@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5188: (2016-03-05 )
MSQNFSFRQAAVIGAGTMGRGIVMCLANAGLDVQWLDSNPQMLNQALGAVADTYAHNVRQGRIGEEEAAARRARITPVQHLAAMREADLVIEAVYENLELKQSIFRELDAALKPSAVLASNTSYLDIDAIAAVTARPRQVLGLHFFSPAHIMRLLEIVRGAQTAPAVLEAALALGERMGKVSVVAGNCHGFIGNRMLEPYATEARLMLLEGALPYQVDRALQAFGFAMGPFRMYDVVGIDLEWRARELAGVGQDQPAVQVDNRLCEMGRFGQKSGAGYYRYAPGSRQAEHDTEVDALVLRVAETLGYPRRDFADEEILERCLLALVNEGAKILDEGIAARSADIDTVYLNGYGFPAAEGGPMAWADRLGAADLLQRLRFLEQRHGARWKPASLVERLAAEGGAFADLQEVR
Atome Classification :
(44 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50..--------......60-----...-----.....70........-80-........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200..-.....210-........220.-..-.....230.......240------..--------....--.250.--------.-----..--..----.----.260.-----------......270.......280......-..290.-----------------...---..-----------------------------------------------.300.......-310.-......320.......330.......340.......350.......360..------.....370......--.380....--...390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSQNFSF
R
Q
A
A
V
IGAGTMG
R
G
I
V
M
C
LANAG
L
D
V
Q
WLDS
N
P
Q
M
L
N
Q
A
L
G
A
V
A
D
T
--------
Y
A
H
NVRQG-----RIG-----
E
E
E
A
A
ARRARI
T
P
V
Q
-
H
L
-
A
A
M
R
E
A
D
L
V
I
E
A
V
Y
E
N
L
E
L
K
Q
S
I
F
R
E
L
D
A
ALKP
S
A
V
LASNT
S
Y
L
D
I
D
A
I
A
A
VTARP
R
Q
V
L
G
L
HFF
S
P
A
H
I
M
R
L
L
E
I
V
RGAQ
T
A
P
A
V
L
E
A
A
L
A
L
G
E
RMG
K
V
S
V
V
AGNCHGFIGNRMLEPYATE
A
-
R
L
M
L
LE-G-AL
P
Y
Q
V
D
R
A
L
-
Q
-
A
F
-GFAMGP
F
R
M
Y
D
V
V
GID
L
E
------
W
R
--------
A
R
E
L
--AG-VG--------Q-----DQ--P
A
----
V
----
Q
V
D
N
R
-----------
L
C
EMGRFGQKSGAG
Y
Y
R
Y-APGSRQ-AEHD
T
E
-----------------
V
D
A
---
L
V
-----------------------------------------------
L
R
V
A
E
T
LGYPR-RDFA-
D
E
E
I
L
E
R
C
L
L
A
L
V
NE
G
A
K
I
L
D
E
G
IAARSADI
D
T
V
Y
LNGYGFPAAEGG
P
M
A
W
------
A
D
RL
G
A
A
D
L
L
Q
R
L
R
--
F
L
E
Q
RHGA--RWK
P
A
S
L
V
E
R
L
A
AEGGAFADLQEVR
119
HHSearch
96.21
38%
-97
- C2 -
1ZCJ
-
ECHP_RAT
A:
[293-713]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
--
A
S
A
K
P
K
L
R
F
S
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
GPSLPPGT
P
VRKRG
N
S
--
R
Y
----
S
----
P
L
G
D
M
-----------
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
-
D
K
P
L
G
R
I
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
--
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
--
K
Y
Y
R
Q
N
P
D
IP
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
S
P
P
L
K
E
W
Q
S
-
21
PsiBlast_CBE
95.33
39%
-107
- C2 -
2X58
2
ECHP_RAT
B:
[306-709]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
5
PsiBlast_PDB
95.10
39%
-108
- C2 -
3ZW9
2
ECHP_RAT
A:
[321-724]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
2
PsiBlast_PDB
95.06
39%
-106
- C2 -
2X58
1
ECHP_RAT
A:
[306-709]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
7
PsiBlast_PDB
95.05
39%
-107
- C2 -
3ZWC
2
ECHP_RAT
A:
[321-724]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
1
PsiBlast_PDB
94.87
39%
-102
- C2 -
1ZCJ
-
ECHP_RAT
A:
[301-704]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GNSRYSP
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
25
PsiBlast_CBE
94.44
39%
-107
- C2 -
3ZW9
2
ECHP_RAT
B:
[321-724]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
4
PsiBlast_PDB
94.14
39%
-103
- C2 -
3ZW8
2
ECHP_RAT
A:
[321-724]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
