@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5192: (2016-03-05 )
MTQANNAVYTDISAAQLVEEAIRRGEGELAANGSLVVRTGHRTGRSPVDRFIVEEPSTKDAIAWGNINRPFPADKFDALWARVEAFNNAQDHFVSHVHVGSAEAYYLPVKMTTATAWQNLFGRCLFIEPEQYNPAGKDEWQVLNVANFECVPERDGTNSDGCVILNFAQKKVLIAGMRYAGEMKKAMFSVQNFLLPERDVLPMHCAANIGEAGDVTLFFGLSGTGKTTLSADESRYLIGDDEHGWGEGVVFNVEGGCYAKCIDLSEKNEPVIWKAIKFGAVLENVVLDEERVPNYADDSLTQNSRAAYPLEHVEKRSEKNLGGEPNAVIFLTCDLTGVLPPVSILNNEQAAYHFLSGYTALVGSTEMGSGGGIKSTFSTCFGAPFFPRPAGVYAELLIKRIKAFGSKVYLVNTGWTGGGYGVGKRFNIPTTRGVIAAIQSGALIGAETEHLEIINLDVPKAVPGVETNLLNPRNTWADKAAYDEAAKGLAKQFIENFKKFEVSDAIKAAGPQL
Atome Classification :
(23 SA)
.........10........20..-----.-----.-----.-...30........40........50........60...-----.------..------..70........80......----.-.90.-.......100.......110.......120.....--..--130.....-...-------140..-----.....150.---.--......160.......170.......180.......190.......200.......210-........220.......230.......240.......250.......260.......270....-...280......-.290..-......300.......310.......-320.-.....--..330.......340.......350.......360.......370.......380.......390.......400.......410.......420.-......430.......440.......450.......460.......470.......480.......490......-.500-.---..-.---...--..510.----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTQANN
A
V
Y
TD
I
S
A
A
Q
L
V
E
E
A
I
R-----R-----G-----E-GELAAN
G
S
L
V
V
R
TGHRTGR
S
P
V
D
R
F
IVEEPSTKD
A
I
A
W-----G------NI------NRPFPA
D
K
F
D
A
L
W
A
R
V
E
A
FN----N-
A
Q
D
H
-
F
V
S
H
V
HVGSA
E
A
Y
Y
L
P
V
K
M
T
T
A
T
A
W
Q
N
LFG
R
C
L
F
I--EP--EQ-YNPAG-KD
E
-------
W
Q
V
L
N
-----VAN
F
E
C
V-P---E--RDGTNSD
G
C
V
I
L
NFAQ
K
K
V
L
I
A
G
M
R
Y
A
G
E
M
K
K
A
M
F
S
V
Q
N
FLLPERDVLPMHCAANIG-E-AG
D
V
T
L
F
F
GLSGTG
K
T
T
LSADE
S
R
Y
L
IGDDEHGWGE
G
V
V
F
NVEG
G
C
Y
A
K
C
IDLSEKNE
P
V
I
W
K
A
I
-
K
F
G
A
V
L
E
N
V
VL
D
-
E
E
-RVP-NYADDSLTQNSRAAY
P
L
E
H
V
E
K
R
S
EK-NL-G-GEP
N
A
--
V
I
F
L
T
CDLTGVLP
P
V
S
ILNN
E
Q
A
A
Y
H
F
L
S
G
Y
T
A
L
VGSTEMGSGGG
I
K
S
T
F
S
T
CFGAPFFPR
P
A
G
V
Y
A
E
L
L
I
K
R
I
K
A
FG
S
K
V
Y
L
V
NTGWTGGGYGVG-KRFNIPT
T
R
G
V
I
A
A
I
QSG
A
L
IGAET
E
H
L
E
I
I
NLDVPKAVPGVETNLLNPRNTWA
D
K
A
A
Y
D
E
A
A
K
G
L
A
K
Q
F
I
E
N
F
K
-
K
F
---
E
---
V
S
-
D
---
A
I
K
--AAGPQL----
21
PsiBlast_CBE
99.85
48%
-95
- C3 -
2PC9
8
PCKA_THET8
C:
[15-527]
-------
V
F
W
N
T
V
S
P
V
L
V
E
H
T
L
L
-----
R
-----
G
-----
E
-
G
L
L
A
H
H
G
P
L
V
V
D
T
T
P
Y
T
G
R
S
P
K
D
K
F
V
V
R
E
P
E
V
E
G
E
I
W
W
-----
G
------
E
V
------
N
Q
P
F
A
P
E
A
F
E
A
L
Y
Q
R
V
V
Q
Y
L
----
S
-
E
R
D
L
-
Y
V
Q
D
L
Y
A
G
A
D
R
R
Y
R
L
A
V
R
V
V
T
E
S
P
W
H
A
L
F
A
R
N
M
F
I
--
L
P
--
R
R
-
F
---
G
-
N
--VE
A
F
V
P
G
F
T
V
V
H
-----
A
P
Y
F
Q
A
V
-
P
---
E
--
R
D
G
T
R
S
E
V
F
V
G
I
S
F
Q
R
R
L
V
L
I
V
G
T
K
Y
A
G
E
I
K
K
S
I
F
T
V
M
N
Y
L
M
P
K
R
G
V
F
P
M
H
A
S
A
N
V
G
-
K
-
E
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
E
R
P
L
I
G
D
D
E
H
G
W
S
E
D
G
V
F
N
F
E
G
G
C
Y
A
K
V
I
R
L
S
P
E
H
E
P
L
I
Y
K
A
S
N
Q
F
E
A
I
L
E
N
V
V
V
N
P
E
S
-
R
R
V
-
Q
W
D
D
D
S
K
T
E
N
T
R
S
S
Y
P
I
A
H
L
E
N
V
V
E
S
-
G
V
-
A
-
G
H
P
R
A
--
I
F
F
L
S
A
D
A
Y
G
V
L
P
P
I
A
R
L
S
P
E
E
A
M
Y
Y
F
L
S
G
Y
T
A
R
-------
V
T
E
P
-
R
A
T
F
S
A
C
F
G
A
P
F
L
P
M
H
P
G
V
Y
A
R
M
L
G
E
K
I
R
K
H
A
P
R
V
Y
L
V
N
T
G
W
T
G
G
P
Y
G
V
G
-
Y
R
F
P
L
P
V
T
R
A
L
L
K
A
A
L
S
G
A
L
E
N
V
P
Y
R
R
D
P
V
F
G
F
E
V
P
L
E
A
P
G
V
P
Q
E
L
L
N
P
R
E
T
W
A
D
K
E
A
Y
D
Q
Q
A
R
K
L
A
R
L
F
Q
E
N
F
Q
-
K
Y
---
A
SG-
V
A
-
K
---
E
V
A
--
E
A
G
P
R
-----
2
PsiBlast_PDB
99.33
48%
-94
- C3 -
2PC9
4
PCKA_THET8
A:
[15-527]
-------
V
F
W
N
T
V
S
P
V
L
V
E
H
T
L
L
-----
R
-----
G
-----
E
-
G
L
L
A
H
H
G
P
L
V
V
D
T
T
P
Y
T
G
R
S
P
K
D
K
F
V
V
R
E
P
E
V
E
G
E
I
W
W
-----
G
------
E
V
------
N
Q
P
F
A
P
E
A
F
E
A
L
Y
Q
R
V
V
Q
Y
L
----
S
-
E
R
D
L
-
Y
V
Q
D
L
Y
A
G
A
D
R
R
Y
R
L
A
V
R
V
V
T
E
S
P
W
H
A
L
F
A
R
N
M
F
I
--
L
P
--
R
R
-
F
---
G
-
N
--AFVPG--
F
T
V
V
H
-----
A
P
Y
F
Q
A
V
-
P
---
E
--
R
D
G
T
R
S
E
V
F
V
G
I
S
F
Q
R
R
L
V
L
I
V
G
T
K
Y
A
G
E
I
K
K
S
I
F
T
V
M
N
Y
L
M
P
K
R
G
V
F
P
M
H
A
S
A
N
V
G
-
K
-
E
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
E
R
P
L
I
G
D
D
E
H
G
W
S
E
D
G
V
F
N
F
E
G
G
C
Y
A
K
V
I
R
L
S
P
E
H
E
P
L
I
Y
K
A
S
N
Q
F
E
A
I
L
E
N
V
V
V
N
P
E
S
-
R
R
V
-
Q
W
D
D
D
S
