@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5100: (2016-03-04 )
MTTPSKFRDIEIRAPRGTTLTAKSWLTEAPLRMLMNNLDPEVAENPRELVVYGGIGRAARNWECYDRIVETLKQLNDDETLLVQSGKPVGVFKTHANAPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYDGNLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLRSRYVDEQAKDLDDALARIQRYTAEGKAISIALLGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPAGWSWEEYRDRAQTDPAAVVKAAKQSMAVHVRAMLAFQQQGVPTFDYGNNIRQMAKEEGVANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPQDIYKTDAKVKQLIPDDAHLHRWLDMARERISFQGLPARICWVGLGLRAKLGLAFNEMVRTGELSAPIVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVIVCDGSDEAAERIARVLTNDPGTGVMRHADAGYQVAIDCAKEQGLNLPMITAQR
Atome Classification :
(20 SA)
------------------------------------------------------------.........10.....--...20........30........40........50........60....-...--------.70..---......----------80........90........100......--------.110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220....-...230.......240.------......250.......260....--------...270.......280.......290--........300...---------....310.....-..320----.....-...330...-------....340....-.-----..350....-...360.......---370.......380.......390....--...400....-...410...-------...---.420.......430.......440.......450.......460------.........470......----.480.......490.......500.......510-........520..--.....530.......540.......550.......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------MTTPS
K
F
R
D
I
E
I
RAPR--G
T
T
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
NL
D
P
E
VAENP
R
E
L
V
V
YGGIGRAARN
W
E
C
Y
-
D
R
I
--------
V
E
T
L
K
---QLNDD
E
----------
T
L
L
VQSGK
P
V
G
V
F
KTHANA
P
R
V
L
I
ANSNL--------VPHW
A
T
W
E
H
F
N
ELDA
K
G
L
A
M
Y
G
QMTAG
S
W
I
Y
IGSQGIVQ
G
T
Y
E
T
F
V
E
AGRQHYDGNL
K
G
R
W
V
L
TAGLGGMGGA
Q
P
L
A
A
T
LAG
A
C
S
L
N
I
E
C
QQSR
I
D
F
R
L
R
S
R
Y
V
D
E
Q
A
K
D
L
D
D
A
L
A
R
I
-
Q
R
YTAEG
K
A
I
S
I
A
LLG
N
------
A
A
E
I
L
P
E
L
V
RRGVRPDMVTDQTS--------AHDPLNGYLPAGW
S
W
E
E
Y
R
D
RAQT
D
---
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
---------
H
V
R
A
M
L
A
F
Q
QQG-
V
P
TF-----DYG
N
N
-
I
R
Q
M
A
K
EEG-------VANAFDFPGF
V
-
P
-----
A
Y
I
R
P
L
F
CR-GIGP
F
R
W
AALSG
D
---
P
Q
D
I
Y
K
T
D
A
K
V
K
Q
LIPD
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
ISFQGL-PA
R
I
C
W
V
GL-------G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
RTGELSA
P
I
V
I
GRDHLDSGSVASPNR
E
T
E
A
M--------QDGSDAVSD
W
P
L
L
N
A
L
L
N----TASG
A
T
W
V
S
L
HHGGGVGMGFSQHS
G
M
V
I
V
CDGS--
D
E
A
A
E
R
I
A
R
V
LTN--DPGTGVMRHADAG
Y
Q
V
A
I
D
C
A
K
EQGLNLPMITAQR---
12
PsiBlast_CBE
98.77
91%
-102
- C- -
1W1U
2
HUTU_PSEPU
B:
[5-555]
----------------------------------------------------------------
N
N
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
---
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
-------
3
PsiBlast_PDB
98.31
91%
-103
- C- -
1W1U
2
HUTU_PSEPU
A:
[5-555]
----------------------------------------------------------------
N
N
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
---
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
