@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5201: (2016-03-05 )
MDSINTRIAEELSALPSGRVQPQQVAAAVALLDEGSTVPFIARYRKEVTGSLDDTQLRMLEERLRYLRELEERRGAILASIEEQGKLTPELARDIKLADTKTRLEDLYLPYKQKRRTKGQIALEAGLGALADALFDDPTLVPESEAARFVDAEKGFADVKAVLEGAKYILMERFAEDATLLDKLRVFMKNEATLTARVVPGKEQEGAKFSDYFEHDEPLKSAPSHRALAIFRGRNEGVLSASLKVGEEAPGTLHPCEVMIAERFGLSNQGRAADKWLAEVVRWTWKVKLYTHLETDLFGELRDGAEDEAISVFARNLHDLLLAAPAGPRATLGLDPGLRTGVKVAVVDATGKLLDTATVYPHAPKNQWDQTLAVLAALCAKHQVELIAIGNGTASRETDKLAGELIKKYPGMKLTKIMVSEAGASVYSASELAAKEFPELDVSLRGAVSIARRLQDPLAELVKIEPKSIGVGQYQHDVSQLKLARSLDAVVEDCVNAVGVDVNTASAALLARISGLNSTLAQNIVAHRDANGAFRTRDELKKVSRLGEKTFEQAAGFLRVMNGDNPLDASAVHPETYPLVQRIAADTERDIRSLIGDSAFLKRLDPKKFTDETFGLPTVTDILKELDKPGRDPRPEFKTAEFQEGVESLKDLKPGMVLEGVVTNVTNFGAFVDIGVHQDGLVHISALSEKFVKDPYEVVKAGDIVKVKVMEVDIPRNRVGLSMRMSDTPGEKVEGQRGGRPTGSGQPRQERGAPRGQSAPPANNAMAALFANAKQLKKK
Atome Classification :
(20 SA)
--------------------------------------------------.........10........20........30---........40........50-------........60........70........80........90........100.......110......----------------------.120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220----.........230.......240.......250.....--..260.....---..270........280.......290.......300.......310.......320.......330.......340----------........350.......360..-.....370.......380.......390.......400.......410------.........420.......430.......440.......450.......460..---.....470.......480.......490.......500...-----.-----...510.......520...-....530.-......540.......550.......560..-----..----...570.......580.......590.......600......-.610.......620.......630.......640.......650....--...660.......670..-.--.---...680.......-690.......700.......710.....--..720.......730.......740.......750.......760.......770.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------MD
S
I
N
T
R
I
A
E
E
L
S
ALPSGRV
Q
P
Q
Q
V
A
A
A
V
A
L---LDEGST
V
P
F
I
A
R
Y
R
K
E
VTGS-------L
D
D
T
Q
L
R
M
L
E
E
R
L
R
Y
L
R
E
L
E
E
RR
G
A
I
L
A
S
I
E
EQGKL
T
P
E
L
A
R
D
IKLAD
T
K
T
R
L
E
D
LYLP
Y
K
Q
KRRTK----------------------
G
Q
I
A
L
E
A
G
L
G
A
L
A
D
A
LFDDPTLV
P
E
S
E
A
A
R
F
V
D
A
EK
G
F
A
D
V
K
A
V
L
EG
A
K
Y
I
L
M
E
R
FA
E
D
A
T
L
L
D
K
L
R
V
F
MKNE
A
T
L
T
A
R
VVPGKEQEGAKFSDYFEHDE
P
L
K------SAPSH
R
A
L
A
I
F
RGRNEG
V
L
S
ASLKVGEEAPGTL
H
P
C
E
--
V
M
I
A
E
RFGLS---NQG
R
-
A
A
D
K
W
L
A
E
V
V
R
W
T
W
K
V
K
L
Y
T
HL
E
T
D
L
F
G
E
L
RDGAE
D
E
A
I
S
V
F
A
R
N
L
H
D
L
L
LAAPAGPRATLGLDPGLRT
G
-----------
V
K
V
A
V
VDATG
K
L
L
D
T
ATVYPHAP-KN
Q
W
D
Q
T
L
A
V
L
A
A
L
C
AKH
Q
V
E
L
I
A
IGNGTASR
E
T
D
K
L
A
G
E
L
I
K
KYP--------G
M
K
L
T
K
I
M
VSEAGASVY
S
A
S
E
L
A
A
K
EFPEL
D
V
S
L
R
G
A
V
S
I
A
R
R
L
Q
D
P
L
A
E
L
V
KI---EPKSIGV
G
Q
Y
Q
H
D
V
S
Q
L
K
L
A
R
S
L
D
A
V
V
E
D
C
V
N
A
VGVDV
N
T
A
-----
S
-----
A
A
L
L
A
R
I
SG
L
N
S
T
L
A
Q
N
I
V
-
A
HRDANGA-FR
T
R
D
E
L
K
K
V
S
R
L
G
E
K
T
F
E
Q
A
A
G
F
L
R
VMNGD-----NP----LDASAVHP
E
T
Y
P
L
V
Q
R
I
AAD
T
E
R
D
I
R
S
LIG
D
S
A
F
L
K
RLDPKK-FTDETFGL
P
T
V
T
D
I
L
K
E
L
DKPGRDPRPEFK
T
A
E
F
Q
E
G
V
E
S
L
K
DLKPG
M
--
V
L
E
G
V
V
TNVTNF
G
A
F
V
D
I
-G--V---HQD
G
L
V
H
I
S
A
L
S
E
-
K
F
V
K
D
P
Y
E
V
VKAG
D
I
V
K
V
K
V
M
E
V
DIPRN--RV
G
L
S
M
R
MSDTPGEKVEGQRGGRPTGSGQP
R
Q
ERGAPRGQSAPPA
N
N
A
M
A
A
L
F
A
N
A
K
Q
LKKK
47
Fugue
95.82
100%
-104
- C2 -
3BZC
-
?