K
T
E
N
T
R
S
S
Y
P
I
A
H
L
E
N
V
V
E
S
-
G
V
-
A
-
G
H
P
R
A
--
I
F
F
L
S
A
D
A
Y
G
V
L
P
P
I
A
R
L
S
P
E
E
A
M
Y
Y
F
L
S
G
Y
T
A
R
-------
V
T
E
P
-
R
A
T
F
S
A
C
F
G
A
P
F
L
P
M
H
P
G
V
Y
A
R
M
L
G
E
K
I
R
K
H
A
P
R
V
Y
L
V
N
T
G
W
T
G
G
P
Y
G
V
G
-
Y
R
F
P
L
P
V
T
R
A
L
L
K
A
A
L
S
G
A
L
E
N
V
P
Y
R
R
D
P
V
F
G
F
E
V
P
L
E
A
P
G
V
P
Q
E
L
L
N
P
R
E
T
W
A
D
K
E
A
Y
D
Q
Q
A
R
K
L
A
R
L
F
Q
E
N
F
Q
-
K
Y
---
A
SG-
V
A
-
K
---
E
V
A
--
E
A
G
P
R
-----
22
PsiBlast_CBE
98.77
48%
-91
- C3 -
2PC9
5
PCKA_THET8
B:
[15-527]
-------
V
F
W
N
T
V
S
P
V
L
V
E
H
T
L
L
-----
R
-----
G
-----
E
-
G
L
L
A
H
H
G
P
L
V
V
D
T
T
P
Y
T
G
R
S
P
K
D
K
F
V
V
R
E
P
E
V
E
G
E
I
W
W
-----
G
------
E
V
------
N
Q
P
F
A
P
E
A
F
E
A
L
Y
Q
R
V
V
Q
Y
L
----
S
-
E
R
D
L
-
Y
V
Q
D
L
Y
A
G
A
D
R
R
Y
R
L
A
V
R
V
V
T
E
S
P
W
H
A
L
F
A
R
N
M
F
I
--
L
P
--
R
R
-
F
--------FVPG---
F
T
V
V
H
-----
A
P
Y
F
Q
A
V
-
P
---
E
--
R
D
G
T
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F
V
G
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A
G
E
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Y
L
M
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V
F
P
M
H
A
S
A
N
V
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-
K
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E
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A
V
F
F
G
L
S
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T
G
K
T
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P
L
I
G
D
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H
G
W
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G
C
Y
A
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V
I
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L
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P
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K
A
S
N
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L
E
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V
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R
V
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W
D
D
D
S
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S
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P
I
A
H
L
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N
V
V
E
S
-
G
V
-
A
-
G
H
P
R
A
--
I
F
F
L
S
A
D
A
Y
G
V
L
P
P
I
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R
L
S
P
E
E
A
M
Y
Y
F
L
S
G
Y
T
A
R
--------
T
E
P
-
R
A
T
F
S
A
C
F
G
A
P
F
L
P
M
H
P
G
V
Y
A
R
M
L
G
E
K
I
R
K
H
A
P
R
V
Y
L
V
N
T
G
W
T
G
G
P
Y
G
V
G
-
Y
R
F
P
L
P
V
T
R
A
L
L
K
A
A
L
S
G
A
L
E
N
V
P
Y
R
R
D
P
V
F
G
F
E
V
P
L
E
A
P
G
V
P
Q
E
L
L
N
P
R
E
T
W
A
D
K
E
A
Y
D
Q
Q
A
R
K
L
A
R
L
F
Q
E
N
F
Q
-
K
Y
---
A
SG-
V
A
-
K
---
E
V
A
--
E
A
G
P
R
-----
1
PsiBlast_PDB
98.66
48%
-93
- C3 -
1XKV
5
PCKA_THET8
A:
[15-527]
-------
V
F
W
N
T
V
S
P
V
L
V
E
H
T
L
L
-----
R
-----
G
-----
E
-
G
L
L
A
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G
P
L
V
V
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T
T
P
Y
T
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R
S
P
K
D
K
F
V
V
R
E
P
E
V
E
G
E
I
W
W
-----
G
------
E
V
------
N
Q
P
F
A
P
E
A
F
E
A
L
Y
Q
R
V
V
Q
Y
L
----
S
-
E
R
D
L
-
Y
V
Q
D
L
Y
A
G
A
D
R
R
Y
R
L
A
V
R
V
V
T
E
S
P
W
H
A
L
F
A
R
N
M
F
I
--
L
P
--
R
R
-
F
---
G
----AFVPG--
F
T
V
V
H
-----
A
P
Y
F
Q
A
V
-
P
---
E
--
R
D
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V
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L
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Y
A
G
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K
S
I
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M
N
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L
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V
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A
S
A
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-
K
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A
V
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G
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V
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H
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K
A
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E
A
I
L
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V
