@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5150: (2016-03-05 )
MAERKTLLLTGASRGIGHATVKYFNAAGWRVFTASRQSWASECPWADGEENHIHLDLEDIPGVEASLELIREKLGDGRLHALVDNAGISPKGEGGERLGVLETDYATWLRVFNVNLFSTALLARGLFAELKAAQGTVINVTSIAGSKVHPFAGVAYATSKAALSALTREMAHDFGPHGVRVNAIAPGEIDTSILSPGTEEIVERSIPLHRLGRPEEIASLIYFLCTSGASYVNGAEIHVNGGQHV
Atome Classification :
(32 SA)
.........10........20........30-.-.......40--.....-----....50.-.......60........70...--.....80.......-.90........100.......110.......120.....-..130.-...----....140.......---------------------------150...-....160.......170......--.180.......190.---......200...-----...---.210.......220.......230.......240...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAE
R
K
T
L
L
L
TGASRGIG
H
A
T
V
K
Y
FNAA
G
W
R
V
-
F
-
T
A
S
R
Q
S
W
A
---SECPW-----ADGEE
N
H
-
I
H
L
DLEDIPG
V
E
A
S
L
E
L
I
R
E
KL--GDG
R
L
H
A
L
VDNAGI-SPKGEGG
E
R
LGVLET
D
Y
A
T
W
L
R
V
FN
V
N
L
F
S
T
A
L
L
A
R
G
L
F
-
A
E
L
-KA-AQ
G
----
T
V
I
N
V
T
SIAGSKVH---------------------------PFA
G
V
A
-
Y
A
T
S
K
A
A
L
S
A
L
T
R
E
M
A
H
DFGPH
G
--
V
R
V
N
A
IAPGEI
D
T
SI---LSP
G
T
E
E
I
V
E
RS-----I
P
L
---HRLG
R
P
E
E
I
A
S
L
I
Y
F
L
CTSGASYVN
G
A
E
I
H
VNGGQHV
1
PsiBlast_PDB
96.13
64%
-102
- C2 -
4X54
2
?
A:
[34-271]
---
R
K
T
L
V
L
T
G
A
S
R
G
I
G
H
A
T
V
K
R
F
S
L
A
G
W
R
V
-
I
-
T
C
S
R
Q
D
-----------------
G
P
E
D
H
-
I
K
V
D
L
S
D
P
E
D
I
G
K
A
I
A
E
I
R
R
R
L
E
A
N
G
S
K
L
H
A
L
V
N
N
A
G
I
-
S
P
K
A
E
G
G
R
R
M
N
S
I
E
T
P
M
A
V
W
R
D
V
F
Q
V
N
F
M
A
P
I
M
L
A
R
G
L
F
-
K
E
L
-
E
A
-
A
Q
G
----
S
V
V
N
V
T
S
I
A
G
S
R
V
H
---------------------------
P
F
A
G
T
A
-
Y
A
T
S
K
A
A
L
A
A
L
T
R
E
M
A
S
D
F
G
P
Y
G
--
I
R
V
N
A
I
A
P
G
E
I
D
T
A
I
---
L
S
------------------------
G
K
T
S
E
V
A
E
T
I
Y
F
L
C
T
E
T
S
S
Y
V
T
G
S
E
I
H
I
N
-----
94
PsiBlast_CBE
78.33
33%
-95
- C2 -
4NBT
1
?
C:
[5-240]
--
E
G
K
V
A
V
I
T
G
G
A
K
G
L
G
Q
A
I
A
L
A
Y
A
E
E
G
A
K
V
-
I
-
A
G
D
L
G
D
L
T
---
Y
S
H
P
N
-----
V
E
G
-----
M
Y
L
N
V
T
D
V
T
G
V
E
K
F
Y
Q
S
V
I
D
K
Y
--
G
--
K
I
D
I
L
V
N
N
A
G
I
-
T
K
D
A
M
------
T
R
K
M
T
E
A
Q
W
D
A
V
I
D
V
N
L
K
G
V
F
N
L
T
R
L
V
G
-
P
Q
M
-
Q
T
N
G
Y
G
----
S
I
I
N
I
S
S
V
V
G
--
V
F
---------------------------
G
N
I
G
Q
A
N
Y
A
A
T
K
A
G
V
I
G
L
T
M
T
W
A
K
E
F
A
L
K
G
AN
V
R
V
N
A
I
A
P
G
Y
I
M
T
D
I
---
L
K
T
V
P
Q
D
L
L
D
K
F
-----
A
A
L
TML
N
R
L
G
Q
P
E
E
I
A
K
V
A
L
F
L
A
S
D
D
A
S
Y
V
T
G
Q
T
I
N
V
N
G
G
M
R
L
95
PsiBlast_CBE
77.51
33%
-96
- C2 -
4NBT
1
?
