
R
E
V
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
--
P
M
R
V
--
R
RW
P
R
E
K
A
E
K
-----
K
----
A
L
E
L
L
E
R
V
--
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
--
Q
--
G
G
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
-
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
------------------------
101
PsiBlast_CBE
39.81
31%
-95
- C2 -
4MKI
4
ECFA2_CALS4
B:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
V
E
N
V
S
F
I
Y
N
E
G
-
T
-
P
Y
-
A
T
VA
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
---
K
G
K
I
Y
I
N
G
I
D
I
T
D
K
K
VS
L
K
D
I
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
-
E
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
L
--
S
--
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
GI
S
K
E
L
A
D
K
S
P
--
F
E
---------
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
--
D
--
K
Y
K
M
I
T
I
-
L
V
S
H
N
M
E
-
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
------
A
E
R
L
E
K
I
G
L
---------