A:
[1-730]
--------------------------------------------------
M
D
S
I
N
T
R
I
A
E
E
L
S
A
L
P
S
G
R
V
Q
P
Q
Q
V
A
A
A
V
A
L
---
L
D
E
G
S
T
V
P
F
I
A
R
Y
R
K
E
V
T
G
S
-------
L
D
D
T
Q
L
R
M
L
E
E
R
L
R
Y
L
R
E
L
E
E
R
R
G
A
I
L
A
S
I
E
E
Q
G
K
L
T
P
E
L
A
R
D
I
K
L
A
D
T
K
T
R
L
E
D
L
Y
L
P
Y
K
Q
K
R
R
T
K
----------------------
G
Q
I
A
L
E
A
G
L
G
A
L
A
D
A
L
F
D
D
P
T
L
V
P
E
S
E
A
A
R
F
V
D
A
E
K
G
F
A
D
V
K
A
V
L
E
G
A
K
Y
I
L
M
E
R
F
A
E
D
A
T
L
L
D
K
L
R
V
F
M
K
N
E
A
T
L
T
A
R
V
V
P
G
K
E
Q
E
G
A
K
F
S
D
Y
F
E
H
D
E
P
L
K
------
S
A
P
S
H
R
A
L
A
I
F
R
G
R
N
E
G
V
L
S
A
S
L
K
V
G
E
E
A
P
G
T
L
H
P
C
E
--
V
M
I
A
E
R
F
G
L
S
---
N
Q
G
R
-
A
A
D
K
W
L
A
E
V
V
R
W
T
W
K
V
K
L
Y
T
H
L
E
T
D
L
F
G
E
L
R
D
G
A
E
D
E
A
I
S
V
F
A
R
N
L
H
D
L
L
L
A
A
P
A
G
P
R
A
T
L
G
L
D
P
G
L
R
T
G
-----------
V
K
V
A
V
V
D
A
T
G
K
L
L
D
T
A
T
V
Y
P
H
A
P
-
K
N
Q
W
D
Q
T
L
A
V
L
A
A
L
C
A
K
H
Q
V
E
L
I
A
I
G
N
G
T
A
S
R
E
T
D
K
L
A
G
E
L
I
K
K
Y
P
--------
G
M
K
L
T
K
I
M
V
S
E
A
G
A
S
V
Y
S
A
S
E
L
A
A
K
E
F
P
E
L
D
V
S
L
R
G
A
V
S
I
A
R
R
L
Q
D
P
L
A
E
L
V
K
I
---
E
P
K
S
I
G
V
G
Q
Y
Q
H
D
V
S
Q
L
K
L
A
R
S
L
D
A
V
V
E
D
C
V
N
A
V
G
V
D
V
N
T
A
-----
S
-----
A
A
L
L
A
R
I
S
G
L
N
S
T
L
A
Q
N
I
V
-
A
H
R
D
A
N
G
A
-
F
R
T
R
D
E
L
K
K
V
S
R
L
G
E
K
T
F
E
Q
A
A
G
F
L
R
V
M
N
G
D
-----
N
P
----
L
D
A
S
A
V
H
P
E
T
Y
P
L
V
Q
R
I
A
A
D
T
E
R
D
I
R
S
L
I
G
D
S
A
F
L
K
R
L
D
P
K
K
-
F
T
D
E
T
F
G
L
P
T
V
T
D
I
L
K
E
L
D
K
P
G
R
D
P
R
P
E
F
K
T
A
E
F
Q
E
G
V
E
S
L
K
D
L
K
P
G
M
--
V
L
E
G
V
V
T
N
V
T
N
F
G
A
F
V
D
I
-
G
--
V
---
H
Q
D
G
L
V
H
I
S
A
L
S
E
-
K
F
V
K
D
P
Y
E
V
V
K
A
G
D
I
V
K
V
K
V
M
E
V
D
I
P
R
N
--
R
V
G
L
S
M
R
M
S
D
T
P
G
-------------------------------------------------
3
PsiBlast_PDB
95.78
100%
-102
- C2 -
3BZK
-
?