B:
[5-240]
--
E
G
K
V
A
V
I
T
G
G
A
K
G
L
G
Q
A
I
A
L
A
Y
A
E
E
G
A
K
V
-
I
-
A
G
D
L
G
D
L
T
---
Y
S
H
P
N
-----
V
E
G
-----
M
Y
L
N
V
T
D
V
T
G
V
E
K
F
Y
Q
S
V
I
D
K
Y
--
G
--
K
I
D
I
L
V
N
N
A
G
I
-
T
K
D
A
M
------
T
R
K
M
T
E
A
Q
W
D
A
V
I
D
V
N
L
K
G
V
F
N
L
T
R
L
V
G
-
P
Q
M
-
Q
T
N
G
Y
G
----
S
I
I
N
I
S
S
V
V
G
--
V
F
---------------------------
G
N
I
G
Q
A
N
Y
A
A
T
K
A
G
V
I
G
L
T
M
T
W
A
K
E
F
A
L
K
G
AN
V
R
V
N
A
I
A
P
G
Y
I
M
T
D
I
---
L
K
T
V
P
Q
D
L
L
D
K
F
-----
A
A
L
TML
N
R
L
G
Q
P
E
E
I
A
K
V
A
L
F
L
A
S
D
D
A
S
Y
V
T
G
Q
T
I
N
V
N
G
G
M
R
L
93
PsiBlast_CBE
77.46
33%
-94
- C2 -
4NBT
1
?
D:
[5-240]
--
E
G
K
V
A
V
I
T
G
G
A
K
G
L
G
Q
A
I
A
L
A
Y
A
E
E
G
A
K
V
-
I
-
A
G
D
L
G
D
L
T
---
Y
S
H
P
N
-----
V
E
G
-----
M
Y
L
N
V
T
D
V
T
G
V
E
K
F
Y
Q
S
V
I
D
K
Y
--
G
--
K
I
D
I
L
V
N
N
A
G
I
-
T
K
D
A
M
------
T
R
K
M
T
E
A
Q
W
D
A
V
I
D
V
N
L
K
G
V
F
N
L
T
R
L
V
G
-
P
Q
M
-
Q
T
N
G
Y
G
----
S
I
I
N
I
S
S
V
V
G
--
V
F
---------------------------
G
N
I
G
Q
A
N
Y
A
A
T
K
A
G
V
I
G
L
T
M
T
W
A
K
E
F
A
L
K
G
AN
V
R
V
N
A
I
A
P
G
Y
I
M
T
D
I
---
L
K
T
V
P
Q
D
L
L
D
K
F
-----
A
A
L
TML
N
R
L
G
Q
P
E
E
I
A
K
V
A
L
F
L
A
S
D
D
A
S
Y
V
T
G
Q
T
I
N
V
N
G
G
M
R
L
113
HHSearch
76.19
32%
-103
- C2 -
1FJH
-
DIDH_COMTE
A:
[1-249]
---
M
S
I
I
V
I
S
G
C
A
T
G
I
G
A
A
T
R
K
V
L
E
A
A
G
H
Q
I
-
V
-
G
I
D
I
R
D
A
E
---------------------
V
I
A
D
L
S
T
A
E
G
R
K
Q
A
I
A
D
V
L
A
K
C
--
S
-
K
G
M
D
G
L
V
L
C
A
G
L
-
G
P
Q
-------------
T
K
V
L
G
N
V
V
S
V
N
Y
F
G
A
T
E
L
M
D
A
F
L
-
P
A
L
-
K
K
G
H
Q
P
----
A
A
V
V
I
S
S
V
A
S
A
H
L
A
FDKNPL
A
L
A
L
E
A
GE
E
A
K
A
R
A
I
V
E
H
AGE
Q
G
G
N
L
A
-
Y
A
G
S
K
N
A
L
T
V
A
V
R
K
R
A
A
A
W
G
E
A
G
--
V
R
L
N
T
I
A
P
G
A
------------------
F
V
-----
P
P
M
---
G
R
R
A
E
P
S
E
M
A
S
V
I
A
F
L
M
S
P
A
A
S
Y
V
H
G
A
Q
I
V
I
D
G
G
I
D
-
62
PsiBlast_CBE
75.89
37%
-91
- C2 -
4BNV
1
FABG_PSEAE
B:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-------------------
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
---------------------------------
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
32
PsiBlast_CBE
75.88
37%
-94
- C2 -
4BO6
1
FABG_PSEAE
B:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-
T
----------------
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
--------------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
TRE
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
50
PsiBlast_CBE
75.71
37%
-91
- C2 -
4BNZ
1
FABG_PSEAE
B:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-
T
R
-----
D
---------
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
--------------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
29
PsiBlast_CBE
75.20
37%
-94
- C2 -
4BO7
1
FABG_PSEAE
B:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-------------------
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
--------------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
14
PsiBlast_PDB
74.96
37%
-86
- C2 -
4BNZ
1
FABG_PSEAE
A:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
--------------
R
M
K
D
-
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
A
M
G
N
---------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
TRE
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
10
PsiBlast_PDB
74.84
37%
-92
- C2 -
4BNV
1
FABG_PSEAE
A:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-------------------
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
---------------------------------
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
TRE
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
44
PsiBlast_CBE
74.71
37%
-89
- C2 -
4BO2
1
FABG_PSEAE
B:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
------------------
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
A
M
G
N
---------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
25
PsiBlast_CBE
74.70
37%
-88
- C2 -
4BO8
2
FABG_PSEAE
C:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
-------------------
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
-------------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
59
PsiBlast_CBE
74.67
37%
-89
- C2 -
4BNW
1
FABG_PSEAE
B:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-
T
R
-----
D
----------
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
--------------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
TRE
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
46
PsiBlast_CBE
74.63
37%
-89
- C2 -
4BO0
1
FABG_PSEAE
C:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-
T
R
-----
D
----------
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
----------------------------------
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