-------
1
PsiBlast_PDB
98.27
91%
-101
- C- -
1UWL
1
HUTU_PSEPU
A:
[5-555]
----------------------------------------------------------------
N
N
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
---
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
-------
11
PsiBlast_CBE
97.88
91%
-82
- C3 -
1UWK
2
HUTU_PSEPU
B:
[5-556]
----------------------------------------------------------------
N
K
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
---
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
D
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
------
40
Fugue
97.86
91%
-82
- C3 -
1UWK
2
HUTU_PSEPU
A:
[4-557]
---------------------------------------------------------------
N
N
K
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
---
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
D
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
G
-----
13
PsiBlast_CBE
97.70
91%
-88
- C3 -
2V7G
8
HUTU_PSEPU
D:
[5-556]
----------------------------------------------------------------
N
K
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
---
P
A
A
V
V
K
A
A
K
A
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
------
19
HHSearch
97.61
91%
-82
- C3 -
1UWK
2
HUTU_PSEPU
A:
[4-556]
---------------------------------------------------------------
N
N
K
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
---
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
D
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
------
2
PsiBlast_PDB
97.61
91%
-82
- C3 -
1UWK
2
HUTU_PSEPU
A:
[4-556]
---------------------------------------------------------------
N
N
K
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
---
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
D
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
A
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
------
15
PsiBlast_CBE
97.55
91%
-83
- C3 -
2V7G
7
HUTU_PSEPU
B:
[5-556]
----------------------------------------------------------------
N
K
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
---
P
A
A
V
V
K
A
A
K
A
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
------
4
PsiBlast_PDB
97.13
91%
-83
- C3 -
2V7G
5
HUTU_PSEPU
A:
[5-556]
----------------------------------------------------------------
N
K
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
---
P
A
A
V
V
K
A
A
K
A
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
------
10
PsiBlast_CBE
97.06
91%
-84
- C3 -
1UWL
1
HUTU_PSEPU
B:
[5-554]
----------------------------------------------------------------
N
N
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
A
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
E
---
P
A
A
V
V
K
A
A
K
Q
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
--------
14
PsiBlast_CBE
96.49
91%
-88
- C3 -
2V7G
3
HUTU_PSEPU
C:
[5-556]
----------------------------------------------------------------
N
K
Y
R
D
V
E
I
R
A
P
R
--
G
N
K
L
T
A
K
S
W
L
T
E
A
P
L
R
M
L
M
N
N
L
D
P
Q
V
A
E
N
P
K
E
L
V
V
Y
G
G
I
G
R
A
A
R
N
W
E
C
Y
-
D
K
I
--------
V
E
T
L
T
---
R
L
E
D
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