A:
[1-730]
--------------------------------------------------
M
D
S
I
N
T
R
I
A
E
E
L
S
A
L
P
S
G
R
V
Q
P
Q
Q
V
A
A
A
V
A
L
---
L
D
E
G
S
T
V
P
F
I
A
R
Y
R
K
E
V
T
G
S
-------
L
D
D
T
Q
L
R
M
L
E
E
R
L
R
Y
L
R
E
L
E
E
R
R
G
A
I
L
A
S
I
E
E
Q
G
K
L
T
P
E
L
A
R
D
I
K
L
A
D
T
K
T
R
L
E
D
L
Y
L
P
Y
K
Q
K
R
R
T
K
----------------------
G
Q
I
A
L
E
A
G
L
G
A
L
A
D
A
L
F
D
D
P
T
L
V
P
E
S
E
A
A
R
F
V
D
A
E
K
G
F
A
D
V
K
A
V
L
E
G
A
K
Y
I
L
M
E
R
F
A
E
D
A
T
L
L
D
K
L
R
V
F
M
K
N
E
A
T
L
T
A
R
V
V
P
G
K
E
Q
E
G
A
K
F
S
D
Y
F
E
H
D
E
P
L
K
------
S
A
P
S
H
R
A
L
A
I
F
R
G
R
N
E
G
V
L
S
A
S
L
K
V
G
--
A
P
G
T
L
H
P
C
E
--
V
M
I
A
E
R
F
G
L
S
---
N
Q
G
R
-
A
A
D
K
W
L
A
E
V
V
R
W
T
W
K
V
K
L
Y
T
H
L
E
T
D
L
F
G
E
L
R
D
G
A
E
D
E
A
I
S
V
F
A
R
N
L
H
D
L
L
L
A
A
P
A
G
P
R
A
T
L
G
L
D
P
G
L
R
T
G
-----------
V
K
V
A
V
V
D
A
T
G
K
L
L
D
T
A
T
V
Y
P
H
A
P
-
K
N
Q
W
D
Q
T
L
A
V
L
A
A
L
C
A
K
H
Q
V
E
L
I
A
I
G
N
G
T
A
S
R
E
T
D
K
L
A
G
E
L
I
K
K
Y
P
--------
G
M
K
L
T
K
I
M
V
S
E
A
G
A
S
V
Y
S
A
S
E
L
A
A
K
E
F
P
E
L
D
V
S
L
R
G
A
V
S
I
A
R
R
L
Q
D
P
L
A
E
L
V
K
I
---
E
P
K
S
I
G
V
G
Q
Y
Q
H
D
V
S
Q
L
K
L
A
R
S
L
D
A
V
V
E
D
C
V
N
A
V
G
V
D
V
N
T
A
-----
S
-----
A
A
L
L
A
R
I
S
G
L
N
S
T
L
A
Q
N
I
V
-
A
H
R
D
A
N
G
A
-
F
R
T
R
D
E
L
K
K
V
S
R
L
G
E
K
T
F
E
Q
A
A
G
F
L
R
V
M
N
G
D
-----
N
P
----
L
D
A
S
A
V
H
P
E
T
Y
P
L
V
Q
R
I
A
A
D
T
E
R
D
I
R
S
L
I
G
D
S
A
F
L
K
R
L
D
P
K
K
-
F
T
D
E
T
F
G
L
P
T
V
T
D
I
L
K
E
L
D
K
P
G
R
D
P
R
P
E
F
K
T
A
E
F
Q
E
G
V
E
S
L
K
D
L
K
P
G
M
--
V
L
E
G
V
V
T
N
V
T
N
F
G
A
F
V
D
I
-
G
--
V
---
H
Q
D
G
L
V
H
I
S
A
L
S
E
-
K
F
V
K
D
P
Y
E
V
V
K
A
G
D
I
V
K
V
K
V
M
E
V
D
I
P
R
N
--
R
V
G
L
S
M
R
M
S
D
T
P
G
-------------------------------------------------
2
PsiBlast_PDB
95.22
100%
-104
- C2 -
3BZC
-
?
A:
[1-730]
--------------------------------------------------
M
D
S
I
N
T
R
I
A
E
E
L
S
A
L
P
S
G
R
V
Q
P
Q
Q
V
A
A
A
V
A
L
---
L
D
E
G
S
T
V
P
F
I
A
R
Y
R
K
E
V
T
G
S
-------
L
D
D
T
Q
L
R
M
L
E
E
R
L
R
Y
L
R
E
L
E
E
R
R
G
A
I
L
A
S
I
E
E
Q
G
K
L
T
P
E
L
A
R
D
I
K
L
A
D
T
K
T
R
L
E
D
L
Y
L
P
Y
K
Q
K
R
R
T
K
----------------------
G
Q
I
A
L
E
A
G
L
G
A
L
A
D
A
L
F
D
D
P
T
L
V
P
E
S
E
A
A
R
F
V
D
A
E
K
G
F
A
D
V
K
A
V
L
E
G
A
K
Y
I
L
M
E
R
F
A
E
D
A
T
L
L
D
K
L
R
V
F
M
K
N
E
A
T
L
T
A
R
V
V
P
G
K
E
Q
E
G
A
K
F
S
D
Y
F
E
H
D
E
P
L
K
------
S
A
P
S
H
R
A
L
A
I
F
R
G
R
N
E
G
V
L
S
A
S
L
K
V
G
E
E
A
P
G
T
L
H
P
C
E
--
V
M
I
A
E
R
F
G
L
S
---
N
Q
G
R
-
A
A
D
K
W
L
A
E
V
V
R
W
T
W
K
V
K
L
Y
T
H
L
E
T
D
L
F
G
E
L
R
D
G
A
E
D
E
A
I
S
V
F
A
R
N
L
H
D
L
L
L
A
A
P
A
G
P
R
A
T
L
G
L
D
P
G
L
R
T
G
-----------
V
K
V
A
V
V
D
A
T
G
K
L
L
D
T
A
T
V
Y
P
H
A
P
-
K
N
Q
W
D
Q
T
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A
V
L
A
A
L
C
A
K
H
Q
V
E
L
I
A
I
G
N
G
T
A
S
R
E
T
D
K
L
A
G
E
L
I
K
K
Y
P
--------
G
M
K
L
T
K
I
M
V
S
E
A
G
A
S
V
Y
S
A
S
E
L
A
A
K
E
F
P
E
L
D
V
S
L
R
G
A
V
S
I
A
R
R
L
Q
D
P
L
A
E
L
V
K
I
---
E
P
K
S
I
G
V
G
Q
Y
Q
H
D
V
S
Q
L
K
L
A
R
S
L
D
A
V
V
E
D
C
V
N
A
V
G
V
D
V
N
T
A
-----
S
-----
A
A
L
L
A
R
I
S
G
L
N
S
T
L
A
Q
N
I
V
-
A
H
R
D
A
N
G
A
-
F
R
T
R
D
E
L
K
K
V
S
R
L
G
E
K
T
F
E
Q
A
A
G
F
L
R
V
M
N
G
D
-----
N
P
----
L
D
A
S
A
V
H
P
E
T
Y
P
L
V
Q
R
I
A
A
D
T
E
R
D
I
R
S
L
I
G
D
S
A
F
L
K
R
L
D
P
K
K
-
F
T
D
E
T
F
G
L
P
T
V
T
D
I
L
K
E
L
D
K
P
G
R
D
P
R
P
E
F
K
T
A
E
F
Q
E
G
V
E
S
L
K
D
L
K
P
G
M
--
V
L
E
G
V
V
T
N
V
T
N
F
G
A
F
V
D
I
-
G
--
V
---
H
Q
D
G
L
V
H
I
S
A
L
S
E
-
K
F
V
K
D
P
Y
E
V
V
K
A
G
D
I
V
K
V
K
V
M
E
V
D
I
P
R
N
--
R
V
G
L
S
M
R
M
S
D
T
P
G
-------------------------------------------------