V
V
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R
R
V
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W
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D
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T
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N
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A
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V
V
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G
V
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A
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A
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Y
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Y
T
A
R
-------
V
T
E
P
-
R
A
T
F
S
A
C
F
G
A
P
F
L
P
M
H
P
G
V
Y
A
R
M
L
G
E
K
I
R
K
H
A
P
R
V
Y
L
V
N
T
G
W
T
G
G
P
Y
G
V
G
-
Y
R
F
P
L
P
V
T
R
A
L
L
K
A
A
L
S
G
A
L
E
N
V
P
Y
R
R
D
P
V
F
G
F
E
V
P
L
E
A
P
G
V
P
Q
E
L
L
N
P
R
E
T
W
A
D
K
E
A
Y
D
Q
Q
A
R
K
L
A
R
L
F
Q
E
N
F
Q
-
K
Y
---
A
SG-
V
A
-
K
---
E
V
A
--
E
A
G
P
R
-----
4
PsiBlast_PDB
94.76
43%
-85
- C3 -
1YLH
10
PCKA_ACTSZ
A:
[38-559]
L
T
D
V
K
E
I
V
Y
-
N
P
S
Y
E
Q
L
F
E
E
E
T
K
-----
P
-----
G
LEGFD
K
-
G
T
L
T
T
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
C
D
E
T
T
K
D
T
V
W
W
-----
N
SEAAK-
N
D
------
N
K
P
M
T
Q
E
T
W
K
S
L
R
E
L
V
A
K
Q
L
----
S
-
G
K
R
L
-
F
V
V
E
G
Y
C
G
A
S
E
K
H
R
I
G
V
R
M
V
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
T
D
-
E
E
L
K
N
F
K
A
D
-------
F
T
V
L
N
-----
G
A
--
K
C
T
-
N
PNW
K
--
E
Q
G
L
N
S
E
N
F
V
A
F
N
I
T
E
G
I
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
F
L
P
L
K
G
V
A
S
M
H
C
S
A
N
V
G
-
K
-
D
G
D
V
A
I
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
Q
L
I
G
D
D
E
H
G
W
D
E
S
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
N
L
S
Q
E
N
E
P
D
I
Y
G
A
I
-
R
R
D
A
L
L
E
N
V
V
V
R
-
A
D
-
G
S
V
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
R
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
K
L
T
P
E
Q
T
E
Y
Y
F
L
S
G
F
T
A
-----------
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
I
Q
Y
A
D
V
L
V
E
R
M
K
A
S
G
A
E
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
G
I
I
D
A
I
L
D
G
S
I
E
K
A
E
M
G
E
L
P
I
F
N
L
A
I
P
K
A
L
P
G
V
D
P
A
I
L
D
P
R
D
T
Y
A
D
K
A
Q
W
Q
V
K
A
E
D
L
A
N
R
F
V
K
N
F
V
-
K
Y
---
T
---
A
N
P
E
---
A
A
K
L
V
G
A
G
P
K
-----
3
PsiBlast_PDB
94.07
43%
-85
- C3 -
1YGG
3
PCKA_ACTSZ
A:
[38-559]
L
T
D
V
K
E
I
V
Y
-
N
P
S
Y
E
Q
L
F
E
E
E
T
K
-----
P
-----
G
LEGFD
K
-
G
T
L
T
T
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
C
D
E
T
T
K
D
T
V
W
W
-----
N
SEAAK-
N
D
------
N
K
P
M
T
Q
E
T
W
K
S
L
R
E
L
V
A
K
Q
L
----
S
-
G
K
R
L
-
F
V
V
E
G
Y
C
G
A
S
E
K
H
R
I
G
V
R
M
V
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
T
D
-
E
E
L
K
N
F
K
A
D
-------
F
T
V
L
N
-----
G
A
--
K
C
T
-
N
PNW
K
--
E
Q
G
L
N
S
E
N
F
V
A
F
N
I
T
E
G
I
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
F
L
P
L
K
G
V
A
S
M
H
C
S
A
N
V
G
-
K
-
D
G
D
V
A
I
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
Q
L
I
G
D
D
E
H
G
W
D
E
S
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
N
L
S
Q
E
N
E
P
D
I
Y
G
A
I
-
R
R
D
A
L
L
E
N
V
V
V
R
-
A
D
-
G
S
V
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
R
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
K
L
T
P
E
Q
T
E
Y
Y
F
L
S
G
F
T
A
K
L
--------
E
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
I
Q
Y
A
D
V
L
V
E
R
M
K
A
S
G
A
E
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
G
I
I
D
A
I
L
D
G
S
I
E
K
A
E
M
G
E
L
P
I
F
N
L
A
I
P
K
A
L
P
G
V
D
P
A
I
L
D
P
R
D
T
Y
A
D
K
A
Q
W
Q
V
K
A
E
D
L
A
N
R
F
V
K
N
F
V
-
K
Y
---
T
---
A
N
P
E
---
A
A
K
LV
G
A
G
P
K
-----
48
Fugue
93.79
40%
-79
- C3 -
1II2
1
PCKA_TRYCR
A:
[1-522]
----
P
P
T
I
H
R
N
L
L
S
P
E
L
V
Q
W
A
L
K
I----
E
-----
K
-----
D
-
S
R
L
T
A
R
G
A
L
A
V
M
S
Y
A
K
T
G
R
S
P
L
D
K
R
I
V
D
T
D
D
V
R
E
N
V
D
W
-----
G
------
K
V
------
N
M
K
L
S
E
E
S
F
A
R
V
R
K
I
A
K
E
F
L
----
D
-
T
R
E
H
L
F
V
V
D
C
F
A
G
H
D
E
R
Y
R
L
K
V
R
V
F
T
T
R
P
Y
H
A
L
F
M
R
D
M
L
I
--
V
P
T
P
E
E
-
L
A
T
F
G
-
E
P
D
-------
Y
V
I
Y
N
-----
A
G
E
C
K
A
D
-
P
---
S
--
I
P
G
L
T
S
T
T
C
V
A
L
N
F
K
T
R
E
Q
V
I
L
G
T
E
Y
A
G
E
M
K
K
G
I
L
T
V
M