V
F
K
T
H
S
N
A
P
R
V
L
I
A
N
S
N
L
--------
V
P
H
W
A
N
W
E
H
F
N
E
L
D
A
K
G
L
A
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
V
Q
G
T
Y
E
T
F
V
E
A
G
R
Q
H
Y
G
G
S
L
K
G
K
W
V
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
A
A
T
L
A
G
A
C
S
L
N
I
E
S
Q
Q
S
R
I
D
F
R
L
E
T
R
Y
V
D
E
Q
A
T
D
L
D
D
A
L
V
R
I
-
A
K
Y
T
A
E
G
K
A
I
S
I
A
L
H
G
N
------
A
A
E
I
L
P
E
L
V
K
R
G
V
R
P
D
M
V
T
D
Q
T
S
--------
A
H
D
P
L
N
G
Y
L
P
I
G
W
T
W
E
Q
Y
R
D
R
A
Q
T
I
---
P
A
A
V
V
K
A
A
K
A
S
M
A
V
---------
H
V
Q
A
M
L
D
F
Q
K
Q
G
-
V
P
T
F
-----
D
Y
G
N
N
-
I
R
Q
M
A
K
E
E
G
-------
V
A
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
R
-
G
V
G
P
F
R
W
A
A
L
S
G
E
---
A
E
D
I
Y
K
T
D
A
K
V
K
E
L
I
P
D
D
A
H
L
H
R
W
L
D
M
--
A
R
E
R
I
S
F
Q
G
L
-
P
A
R
I
C
W
V
G
L
-------
G
L
R
---
A
K
L
G
L
A
F
N
E
M
V
R
S
G
E
L
S
A
P
V
V
I
G
R
D
H
L
D
S
G
S
V
S
S
P
N
R
E
T
E
A
M
--------
R
D
G
S
D
A
V
S
D
W
P
L
L
N
A
L
L
N
----
T
A
G
G
A
T
W
V
S
L
H
H
G
G
G
V
G
M
G
F
S
Q
H
S
G
M
V
I
V
C
D
G
T
--
D
E
A
A
E
R
I
A
R
V
L
T
N
--
D
P
G
T
G
V
M
R
H
A
D
A
G
Y
D
I
A
I
D
C
A
K
E
Q
G
L
D
L
P
M
I
T
------
16
PsiBlast_CBE
88.07
66%
-78
- C3 -
2FKN
2
HUTU_BACSU
D:
[8-550]
-----------------------------------------------------------------------
I
R
A
N
R
--
G
T
E
L
E
C
L
G
W
E
Q
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
-
H
A
I
--------
E
H
S
L
K
---
T
L
K
N
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
A
P
R
V
L
L
A
N
S
V
L
--------
V
P
K
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
S
V
T
M
N
E
G
V
V
I
A
V
E
V
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
-
E
E
A
K
L
A
G
K
P
L
S
I
A
L
L
G
N
------
A
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
--------
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
---
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
---------
H
V
E
A
M
L
A
F
Q
Q
K
G
-
S
I
V
F
-----
D
Y
G
N
N
-
I
R
Q
V
A
K
D
E
G
-------
L
E
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
E
-
G
K
G
P
F
R
W
A
A
L
S
G
D
---
P
A
D
I
Y
R
T
D
A
L
L
K
E
L
F
P
T
N
K
A
L
H
R
W
I
D
M
--
A
Q
E
K
V
T
F
Q
G
L
-
P
S
R
I
C
W
L
G
Y
-------
G
E
R
---
K
K
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
S
P
N
R
E
T
E
A
M
--------
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
----
T
A
A
G
A
S
W
V
S
F
H
H
G
G
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
--
E
L
A
D
E
R
L
A
R
V
L
T
S
--
D
P
G
M
G
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
--------
17
PsiBlast_CBE
87.52
66%
-77
- C3 -
2FKN
2
HUTU_BACSU
C:
[8-550]
-----------------------------------------------------------------------
I
R
A
N
R
--
G
T
E
L
E
C
L
G
W
E
Q
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
-
H
A
I
--------
E
H
S
L
K
---
T
L
K
N
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
A
P
R
V
L
L
A
N
S
V
L
--------
V
P
K
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
S
V
T
M
N
E
G
V
V
I
A
V
E
V
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
-
E
E
A
K
L
A
G
K
P
L
S
I
A
L
L
G
N
------
A
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