26
PsiBlast_CBE
93.85
39%
-107
- C2 -
3ZW8
1
ECHP_RAT
B:
[321-724]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
6
PsiBlast_PDB
93.58
39%
-105
- C2 -
3ZWA
1
ECHP_RAT
A:
[321-724]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
24
PsiBlast_CBE
93.38
39%
-105
- C2 -
3ZWA
2
ECHP_RAT
B:
[321-724]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
23
PsiBlast_CBE
93.00
39%
-107
- C2 -
3ZWC
2
ECHP_RAT
B:
[321-724]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
3
PsiBlast_PDB
92.88
39%
-104
- C2 -
3ZWB
2
ECHP_RAT
A:
[321-724]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
22
PsiBlast_CBE
92.20
39%
-105
- C2 -
3ZWB
2
ECHP_RAT
B:
[321-724]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
--------
L
E
K
E
A
S
R
A
-----
H
Q
N
-----
G
Q
A
S
A
K
P
K
L
R
F
S
--
S
-
S
T
-
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
-
F
F
L
L
E
E
-
G
-
S
K
P
E
D
V
D
G
V
L
-
E
-
E
F
-
G
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
------
W
K
--------
I
R
K
G
--
Q
G
-
L
T
--------
G
-----
P
S
LP
P
G
----
T
----
P
V
R
K
R
GN
S
R
Y
S
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
D
K
P
L
G
R
I
-
H
K
P
D
P
W
-----------------
L
S
T
---
F
L
-----------------------------------------------
S
Q
Y
R
E
V
H
H
I
E
Q
-
R
T
I
S
-
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
------
A
A
S
V
G
L
P
T
V
L
E
K
L
Q
K
Y
Y
R
Q
N
P
D
I
P
--
Q
L
E
P
S
D
Y
L
R
R
L
V
A
Q
G
----------
30
PsiBlast_CBE
91.65
32%
-97
- C2 -
1WDK
2
FADB_PSEFR
B:
[315-713]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
--------
L
V
G
R
V
D
K
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
-
S
Y
-
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
-
A
K
L
V
S
A
-
G
-
V
D
F
V
R
I
D
K
V
M
-
E
-
K
F
-
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
------
H
H
--------
G
R
D
V
--
M
A
-
E
G
---------------
F
--
P
D
----
R
----
M
K
D
D
R
RSAIDA-----
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
-
E
-
A
D
-----
Q
K
K
L
-----------------
V
D
S
---
S
V
-----------------------------------------------
L
E
V
L
K
P
I
V
Y
E
Q
-
R
D
V
T
-
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
------
I
D
S
I
G
V
A
E
F
V
A
-
L
A
--
D
Q
Y
A
E
L
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
-------
108
Fugue
91.16
30%
-90
- C2 -
1WDK
4
FADB_PSEFR
A:
[1-715]
MIYEGKA
I
T
V
T
A
L
E
SG
I
V
E
L
K
F
D
LKGESVNKFN
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
DASVK
G
V
I
V
S
S
GKDVF
I
V
G
A
D
I
T
E
F
V
E
N
F
K
LP
D
A
E
L
I
A
G
N
L
E
A
N
K
I
F
S
D
F
E
D
LN
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
AD
F
R
V
M
A
DS
A
K
I
G
L
PEVKLGIYPGFGGTV
R
L
P
R
L
IG
V
D
N
A
V
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
SAVD
A
V
V
T
ADK
L
G
A
A
A
L
D
L
I
K
R
A
I
S
GELD
Y
K
A
K
R
QPKLEKLKLN
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
AGPNYP
A
P
V
E
A
I
K
T
I
Q
K
A
A
NFG
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
L
K
K
K
A
K
V
Y
D
K
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
--------
L
V
G
R
V
D
K
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
-
S
Y
-
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
-
A
K
L
V
S
A
-
G
-
V
D
F
V
R
I
D
K
V
M
-
E
-
K
F
-
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
------
H
H
--------
G
R
D
V
--
M
A
-
E
G
--------
F
-----
P
D
--
R
M
KDDR
R
----
