@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5171: (2016-03-05 )
MSTEKTKLGVHSEAGKLRKVMVCSPGLAHQRLTPSNCDELLFDDVIWVNQAKRDHFDFVTKMRERGIDVLEMHNLLTETIQNPEALKWILDRKITADSVGLGLTSELRSWLESLEPRKLAEYLIGGVAADDLPASEGANILKMYREYLGHSSFLLPPLPNTQFTRDTTCWIYGGVTLNPMYWPARRQETLLTTAIYKFHPEFANAEFEIWYGDPDKDHGSSTLEGGDVMPIGNGVVLIGMGERSSRQAIGQVAQSLFAKGAAERVIVAGLPKSRAAMHLDTVFSFCDRDLVTVFPEVVKEIVPFSLRPDPSSPYGMNIRREEKTFLEVVAESLGLKKLRVVETGGNSFAAEREQWDDGNNVVCLEPGVVVGYDRNTYTNTLLRKAGVEVITISASELGRGRGGGHCMTCPIVRDPIDY
Atome Classification :
(20 SA)
.........---10........20........30........40........50........60........70........--80--..--......90........-100-......--.----.110..-.-.-...120.......130.---......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260..--.--......270.......280.......290...---..--..----300.......310.......320.......330.....---..340...-..---..350.......360.......370.......380.......390.......400.......410......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTEKTKLG---VHSEAG
K
L
R
K
V
M
V
CSPGLAHQRL
T
P
S
N
C
D
E
L
L
F
DD
V
I
WVNQAK
R
D
H
F
D
F
V
T
K
M
R
E
RGI
D
V
L
E
M
H
N
L
L
T
E
T
--IQ--
N
P
--
E
A
L
K
W
I
L
DRKITADSV-GL--G
L
T
S
E
L
--
R
----
S
W
L
E
SL-
E
-
P
-
R
K
L
A
E
Y
L
IGGVAADDLP---ASE
G
A
N
I
L
K
M
Y
R
E
Y
LGHS
S
F
LLPPLPNTQFTRD
T
T
C
W
I
YG
G
V
T
LNPMYWPARR
Q
E
T
L
L
T
T
A
I
Y
KFHPEFANA
E
F
E
I
W
YGDPDKDHGSSTLEGG
D
V
M
PIGN
G
V
V
L
I
GMGE
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
AKG--AA--E--
R
V
I
V
AGLPK
S
R
A
A
M
H
L
D
T
V
F
S
F
CD
R
D
L
V
T
V
F
P
---
E
V
--
V
K
----
E
IVPFSLRPDPSSPYGMNIR
R
E
E
K
T
F
L
E
V
V
A
E
SLGL
K
K
---
L
R
V
V
ETGG-NS---F
A
A
E
R
EQWDDGN
N
V
V
C
LEP
G
V
V
V
G
YDRN
T
Y
T
N
T
L
L
R
KAG
V
E
V
I
T
I
S
A
S
E
LGRGRGG
G
H
C
M
TCPIVRDPIDY
4
PsiBlast_PDB
99.09
99%
-115
- C2 -
2AAF
-
ARCA_PSEAE
A:
[6-417]
-----
T
K
L
G
---
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
--
N
P
--
E
A
L
K
W
I
L
D
R
K
I
T
A
D
S
V
-
G
L
--
G
L
T
S
E
L
--
R
----
S
W
L
E
S
L
-
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
---
A
S
E
G
A
N
I
L
K
M
Y
R
E
Y
L
G
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
D
P
D
K
D
H
G
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
K
G
--
A
A
--
E
--
R
V
I
V
A
G
L
P
K
S
R
A
A
M
A
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
---
E
V
--
V
K
----
E
I
V
P
F
S
L
R
P
D
P
S
S
P
Y
G
M
N
I
R
R
E
E
K
T
F
L
E
V
V
A
E
S
L
G
L
K
K
---
L
R
V
V
E
T
G
-----------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
-
M
T
C
P
I
V
R
D
P
I
D
-
19
PsiBlast_CBE
99.04
99%
-113
- C2 -
2A9G
1
ARCA_PSEAE
B:
[6-416]
-----
T
K
L
G
---
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
--
N
P
--
E
A
L
K
W
I
L
D
R
K
I
T
A
D
S
V
-
G
L
--
G
L
T
S
E
L
--
R
----
S
W
L
E
S
L
-
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
---
A
S
E
G
A
N
I
L
K
M
Y
R
E
Y
L
G
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
D
P
D
K
D
H
G