F
E
L
M
P
Q
M
N
H
L
C
M
H
A
S
A
N
V
G
-
K
-
Q
G
D
V
T
V
F
F
G
L
S
G
T
G
K
T
T
L
S
A
D
P
H
R
N
L
I
G
D
D
E
H
V
W
T
D
R
G
V
F
N
I
E
G
G
C
Y
A
K
A
I
G
L
N
P
K
T
E
K
D
I
Y
D
A
V
-
R
F
G
A
V
A
E
N
C
V
L
D
-
K
R
T
G
E
I
-
D
F
Y
D
E
S
I
C
K
N
T
R
V
A
Y
P
L
S
H
I
E
G
A
L
S
K
-
A
I
-
A
-
G
H
P
K
N
--
V
I
F
L
T
N
D
A
F
G
V
M
P
P
V
A
R
L
T
S
A
Q
A
M
F
W
F
V
M
G
Y
T
A
N
V
P
G
V
E
A
G
G
T
R
T
A
R
P
I
F
S
S
C
F
G
G
P
F
L
V
R
H
A
T
F
Y
G
E
Q
L
A
E
K
M
Q
K
H
N
S
R
V
W
L
L
N
T
G
Y
A
G
G
R
A
D
R
G
A
K
R
M
P
L
R
V
T
R
A
I
I
D
A
I
H
D
G
T
L
D
R
T
E
Y
E
E
Y
P
G
W
G
L
H
I
P
K
Y
V
A
K
V
P
E
H
L
L
N
P
R
K
A
W
K
D
V
R
Q
F
N
E
T
S
K
E
L
V
A
M
F
Q
E
S
F
S
-
A
R
FAA
K
---
A
S
-
Q
---
E
M
K
--
S
A
V
P
R
Y
V
E
FA
25
HHSearch
93.64
40%
-78
- C3 -
1II2
1
PCKA_TRYCR
A:
[1-518]
----
P
P
T
I
H
R
N
L
L
S
P
E
L
V
Q
W
A
L
K
-----
I
-----
E
-----
K
D
S
R
L
T
A
R
G
A
L
A
V
M
S
Y
A
K
T
G
R
S
P
L
D
K
R
I
V
D
T
D
D
V
R
E
N
V
D
W
-----
G
------
K
V
------
N
M
K
L
S
E
E
S
F
A
R
V
R
K
I
A
K
E
F
L
----
D
T
R
E
H
L
-
F
V
V
D
C
F
A
G
H
D
E
R
Y
R
L
K
V
R
V
F
T
T
R
P
Y
H
A
L
F
M
R
D
M
L
I
--
V
P
--
T
P
E
E
L
A
T
F
G
E
P
D
-------
Y
V
I
Y
N
-----
A
G
E
C
K
A
D
-
P
---
S
--
I
P
G
L
T
S
T
T
C
V
A
L
N
F
K
T
R
E
Q
V
I
L
G
T
E
Y
A
G
E
M
K
K
G
I
L
T
V
M
F
E
L
M
P
Q
M
N
H
L
C
M
H
A
S
A
N
V
G
-
K
-
Q
G
D
V
T
V
F
F
G
L
S
G
T
G
K
T
T
L
S
A
D
P
H
R
N
L
I
G
D
D
E
H
V
W
T
D
R
G
V
F
N
I
E
G
G
C
Y
A
K
A
I
G
L
N
P
K
T
E
K
D
I
Y
D
A
V
-
R
F
G
A
V
A
E
N
C
V
L
D
-
K
R
T
G
E
I
-
D
F
Y
D
E
S
I
C
K
N
T
R
V
A
Y
P
L
S
H
I
E
G
A
L
S
K
-
A
I
-
A
-
G
H
P
K
N
--
V
I
F
L
T
N
D
A
F
G
V
M
P
P
V
A
R
L
T
S
A
Q
A
M
F
W
F
V
M
G
Y
T
A
N
V
P
G
V
E
A
G
G
T
R
T
A
R
P
I
F
S
S
C
F
G
G
P
F
L
V
R
H
A
T
F
Y
G
E
Q
L
A
E
K
M
Q
K
H
N
S
R
V
W
L
L
N
T
G
Y
A
G
G
R
A
D
R
G
A
K
R
M
P
L
R
V
T
R
A
I
I
D
A
I
H
D
G
T
L
D
R
T
E
Y
E
E
Y
P
G
W
G
L
H
I
P
K
Y
V
A
K
V
P
E
H
L
L
N
P
R
K
A
W
K
D
V
R
Q
F
N
E
T
S
K
E
L
V
A
M
F
Q
E
S
F
S
A
R
F
A--
A
K--
A
S
-
Q
---
E
M
K
--
S
A
V
P
R
Y
----
27
HHSearch
93.52
44%
-81
- C3 -
2OLR
5
PCKA_ECOLI
A:
[17-540]
-
I
S
D
V
H
D
I
V
Y
N
P
S
Y
D
L
L
Y
Q
E
E
L
D
PSLTG
Y
-----
E
-----
R
-
G
V
L
T
N
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
R
D
D
T
T
R
D
T
F
W
W
-----
A
------
D
K
GKGKND
N
K
P
L
S
P
E
T
W
Q
H
L
K
G
L
V
T
R
Q
L
----
S
-
G
K
R
L
-
F
V
V
D
A
F
C
G
A
N
P
D
T
R
L
S
V
R
F
I
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
S
D
E
E
L
A
G
F
-
K
P
D
-------
F
I
V
M
N
-----
G
A
K
C
T
N
P
-
Q
W--
K
--
E
Q
G
L
N
S
E
N
F
V
A
F
N
L
T
E
R
M
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
L
L
P
L
K
G
I
A
S
M
H
C
S
A
N
V
G
-
E
-
K
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
R
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
K
L
S
K
E
A
E
P
E
I
Y
N
A
I
-
R
R
D
A
L
L
E
N
V
T
V
R
-
E
D
-
G
T
I
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
K
P
-
V
S
K
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
R
L
T
A
D
Q
T
Q
Y
H
F
L
S
G
F
T
A
K
L
A
G
T
E
R
G
I
T
-
E
P
T
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
T
Q
Y
A
E
V
L
V
K
R
M
Q
A
A
G
A
Q
A
Y
L
V
N
T
G
W
N
G
T
----
G
-
K
R
I
S
I
K
D
T
R
A
I
I
D
A
I
L
N
G
S
L
D
N
A
E
T
F
T
L
P
M
F
N
L
A
I
P
T
E
L
P
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
S
P
E
Q
W
Q
E
K
A
E
T
L
A
K
L
F
I
D
N
F
D
-
K
Y
TD-
T
P
--
A
G
-
A
---
A
L
V
--
A
A
G
P
K
L
----
6
PsiBlast_PDB
93.21
44%
-84
- C3 -
1K3D
3
PCKA_ECOLI
A:
[46-540]
----------------------------------------
R
-
G
V
L
T
N
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
R
D
D
T
T
R
D
T
F
W
W
-----
A
DKGKGK
N
D
------
N
K
P
L
S
P
E
T
W
Q
H
L
K
G
L
V
T
R
Q
L
----
S
-
G
K
R
L
-
F
V
V
D
A
F
C
G
A
N
P
D
T
R
L
S
V
R
F
I
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
S
D
-
E
E
L
A
G
F
K
P
D
-------
F
I
V
M
N
-----
G
A
--
K
C
T
N
P
---
Q
WK
E
Q
G
L
N
S
E
N
F
V
A
F
N
L
T
E
R
M
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
L
L
P
L
K
G
I
A
S
M
H
C
S
A
N
V
G
-
E
-
K
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
R
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
K
L
S
K
E
A
E
P
E
I
Y
N
A
I
-
R
R
D
A
L
L
E
N
V
T
V
R
-
E
D
-
G
T
I
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
K
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
R
L
T
A
D
Q
T
Q
Y
H
F
L
S
G
F
T
A
K
L
A
G
T
E
R
G
I
T
E