43
PsiBlast_CBE
74.58
37%
-89
- C2 -
4BO2
1
FABG_PSEAE
C:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
------------------
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
A
M
G
N
---------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
41
PsiBlast_CBE
74.21
37%
-89
- C2 -
4BO3
2
FABG_PSEAE
B:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
--------------------
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
-------------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
61
PsiBlast_CBE
74.08
37%
-91
- C2 -
4BNV
1
FABG_PSEAE
C:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
--------------------
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
---
N
---------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
28
PsiBlast_CBE
73.92
37%
-86
- C2 -
4BO7
1
FABG_PSEAE
C:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-
T
R
-----
D
----------
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
A
M
G
N
---------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
11
PsiBlast_PDB
73.80
37%
-85
- C2 -
4BNW
1
FABG_PSEAE
A:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-------------
R
M
K
D
-
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
A
M
G
N
---------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
TRE
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
7
PsiBlast_PDB
72.71
37%
-74
- C2 -
4AG3
4
FABG_PSEAE
A:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-
T
R
-----
D
N
L
L
V
R
M
K
D
-
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
A
M
G
N
---------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
82
PsiBlast_CBE
72.14
33%
-88
- C2 -
4WK6
1
?
B:
[11-249]
--
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
T
A
T
S
E
S
G
A
---
Q
A
I
S
D
-----
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
-
T
R
D
N
L
------
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
-
K
K
-
R
Q
G
----
R
I
I
N
V
A
S
V
V
G
T
M
---------------------------------
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
---
T
K
A
L
N
D
E
--
Q
R
T
A
T
L
A
Q
V
P
A
---
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
-
80
PsiBlast_CBE
72.05
33%
-93
- C2 -
4WK6
2
?
D:
[11-249]
--
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
T
A
T
S
E
S
G
A
---
Q
A
I
S
D
-----
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
-
T
---
L
------
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
-
K
K
-
R
Q
G
----
R
I
I
N
V
A
S
--------------------------------------
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
---
T
K
A
L
N
D
E
--
Q
R
T
A
T
L
A
Q
V
P
A
---
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
-
70
PsiBlast_CBE
71.72
37%
-73
- C2 -
4AG3
3
FABG_PSEAE
C:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-
T
R
-----
D
N
L
L
V
R
M
K
D
-
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
A
M
G
N
---------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
71
PsiBlast_CBE
71.58
37%
-72
- C2 -
4AG3
3
FABG_PSEAE
B:
[28-268]
----
K
V
A
L
V
T
G
A
S
R
G
I
G
Q
A
I
A
L
E
L
G
R
L
G
A
V
V
-
I
G
T
A
T
S
A
S
G
A
E
K
I
A
E
T
L
K
-----
A
N
G
V
E
G
A
G
L
V
L
D
V
S
S
D
E
S
V
A
A
T
L
E
H
I
Q
Q
H
L
--
G
Q
P
L
I
--
V
V
N
N
A
G
I
-
T
R
-----
D
N
L
L
V
R
M
K
D
-
D
E
W
F
D
V
V
N
T
N
L
N
S
L
Y
R
L
S
K
A
V
L
-
R
G
M
T
K
A
-
R
W
G
----
R
I
I
N
I
G
S
V
V
G
A
M
G
N
---------------------------
A
-
G
Q
T
N
-
Y
A
A
A
K
A
G
L
E
G
F
T
R
A
L
A
R
E
V
G
S
R
A
--
I
T
V
N
A
V
A
P
G
F
I
D
T
D
M
T
R
E
L
P
E
A
Q
R
E
A
L
L
G
Q
-----
I
P
L
---
G
R
L
G
Q
A
E
E
I
A
K
V
V
G
F
L
A
S
D
G
A
A
Y
V
T
G
A
T
V
P
V
N
G
G
M
Y
M
88
PsiBlast_CBE
70.45
33%
-79
- C2 -
4I08
6
FABG_VIBCH
A:
[11-250]
--
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
T
A
T
S
E
S
G
A
---
Q
A
I
S
D
-----
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
-
T
R
D
N
L
------
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
-
K
K
-
R
Q
G
----
R
I
I
N
V
G
S
V
V
G
T
M
G
N
-----------------------------
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
-------
N
D
E
--
Q
R
T
A
T
L
A
Q
V
P
A
---
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
M
89
PsiBlast_CBE
70.02
33%
-77
- C2 -
3RSH
12
FABG_VIBCH
B:
[11-250]
--
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
T
A
T
S
E
S
G
A
---
Q
A
I
S
D
-----
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
-
T
R
D
N
L
------
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
-
K
K
-
R
Q
G
----
R
I
I
N
V
G
S
V
V
G
T
M
G
N
-----------------------------
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
---
T
K
-
L
N
D
E
--
Q
R
T
A
T
L
A
Q
V
P
A
---
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
M
99
PsiBlast_CBE
69.99
32%
-97
- C2 -
3TZC
5
?
