@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5034: (2016-03-03 )
MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRATRAKAGDFMSLCMNPELACEVTLQPLDRYPQLDAAILFSDILTIPDAMGQGLYFETGEGPRFRKVVSSLADIEALPVPDPEQDLGYVMDAVRTIRRELNGRVPLIGFSGSPWTLATYMVEGGSSKDFRKSKAMLYDNPKAMHALLDKLAQSVTSYLNGQIHAGAQAVQIFDSWGGSLSAAAYQEFSLAYMRKIVDGLIREHDGRRVPVILFTKGGGLWLESMAEVGAEALGLDWTCDIGSARARVGERVALQGNMDPSVLYANPAAIRAEVARILAAYGKGTGHVFNLGHGITPEVDPAHAGAFFEAVHELSAQYHG
Atome Classification :
(20 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110..-.....---120.......130......-----.140.......150.......160.......170.......180.......190.......200.......210.......220.......---230.......-240-..--.......250.......260.......270.......280.......290.......300.......310.---......320.......330.......340.......350...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MTALK
N
D
R
F
L
R
A
L
L
KQPVDV
T
P
V
W
M
M
R
Q
AGRY
L
P
E
Y
R
A
T
RAKA
G
D
F
M
S
L
CMNPE
L
A
C
E
V
T
LQ
P
L
DRYPQL
D
A
A
I
L
F
S
D
I
L
TI
P
D
AMGQG
L
Y
F
ETGEG
P
R
F
R
K
V
V
S
S
LADIEALP-VPDP
E
---
Q
D
L
G
Y
V
M
D
A
V
R
T
I
R
R
ELNG-----RV
P
L
I
GFSGSP
W
T
L
A
T
Y
M
VEGGSS
K
D
F
R
KSKAMLYDN
P
K
A
M
H
A
L
L
D
K
L
A
Q
S
V
T
S
Y
LNGQIHAG
A
Q
A
V
Q
I
F
D
SWGGS
L
S
A
A
A
Y
Q
E
F
S
L
A
Y
M
R
---
K
I
V
D
G
L
I
R
EH-D---G
R
--
R
V
P
V
I
L
F
TKGG
G
L
W
L
E
S
M
A
E
V
G
A
E
ALG
L
D
W
TCDIG
S
A
R
A
RVG
E
R
V
A
LQGNMDP
S
V
L
YAN
P
A
A
I
R
A
E
V
A
R
I
L
---
A
A
YGKGTG
H
V
F
NLGHGITPEVDPAH
A
G
A
F
F
E
A
V
H
E
L
S
AQYHG
1
PsiBlast_PDB
99.35
100%
-117
- C6 -
4WSH
8
DCUP_PSEAE
A:
[9-363]
-
M
T
A
L
K
N
D
R
F
L
R
A
L
L
K
Q
P
V
D
V
T
P
V
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
A
T
R
A
K
A
G
D
F
M
S
L
C
M
N
P
E
L
A
C
E
V
T
L
Q
P
L
D
R
Y
P
Q
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
M
G
Q
G
L
Y
F
E
T
G
E
G
P
R
F
R
K
V
V
S
S
L
A
D
I
E
A
L
P
-
V
P
D
P
E
---
Q
D
L
G
Y
V
M
D
A
V
R
T
I
R
R
E
L
N
G
-----
R
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
D
F
R
K
S
K
A
M
L
Y
D
N
P
K
A
M
H
A
L
L
D
K
L
A
Q
S
V
T
S
Y
L
N
G
Q
I
H
A
G
A
Q
A
V
Q
I
F
D
S
W
G
G
S
L
S
A
A
A
Y
Q
E
F
S
L
A
Y
M
R
---
K
I
V
D
G
L
I
R
E
H
-
D
---
G
R
--
R
V
P
V
I
L
F
T
K
G
G
G
L
W
L
E
S
M
A
E
V
G
A
E
A
L
G
L
D
W
T
C
D
I
G
S
A
R
A
R
V
G
E
R
V
A
L
Q
G
N
M
D
P
S
V
L
Y
A
N
P
A
A
I
R
A
E
V
A
R
I
L
---
A
A
Y
G
K
G
T
G
H
V
F
N
L
G
H
G
I
T
P
E
V
D
P
A
H
A
G
A
F
F
E
A
V
H
E
L
S
A
Q
Y
H
G
21
PsiBlast_CBE
98.36
100%
-119
- C6 -
4WSH
3
DCUP_PSEAE
B:
[11-363]
---
A
L
K
N
D
R
F
L
R
A
L
L
K
Q
P
V
D
V
T
P
V