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
K
G
--
A
A
--
E
--
R
V
I
V
A
G
L
P
K
S
R
--
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
---
E
V
--
V
K
----
E
I
V
P
F
S
L
R
P
D
P
S
S
P
Y
G
M
N
I
R
R
E
E
K
T
F
L
E
V
V
A
E
S
L
G
L
K
K
---
L
R
V
V
E
T
G
--------
A
A
E
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
A
M
T
C
P
I
V
R
D
P
I
--
27
HHSearch
98.70
100%
-111
- C2 -
2A9G
1
ARCA_PSEAE
A:
[6-417]
-----
T
K
L
G
---
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
--
N
P
--
E
A
L
K
W
I
L
D
R
K
I
T
A
D
S
V
-
G
L
--
G
L
T
S
E
L
--
R
----
S
W
L
E
S
L
-
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
---
A
S
E
G
A
N
I
L
K
M
Y
R
E
Y
L
G
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
D
P
D
K
D
H
G
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
K
G
--
A
A
--
E
--
R
V
I
V
A
G
L
P
K
S
R
A
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
---
E
V
--
V
K
----
E
I
V
P
F
S
L
R
P
D
P
S
S
P
Y
G
M
N
I
R
R
E
E
K
T
F
L
E
V
V
A
E
S
L
G
L
K
K
---
L
R
V
V
E
T
G
-----------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
A
M
T
C
P
I
V
R
D
P
I
D
-
2
PsiBlast_PDB
98.49
99%
-111
- C2 -
2A9G
1
ARCA_PSEAE
A:
[6-417]
-----
T
K
L
G
---
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
--
N
P
--
E
A
L
K
W
I
L
D
R
K
I
T
A
D
S
V
-
G
L
--
G
L
T
S
E
L
--
R
----
S
W
L
E
S
L
-
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
---
A
S
E
G
A
N
I
L
K
M
Y
R
E
Y
L
G
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
D
P
D
K
D
H
G
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
K
G
--
A
A
--
E
--
R
V
I
V
A
G
L
P
K
S
R
A
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
---
E
V
--
V
K
----
E
I
V
P
F
S
L
R
P
D
P
S
S
P
Y
G
M
N
I
R
R
E
E
K
T
F
L
E
V
V
A
E
S
L
G
L
K
K
---
L
R
V
V
E
T
G
-----------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
A
M
T
C
P
I
V
R
D
P
I
D
-
3
PsiBlast_PDB
98.33
99%
-115
- C2 -
2ABR
-
ARCA_PSEAE
A:
[6-417]
-----
T
K
L
G
---
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
--
N
P
--
E
A
L
K
W
I
L
D
R
K
I
T
A
D
S
V
-
G
L
--
G
L
T
S
E
L
--
R
----
S
W
L
E
S
L
-
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
---
A
S
E
G
A
N
I
L
K
M
Y
R
E
Y
L
G
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
D
P
D
K
D
H
G
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
K
G
--
A
A
--
E
--
R
V
I
V
A
G
L
P
K
S
---
M
H
L
A
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
---
E
V
--
V
K
----
E
I
V
P
F
S
L
R
P
D
P
S
S
P
Y
G
M
N
I
R
R
E
E
K
T
F
L
E
V
V
A
E
S
L
G
L
K
K
---
L
R
V
V
E
T
G
-----------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
-
M
T
C
P
I
V
R
D
P
I
D
-
1
PsiBlast_PDB
98.00
99%
-112
- C2 -
2ACI
-
ARCA_PSEAE
A:
[6-417]
-----
T
K
L
G
---
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
--
N
P
--
E
A
L
K
W
I
L
D
R
K
I
T
A
D
S
V
-
G
L
--
G
L
T
S
E
L
--
R
----
S
W
L
E
S
L
-
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
---
A
S
E
G
A
N
I
L