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
T
Q
Y
A
E
V
L
V
K
R
M
Q
A
A
G
A
Q
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
A
I
I
D
A
I
L
N
G
S
L
D
N
A
E
T
F
T
L
P
M
F
N
L
A
I
P
T
E
L
P
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
S
P
E
Q
W
Q
E
K
A
E
T
L
A
K
L
F
I
D
N
F
D
-
K
Y
---
T
---
D
T
-
P
A
G
A
A
L
V
--
A
A
G
P
K
L
----
16
PsiBlast_PDB
93.16
40%
-81
- C3 -
1II2
1
PCKA_TRYCR
A:
[4-517]
-------
I
H
R
N
L
L
S
P
E
L
V
Q
W
A
L
K
I----
E
-----
K
-----
D
-
S
R
L
T
A
R
G
A
L
A
V
M
S
Y
A
K
T
G
R
S
P
L
D
K
R
I
V
D
T
D
D
V
R
E
N
V
D
W
-----
G
------
K
V
------
N
M
K
L
S
E
E
S
F
A
R
V
R
K
I
A
K
E
F
L
----
D
-
T
R
E
H
L
F
V
V
D
C
F
A
G
H
D
E
R
Y
R
L
K
V
R
V
F
T
T
R
P
Y
H
A
L
F
M
R
D
M
L
I
V
P
T
P
--
E
E
-
L
A
T
F
G
-
E
P
D
-------
Y
V
I
Y
N
-----
A
G
E
C
K
A
D
-
P
---
S
--
I
P
G
L
T
S
T
T
C
V
A
L
N
F
K
T
R
E
Q
V
I
L
G
T
E
Y
A
G
E
M
K
K
G
I
L
T
V
M
F
E
L
M
P
Q
M
N
H
L
C
M
H
A
S
A
N
V
G
-
K
-
Q
G
D
V
T
V
F
F
G
L
S
G
T
G
K
T
T
L
S
A
D
P
H
R
N
L
I
G
D
D
E
H
V
W
T
D
R
G
V
F
N
I
E
G
G
C
Y
A
K
A
I
G
L
N
P
K
T
E
K
D
I
Y
D
A
V
-
R
F
G
A
V
A
E
N
C
V
L
D
-
K
R
-
T
G
E
I
D
F
Y
D
E
S
I
C
K
N
T
R
V
A
Y
P
L
S
H
I
E
G
A
L
S
K
-
A
I
-
A
-
G
H
P
K
N
--
V
I
F
L
T
N
D
A
F
G
V
M
P
P
V
A
R
L
T
S
A
Q
A
M
F
W
F
V
M
G
Y
T
A
N
V
P
G
V
E
A
G
G
T
R
T
A
R
P
I
F
S
S
C
F
G
G
P
F
L
V
R
H
A
T
F
Y
G
E
Q
L
A
E
K
M
Q
K
H
N
S
R
V
W
L
L
N
T
G
Y
A
G
G
R
A
D
R
G
A
K
R
M
P
L
R
V
T
R
A
I
I
D
A
I
H
D
G
T
L
D
R
T
E
Y
E
E
Y
P
G
W
G
L
H
I
P
K
Y
V
A
K
V
P
E
H
L
L
N
P
R
K
A
W
K
D
V
R
Q
F
N
E
T
S
K
E
L
V
A
M
F
Q
E
S
F
S
A
R
F
AA-
K
---
A
S
-
Q
---
E
M
K
--
S
A
V
P
R
-----
24
PsiBlast_CBE
93.15
40%
-84
- C3 -
1II2
1
PCKA_TRYCR
B:
[4-517]
-------
I
H
R
N
L
L
S
P
E
L
V
Q
W
A
L
K
I----
E
-----
K
-----
D
-
S
R
L
T
A
R
G
A
L
A
V
M
S
Y
A
K
T
G
R
S
P
L
D
K
R
I
V
D
T
D
D
V
R
E
N
V
D
W
-----
G
------
K
V
------
N
M
K
L
S
E
E
S
F
A
R
V
R
K
I
A
K
E
F
L
----
D
-
T
R
E
H
L
F
V
V
D
C
F
A
G
H
D
E
R
Y
R
L
K
V
R
V
F
T
T
R
P
Y
H
A
L
F
M
R
D
M
L
I
V
P
T
P
--
E
E
-
L
A
T
F
G
-
E
P
D
-------
Y
V
I
Y
N
-----
A
G
E
C
K
A
D
-
P
---
S
--
I
P
G
L
T
S
T
T
C
V
A
L
N
F
K
T
R
E
Q
V
I
L
G
T
E
Y
A
G
E
M
K
K
G
I
L
T
V
M
F
E
L
M
P
Q
M
N
H
L
C
M
H
A
S
A
N
V
G
-
K
-
Q
G
D
V
T
V
F
F
G
L
S
G
T
G
K
T
T
L
S
A
D
P
H
R
N
L
I
G
D
D
E
H
V
W
T
D
R
G
V
F
N
I
E
G
G
C
Y
A
K
A
I
G
L
N
P
K
T
E
K
D
I
Y
D
A
V
-
R
F
G
A
V
A
E
N
C
V
L
D
-
K
R
-
T
G
E
I
D
F
Y
D
E
S
I
C
K
N
T
R
V
A
Y
P
L
S
H
I
E
G
A
L
S
K
-
A
I
-
A
-
G
H
P
K
N
--
V
I
F
L
T
N
D
A
F
G
V
M
P
P
V
A
R
L
T
S
A
Q
A
M
F
W
F
V
M
G
Y
T
A
N
V
P
--------
T
A
R
P
I
F
S
S
C
F
G
G
P
F
L
V
R
H
A
T
F
Y
G
E
Q
L
A
E
K
M
Q
K
H
N
S
R
V
W
L
L
N
T
G
Y
A
G
G
R
A
D
R
G
A
K
R
M
P
L
R
V
T
R
A
I
I
D
A
I
H
D
G
T
L
D
R
T
E
Y
E
E
Y
P
G
W
G
L
H
I
P
K
Y
V
A
K
V
P
E
H
L
L
N
P
R
K
A
W
K
D
V
R
Q
F
N
E
T
S
K
E
L
V
A
M
F
Q
E
S
F
S
A
R
F
AA-
K
---
A
S
-
Q
---
E
M
K
--
S
A
V
P
R
-----
5
PsiBlast_PDB
93.15
44%
-84
- C3 -
1K3C
4
PCKA_ECOLI
A:
[46-540]
----------------------------------------
R
-
G
V
L
T
N
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
R
D
D
T
T
R
D
T
F
W
W
-----
A
DKGKGK
N
D
------
N
K
P
L
S
P
E
T
W
Q
H
L
K
G
L
V
T
R
Q
L
----
S
-
G
K
R
L
-
F
V
V
D
A
F
C
G
A
N
P
D
T
R
L
S
V
R
F
I
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
S
D
-
E
E
L
A
G
F
K
P
D
-------
F
I
V
M
N
-----
G
A
--
K
C
T
N
P
---
Q
WK
E
Q
G
L
N
S
E
N
F
V
A
F
N
L
T
E
R
M
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
L
L
P
L
K
G
I
A
S
M
H
C
S
A
N
V
G
-
E
-
K
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
R
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
K
L
S
K
E
A
E
P
E
I
Y
N
A
I
-
R
R
D
A
L
L
E
N
V
T
V
R
-
E
D
-
G
T
I
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
K
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
R
L
T
A
D
Q
T
Q
Y
H
F
L
S
G
F
T
A
K
L
A
G
T
E
R
G
I
T
E
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
T
Q
Y
A
E
V
L
V
K
R
M
Q
A
A
G
A
Q
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
A
I
I
D
A
I
L
N
G
S
L
D
N
A
E
T
F
T
L
P
M
F
N
L
A
I
P
T
E
L
P
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
S
P
E
Q
W
Q
E
K
A
E
T
L
A
K
L
F
I
D
N
F
D
-
K
Y
---
T
---
D
T
-
P
A
G
A
A
L
V
--
A
A
G
P
K
L
----
12
PsiBlast_PDB
93.11
44%
-82
- C3 -
2PY7
3
PCKA_ECOLI
X:
[46-540]
----------------------------------------
R
-
G