48
Fugue
94.37
100%
-102
- C2 -
2OCE
-
?
A:
[2-730]
---------------------------------------------------
D
S
I
N
T
R
I
A
E
E
L
S
A
L
P
S
G
R
V
Q
P
Q
Q
V
A
A
A
V
A
L
---
L
D
E
G
S
T
V
P
F
I
A
R
Y
R
K
E
V
T
G
S
-------
L
D
D
T
Q
L
R
M
L
E
E
R
L
R
Y
L
R
E
L
E
E
R
R
G
A
I
L
A
S
I
E
E
Q
G
K
L
T
P
E
L
A
R
D
I
K
L
A
D
T
K
T
R
L
E
D
L
Y
L
P
Y
K
Q
K
R
R
T
K
----------------------
G
Q
I
A
L
E
A
G
L
G
A
L
A
D
A
L
F
D
D
P
T
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P
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A
A
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A
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Y
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F
A
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A
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L
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L
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V
F
M
K
N
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L
T
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V
P
G
K
E
Q
E
G
A
K
F
S
D
Y
F
E
H
D
E
P
L
K
------
S
A
P
S
H
R
A
L
A
I
F
R
G
R
N
E
G
V
L
S
A
S
L
K
V
G
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E
A
P
G
T
L
H
P
C
E
--
V
M
I
A
E
R
F
G
L
S
---
N
Q
G
R
-
A
A
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K
W
L
A
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V
V
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W
T
W
K
V
K
L
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L
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L
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L
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A
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D
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L
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L
L
L
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A
P
A
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A
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L
G
L
D
P
G
L
R
T
G
-----------
V
K
V
A
V
V
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A
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G
K
L
L
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A
T
V
Y
P
H
A
P
-
K
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Q
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L
A
A
L
C
A
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H
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A
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N
G
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A
S
R
E
T
D
K
L
A
G
E
L
I
K
K
Y
P
--------
G
M
K
L
T
K
I
M
V
S
E
A
G
A
S
V
Y
S
A
S
E
L
A
A
K
E
F
P
E
L
D
V
S
L
R
G
A
V
S
I
A
R
R
L
Q
D
P
L
A
E
L
V
K
I
---
E
P
K
S
I
G
V
G
Q
Y
Q
H
D
V
S
Q
L
K
L
A
R
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L
D
A
V
V
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D
C
V
N
A
V
G
V
D
V
N
T
A
-----
S
-----
A
A
L
L
A
R
I
S
G
L
N
S
T
L
A
Q
N
I
V
-
A
H
R
D
A
N
G
A
-
F
R
T
R
D
E
L
K
K
V
S
R
L
G
E
K
T
F
E
Q
A
A
G
F
L
R
V
M
N
G
D
-----
N
P
----
L
D
A
S
A
V
H
P
E
T
Y
P
L
V
Q
R
I
A
A
D
T
E
R
D
I
R
S
L
I
G
D
S
A
F
L
K
R
L
D
P
K
K
-
F
T
D
E
T
F
G
L
P
T
V
T
D
I
L
K
E
L
D
K
P
G
R
D
P
R
P
E
F
K
T
A
E
F
Q
E
G
V
E
S
L
K
D
L
K
P
G
M
--
V
L
E
G
V
V
T
N
V
T
N
F
G
A
F
V
D
I
-
G
--
V
---
H
Q
D
G
L
V
H
I
S
A
L
S
E
-
K
F
V
K
D
P
Y
E
V
V
K
A
G
D
I
V
K
V
K
V
M
E
V
D
I
P
R
N
--
R
V
G
L
S
M
R
M
S
D
T
P
G
-------------------------------------------------
22
HHSearch
94.16
98%
-100
- C2 -
3BZC
-
?