S
A
I
D
A
-----------
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
-
E
K
K
L
V
D
-
S
S
V
L
E
V
-----------------
L
K
P
---
I
-------------------------------------------------------
V
Y
E
Q
-
R
D
V
T
-
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
------
I
D
S
I
G
V
A
E
F
V
A
L
A
D
--
Q
Y
A
E
L
-
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
-----
121
HHSearch
90.52
33%
-99
- C2 -
3MOG
1
PAAH_ECOLI
A:
[4-473]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
Q
T
V
A
V
I
G
S
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
V
L
L
Y
D
I
S
A
E
A
L
T
R
A
I
D
G
I
H
A
R
--------
L
N
S
R
V
T
R
G
-----
K
L
T
-----
A
E
T
C
E
R
T
L
K
R
L
I
P
V
T
-
D
I
-
H
A
L
A
A
A
D
L
V
I
E
A
A
S
E
R
L
E
V
K
K
A
L
F
A
Q
L
A
E
V
C
P
P
Q
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
A
A
E
I
K
N
P
E
R
V
A
G
L
H
F
F
N
P
A
P
V
M
K
L
V
E
V
V
S
G
L
A
T
A
A
E
V
V
E
Q
L
C
E
L
T
L
S
W
G
K
Q
P
V
R
C
H
S
T
P
G
F
I
V
N
R
V
A
R
P
Y
Y
S
E
A
-
W
R
A
L
E
E
-
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
-
G
A
-
G
F
P
M
G
P
L
E
L
T
D
L
I
G
Q
D
V
N
------
F
A
--------
V
T
C
S
--
V
F
-
N
A
F
W------
Q
ER---
R
F
--
L
P
----
S
----
L
V
Q
Q
E
-----------
L
V
I
G
G
R
L
G
K
K
S
G
L
G
V
Y
D
W
-
R
A
E
R
E
A
--
V
V
G
L
E
AVSDSFSPM
K
V
E
K
K
SDG
V
T
E
I
DD
V
L
L
I
E
T
QGET
A
Q
A
L
A
I
R
L
A
R
P
V
V
V
I
D
K
M
AGK
V
V
T
I
A
A
A
AVNP
D
S
A
T
R
K
A
I
Y
Y
L
Q
Q
Q
G
K
T
V
L
Q
I
A
D
Y
P
G
M
L
I
W
R
T
V
A
M
I
I
N
E
A
L
D
A
L
Q
K
G
V
A
-
S
E
Q
D
I
D
T
A
M
R
L
G
V
N
Y
P
Y
---
G
P
L
A
W
------
G
A
Q
L
G
W
Q
R
I
L
R
L
L
E
--
N
L
Q
H
H
Y
G
E
E-
R
Y
R
P
C
S
L
L
R
Q
R
A
L
L
E
S
G
Y
-------
27
PsiBlast_CBE
90.06
32%
-94
- C2 -
2D3T
1
FADB_PSEFR
B:
[315-713]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
--------
L
V
G
R
V
D
K
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
-
S
Y
-
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
-
A
K
L
V
S
A
-
G
-
V
D
F
V
R
I
D
K
V
M
-
E
-
K
F
-
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
------
H
H
--------
G
R
D
V
--
M
A
-
E
G
---------------
F
--
P
D
----
R
----
M
K
D
D
R
RSAIDA-----
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
-
E
-
A
D
-----
Q
K
K
L
-----------------
V
D
S
---
S
V
-----------------------------------------------
L
E
V
L
K
P
I
V
Y
E
Q
-
R
D
V
T
-
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
------
I
D
S
I
G
V
A
E
F
V
A
-
L
A
--
D
Q
Y
A
E
L
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
-------
10
PsiBlast_PDB
89.92
32%
-98
- C2 -
1WDL
3
FADB_PSEFR
A:
[315-713]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
--------
L
V
G
R
V
D
K
G
-----
R
M
T
-----
P
A
K
M
A
E
V
L
N
G
I
R
P
T
L
-
S
Y
-
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
G
G
F
-
A
K
L
V
S
A
-
G
-
V
D
F
V
R
I
D
K
V
M
-
E
-
K
F
-
G
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
------
H
H
--------
G
R
D
V
--
M
A
-
E
G
---------------
F
--
P
D
----
R
----
M
K
D
D
R
RS
A
I
D
A
-----
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
-
E
-
A
D
K
K
-
G
K
Q
K
K
L
-----------------
V
D
S
---
S
V
-----------------------------------------------
L
E
V
L
K
P
I
V
Y
E
Q
-
R
D
V
T
-
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
------
I
D
S
I
G
V
A
E
F
V
A
-
L
A
--
D
Q
Y
A
E
L
G
A
--
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
-------
12
PsiBlast_PDB
89.83
31%
-101
- C2 -
4B3H
7
?