V
L
T
N
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
R
D
D
T
T
R
D
T
F
W
W
-----
A
DKGKGK
N
D
------
N
K
P
L
S
P
E
T
W
Q
H
L
K
G
L
V
T
R
Q
L
----
S
-
G
K
R
L
-
F
V
V
D
A
F
C
G
A
N
P
D
T
R
L
S
V
R
F
I
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
S
D
-
E
E
L
A
G
F
K
P
D
-------
F
I
V
M
N
-----
G
A
--
K
C
T
N
P
---
Q
WK
E
Q
G
L
N
S
E
N
F
V
A
F
N
L
T
E
R
M
Q
L
I
G
G
T
W
Y
G
G
E
M
K
S
G
M
F
S
M
M
N
Y
L
L
P
L
K
G
I
A
S
M
H
C
S
A
N
V
G
-
E
-
K
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
R
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
K
L
S
K
E
A
E
P
E
I
Y
N
A
I
-
R
R
D
A
L
L
E
N
V
T
V
R
-
E
D
-
G
T
I
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
K
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
R
L
T
A
D
Q
T
Q
Y
H
F
L
S
G
F
T
A
K
L
A
G
T
E
R
G
I
T
E
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
T
Q
Y
A
E
V
L
V
K
R
M
Q
A
A
G
A
Q
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
A
I
I
D
A
I
L
N
G
S
L
D
N
A
E
T
F
T
L
P
M
F
N
L
A
I
P
T
E
L
P
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
S
P
E
Q
W
Q
E
K
A
E
T
L
A
K
L
F
I
D
N
F
D
-
K
Y
---
T
---
D
T
-
P
AGA
A
L
V
--
A
A
G
P
K
L
----
7
PsiBlast_PDB
92.62
44%
-79
- C3 -
1OS1
4
PCKA_ECOLI
A:
[46-540]
----------------------------------------
R
-
G
V
L
T
N
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
R
D
D
T
T
R
D
T
F
W
W
-----
A
DKGKGK
N
D
------
N
K
P
L
S
P
E
T
W
Q
H
L
K
G
L
V
T
R
Q
L
----
S
-
G
K
R
L
-
F
V
V
D
A
F
C
G
A
N
P
D
T
R
L
S
V
R
F
I
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
S
D
-
E
E
L
A
G
F
K
P
D
-------
F
I
V
M
N
-----
G
A
--
K
C
T
N
P
---
Q
WK
E
Q
G
L
N
S
E
N
F
V
A
F
N
L
T
E
R
M
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
L
L
P
L
K
G
I
A
S
M
H
C
S
A
N
V
G
-
E
-
K
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
R
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
K
L
S
K
E
A
E
P
E
I
Y
N
A
I
-
R
R
D
A
L
L
E
N
V
T
V
R
-
E
D
-
G
T
I
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
K
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
R
L
T
A
D
Q
T
Q
Y
H
F
L
S
G
F
T
A
K
L
A
G
T
E
R
G
I
T
E
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
T
Q
Y
A
E
V
L
V
K
R
M
Q
A
A
G
A
Q
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
A
I
I
D
A
I
L
N
G
S
L
D
N
A
E
T
F
T
L
P
M
F
N
L
A
I
P
T
E
L
P
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
S
P
E
Q
W
Q
E
K
A
E
T
L
A
K
L
F
I
D
N
F
D
-
K
Y
---
T
---
D
T
-
P
A
G
A
A
L
V
--
A
A
G
P
K
L
----
8
PsiBlast_PDB
92.60
44%
-83
- C3 -
2OLQ
4
PCKA_ECOLI
A:
[46-540]
----------------------------------------
R
-
G
V
L
T
N
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
R
D
D
T
T
R
D
T
F
W
W
-----
A
DKGKGK
N
D
------
N
K
P
L
S
P
E
T
W
Q
H
L
K
G
L
V
T
R
Q
L
----
S
-
G
K
R
L
-
F
V
V
D
A
F
C
G
A
N
P
D
T
R
L
S
V
R
F
I
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
S
D
-
E
E
L
A
G
F
K
P
D
-------
F
I
V
M
N
-----
G
A
--
K
C
T
N
P
---
Q
WK
E
Q
G
L
N
S
E
N
F
V
A
F
N
L
T
E
R
M
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
L
L
P
L
K
G
I
A
S
M
H
C
S
A
N
V
G
-
E
-
K
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
R
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
K
L
S
K
E
A
E
P
E
I
Y
N
A
I
-
R
R
D
A
L
L
E
N
V
T
V
R
-
E
D
-
G
T
I
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
K
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
R
L
T
A
D
Q
T
Q
Y
H
F
L
S
G
F
T
A
K
L
A
G
T
E
R
G
I
T
E
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
T
Q
Y
A
E
V
L
V
K
R
M
Q
A
A
G
A
Q
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
A
I
I
D
A
I
L
N
G
S
L
D
N
A
E
T
F
T
L
P
M
F
N
L
A
I
P
T
E
L
P
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
S
P
E
Q
W
Q
E
K
A
E
T
L
A
K
L
F
I
D
N
F
D
-
K
Y
---
T
---
D
T
-
P
AGA
A
L
V
--
A
A
G
P
K
L
----
10
PsiBlast_PDB
92.47
44%
-83
- C3 -
1AQ2
4
PCKA_ECOLI
A:
[46-540]
----------------------------------------
R
-
G
V
L
T
N
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
R
D
D
T
T
R
D
T
F
W
W
-----
A
DKGKGK
N
D
------
N
K
P
L
S
P
E
T
W
Q
H
L
K
G
L
V
T
R
Q
L
----
S
-
G
K
R
L
-
F
V
V
D
A
F
C
G
A
N
P
D
T
R
L
S
V
R
F
I
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
S
D
-
E
E
L
A
G
F
K
P
D
-------
F
I
V
M
N
-----
G
A
--
K
C
T
N
P