K
M
Y
R
E
Y
L
G
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
A
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
D
P
D
K
D
H
G
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
K
G
--
A
A
--
E
--
R
V
I
V
A
G
L
P
K
---
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
---
E
V
--
V
K
----
E
I
V
P
F
S
L
R
P
D
P
S
S
P
Y
G
M
N
I
R
R
E
E
K
T
F
L
E
V
V
A
E
S
L
G
L
K
K
---
L
R
V
V
E
T
G
-----------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
C
M
T
C
P
I
V
R
D
P
I
D
-
18
PsiBlast_CBE
97.97
99%
-108
- C2 -
2A9G
1
ARCA_PSEAE
C:
[6-417]
-----
T
K
L
G
---
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
--
N
P
--
E
A
L
K
W
I
L
D
R
K
I
T
A
D
S
V
-
G
L
--
G
L
T
S
E
L
--
R
----
S
W
L
E
S
L
-
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
---
A
S
E
G
A
N
I
L
K
M
Y
R
E
Y
L
G
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
D
P
D
K
D
H
G
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
K
G
--
A
A
--
E
--
R
V
I
V
A
G
L
P
K
---
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
---
E
V
--
V
K
----
E
I
V
P
F
S
L
R
P
D
P
S
S
P
Y
G
M
N
I
R
R
E
E
K
T
F
L
E
V
V
A
E
S
L
G
L
K
K
---
L
R
V
V
E
T
G
-----------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
A
M
T
C
P
I
V
R
D
P
I
D
-
17
PsiBlast_CBE
97.47
99%
-110
- C2 -
2A9G
1
ARCA_PSEAE
D:
[6-417]
-----
T
K
L
G
---
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
--
N
P
--
E
A
L
K
W
I
L
D
R
K
I
T
A
D
S
V
-
G
L
--
G
L
T
S
E
L
--
R
----
S
W
L
E
S
L
-
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
---
A
S
E
G
A
N
I
L
K
M
Y
R
E
Y
L
G
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
D
P
D
K
D
H
G
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
K
G
--
A
A
--
E
--
R
V
I
V
A
G
L
P
K
S
R
A
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
---
E
V
--
V
K
----
E
I
V
P
F
S
L
R
P
D
P
S
S
P
Y
G
M
N
I
R
R
E
E
K
T
F
L
E
V
V
A
E
S
L
G
L
K
K
---
L
R
V
V
E
T
G
G
----------
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
A
M
T
C
P
I
V
R
D
P
I
D
-
20
PsiBlast_CBE
77.20
33%
-93
- C2 -
4BOF
3
ARCA_STRPY
H:
[4-411]
----
Q
T
P
I
H
---
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
--
T
P
--
E
I
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
R
--
A
T
K
K
A
I
--
R
----
E
L
L
M
A
I
-
E
-
D
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
EIP
A
S
E
K
G
L
T
D
L
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
---
D
R
N
E
-
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
Q
N
--
L
G
F-
K
--
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
---
E
I
--
E
G
----
D
L
R
V
Y
S
V
T
Y
D
N
E
E
---
L
H
I
V
E
E
K
G
D
L
A
E
L
L
A
A
N
L
G
V
E
K
---
V
D
L
I
R
C
G
G
D
N
L
---
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
--
25
PsiBlast_CBE
76.75
33%
-92
- C2 -
4BOF
3
ARCA_STRPY
C:
[3-411]
---
A
Q
T
P
I
H
---
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
--
T
P
--
E
I