--------
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
---
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
---------
H
V
E
A
M
L
A
F
Q
Q
K
G
-
S
I
V
F
-----
D
Y
G
N
N
-
I
R
Q
V
A
K
D
E
G
-------
L
E
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
E
-
G
K
G
P
F
R
W
A
A
L
S
G
D
---
P
A
D
I
Y
R
T
D
A
L
L
K
E
L
F
P
T
N
K
A
L
H
R
W
I
D
M
--
A
Q
E
K
V
T
F
Q
G
L
-
P
S
R
I
C
W
L
G
Y
-------
G
E
R
---
K
K
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
S
P
N
R
E
T
E
A
M
--------
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
----
T
A
A
G
A
S
W
V
S
F
H
H
G
G
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
--
E
L
A
D
E
R
L
A
R
V
L
T
S
--
D
P
G
M
G
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
--------
21
HHSearch
87.41
65%
-79
- C3 -
2FKN
2
HUTU_BACSU
A:
[7-550]
----------------------------------------------------------------------
S
I
R
A
N
R
--
G
T
E
L
E
C
L
G
W
E
Q
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
-
H
A
I
--------
E
H
S
L
K
---
T
L
K
N
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
A
P
R
V
L
L
A
N
S
V
L
--------
V
P
K
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
S
V
T
M
N
E
G
V
V
I
A
V
E
V
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
-
E
E
A
K
L
A
G
K
P
L
S
I
A
L
L
G
N
------
A
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
--------
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
---
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
---------
H
V
E
A
M
L
A
F
Q
Q
K
G
-
S
I
V
F
-----
D
Y
G
N
N
-
I
R
Q
V
A
K
D
E
G
-------
L
E
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
E
-
G
K
G
P
F
R
W
A
A
L
S
G
D
---
P
A
D
I
Y
R
T
D
A
L
L
K
E
L
F
P
T
N
K
A
L
H
R
W
I
D
M
--
A
Q
E
K
V
T
F
Q
G
L
-
P
S
R
I
C
W
L
G
Y
-------
G
E
R
---
K
K
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
S
P
N
R
E
T
E
A
M
--------
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
----
T
A
A
G
A
S
W
V
S
F
H
H
G
G
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
--
E
L
A
D
E
R
L
A
R
V
L
T
S
--
D
P
G
M
G
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
--------
18
PsiBlast_CBE
87.18
66%
-80
- C3 -
2FKN
2
HUTU_BACSU
B:
[8-550]
-----------------------------------------------------------------------
I
R
A
N
R
--
G
T
E
L
E
C
L
G
W
E
Q
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
-
H
A
I
--------
E
H
S
L
K
---
T
L
K
N
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
A
P
R
V
L
L
A
N
S
V
L
--------
V
P
K
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
S
V
T
M
N
E
G
V
V
I
A
V
E
V
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
-
E
E
A
K
L
A
G
K
P
L
S
I
A
L
L
G
N
------
A
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
--------
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
---
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
---------
H
V
E
A
M
L
A
F
Q
Q
K
G
-
S
I
V
F
-----
D
Y
G
N
N
-
I
R
Q
V
A
K
D
E
G
-------
L
E
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
E
-
G
K
G
P
F
R
W
A
A
L
S
G
D
---
P
A
D
I
Y
R
T
D
A
L
L
K
E
L
F
P
T
N
K
A
L
H
R