A:
[1-730]
--------------------------------------------------
M
D
S
I
N
T
R
I
A
E
E
L
S
A
L
P
S
G
R
V
Q
P
Q
Q
V
A
A
A
V
A
L
---
L
D
E
G
S
T
V
P
F
I
A
R
Y
R
K
E
V
T
G
S
-------
L
D
D
T
Q
L
R
M
L
E
E
R
L
R
Y
L
R
E
L
E
E
R
R
G
A
I
L
A
S
I
E
E
Q
G
K
L
T
P
E
L
A
R
D
I
K
L
A
D
T
K
T
R
L
E
D
L
Y
L
P
Y
K
Q
K
R
R
T
K
----------------------
G
Q
I
A
L
E
A
G
L
G
A
L
A
D
A
L
F
D
D
P
T
L
V
P
E
S
E
A
A
R
F
V
D
A
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K
G
F
A
D
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A
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L
E
G
A
K
Y
I
L
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F
A
E
D
A
T
L
L
D
K
L
R
V
F
M
K
N
E
A
T
L
T
A
R
V
V
P
G
K
E
Q
E
G
A
K
F
S
D
Y
F
E
H
D
E
P
L
K
------
S
A
P
S
H
R
A
L
A
I
F
R
G
R
N
E
G
V
L
S
A
S
L
K
V
G
E
--
E
A
P
G
T
L
H
P
C
E
V
M
I
A
E
R
F
G
-
L
SNQ
G
R
A
A
D
K
W
L
---
A
E
V
V
R
W
T
W
K
V
K
L
Y
T
H
L
E
T
D
L
F
G
E
L
R
D
G
A
E
D
E
A
I
S
V
F
A
R
N
L
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L
L
L
A
A
P
A
G
P
R
A
T
L
G
L
D
P
G
L
R
T
G
-----------
V
K
V
A
V
V
D
A
T
G
K
L
L
D
T
A
T
V
Y
P
H
A
P
-
K
N
Q
W
D
Q
T
L
A
V
L
A
A
L
C
A
K
H
Q
V
E
L
I
A
I
G
N
G
T
A
S
R
E
T
D
K
L
A
G
E
L
I
K
K
Y
P
--------
G
M
K
L
T
K
I
M
V
S
E
A
G
A
S
V
Y
S
A
S
E
L
A
A
K
E
F
P
E
L
D
V
S
L
R
G
A
V
S
I
A
R
R
L
Q
D
P
L
A
E
L
V
K
I
---
E
P
K
S
I
G
V
G
Q
Y
Q
H
D
V
S
Q
L
K
L
A
R
S
L
D
A
V
V
E
D
C
V
N
A
V
G
V
D
V
N
T
A
-----
S
-----
A
A
L
L
A
R
I
S
G
L
N
S
T
L
A
Q
N
I
V
-
A
H
R
D
A
N
G
A
-
F
R
T
R
D
E
L
K
K
V
S
R
L
G
E
K
T
F
E
Q
A
A
G
F
L
R
V
M
N
G
D
-----
N
P
----
L
D
A
S
A
V
H
P
E
T
Y
P
L
V
Q
R
I
A
A
D
T
E
R
D
I
R
S
L
I
G
D
S
A
F
L
K
R
L
D
P
K
K
F
T
D
E
-
T
F
G
L
P
T
V
T
D
I
L
K
E
L
D
K
P
G
R
D
P
R
P
E
F
K
T
A
E
F
Q
E
G
V
E
S
L
K
D
L
K
P
G
M
--
V
L
E
G
V
V
T
N
V
T
N
F
G
A
F
V
D
I
-
G
--
V
---
H
Q
D
G
L
V
H
I
S
A
L
S
E
-
K
F
V
K
D
P
Y
E
V
V
K
A
G
D
I
V
K
V
K
V
M
E
V
D
I
P
R
N
--
R
V
G
L
S
M
R
M
S
D
T
P
G
-------------------------------------------------
1
PsiBlast_PDB
93.58
99%
-102
- C2 -
2OCE
-
?