A:
[11-249]
--
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
T
A
T
S
E
S
G
A
---
Q
A
I
S
D
-----
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
-
T
R
----------
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
-
K
K
-
R
Q
G
----
R
I
I
N
V
G
S
V
V
-----------------------------------------
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
--------
D
E
--
Q
R
T
A
T
L
A
Q
V
P
A
---
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
-
87
PsiBlast_CBE
69.97
33%
-77
- C2 -
4I08
9
FABG_VIBCH
B:
[11-250]
--
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
T
A
T
S
E
S
G
A
---
Q
A
I
S
D
-----
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
-
T
R
D
N
L
------
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
-
K
K
-
R
Q
G
----
R
I
I
N
V
G
S
V
V
G
T
M
G
N
-----------------------------
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
-----
T
K
A
L
N
D
E
--
Q
R
T
A
T
L
A
Q
V
P
A
---
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
M
83
PsiBlast_CBE
68.37
33%
-85
- C2 -
4WK6
1
?
A:
[11-249]
--
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
T
A
T
S
E
S
G
A
---
Q
A
I
S
D
-----
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
-
T
R
D
N
L
------
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
-
K
K
-
R
Q
G
----
R
I
I
N
V
A
S
V
V
G
T
M
G
N
-----------------------------
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
---
T
K
A
L
N
D
E
--
Q
R
T
A
T
L
A
Q
V
P
A
---
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
-
90
PsiBlast_CBE
67.94
33%
-81
- C2 -
3RSH
11
FABG_VIBCH
A:
[11-250]
--
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
T
A
T
S
E
S
G
A
---
Q
A
I
S
D
-----
Y
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
--
G
G
--
V
D
I
L
V
N
N
A
G
I
-
T
R
D
N
L
------
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
-
K
K
-
R
Q
G
----
R
I
I
N
V
G
S
V
V
G
T
M
G
N
-----------------------------
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
--
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
---
T
K
---
D
E
--
Q
R
T
A
T
L
A
Q
V
P
A
---
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
M
102
PsiBlast_CBE
65.64
35%
-78
- C2 -
4JIG
3
?
A:
[13-261]
-
S
D
R
K
A
V
L
I
T
G
A
S
R
G
I
G
R
A
T
A
V
L
A
A
E
R
G
W
D
V
G
I
-
N
Y
A
R
D
A
A
A
---
A
E
L
T
A
Q
A
V
R
D
A
G
G
R
A
C
I
-
V
A
G
D
V
A
N
E
A
D
V
V
A
M
F
D
T
V
A
A
A
F
--
G
--
R
L
D
A
L
V
N
N
A
G
I
V
A
P
S
------
M
P
L
A
D
M
P
V
D
R
L
R
R
M
F
D
T
N
V
L
G
A
Y
L
C
A
R
E
A
A
-
R
R
L
-
S
T
-
D
R
G
GR
G
G
A
I
V
N
V
S
S
I
A
S
R
L
G
S
---------------------------
P
N
E
Y
V
D
-
Y
A
G
S
K
G
A
V
D
S
L
T
I
G
L
A
K
E
L
G
P
H
G
--
V
R
V
N
A
V
R
P
G
L
I
E
T
------------
R
L
G
A
Q
-----
T
P
L
---
G
R
A
G
E
A
Q
E
V
A
E
A
I
V
W
L
L
G
D
T
A
S
Y
T
T
G
A
L
L
D
V
G
G
G
R
--