W
I
D
M
--
A
Q
E
K
V
T
F
Q
G
L
-
P
S
R
I
C
W
L
G
Y
-------
G
E
R
---
K
K
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
S
P
N
R
E
T
E
A
M
--------
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
----
T
A
A
G
A
S
W
V
S
F
H
H
G
G
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
--
E
L
A
D
E
R
L
A
R
V
L
T
S
--
D
P
G
M
G
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
--------
5
PsiBlast_PDB
87.18
66%
-79
- C3 -
2FKN
2
HUTU_BACSU
A:
[8-550]
-----------------------------------------------------------------------
I
R
A
N
R
--
G
T
E
L
E
C
L
G
W
E
Q
E
A
V
L
R
M
L
R
N
N
L
D
P
E
V
A
E
K
P
E
D
L
I
V
Y
G
G
I
G
K
A
A
R
D
W
D
A
F
-
H
A
I
--------
E
H
S
L
K
---
T
L
K
N
D
E
----------
T
L
L
V
Q
S
G
K
P
V
G
M
F
R
T
H
P
Q
A
P
R
V
L
L
A
N
S
V
L
--------
V
P
K
W
A
D
W
E
H
F
H
E
L
E
K
K
G
L
M
M
Y
G
Q
M
T
A
G
S
W
I
Y
I
G
S
Q
G
I
L
Q
G
T
Y
E
T
F
A
E
L
A
R
Q
H
F
G
G
S
L
K
G
T
L
T
L
T
A
G
L
G
G
M
G
G
A
Q
P
L
S
V
T
M
N
E
G
V
V
I
A
V
E
V
D
E
K
R
I
D
K
R
I
E
T
K
Y
C
D
R
K
T
A
S
I
E
E
A
L
A
W
A
-
E
E
A
K
L
A
G
K
P
L
S
I
A
L
L
G
N
------
A
A
E
V
H
H
T
L
L
N
R
G
V
K
I
D
I
V
T
D
Q
T
S
--------
A
H
D
P
L
I
G
Y
V
P
E
G
Y
S
L
D
E
A
D
R
L
R
Q
D
T
---
P
E
L
Y
V
R
L
A
K
Q
S
M
K
K
---------
H
V
E
A
M
L
A
F
Q
Q
K
G
-
S
I
V
F
-----
D
Y
G
N
N
-
I
R
Q
V
A
K
D
E
G
-------
L
E
N
A
F
D
F
P
G
F
V
-
P
-----
A
Y
I
R
P
L
F
C
E
-
G
K
G
P
F
R
W
A
A
L
S
G
D
---
P
A
D
I
Y
R
T
D
A
L
L
K
E
L
F
P
T
N
K
A
L
H
R
W
I
D
M
--
A
Q
E
K
V
T
F
Q
G
L
-
P
S
R
I
C
W
L
G
Y
-------
G
E
R
---
K
K
M
G
L
A
I
N
E
L
V
R
T
G
E
L
K
A
P
V
V
I
G
R
D
H
L
D
C
G
S
V
A
S
P
N
R
E
T
E
A
M
--------
K
D
G
S
D
A
V
G
D
W
A
V
L
N
A
L
V
N
----
T
A
A
G
A
S
W
V
S
F
H
H
G
G
G
V
G
M
G
Y
S
L
H
A
G
M
V
A
V
A
D
G
S
--
E
L
A
D
E
R
L
A
R
V
L
T
S
--
D
P
G
M
G
I
I
R
H
A
D
A
G
Y
E
R
A
V
E
V
A
K
E
Q
D
I
I
V
P
M
--------
49
Fugue
37.51
17%
-31
* C1 *
4J1Q
1
A:
[20-445]
------------------------------------------------------------
H
M
E
R
L
M
L
E
P
V
W
E
K
Q
N
E
--
E
L
S
Y
T
E
H
I
I
V
L
F
E
T
E
R
S
V
T
D
S
I
A
S
H
M
-
K
D
A
R
V
I
T
L
N
E
A
V
G
H
I
A
E
R
Y
Q
C
Y
M
Q
N
I
--------
F
E
L
L
Q
S
K
V
R
K
L
S
A
G
----------
R
I
I
I
Q
A
I
V
P
L
E
K
E
K
Q
L
F
A
G
V
S
G
L
F
K
T
A
E
I
E
F
SK
L
T
A
Q
V
I
E
I
E
K
P
E
E
M
I
D
L
H
L
K
L
K
D
D
S
R
R
P
F
D
K
Q
I
R
Y
E
A
G
Y
R
F
V
K
G
W
R
E
M
---
V
D
T
L
H
M
P
W
R
D
E
G
V
Y
L
I
T
------
G
G
A
G
S
L
G
L
L
F
A
K
E
I
A
N
R
T
G
--
R
S
T
I
V
L
T
G
R
S
V
L
S
E
D
K
E
N
E
L
E
A
L
R
S
I
G
-
A
E
V
V
Y
R
E
A
D
V
S
D
--
Q
H
A
------
V
R
H
L
L
E
E
I
K
E
R
---------------------
Y
G
T
L
N
G
----------------------------------------------------------------------------------------------------------------
I
I
H
-
G
A
G
S
------
S
K
D
---
R
F
I
I
H
K
T
N
E
E
F
Q
E
V
L
Q
P
K
V
S
G
L
L
H
V
D
E
--
C
-----
S
K
D
F
-
P
L
D
F
F
I
F
F
S
-------
S
V
S
---
G
C
L
G
-------
N
A
G
Q
--
A
D
Y
A
A
A
N
S
F
M
D
A
F
A
E
Y
R
R
S
L
A
A
S
K
K
--------
R
F
G
S
T
I
S
F
N
W
P
L
W
E
----------
E
G
G
M
Q
V
----
G
A
E
D
E
K
R
M
L
K
T
T
G
M
V
P
M
--
P
T
--
D
S
G
L
K
A
F
Y
Q
G
I
V
S
--
D
K
P
-----------
Q
V
F
V
M
E
G
Q
L
Q
K
M
K
Q
K
L
L
-------
41
Fugue
33.15
17%
-34
* C4 *
4M59
3
?