A:
[2-730]
---------------------------------------------------
D
S
I
N
T
R
I
A
E
E
L
S
A
L
P
S
G
R
V
Q
P
Q
Q
V
A
A
A
V
A
L
---
L
D
E
G
S
T
V
P
F
I
A
R
Y
R
K
E
V
T
G
S
-------
L
D
D
T
Q
L
R
M
L
E
E
R
L
R
Y
L
R
E
L
E
E
R
R
G
A
I
L
A
S
I
E
E
Q
G
K
L
T
P
E
L
A
R
D
I
K
L
A
D
T
K
T
R
L
E
D
L
Y
L
P
Y
K
Q
K
R
R
T
K
----------------------
G
Q
I
A
L
E
A
G
L
G
A
L
A
D
A
L
F
D
D
P
T
L
V
P
E
S
E
A
A
R
F
V
D
A
E
K
G
F
A
D
V
K
A
V
L
E
G
A
K
Y
I
L
M
E
R
F
A
E
D
A
T
L
L
D
K
L
R
V
F
M
K
N
E
A
T
L
T
A
R
V
V
P
G
K
E
Q
E
G
A
K
F
S
D
Y
F
E
H
D
E
P
L
K
------
S
A
P
S
H
R
A
L
A
I
F
R
G
R
N
E
G
V
L
S
A
S
L
K
V
G
E
E
A
P
G
T
L
H
P
C
E
--
V
M
I
A
E
R
F
G
L
S
---
N
Q
G
R
-
A
A
D
K
W
L
A
E
V
V
R
W
T
W
K
V
K
L
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T
H
L
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T
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L
F
G
E
L
R
D
G
A
E
D
E
A
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A
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L
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D
L
L
L
A
A
P
A
G
P
R
A
T
L
G
L
D
P
G
L
R
T
G
-----------
V
K
V
A
V
V
D
A
T
G
K
L
L
D
T
A
T
V
Y
P
H
A
P
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K
N
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W
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Q
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L
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V
L
A
A
L
C
A
K
H
Q
V
E
L
I
A
I
G
N
G
T
A
S
R
E
T
D
K
L
A
G
E
L
I
K
K
Y
P
--------
G
M
K
L
T
K
I
M
V
S
E
A
G
A
S
V
Y
S
A
S
E
L
A
A
K
E
F
P
E
L
D
V
S
L
R
G
A
V
S
I
A
R
R
L
Q
D
P
L
A
E
L
V
K
I
---
E
P
K
S
I
G
V
G
Q
Y
Q
H
D
V
S
Q
L
K
L
A
R
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L
D
A
V
V
E
D
C
V
N
A
V
G
V
D
V
N
T
A
-----
S
-----
A
A
L
L
A
R
I
S
G
L
N
S
T
L
A
Q
N
I
V
-
A
H
R
D
A
N
G
A
-
F
R
T
R
D
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L
K
K
V
S
R
L
G
E
K
T
F
E
Q
A
A
G
F
L
R
V
M
N
G
D
-----
N
P
----
L
D
A
S
A
V
H
P
E
T
Y
P
L
V
Q
R
I
A
A
D
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D
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L
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F
L
K
R
L
D
P
K
K
-
F
T
D
E
T
F
G
L
P
T
V
T
D
I
L
K
E
L
D
K
P
G
R
D
P
R
P
E
F
K
T
A
E
F
Q
E
G
V
E
S
L
K
D
L
K
P
G
M
--
V
L
E
G
V
V
T
N
V
T
N
F
G
A
F
V
D
I
-
G
--
V
---
H
Q
D
G
L
V
H
I
S
A
L
S
E
-
K
F
V
K
D
P
Y
E
V
V
K
A
G
D
I
V
K
V
K
V
M
E
V
D
I
P
R
N
--
R
V
G
L
S
M
R
M
S
D
T
P
G
-------------------------------------------------
49
Fugue
58.55
17%
-47
- C2 -
3PSF
-
SPT6_YEAST
A:
[298-1248]
D
I
Y
D
L
E
D
L
K
K
N
LMT
E
G
D
M
K
I
R
K
TDIP
E
R
Y
Q
E
L
R
A
GITDYGNMS
S
E
D
Q
E
L
E
R
N
W
I
A
E
K
I
S
V
D
K
N
F
D
A
N
Y
D
L
T
E
F
K
E
A
I
G
N
A
I
K
F
I
T
K
E
N
L
E
V
P
F
I
Y
A
Y
R
R
N
Y
I
S
S
REKDGFL
L
T
E
D
D
L
W
D
I
V
S
L
D
I
E
F
H
S
L
V
N
K
K
D
Y
V
Q
R
F
Y
A
E
L
H
I
D
D
P
I
V
T
E
Y
F
K
N
Q
N
S
L
Q
D
I
Y
D
Y
L
E
F
K
Y
A
N
E
I
N
E
MS
Y
E
K
F
K
A
SPL
Y
Q
A
V
S
D
IGIS
A
E
D
V
G
E
N
I
S
S
Q
H
Q
I
H
P
P
V
D
H
P
S
S
K
P
V
E
V
I
E
S
I
L
N
A
N
S
G
D
L
Q
T
K
L
A
I
D
T
V
Q
K
Y
Y
S