---
Q
WK
E
Q
G
L
N
S
E
N
F
V
A
F
N
L
T
E
R
M
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
L
L
P
L
K
G
I
A
S
M
H
C
S
A
N
V
G
-
E
-
K
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
R
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
K
L
S
K
E
A
E
P
E
I
Y
N
A
I
-
R
R
D
A
L
L
E
N
V
T
V
R
-
E
D
-
G
T
I
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
K
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
R
L
T
A
D
Q
T
Q
Y
H
F
L
S
G
F
T
A
K
L
A
G
T
---
I
T
E
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
T
Q
Y
A
E
V
L
V
K
R
M
Q
A
A
G
A
Q
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
A
I
I
D
A
I
L
N
G
S
L
D
N
A
E
T
F
T
L
P
M
F
N
L
A
I
P
T
E
L
P
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
S
P
E
Q
W
Q
E
K
A
E
T
L
A
K
L
F
I
D
N
F
D
-
K
Y
---
T
---
D
T
-
P
A
G
A
A
L
V
--
A
A
G
P
K
L
----
9
PsiBlast_PDB
92.41
44%
-81
- C3 -
2OLR
5
PCKA_ECOLI
A:
[46-540]
----------------------------------------
R
-
G
V
L
T
N
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
R
D
D
T
T
R
D
T
F
W
W
-----
A
DKGKGK
N
D
------
N
K
P
L
S
P
E
T
W
Q
H
L
K
G
L
V
T
R
Q
L
----
S
-
G
K
R
L
-
F
V
V
D
A
F
C
G
A
N
P
D
T
R
L
S
V
R
F
I
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
S
D
-
E
E
L
A
G
F
K
P
D
-------
F
I
V
M
N
-----
G
A
--
K
C
T
N
P
---
Q
WK
E
Q
G
L
N
S
E
N
F
V
A
F
N
L
T
E
R
M
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
L
L
P
L
K
G
I
A
S
M
H
C
S
A
N
V
G
-
E
-
K
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
R
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
K
L
S
K
E
A
E
P
E
I
Y
N
A
I
-
R
R
D
A
L
L
E
N
V
T
V
R
-
E
D
-
G
T
I
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
K
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
R
L
T
A
D
Q
T
Q
Y
H
F
L
S
G
F
T
A
K
L
A
G
T
E
R
G
I
T
E
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
T
Q
Y
A
E
V
L
V
K
R
M
Q
A
A
G
A
Q
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
A
I
I
D
A
I
L
N
G
S
L
D
N
A
E
T
F
T
L
P
M
F
N
L
A
I
P
T
E
L
P
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
S
P
E
Q
W
Q
E
K
A
E
T
L
A
K
L
F
I
D
N
F
D
-
K
Y
---
T
---
D
T
-
P
A
G
A
A
L
V
--
A
A
G
P
K
L
----
11
PsiBlast_PDB
92.01
44%
-84
- C3 -
2PXZ
5
PCKA_ECOLI
X:
[46-540]
----------------------------------------
R
-
G
V
L
T
N
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
R
D
D
T
T
R
D
T
F
W
W
-----
A
DKGKGK
N
D
------
N
K
P
L
S
P
E
T
W
Q
H
L
K
G
L
V
T
R
Q
L
----
S
-
G
K
R
L
-
F
V
V
D
A
F
C
G
A
N
P
D
T
R
L
S
V
R
F
I
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
S
D
-
E
E
L
A
G
F
K
P
D
-------
F
I
V
M
N
-----
G
A
--
K
C
T
N
P
---
Q
WK
E
Q
G
L
N
S
E
N
F
V
A
F
N
L
T
E
R
M
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
L
L
P
L
K
G
I
A
S
M
H
C
S
A
N
V
G
-
E
-
K
G
D
V
A
V
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
R
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
T
I
K
L
S
K
E
A
E
P
E
I
Y
N
A
I
-
R
R
D
A
L
L
E
N
V
T
V
R
-
E
D
-
G
T
I
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
K
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
R
L
T
A
D
Q
T
Q
Y
H
F
L
S
G
F
T
A
K
L
A
G
------
E
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
T
Q
Y
A
E
V
L
V
K
R
M
Q
A
A
G
A
Q
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
A
I
I
D
A
I
L
N
G
S
L
D
N
A
E
T
F
T
L
P
M
F
N
L
A
I
P
T
E
L
P
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
S
P
E
Q
W
Q
E
K
A
E
T
L
A
K
L
F
I
D
N
F
D
-
K
Y
---
T
---
D
T
-
P
AGA
A
L
V
--
A
A
G
P
K
L
----
13
PsiBlast_PDB
91.98
44%
-91
- C3 -
1OEN
1
PCKA_ECOLI
A:
[46-540]
----------------------------------------
R
-
G
V
L
T
N
L
G
A
V
A
V
D
T
G
I
F
T
G
R
S
P
K
D
K
Y
I
V
R
D
D
T
T
R
D
T
F
W
W
-----
A
DKGKGK
N
D
------
N
K
P
L
S
P
E
T
W
Q
H
L
K
G
L
V
T
R
Q
L
----
S
-
G
K
R
L
-
F
V
V
D
A
F
C
G
A
N
P
D
T
R
L
S
V
R
F
I
T
E
V
A
W
Q
A
H
F
V
K
N
M
F
I
--
R
P
--
S
D
-
E
E
L
A
G
F
K
P
D
-------
F
I
V
M
N
-----
G
A
--
K
C
T
N
P
---
Q
WK
E
Q
G
L
N
S
E
N
F
V
A
F
N
L
T
E
R
M
Q
L
I
G
G
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
Y
L
L
P
L
K
G
I
A
S
M
H
C
S
A
N
V
G
-
E
-
A
G
D
V
A
V
F
F
G
L
S
G
S
G
K
T
T
L
S
T
D
P
A
R
R
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
S
Y
A
K
T
I
K
L
S
K
E
A
E
P
E
I
Y
A
A
I
-
R
R
D
A
L
L
E
N
V
T
V
R
-
A
G
-
G
T