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
R
--
A
T
K
K
A
I
--
R
----
E
L
L
M
A
I
-
E
-
D
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
EIP
A
S
E
K
G
L
T
D
L
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
---
D
R
N
E
-
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
Q
N
--
L
G
F-
K
--
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
---
E
I
--
E
G
----
D
L
R
V
Y
S
V
T
Y
D
N
E
E
---
L
H
I
V
E
E
K
G
D
L
A
E
L
L
A
A
N
L
G
V
E
K
---
V
D
L
I
R
C
G
G
D
N
L
---
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
--
6
PsiBlast_PDB
76.74
33%
-96
- C2 -
4BOF
4
ARCA_STRPY
A:
[4-411]
----
Q
T
P
I
H
---
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
--
T
P
--
E
I
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
R
--
A
T
K
K
A
I
--
R
----
E
L
L
M
A
I
-
E
-
D
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
EIP
A
S
E
K
G
L
T
D
L
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
---
D
R
N
E
-
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
Q
N
--
L
G
F-
K
--
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
---
E
I
--
E
G
----
D
L
R
V
Y
S
V
T
Y
D
N
E
E
---
L
H
I
V
E
E
K
G
D
L
A
E
L
L
A
A
N
L
G
V
E
K
---
V
D
L
I
R
C
G
G
D
N
L
---
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
--
26
PsiBlast_CBE
76.62
33%
-94
- C2 -
4BOF
3
ARCA_STRPY
B:
[2-411]
--
T
A
Q
T
P
I
H
---
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
--
T
P
--
E
I
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
R
--
A
T
K
K
A
I
--
R
----
E
L
L
M
A
I
-
E
-
D
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
EIP
A
S
E
K
G
L
T
D
L
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
---
D
R
N
E
-
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
Q
N
--
L
G
F-
K
--
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
---
E
I
--
E
G
----
D
L
R
V
Y
S
V
T
Y
D
N
E
E
---
L
H
I
V
E
E
K
G
D
L
A
E
L
L
A
A
N
L
G
V
E
K
---
V
D
L
I
R
C
G
G
D
N
L
---
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
--
21
PsiBlast_CBE
76.61
33%
-93
- C2 -
4BOF
4
ARCA_STRPY
G:
[4-411]
----
Q
T
P
I
H
---
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
--
T
P
--
E
I
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
R
--
A
T
K
K
A
I
--
R
----
E
L
L
M
A
I
-
E
-
D
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
EIP
A
S
E
K
G
L
T
D
L
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
---
D
R
N
E
-
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
Q
N
--
L
G
F-
K
--
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
---
E
I
--
E
G
----
D
L
R
V
Y
S
V
T
Y
D
N
E
E
---
L
H
I
V
E
E
K
G
D
L
A
E
L
L
A
A
N
L
G
V
E
K
---
V
D
L
I
R
C
G
G
D
N
L
---
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
--
22
PsiBlast_CBE
76.59
33%
-95
- C2 -
4BOF
5
ARCA_STRPY
F:
[3-411]
---
A
Q
T
P
I
H
---
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
--
T
P
--
E
I
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
R
--
A