L
E
L
S
K
N
T
K
I
R
E
K
V
R
S
D
F
S
K
Y
Y
L
A
D
V
V
L
T
A
K
G
K
K
E
I
Q
K
G
S
L
Y
E
D
I
K
Y
A
I
N
RT
P
M
H
F
R
R
D
P
D
V
F
L
K
M
V
E
A
E
S
L
N
L
L
S
V
K
L
H
M
S
S
Q
A
Q
Y
I
E
H
L
F
Q
--
I
A
L
E
T
T
-
N
T
S
---
D
I
A
I
-
E
W
N
N
F
R
K
L
A
F
N
Q
A
M
D
-
K
I
F
Q
D
I
S
Q
E
V
K
D
N
L
T
K
N
C
Q
K
L
V
A
K
T
V
R
H
K
F
M
T
K
L
D
Q
A
P
F
I
P
N
V
R
D
P
K
I
P
K
I
L
S
L
T
CGQGRFGA
D
A
I
I
A
V
Y
V
N
R
K
G
D
F
I
R
D
Y
K
I
V
D
N
P
F
D
K
T
N
P
E
K
F
E
D
T
L
D
N
I
I
Q
S
C
Q
P
N
A
I
G
I
N
--
G
P
N
P
K
T
Q
K
F
Y
K
R
L
Q
E
V
L
H
K
K
QIVDSR
G
H
T
I
P
I
I
Y
V
E
D
E
V
A
I
R
Y
Q
N
S
E
R
A
A
Q
E
F
P
N
K
P
P
L
V
K
Y
C
I
A
L
A
R
Y
M
H
S
P
L
L
E
Y
A
N
L
T
S
E
E
V
R
S
L
S
I
H
P
H
Q
N
L
L
S
S
E
Q
L
S
W
A
L
E
T
A
F
V
D
I
V
N
L
V
S
V
E
V
N
K
A
T
D
N
NY
Y
-----
A
S
A
L
K
Y
I
S
G
F
G
K
R
K
A
I
D
F
L
-
Q
S
L
Q
R
L
N
E
P
L
L
A
R
Q
Q
L
I
T
H
N
I
L
H
K
T
I
F
M
N
S
A
G
F
L
Y
I
S
W
N
E
-----
D
L
EHDQ
L
D
S
T
R
I
H
P
E
D
Y
H
L
A
T
K
V
A
A
D
A
-----------------------------
L
E
Y
D
P
D
T
I
A
E
K
E
E
Q
G
T
M
S
E
F
I
E
L
L
R
E
D
P
D
R
R
A
K
L
E
S
L
--------------------------------------
N
L
E
S
Y
A
E
-
E
L
E
K
N
T
G
L
R
K
L
N
N
L
N
T
I
V
L
E
L
L
D
G
F
E
E
L
--
R
N
D
F
H
P
L
Q
G
D
E
I
F
Q
S
L
T
G
E
------------
S
S
K
D
P
S
I
W
D
L
K
Q
E
L
E
D
A
E
E
E
R
K
L
M
M
A
E
A
R
A
K
39
HHSearch
44.83
35%
-22
- C2 -
2EQS
-
DHX8_HUMAN
A:
[259-342]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
E
P
T
I
G
D
--
I
Y
N
G
K
V
T
S
I
M
Q
F
G
C
F
V
Q
L
-
E
--
G
LRK
R
W
E
G
L
V
H
I
S
E
L
R
R
E
G
R
V
A
N
V
A
D
V
V
S
K
G
Q
R
V
K
V
K
V
L
S
F
T
G
--
T
--
K
T
S
L
S
M
K
D
V
D
Q
E
T
-------------------------------------------------
13
PsiBlast_PDB
44.48
35%
-50
- C2 -
2CQO
-
NO40_HUMAN
A:
[7-87]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
M
E
N
L
-
P
A
L
Y
T
I
F
Q
G
E
V
A
M
V
T
D
Y
G
A
F
I
K
I
P
G
--
C
---
R
K
Q
G
L
V
H
R
T
H
M
S
S
-
C
R
V
D
K
P
S
E
I
V
D
V
G
D
K
V
W
V
K
L
I
G
R
E
M
K
N
D
--
R
I
K
V
S
L
S
M
------------------------------------------------------
34
HHSearch
43.17
33%
-23
- C2 -
2CQO
-
NO40_HUMAN
A:
[13-95]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
L
Y
T
--
I
F
Q
G
E
V
A
M
V
T
D
Y
G
A
F
I
K
I
-
P
--
G
C--
R
K
Q
G
L
V
H
R
T
H
M
S
S
-
C
R
V
D
K
P
S
E
I
V
D
V
G
D
K
V
W
V
K
L
I
G
R
E
M
K
N
D
R
I
K
V
S
L
S
M
K
V
V
N
Q
G
T
G
------------------------------------------------
8
PsiBlast_PDB
42.90
42%
-21
- C2 -
4NNI
2
RS1_MYCTU
A:
[17-89]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
--
I
V
P
G
K
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
--
E
---
G
I
E
G
L
V
H
I
S
E
L
A
E
-
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
--
R
I
S
L
S
L
K
Q
A
N
----------------------------------------------------
4
PsiBlast_PDB
42.77
28%
-44
- C2 -
3PSI
-
SPT6_YEAST
A:
[841-1035]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
T
I
P
I
I
Y
V
E
D
E
V
A
I
R
Y
Q
N
S
E
R
A
A
Q
E
F
P
N
K
P
P
L
V
K
Y
C
I
A
L
A
R
Y
M
H
S
P
L
L
E
Y
A
N
L
T
S
E
E
V
R
S
L
S
I
H
P
H
Q
N
L
L
S
S
E
Q
L
S
W
A
L
E
T
A
F
V
D
I
V
N
L
V
S
V
E
V
N
K
A
-----
T
D
N
N
YY
A
S
A
L
K
Y
I
S
G
F
G
K
R
K
A
I
D
F
L
Q
S
L
Q
R
L
N
E
P
-
L
L
A
R
Q
Q
L
I
T
H