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
A
T
R
A
K
A
G
D
F
M
S
L
C
M
N
P
E
L
A
C
E
V
T
L
Q
P
L
D
R
Y
P
Q
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
M
G
Q
G
L
Y
------
P
R
F
R
K
V
V
S
S
L
A
D
I
E
A
L
P
-
V
P
D
P
E
---
Q
D
L
G
Y
V
M
D
A
V
R
T
I
R
R
E
L
N
G
-----
R
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
D
F
R
K
S
K
A
M
L
Y
D
N
P
K
A
M
H
A
L
L
D
K
L
A
Q
S
V
T
S
Y
L
N
G
Q
I
H
A
G
A
Q
A
V
Q
I
F
D
S
W
G
G
S
L
S
A
A
A
Y
Q
E
F
S
L
A
Y
M
R
---
K
I
V
D
G
L
I
R
E
H
-
D
---
G
R
--
R
V
P
V
I
L
F
T
K
G
G
G
L
W
L
E
S
M
A
E
V
G
A
E
A
L
G
L
D
W
T
C
D
I
G
S
A
R
A
R
V
G
E
R
V
A
L
Q
G
N
M
D
P
S
V
L
Y
A
N
P
A
A
I
R
A
E
V
A
R
I
L
---
A
A
Y
G
K
G
T
G
H
V
F
N
L
G
H
G
I
T
P
E
V
D
P
A
H
A
G
A
F
F
E
A
V
H
E
L
S
A
Q
Y
H
G
2
PsiBlast_PDB
90.95
75%
-114
- C6 -
3CYV
-
DCUP_SHIFL
A:
[3-353]
---
E
L
K
N
D
R
Y
L
R
A
L
L
R
Q
P
V
D
V
T
P
V
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
K
A
T
R
A
Q
A
G
D
F
M
S
L
C
K
N
A
E
L
A
C
E
V
T
L
Q
P
L
R
R
Y
P
-
L
D
A
A
I
L
F
S
D
I
L
T
V
P
D
A
M
G
L
G
L
Y
F
E
A
G
E
G
P
R
F
T
S
P
V
T
C
K
A
D
V
D
K
L
P
-
I
P
D
P
E
---
D
E
L
G
Y
V
M
N
A
V
R
T
I
R
H
E
L
K
G
-----
E
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
A
F
T
V
I
K
K
M
M
Y
A
D
P
Q
A
L
H
A
L
L
D
K
L
A
K
S
V
T
L
Y
L
N
A
Q
I
K
A
G
A
Q
A
V
M
I
F
D
T
W
G
G
V
L
T
G
R
D
Y
Q
Q
F
S
L
Y
Y
M
H
---
K
I
V
D
G
L
L
R
E
N
-
D
---
G
R
--
R
V
P
V
T
L
F
T
K
G
G
G
Q
W
L
E
A
M
A
E
T
G
C
D
A
L
G
L
D
W
T
T
D
I
A
D
A
R
R
R
V
G
N
K
V
A
L
Q
G
N
M
D
P
S
M
L
Y
A
P
P
A
R
I
E
E
E
V
A
T
I
L
---
A
G
F
G
H
G
E
G
H
V
F
N
L
G
H
G
I
H
Q
D
V
P
P
E
H
A
G
V
F
V
E
A
V
H
R
L
S
E
Q
Y
H
-
4
PsiBlast_PDB
88.62
62%
-115
- C6 -
4EXQ
1
DCUP_BURTA
A:
[9-359]
----
L
I
N
D
T
F
L
R
A
L
L
R
E
P
T
D
Y
T
P
I
W
L
M
R
Q
A
G
R
Y
L
P
E
Y
N
A
T
R
A
R
A
G
S
F
L
G
L
A
K
H
P
D
Y
A
T
E
V
T
L
Q
P
L
E
R
F
P
-
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
M
G
L
G
L
D
F
----
G
P
K
F
A
H
P
V
R
T
E
A
D
V
A
K
L
A
-
V
P
D
I
G
---
A
T
L
G
Y
V
T
D
A
V
R
E
I
R
R
A
L
T
D
GEGRQ
R
V
P
L
I
G
F
S
G
S
P
W
T
L
A
C
Y
M
V
E
G
G
G
S
D
D
F
R
T
V
K
S
M
A
Y
A
R
P
D
L
M
H
R
I
L
D
V
N
A
Q
A
V
A
A
Y
L
N
A
Q
I
E
A
G
A
Q
A
V
M
I
F
D
T
W
G
G
A
L
A
D
G
A
Y
Q
R
F
S
L
D
Y
I
R
---
R
V
V
A
Q
L
K
R
E
H
-
D
---
G
A
--
R
V
P
A
I
A
F
T
K
G
G
G
L
W
L
E
D
L
A
A
T
G
V
D
A
V
G
L
D
W
T
V
N
L
G
R
A
R
E
R
V
A
G
R
V
A
L
Q
G
N
L
D
P
T
I
L
F
A
P
P
E
A
I
R
A
E
A
R
A
V
L
---
D
S
Y
G
N
H
P
G
H
V
F
N
L
G
H
G
I
S
Q
F
T
P
P
E
H
V
A
E
L
V
D
E
V
H
R
H
S
-----
3
PsiBlast_PDB
88.22
67%
-111
- C6 -
4ZR8
6
?