T
K
K
A
I
--
R
----
E
L
L
M
A
I
-
E
-
D
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
EIP
A
S
E
K
G
L
T
D
L
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
---
D
R
N
E
-
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
Q
N
--
L
G
F-
K
--
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
---
E
I
--
E
G
----
D
L
R
V
Y
S
V
T
Y
D
N
E
E
---
L
H
I
V
E
E
K
G
D
L
A
E
L
L
A
A
N
L
G
V
E
K
---
V
D
L
I
R
C
G
G
D
N
L
---
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
--
24
PsiBlast_CBE
76.43
33%
-92
- C2 -
4BOF
2
ARCA_STRPY
D:
[3-411]
---
A
Q
T
P
I
H
---
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
--
T
P
--
E
I
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
R
--
A
T
K
K
A
I
--
R
----
E
L
L
M
A
I
-
E
-
D
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
EIP
A
S
E
K
G
L
T
D
L
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
---
D
R
N
E
-
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
Q
N
--
L
G
F-
K
--
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
---
E
I
--
E
G
----
D
L
R
V
Y
S
V
T
Y
D
N
E
E
---
L
H
I
V
E
E
K
G
D
L
A
E
L
L
A
A
N
L
G
V
E
K
---
V
D
L
I
R
C
G
G
D
N
L
---
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
--
23
PsiBlast_CBE
76.29
33%
-94
- C2 -
4BOF
2
ARCA_STRPY
E:
[6-411]
------
P
I
H
---
V
Y
S
E
I
G
K
L
K
K
V
L
L
H
R
P
G
K
E
I
E
N
L
M
P
D
Y
L
E
R
L
L
F
D
D
I
P
F
L
E
D
A
Q
K
E
H
D
A
F
A
Q
A
L
R
D
E
G
I
E
V
L
Y
L
E
T
L
A
A
E
S
--
L
V
--
T
P
--
E
I
R
E
A
F
I
D
E
Y
L
S
E
A
N
I
R
G
R
--
A
T
K
K
A
I
--
R
----
E
L
L
M
A
I
-
E
-
D
N
Q
E
L
I
E
K
T
M
A
G
V
Q
K
S
E
L
P
EIP
A
S
E
K
G
L
T
D
L
V
E
S
N
Y
----
P
F
A
I
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
T
I
G
T
G
V
S
L
N
H
M
F
S
E
T
R
N
R
E
T
L
Y
G
K
Y
I
F
T
H
H
P
I
Y
G
G
G
K
V
P
M
V
Y
---
D
R
N
E
-
T
T
R
I
E
G
G
D
E
L
V
L
S
K
D
V
L
A
V
G
I
S
Q
R
T
D
A
A
S
I
E
K
L
L
V
N
I
F
K
Q
N
--
L
G
F-
K
--
K
V
L
A
F
E
F
A
N
N
R
K
F
M
H
L
D
T
V
F
T
M
V
D
Y
D
K
F
T
I
H
P
---
E
I
--
E
G
----
D
L
R
V
Y
S
V
T
Y
D
N
E
E
---
L
H
I
V
E
E
K
G
D
L
A
E
L
L
A
A
N
L
G
V
E
K
---
V
D
L
I
R
C
G
G
D
N
L
---
V
A
A
G
R
E
Q
W
N
D
G
S
N
T
L
T
I
A
P
G
V
V
V
V
Y
N
R
N
T
I
T
N
A
I
L
E
S
K
G
L
K
L
I
K
I
H
G
S
E
L
V
R
G
R
G
G
P
R
C
M
S
M
P
F
E
R
E
D
I
--
5
PsiBlast_PDB
72.45
97%
6
- C2 -
1RXX
-
ARCA_PSEAE
A:
[6-417]
-----
T
K
L
G
---
V
H
S
E
A
G
K
L
R
K
V
M
V
C
S
P
G
L
A
H
Q
R
L
T
P
S
N
C
D
E
L
L
F
D
D
V
I
W
V
N
Q
A
K
R
D
H
F
D
F
V
T
K
M
R
E
R
G
I
D
V
L
E
M
H
N
L
L
T
E
T
--
I
Q
--
N
P
--
E
A
L
K
W
I
L
D
R
K
I
T
A
D
S
V
-
G
L
--
G
L
T
S
E
L
--
R
----
S
W
L
E
S
L
-
E
-
P
-
R
K
L
A
E
Y
L
I
G
G
V
A
A
D
D
L
P
---
A
S
E
G
A
N
I
L
K
M
Y
R
E
Y
L
G
H
S
S
F
L
L
P
P
L
P
N
T
Q
F
T
R
D
T
T
C
W
I
Y
G
G
V
T
L
N
P
M
Y
W
P
A
R
R
Q
E
T
L
L
T
T
A
I
Y
K
F
H
P
E
F
A
N
A
E
F
E
I
W
Y
G
D
P
D
K
D
H
G
S
S
T
L
E
G
G
D
V
M
P
I
G
N
G
V
V
L
I
G
M
G
E
R
S
S
R
Q
A
I
G
Q
V
A
Q
S
L
F
A
K
G
--
A
A
--
E
--
R
V
I
V
A
G
L
P
K
--
A
A
M
H
L
D
T
V
F
S
F
C
D
R
D