N
I
L
H
K
T
I
F
M
N
S
A
G
F
L
Y
I
S
W
-------
D
Q
----
L
D
S
T
R
I
H
P
E
D
Y
H
L
A
T
K
V
A
A
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
42.76
42%
-21
- C2 -
4NNI
2
B:
[17-89]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
--
I
V
P
G
K
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
--
E
---
G
I
E
G
L
V
H
I
S
E
L
A
E
-
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
--
R
I
S
L
S
L
K
Q
A
N
----------------------------------------------------
5
PsiBlast_PDB
42.62
28%
-46
- C2 -
3PSF
-
SPT6_YEAST
A:
[841-1125]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
T
I
P
I
I
Y
V
E
D
E
V
A
I
R
Y
Q
N
S
E
R
A
A
Q
E
F
P
N
K
P
P
L
V
K
Y
C
I
A
L
A
R
Y
M
H
S
P
L
L
E
Y
A
N
L
T
S
E
E
V
R
S
L
S
I
H
P
H
Q
N
L
L
S
S
E
Q
L
S
W
A
L
E
T
A
F
V
D
I
V
N
L
V
S
V
E
V
N
K
A
-----
T
D
N
NYY
A
S
A
L
K
Y
I
S
G
F
G
K
R
K
A
I
D
F
L
Q
S
L
Q
R
L
N
E
P
-
L
L
A
R
Q
Q
L
I
T
H
N
I
L
H
K
T
I
F
M
N
S
A
G
F
L
Y
I
S
W
N
-EDLEH
D
Q
----
L
D
S
T
R
I
H
P
E
D
Y
H
L
A
T
K
V
A
A
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
42.50
38%
-29
- C2 -
2K4K
-
GS13_BACSU
A:
[8-107]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
V
Y
T
G
K
V
T
G
L
Q
A
Y
G
A
F
V
A
L
-
D
--
E
---
E
T
Q
G
L
V
H
I
S
E
V
T
H
-
G
F
V
K
D
I
N
E
H
L
S
V
G
D
E
V
Q
V
K
V
L
A
V
D
E
E
K
G
--
K
I
S
L
S
I
R
A
T
Q
A
A
P
E
K
K
E
S
K
P
--
R
K
P
K
A
A
Q
V
S
E
E
A
S
T
P
Q
G
-----------------------
31
HHSearch
42.19
25%
-34
* C2 *
3AEV
-
IF2A_PYRHO
A:
[7-89]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
P
E
E
G
E
--
F
V
V
A
T
V
K
R
I
H
N
Y
G
A
F
L
E
L
-
D
EY
P
---
G
K
E
A
F
M
H
I
S
E
V
A
S
-
T
W
V
R
N
I
R
D
Y
L
K
E
G
Q
K
V
V
A
K
V
I
R
V
D
P
R
K
G
--
H
I
D
L
S
L
R
R
V
T
Q
Q
Q
-------------------------------------------------
10
PsiBlast_PDB
42.12
42%
-20
- C2 -
4NNK
-
A:
[19-91]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
--
I
V
P
G
K
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
--
E
---
G
I
E
G
L
V
H
I
S
E
L
A
E
-
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
--
R
I
S
L
S
L
K
Q
A
N
----------------------------------------------------
25
HHSearch
41.74
40%
-31
- C2 -
2K4K
-
GS13_BACSU
A:
[3-85]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
F
E
V
G
S
--
V
Y
T
G
K
V
T
G
L
Q
A
Y
G
A
F
V
A
L
-
D
--
E
---
E
T
Q
G
L
V
H
I
S
E
V
T
H
-
G
F
V
K
D
I
N
E
H
L
S
V
G
D
E
V
Q
V
K
V
L
A
V
D
E
E
K
G
--
K
I
S
L
S
I
R
A
T
Q
A
A
P
E
K
-----------------------------------------------
9
PsiBlast_PDB
41.72
42%
-17
- C2 -
4NNG
-
A:
[17-89]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
--
I
V
A
G
K
V
T
K
L
V
P
F
G
A
F
V
R
V
-
E
--
E
---
G
I
E
G
L
V
H
I
S
E
L
A
E
-
R
H
V
E
V
P
D
Q
V
V
A
V
G
D
D
A
M
V
K
V
I
D
I
D
L
E
R
R
--
R
I
S
L
S
L
K
Q
A
N
----------------------------------------------------
12
PsiBlast_PDB
40.50
41%
-19
- C2 -
1SRO
-
A:
[2-74]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
E
V
G
R
--
V
Y
T
G
K
V
T
R
I
V
D
F
G
A
F
V
A
I
-
G
--
G
---
G
K
E
G
L
V
H
I
S
Q
I
A
D
-
K
R
V
E
K
V
T
D
Y
L
Q
M
G
Q
E
V
P
V
K
V
L
E
V
D
-
R
Q
G
--
R
I
R
L
S
I
K
-------------------------------------------------------