A:
[6-714]
PD
A
Q
V
L
V
L
A
I
S
S
HPLPT
L
A
A
F
L
A
S
R
R
D
E
L
L
R
AD
I
T
S
L
L
K
A
L
E
L
S
GH
W
E
W
A
L
A
L
L
R
W
A
G
K
E
G
A
A
D
A
S
A
L
E
M
V
V
R
A
L
G
R
E
G
Q
H
D
A
V
C
A
L
L
D
E
T
P
L
P
---
P
G
S
R
L
D
V
R
A
Y
T
T
V
L
H
A
L
S
R
A
G
R
Y
E
R
A
L
E
L
F
-
A
E
L
R
R
Q
G
V
A
P
T
L
V
T
Y
N
---
V
V
L
D
V
Y
G
R
M
GRS
W
P
R
I
V
A
L
L
D
E
M
R
A
A
G
V
E
P
D
G
F
T
A
S
T
V
I
A
A
C
S
R
D
--------
G
L
V
D
E
A
V
A
F
F
E
D
L
K
A
R
G
H
A
-
P
S
V
V
T
Y
N
A
L
L
Q
V
F
G
K
---
A
G
N
Y
T
E
A
L
R
V
L
G
E
M
E
Q
N
G
C
Q
P
D
A
V
T
Y
N
E
L
A
G
T
E
E
A
A
R
C
L
D
T
M
A
S
P
N
----
A
F
T
Y
N
T
V
M
T
A
Y
G
N
V
G
K
V
D
E
A
L
A
L
F
D
Q
M
K
K
T
G
F
V
P
N
V
N
T
Y
N
L
V
L
G
M
L
G
K
K
SR
F
T
V
M
L
E
M
L
G
E
M
S
R
S
G
C
T
P
N
R
V
T
W
N
T
M
L
AVSGKRG
M
E
D
Y
V
T
R
V
L
E
G
M
R
S
S
G
V
E
L
S
R
D
T
Y
N
---
T
L
I
A
A
Y
G
R
C
G
S
R
T
N
---------
A
F
K
M
Y
N
E
M
T
S
A
G
F
T
P
C
I
-----
T
T
Y
N
A
-
L
L
N
V
L
S
R
Q
G
D
W
S
T
A
Q
S
I
V
S
K
M
R
T
K
G
F
K
-
P
N
E
Q
S
Y
S
L
L
L
Q
C
Y
A
K
-
G
G
N
V
A
G
I
A
A
I
E
N
E
V
Y
G
S
G
A
V
F
P
S
W
V
I
L
R
T
L
V
I
A
N
F
K
C
R
R
L
D
G
M
E
T
A
F
Q
E
V
K
A
R
G
Y
N
P
D
L
V
I
F
N
S
M
L
S
I
Y
A
K
N
G
M
Y
---
S
K
A
T
E
V
F
D
S
I
K
R
S
G
-
L
S
P
D
L
I
T
Y
N
S
L
M
D
M
Y
A
K
C
S
E
S
W
E
A
E
K
I
L
N
Q
L
K
C
SQ
T
M
K
P
D
V
V
S
Y
N
T
V
I
N
G
F
C
K
QGL
V
K
E
A
Q
R
V
L
S
E
M
V
A
D
G
M
A
P
C
A
V
T
Y
H
T
L
V
G
G
Y
S
S
L
E
MF
S
E
A
R
E
V
I
G
Y
M
V
Q
H
GL
K
P
M
E
L
T
Y
R
R
V
V
E
S
Y
C
R
A
F
E
E
A
R
G
F
L
S
E
V
K
A
L
E
A
Y
I
E
D
A
47
Fugue
32.24
16%
-35
- C1 -
3OC2
3
?
A:
[35-545]
---------------------------------------------------------------
A
R
S
V
R
H
I
A
I
P
A
H
R
--
G
---------------
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
A
K
E
R
W
-
P
Q
L
--------
A
A
A
L
G
QD-
T
K
L
F
A
D
----------
R
I
E
Q
N
A
E
R
E
F
I
Y
L
V
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
--------
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
--------
E
V
V
A
H
A
V
G
F
T
D
V
D
D
R
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
V
T
K
N
A
K
P
G
K
T
L
A
L
-----
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
----------
K
A
G
S
L
V
I
M
D
---------------
V
K
T
G
E
I
L
A
M
T
N
Q
--
P
--------
T
Y
N
P
N
N
---
R
R
N
L
Q
P
A
A
M
R
N
R
A
M
I
D
VFE
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
GRWKPS
D
I
V
D
V
Y
P
G
T
L
Q
I
G
-
R
Y
T
I
R
D
VSR
N
S
R
Q
L
D
L
T
G
I
L
I
K
S
S
-------
N
V
G
I
S
K
I
A
F
D
I
G
A
-----
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
---
R
V
G
N
L
P
N
H
-------------
R
K
W
P
K
A
--
E
T
A
T
L
A
Y
-----------
G
Y
-------
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
V
Q
V
I
S
P
E
V
A
S
T
V
--------
Q
G
M
L
Q
Q
V
V
E
A
Q
------
G
----
G
V
F
R
A
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
A
Y
R
S
L
F
A
G
F
A
P
A
--
T
D
P
--
R
I
A
M
V
V
V
I
--
D
E
P
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
N
L
-------