L
V
T
V
F
P
---
E
V
--
V
K
----
E
I
V
P
F
S
L
R
P
D
P
S
S
P
Y
G
M
N
I
R
R
E
E
K
T
F
L
E
V
V
A
E
S
L
G
L
K
K
---
L
R
V
V
E
T
G
G
-
N
S
---
F
--
E
R
E
Q
W
D
D
G
N
N
V
V
C
L
E
P
G
V
V
V
G
Y
D
R
N
T
Y
T
N
T
L
L
R
K
A
G
V
E
V
I
T
I
S
A
S
E
L
G
R
G
R
G
G
G
H
C
M
T
C
P
I
V
R
D
P
I
D
-
28
HHSearch
72.30
28%
-92
* C2 *
1S9R
7
ARCA_MYCAR
A:
[6-409]
--
S
K
F
K
G
I
H
---
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
--
Y
D
--
L
A
S
Q
E
A
K
D
K
L
I
E
E
F
L
E
D
S
E
P
-
V
L
S
E
E
H
K
V
V
V
--
R
----
N
F
L
K
A
K
K
T
-
S
-
R
E
L
V
E
I
M
M
A
G
I
T
K
Y
D
L
G
---
I
-------------
E
A
D
H
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
--
T
P
W
Y
Y
---
D
-
P
S
L
K
L
S
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
V
A
N
K
EC
E
F
--
K
--
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
---
I
A
--
N
D
----
V
F
K
F
W
D
Y
D
L
V
N
G
-
G
A
E
P
Q
P
V
E
N
G
L
P
L
E
G
L
L
Q
S
I
I
N
-
K
K
---
P
V
L
I
P
I
A
G
-
E
G
AS
Q
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
-
8
PsiBlast_PDB
72.11
28%
-84
- C2 -
1LXY
3
ARCA_MYCAR
A:
[10-409]
-------
I
H
---
V
Y
S
E
I
G
E
L
E
S
V
L
V
H
E
P
G
R
E
I
D
Y
I
T
P
A
R
L
D
E
L
L
F
S
A
I
L
E
S
H
D
A
R
K
E
H
K
Q
F
V
A
E
L
K
A
N
D
I
N
V
V
E
L
I
D
L
V
A
E
T
Y
D
L
A
--
S
Q
--
E
A
K
D
K
L
I
E
E
F
L
E
D
S
E
P
-
V
L
--
S
E
E
H
K
V
V
V
R
----
N
F
L
K
A
K
-
K
T
S
-
R
E
L
V
E
I
M
M
A
G
I
T
K
Y
D
L
G
---
I
E
-------------
A
D
H
E
L
I
V
D
P
M
P
N
L
Y
F
T
R
D
P
F
A
S
V
G
N
G
V
T
I
H
Y
M
R
Y
K
V
R
Q
R
E
T
L
F
S
R
F
V
F
S
N
H
P
K
L
I
N
T
P
---
W
Y
Y
D
P
S
L
---
K
L
S
I
E
G
G
D
V
F
I
Y
N
N
D
T
L
V
V
G
V
S
E
R
T
D
L
Q
T
V
T
L
L
A
K
N
I
V
A
N
K
--
E
C
--
E
FK
R
I
V
A
I
N
V
P
K
W
T
N
L
M
H
L
D
T
W
L
T
M
L
D
K
D
K
F
L
Y
S
P
IAN
D
V
--
F
K
F
W
D
Y
D
L
V
N
G
G
A
E
P
Q
P
V
---------
E
N
G
L
P
L
E
G
L
L
Q
S
I
I
N
K
K
P
V
L
I
P
I
A
G
E
G
A
-
S
Q
---
M
E
I
E
R
E
T
H
F
D
G
T
N
Y
L
A
I
R
P
G
V
V
I
G
Y
S
R
N
E
K
T
N
A
A
L
E
A
A
G
I
K
V
L
P
F
H
G
N
Q
L
S
L
G
M
G
N
A
R
C
M
S
M
P
L
S
R
K
D
V
K
W
9
PsiBlast_PDB
72.06
28%
-86
- C2 -
4E4J
2
?
A:
[35-429]
---------GIN
V
Y
S
E
I
G
E
L
K
E
V
L
V
H
T
P
G
D
E
I
R
Y
T
A
P
S
R
L
E
E
L
L
F
S
A
V
L
K
A
D
T
A
I
E
E
H
K
G
F
V
K
I
L
Q
N
N
G
I
K
V
I
Q
L
C
D
L
V
A
E
T
--
Y
E
L
C
S
K
--
E
V
R
N
S
F
I
E
Q
Y
L
--
D
E
A
-
L
P
--
V
L
K
K
E
I
--
R
P
V
V
K
D
Y
L
L
S
F
-
P
-
T
-
V
Q
M
V
R
K
M
M
S
G
I
L
A
N
E
L
N
---
I
K
Q
-------------
D
N
P
L
I
I
D
G
M
P
N
L
Y
F
T
R
D
P
F
A
S
M
G
N
G
V
S
I
N
C
M
K
Y
P
T
R
K
R
E
V
I
F
S
R
F
V
F
T
N
N
P
K
Y
K
N
T
P
---
R
Y
F
D
I
V
G
N
N
G
--
T
I
E
G
G
D
I
F
I
Y
N
S
K
T
L
V
I
G
N
S
E
R
T
N
F
A
A
I
E
S
V
A
K
N
I
Q
A
N
K
--
D
C
TF
E
--
R
I
V
V
I
N
V
P
P
M
P
N
L
M
H
L
D
T
W
L
T
M
L
D
Y
D
K
F
L
Y
S
P
---
N
M
MN
V
L
----
K
I
W
E
I
D
L
N
V
K
P
V
K
------
F
V
E
K
K
G
T
L
E
E
V
L
Y
S
I
I
D
K
K
P
I
L
I
P
I
A
G
K
G
A
-
N
Q
---
L
D
I
D
I
E
T
H
F
D
G
T
N
Y
L
T
I
A
P
G
V
V
V
G
Y
E
R
N
E
K
T
Q
K
A
L
V
E
A
G
I
K
V
L
S
F
N
G
S
Q
L
S
L
G
M
G
S
A
R
C
M
S
M
P
L
I
R
E
----