A:
[341-730]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
--------
E
A
K
A
L
E
R
G
-----
R
T
T
-----
Q
E
R
S
D
A
L
L
A
R
I
T
P
T
A
-
D
A
-
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
N
E
A
-
L
A
M
L
G
E
-
G
-
V
E
P
A
S
I
E
Q
A
G
-
S
-
Q
A
-
G
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
------
H
K
I
A
V
A
T
R
K
G
V
E
D
A
--
G
G
-
T
Y
--------
Q
-----
P
H
--
P
A
----
E
----
A
V
V
E
K
-----------
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
-
A
D
G
K
R
S
--------------------------
G
---
L
W
-----------------------------------------------
P
G
L
R
E
T
F
K
S
G
S
-
S
Q
P
P
-
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSG
P
A
G
T
G
K
A
A
F
V
A
R
A
R
--
E
L
A
A
A
Y
G
D
--
R
F
L
P
---------------------
123
HHSearch
76.25
30%
-91
* C2 *
1F0Y
3
HCDH_HUMAN
A:
[12-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
--------
L
R
K
V
A
K
K
K
-----
F
A
E
N
P
K
A
G
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
-
D
A
A
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
-
I
R
L
Y
E
R
G
D
-
A
S
K
E
D
I
D
T
A
M
K
L
-
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
------
K
F
--------
I
V
D
G
--
W
H
-
E
M
D
A------
E
NP---
L
H
--
Q
P
----
S
----
P
S
L
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.34
33%
-100
- C2 -
4KUG
1
?
A:
[1-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
A
T
I
T
K
S
--------
L
S
K
L
V
A
K
E
-----
K
I
T
-----
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
-
D
M
-
K
L
A
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
-
T
F
I
L
Q
E
-
G
V
A
K
E
E
D
I
D
A
A
M
-
K
L
G
A
-
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
------
L
A
--------
I
M
D
V
L
Y
N
E
-
T
G
--------
D
-----
T
K
Y-
R
A
----
S
----
S
L
L
R
K
-----------
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
75.13
33%
-102
- C2 -
4KUG
1
?
B:
[1-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
A
T
I
T
K
S
--------
L
S
K
L
V
A
K
E
-----
K
I
T
-----
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
-
D
M
-
K
L
A
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
-
T
F
I
L
Q
E
-
G
V
A
K
E
E
D
I
D
A
A
M
-
K
L
G
A
-
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
------
L
A
--------
I
M
D
V
LY
N
E
-
T
G
--------
D
-----
T
K
Y-
R
A
----
S
----
S
L
L
R
K
-----------
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
74.98
33%
-101
- C2 -
4KUG
1
?
C:
[1-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
A
T
I
T
K
S
--------
L
S
K
L
V
A
K
E
-----
K
I
T
-----
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
-
D
M
-
K
L
A
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
-
T
F
I
L
Q
E
-
G
V
A
K
E
E
D
I
D
A
A
M
-
K
L
G
A
-
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
------
L
A
--------
I
M
D
V
LY
N
E
-
T
G
--------
D
-----
T
K
Y-
R
A
----
S
----
S
L
L
R
K
-----------
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Fugue
73.68
30%
-93
- C2 -
1IL0
3
HCDH_HUMAN
A:
[12-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
--------
L
R
K
V
A
K
K
K
F
A
EN
P
K
A
G
-----
D
E
F
V
E
K
T
L
S
T
I
A
T
S
T
D
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
-
I
R
L
Y
E
R
-
G
D
A
S
K
E
D
I
D
T
A
M
-
K
-
L
G
A
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
------
K
F
--------
I
V
D
G
--
W
H
-
E
M
--------
D
-----
A
E
--
N
P
----
L
HQPS
P
S
L
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
73.62
31%
-89
- C2 -
1M75
3
HCDH_HUMAN
B:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
LRKVAKKK
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
KFIVDG
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
73.33
33%
-102
- C2 -
4KUG
1
?