I
-
D
F
D
D
G
S
K
T
E
N
T
R
V
S
Y
P
I
Y
H
I
D
N
I
V
K
P
V
S
K
-
A
-
G
H
A
T
K
--
V
I
F
L
T
A
D
A
F
G
V
L
P
P
V
S
R
L
T
A
D
Q
T
Q
Y
H
F
L
S
G
F
T
A
A
A
A
--------
P
T
-
P
T
F
S
A
C
F
G
A
A
F
L
S
L
H
P
T
Q
Y
A
E
V
L
V
K
R
M
Q
A
A
G
A
Q
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
A
A
D
T
R
A
I
I
D
A
I
L
N
G
S
L
D
N
A
E
T
F
T
L
P
M
F
N
L
A
I
P
T
E
L
P
G
V
D
T
G
I
L
D
P
R
N
T
Y
A
---
G
W
Q
E
K
A
E
T
L
A
K
L
F
I
D
N
F
D
-
K
Y
---
T
DT
P
A
G
-
A
---
A
L
V
--
A
A
G
P
A
L
----
28
HHSearch
90.90
42%
-80
- C3 -
1YTM
4
PCKA_ANASU
A:
[11-518]
G
I
T
G
A
T
N
I
V
H
N
P
S
H
E
E
L
F
A
A
E
T
Q
-----
A
SLEGF
E
-----
K
-
G
T
V
T
E
M
G
A
V
N
V
M
T
G
V
Y
T
G
R
S
P
K
D
K
F
I
V
K
N
E
A
-
S
K
E
I
W
W
-----
T
------
S
D
EFKND-
N
K
P
V
T
E
E
A
W
A
Q
L
K
A
L
A
G
K
E
L
----
S
-
N
K
P
L
-
Y
V
V
D
L
F
C
G
A
N
E
N
T
R
L
K
I
R
F
V
M
E
V
A
W
Q
A
H
F
V
T
N
M
F
I
--
R
P
--
T
E
E
E
L
K
G
F
-
E
P
D
-------
F
V
V
L
N
-----
A
S
K
A
K
V
E
-
N
F--
K
--
E
L
G
L
N
S
E
T
A
V
V
F
N
L
A
E
K
M
Q
I
I
L
N
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
F
Y
L
P
L
Q
G
I
A
A
M
H
C
S
A
N
T
D
-
L
E
G
K
N
T
A
I
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
L
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
V
I
N
L
S
K
E
N
E
P
D
I
W
G
A
I
-
K
R
N
A
L
L
E
N
V
T
V
D
-
A
N
-
G
K
V
-
D
F
A
D
K
S
V
T
E
N
T
R
V
S
Y
P
I
F
H
I
K
N
I
V
K
P
-
V
S
-
K
A
P
A
A
K
R
--
V
I
F
L
S
A
D
A
F
G
V
L
P
P
V
S
I
L
S
K
E
Q
T
K
Y
Y
F
L
S
G
F
T
A
K
L
A
G
T
E
R
G
I
T
-
E
P
T
P
T
F
S
S
C
F
G
A
A
F
L
T
L
P
P
T
K
Y
A
E
V
L
V
K
R
M
E
A
S
G
A
K
A
Y
L
V
N
T
G
W
N
G
T
----
G
-
K
R
I
S
I
K
D
T
R
G
I
I
D
A
I
L
D
G
S
I
D
T
A
N
T
A
T
I
P
Y
F
N
F
T
V
P
T
E
L
K
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
D
A
S
E
W
E
V
K
A
K
D
L
A
E
R
F
Q
K
N
F
K
-
K
F
-----------------------------
23
PsiBlast_CBE
89.53
44%
-81
- C3 -
1YTM
4
PCKA_ANASU
B:
[41-518]
----------------------------------------
K
-
G
T
V
T
E
M
G
A
V
N
V
M
T
G
V
Y
T
G
R
S
P
K
D
K
F
I
V
K
N
E
A
S
K
E
-
I
W
W
TSDEF
K
------
N
D
------
N
K
P
V
T
E
E
A
----
W
A
Q
L
K
A
L
A
GKEL
S
-
N
K
P
L
-
Y
V
V
D
L
F
C
G
A
N
E
N
T
R
L
K
I
R
F
V
M
E
V
A
W
Q
A
H
F
V
T
N
M
F
I
--
R
P
--
T
E
-
E
E
L
K
G
F
E
P
D
-------
F
V
V
L
N
ASKAK
V
E
N
F
K
E
L
----------
G
L
N
S
E
T
A
V
V
F
N
L
A
E
K
M
Q
I
I
L
N
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
F
Y
L
P
L
Q
G
I
A
A
M
H
C
S
A
N
T
D
L
E
-
G
K
N
T
A
I
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
L
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
V
I
N
L
S
K
E
N
E
P
D
I
W
G
A
I
-
K
R
N
A
L
L
E
N
V
T
V
D
-
A
N
-
G
K
V
-
D
F
A
D
K
S
V
T
E
N
T
R
V
S
Y
P
I
F
H
I
-
K
N
I
V
K
-
P
V
-
S
-
K
A
P
A
A
KR
V
I
F
L
S
A
D
A
F
G
V
L
P
P
V
S
I
L
S
K
E
Q
T
K
Y
Y
F
L
S
G
F
T
A
K
L
A
G
T
E
R
G
I
T
E
P
T
-
P
T
F
S
S
C
F
G
A
A
F
L
T
L
P
P
T
K
Y
A
E
V
L
V
K
R
M
E
A
S
G
A
K
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
G
I
I
D
A
I
L
D
G
S
I
D
T
A
N
T
A
T
I
P
Y
F
N
F
T
V
P
T
E
L
K
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
D
A
S
E
W
E
V
K
A
K
D
L
A
E
R
F
Q
K
N
F
K
-
K
F
-----------------------------
15
PsiBlast_PDB
89.16
44%
-82
- C3 -
1YTM
4
PCKA_ANASU
A:
[41-518]
----------------------------------------
K
-
G
T
V
T
E
M
G
A
V
N
V
M
T
G
V
Y
T
G
R
S
P
K
D
K
F
I
V
K
N
E
A
S
K
E
-
I
W
W
TSDEF
K
------
N
D
------
N
K
P
V
T
E
E
A
----
W
A
Q
L
K
A
L
A
G
K
E
L
S
-
N
K
P
L
-
Y
V
V
D
L
F
C
G
A
N
E
N
T
R
L
K
I
R
F
V
M
E
V
A
W
Q
A
H
F
V
T
N
M
F
I
--
R
P
--
T
E
-
E
E
L
K
G
F
E
P
D
-------
F
V
V
L
N
ASKAK
V
E
N
F
K
E
L
----------
G
L
N
S
E
T
A
V
V
F
N
L
A
E
K
M
Q
I
I
L
N
T
W
Y
G
G
E
M
K
K
G
M
F
S
M
M
N
F
Y
L
P
L
Q
G
I
A
A
M
H
C
S
A
N
T
D
L
E
-
G
K
N
T
A
I
F
F
G
L
S
G
T
G
K
T
T
L
S
T
D
P
K
R
L
L
I
G
D
D
E
H
G
W
D
D
D
G
V
F
N
F
E
G
G
C
Y
A
K
V
I
N
L
S
K
E
N
E
P
D
I
W
G
A
I
-
K
R
N
A
L
L
E
N
V
T
V
D
-
A
N
-
G
K
V
-
D
F
A
D
K
S
V
T
E
N
T
R
V
S
Y
P
I
F
H
I
-
K
N
I
V
K
-
P
V
-
S
-
K
A
P
A
A
K
R
V
I
F
L
S
A
D
A
F
G
V
L
P
P
V
S
I
L
S
K
E
Q
T
K
Y
Y
F
L
S
G
F
T
A
K
L
A
G
T
E
R
G
I
T
E
P
T
-
P
T
F
S
S
C
F
G
A
A
F
L
T
L
P
P
T
K
Y
A
E
V
L
V
K
R
M
E
A
S
G
A
K
A
Y
L
V
N
T
G
W
N
----
G
T
G
-
K
R
I
S
I
K
D
T
R
G
I
I
D
A
I
L
D
G
S
I
D
T
A
N
T
A
T
I
P
Y
F
N
F
T
V
P
T
E
L
K
G
V
D
T
K
I
L
D
P
R
N
T
Y
A
D
A
S
E
W
E
V
K
A
K
D
L
A
E
R
F
Q
K
N
F
K
-
K
F
-----------------------------