A:
[11-365]
---
T
L
K
N
D
R
F
L
R
A
L
L
R
E
P
V
D
T
T
P
I
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
E
T
R
S
K
A
G
--
L
S
L
C
K
N
T
E
F
A
C
E
V
T
L
Q
P
L
R
R
Y
-
D
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
L
G
L
G
L
Y
F
E
T
G
E
G
P
K
F
H
K
T
V
R
T
E
Q
D
V
A
N
L
P
-
K
L
N
A
K
---
A
D
L
D
Y
V
M
N
A
V
S
T
I
R
S
A
L
G
G
-----
Q
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
E
F
R
F
T
K
Q
M
M
Y
A
Q
P
E
V
L
H
A
L
L
D
H
L
A
D
S
V
I
D
Y
L
N
A
Q
I
D
A
G
A
Q
A
I
Q
I
F
D
S
W
G
G
A
L
A
H
R
E
Y
V
E
F
S
L
N
Y
M
K
---
K
I
I
A
G
L
Q
R
E
K
-
D
---
G
R
--
R
I
P
V
I
V
F
T
K
G
G
G
Q
W
L
E
P
M
I
T
T
G
A
D
A
L
G
L
D
W
T
T
P
L
N
T
A
R
T
T
V
A
G
R
V
A
L
Q
G
N
L
D
P
A
V
L
Y
G
S
A
A
S
I
E
K
A
V
K
A
M
L
D
D
A
Y
A
N
G
E
K
T
G
Y
V
A
N
L
G
H
G
I
T
Q
W
V
D
P
A
Q
P
K
I
F
V
D
T
V
H
E
Y
S
A
K
Y
L
G
22
PsiBlast_CBE
86.88
67%
-107
- C6 -
4ZR8
5
?
B:
[12-365]
----
L
K
N
D
R
F
L
R
A
L
L
R
E
P
V
D
T
T
P
I
W
M
M
R
Q
A
G
R
Y
L
P
E
Y
R
E
T
R
S
K
A
G
D
F
L
S
L
C
K
N
T
E
F
A
C
E
V
T
L
Q
P
L
R
R
Y
-
D
L
D
A
A
I
L
F
S
D
I
L
T
I
P
D
A
L
G
L
G
L
Y
F
E
T
G
E
G
P
K
F
H
K
T
V
R
T
E
Q
D
V
A
N
L
P
-
K
L
N
A
K
---
A
D
L
D
Y
V
M
N
A
V
S
T
I
R
S
A
L
G
G
-----
Q
V
P
L
I
G
F
S
G
S
P
W
T
L
A
T
Y
M
V
E
G
G
S
S
K
E
F
R
F
T
K
Q
M
M
Y
A
Q
P
E
V
L
H
A
L
L
D
H
L
A
D
S
V
I
D
Y
L
N
A
Q
I
D
A
G
A
Q
A
I
Q
I
F
D
S
W
G
G
A
L
A
H
R
E
Y
V
E
F
S
L
N
Y
M
K
---
K
I
I
A
G
L
Q
R
E
K
-
D
---
G
R
--
R
I
P
V
I
V
F
T
K
G
G
G
Q
W
L
E
P
M
I
T
T
G
A
D
A
L
G
L
D
W
T
T
P
L
N
T
A
R
T
T
V
A
G
R
V
A
L
Q
G
N
L
D
P
A
V
L
Y
G
S
A
A
S
I
E
K
A
V
K
A
M
L
D
D
A
Y
A
N
G
E
K
T
G
Y
V
A
N
L
G
H
G
I
T
Q
W
V
D
P
A
Q
P
K
I
F
V
D
T
V
H
E
Y
S
A
K
Y
L
G
17
PsiBlast_PDB
83.70
49%
-111
- C6 -
1R3V
2
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
E
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
28
HHSearch
83.42
48%
-108
- C6 -
1R3S
1
DCUP_HUMAN
A:
[11-364]
-
F
P
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
A
-
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
-
D
P
E
V
V
A
--
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
---
D
V
A
K
Q
V
K
A
R
L
R
E
---
A
G
L
A
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
-
P
H
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
--
48
Fugue
83.35
47%
-107
- C6 -
1URO
1
DCUP_HUMAN
A:
[10-366]
G
F
P
E
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
A
-
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
D
P
E
V
V
A
---