D:
[1-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
A
T
I
T
K
S
--------
L
S
K
L
V
A
K
E
-----
K
I
T
-----
E
A
D
K
E
E
I
L
S
R
I
S
G
T
T
-
D
M
-
K
L
A
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
-
T
F
I
L
Q
E
-
G
V
A
K
E
E
D
I
D
A
A
M
-
K
L
G
A
-
N
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
------
L
A
--------
I
M
D
V
LY
N
E
-
T
G
--------
D
-----
T
K
Y-
R
A
----
S
----
S
L
L
R
K
-----------
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
72.52
31%
-89
- C2 -
1IL0
3
HCDH_HUMAN
A:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
72.26
31%
-91
- C2 -
1LSJ
1
HCDH_HUMAN
B:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
LRKVAKKK
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
KFIVDG
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
72.21
31%
-94
- C2 -
1LSJ
1
HCDH_HUMAN
A:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
Q
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
71.83
31%
-85
- C2 -
1F0Y
3
HCDH_HUMAN
A:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
71.68
31%
-85
- C2 -
1IL0
3
HCDH_HUMAN
B:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
LRKVAKKK
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
Q
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
KFIVDG
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
71.53
31%
-89
- C2 -
1M75
3
HCDH_HUMAN
A:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
S
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
71.42
31%
-87
- C2 -
1M76
3
HCDH_HUMAN
B:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
LRKVAKKK
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
KFIVDG
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
71.18
31%
-87
- C2 -
1F17
1
HCDH_HUMAN
A:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
-----
D
E
C
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
70.87
31%
-87
- C2 -
1M76
3
HCDH_HUMAN
A:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
C
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
70.84
31%
-89
- C2 -
3HAD
1
HCDH_HUMAN
A:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
70.73
31%
-85
- C2 -
1F0Y
3
HCDH_HUMAN
B:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
LRKVAKKK
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
KFIVDG
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
70.63
31%
-91
- C2 -
1F17
1
HCDH_HUMAN
B:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
LRKVAKKK
F
A
E
N
P
K
A
G
-----
D
E
C
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
KFIVDG
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
70.56
31%
-88
- C2 -
1LSO
1
HCDH_HUMAN
A:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
70.33
31%
-93
- C2 -
3HAD
1
HCDH_HUMAN
B:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
LRKVAKKK
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
KFIVDG
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
70.30
31%
-86
- C2 -
3HDH
1
HCDH_PIG
B:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
LRKVAKKK
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
S
I
S
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
KFIIDG
W
H
--------
E
M
D
S
--
Q
N
P
L
F
--------
Q
-----
P
S
--
P
A
----
M
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
69.78
31%
-92
- C2 -
1LSO
1
HCDH_HUMAN
B:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
LRKVAKKK
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
T
I
A
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
N
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
A
S
L
Q
I
T
S
I
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
V
M
K
L
V
E
V
I
K
T
P
M
T
S
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
M
E
A
I
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
KFIVDG
W
H
--------
E
M
D
A
--
E
N
P
L
H
--------
Q
-----
P
S
--
P
S
----
L
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
69.52
31%
-88
- C2 -
3HDH
1
HCDH_PIG
A:
[16-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
-----
D
E
F
-----
V
E
K
T
L
S
S
I
S
--
T
S
T
D
-
A
A
-
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
-
D
-
A
S
K
E
D
I
D
T
A
M
-
K
L
G
A
-
G
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
H
--------
E
M
D
S
--
Q
N
P
L
F
--------
Q
-----
P
S
--
P
A
----
M
-------
N
K
-----------
L
V
A
E
N
K
F
G
K
K
T
G
E
G
F
Y
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------