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
---
D
V
A
K
Q
V
K
A
R
L
-
R
E
A
G
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
-
R
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
R
L
L
R
Q
20
PsiBlast_PDB
83.34
49%
-114
- C6 -
2Q6Z
-
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
R
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
19
PsiBlast_PDB
83.30
49%
-113
- C6 -
2Q71
1
DCUP_HUMAN
A:
[4-351]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
R
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
9
PsiBlast_PDB
83.30
49%
-112
- C6 -
3GVQ
-
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
24
PsiBlast_CBE
83.20
49%
-110
- C6 -
1R3S
1
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
11
PsiBlast_PDB
82.99
49%
-110
- C6 -
3GW3
-
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
N
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
13
PsiBlast_PDB
82.94
49%
-114
- C6 -
3GVV
-
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
Y
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
7
PsiBlast_PDB
82.91
49%
-112
- C6 -
1R3Q
2
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
5
PsiBlast_PDB
82.84
49%
-111
- C6 -
3GW0
-
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
R
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
15
PsiBlast_PDB
82.73
49%
-111
- C6 -
1R3W
1
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
F
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
8
PsiBlast_PDB
82.68
49%
-110
- C6 -
1R3Y
1
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
D
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----
23
PsiBlast_CBE
82.66
49%
-110
- C6 -
1R3T
1
DCUP_HUMAN
A:
[14-361]
----
L
K
N
D
T
F
L
R
A
A
W
G
E
E
T
D
Y
T
P
V
W
C
M
R
Q
A
G
R
Y
L
P
E
F
R
E
T
R
A
-
A
Q
D
F
F
S
T
C
R
S
P
E
A
C
C
E
L
T
L
Q
P
L
R
R
F
P
-
L
D
A
A
I
I
F
S
G
I
L
V
V
P
Q
A
L
G
M
E
V
T
M
V
P
G
K
G
P
S
F
P
E
P
L
R
E
E
Q
D
L
E
R
L
R
---
D
P
E
V
V
A
S
E
L
G
Y
V
F
Q
A
I
T
L
T
R
Q
R
L
A
G
-----
R
V
P
L
I
G
F
A
G
A
P
W
T
L
M
T
Y
M
V
E
G
G
G
S
S
T
M
A
Q
A
K
R
W
L
Y
Q
R
P
Q
A
S
H
Q
L
L
R
I
L
T
D
A
L
V
P
Y
L
V
G
Q
V
V
A
G
A
Q
A
L
Q
L
F
E
S
H
A
G
H
L
G
P
Q
L
F
N
K
F
A
L
P
Y
I
R
D
V
A
K
Q
V
K
A
R
L
R
E
A
-
G
---
L
A
--
P
V
P
M
I
I
F
A
K
D
G
H
F
A
L
E
E
L
A
Q
A
G
Y
E
V
V
G
L
D
W
T
V
A
P
K
K
A
R
E
C
V
G
K
T
V
T
L
Q
G
N
L
D
P
C
A
L
Y
A
S
E
E
E
I
G
Q
L
V
K
Q
M
L
---
D
D
F
G
P
H
R
-
Y
I
A
N
L
G
H
G
L
Y
P
D
M
D
P
E
H
V
G
A
F
V
D
A
V
H
K
H
S
-----