@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5399: (2016-03-07 )
MLDTLLPVLLFAALALAVLGAAKRFLMWRRGRPAKVDWIGGLLQMPRRYLVDLHHVVERDRYMSRTHVATAGGFVLAALLAILVHGFGLHGRILGFALLAATALMFVGALFVARRRLDPPSRLSKGPWMRLPKSLLAFAASFFLATLPVAGILPEGFGGWFLAGLLAIGVAWGVSELFLGMTWGGPMKHAFAGALHLAWHRRAERFGGGRSTGLKALDLADPQAPLGVEKPSDFTWNQLLGFDACVQCGKCEAMCPAFAAGQPLNPKKLIQDMVIGLAGGNDAKFAGSPYPGKPLGEHGGGPHQPIVALDGKALVDADTLWSCTTCRACVEECPMMIEHVDAIVDMRRHLTLEKGATPNKGAEVLDNLIATDNPGGFAPGGRLNWAADLNLPLMSEKKSADVLFWVGDGAFDMRNQRTLRAFVKILKAAAVDFAVLGLEERDSGDVARRLGDEATFQNLARRNIATLAKYRFTRIVSCDPHSFHVLKNEYGALGGDYQVLHHSTFIDELLRAGTLQPGRSKAGSVTYHDPCYLGRYNGEYEAPRNVLRALGIEVKEMQRSGFRSRCCGGGGGAPITDIPGKQRIPDMRMADIRETGAELVAVGCPQCTAMLEGVVAPRPEIKDIAELVAEALIEQAEAPAKKPLRREAVAEVH
Atome Classification :
(20 SA)
.........10........20......---..30........40........50....-----....60------.........70........80........90........100.......110.......120.......130.......140.......150......--.160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260-..-......270.......--280.-......290.......300.......310.......320.......330.......340.....--..350.......360.......370.......380.......390.......400.......410.......420.......---430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.........560....-...570.......580...-....590.......600.......610.......620.......630.......640-.......650.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
D
T
L
L
P
V
L
L
F
A
A
L
A
L
A
V
L
G
A
A
K
R
F
L
M
---WRRGRPA
K
V
D
W
I
G
G
L
L
Q
M
P
R
R
Y
L
V
D
L
H
H
-----
V
V
E
R
D
-------
R
Y
MSRTHVATA
G
G
F
V
L
A
A
L
L
A
I
L
V
H
GFGL
H
G
R
I
L
G
F
A
L
L
A
A
T
A
L
M
F
V
G
A
L
F
V
A
R
RRLD
P
P
S
RLSKG
P
W
M
RL
P
K
S
L
L
A
F
A
A
S
F
F
L
A
TLPVAGILPEGF
G
--
G
W
F
L
A
G
L
L
A
I
G
V
A
W
G
V
S
E
L
F
L
GMTWGG
P
M
K
H
A
F
A
G
A
L
H
L
A
W
H
R
R
A
E
RFGGGRSTG
L
K
A
LDLADPQAPLGVEKPSDF
T
W
N
Q
LL
G
F
D
A
C
V
QCGK
C
E
AMC
P
A
FAAG--QP-L
N
P
K
K
L
I
Q
D
M
V
I
G
LAG--GNDA-KFAGSPYPGKPLGEHGGGPHQ
P
I
V
A
LDG
K
A
L
V
D
A
D
TLW
S
C
T
T
C
R
A
C
V
E
E
C
P
M
M
I
E
H
V
D
A
I
V
D
M
R
--
R
HLTLEKGATPN
K
G
A
E
V
L
D
N
L
IATDNPGGFAPGGR
L
N
W
A
ADLNLPLMSEKKSA
D
V
L
F
W
VGDGAFDM
R
N
Q
R
T
L
R
A
F
V
K
I
L
K
A
A
---
A
V
D
F
A
V
LGLEERDS
G
D
V
A
R
R
LG
D
E
A
T
F
Q
N
L
A
R
R
N
I
A
T
L
A
K
Y
R
F
T
R
I
V
SCDPH
S
F
H
V
L
K
N
EYGALGGD
Y
Q
V
L
H
H
S
T
F
I
D
E
L
L
RAGTLQPGRSKAGS
V
T
YHDP
C
Y
L
GRYNGEY
E
A
P
R
N
V
L
R
A
L--G
I
E
V
K
E
M
Q
RSG
F
R
SRC-CGGGGGAPITDIPGKQRIP-D
M
R
M
A
D
I
R
ETGA
E
L
V
A
VG
C
P
Q
C
T
A
M
L
E
G
VVAPR
P
E
I
K
D
I
A
E
L
V
A
E
A
L
I
E
Q
AEAPAKK-
P
L
R
R
E
A
VAEVH
60
Fugue
84.25
16%
-56
- C3 -
4NFU
3
EDS1L_ARATH
A:
[15-633]
A
F
E
A
L
T
G
I
--
N
G
D
L
I
T
R
S
W
S
A
S
K
Q
A
Y
L
T
ER
Y
H
K
E
E
A
G
A
V
V
I
F
A
F
Q
P
S
F
S
E
K
D
F
F
D
P
D
N
KSSFG
E
I
K
L
N
RVQFPCM
R
K
I
G
K
G
D
V
A
T
V
N
E
A
F
L
K
N
L
E
A
V
I
D
P
R
T
S
F
Q
A
S
V
-
E
M
A
V
R
S
R
K
Q
I
V
F
T
G
H
S
S
G
G
A
T
A
I
L
A
T
V
W
Y
L
E
K
Y
F
I
R
N
P
N
V
Y
L
E
P
R
C
V
T
F
G
A
P
L
V
G
D
S
I
F
S
H
A
L
G
R
E
K
W
--------------
S
R
F
F
V
N
F
V
T
----
R
F
D
I
V
P
R
I
T
L
A
R
K
A
S
V
E
E
---
T
L
P
H
V
L
A
Q
L
D
P
R
N
S
S
V
Q
E
S
E
Q
R
I
T
E
F
Y
T
S
V
M
R
D
T
S
T
V
A
N
Q
A
V
C
E
L
T
G
S
A
E
A
I
L
--
E
T
-
L
S
S
F
L
E
L
--------------------
S
P
Y
--
R
P
A
G
T
F
V
F
S
T
E
K
R
L
V
A
V
N
N
---
S
D
A
I
L
Q
M
L
F
Y
T
C
Q
A
S
D
E
Q
E
W
S
L
I
-
P
F
R
S
I
R
D
H
H
S
Y
E
E
L
V
Q
S
M
G
M
K
L
F
N
H
L
D
G
E
N
S
I
E
S
S
L
N
D
L
G
V
S
T
R
G
R
Q
Y
V
Q
A
A
L
E
E
E
K
K
R
V
E
N
Q
K
K
I
I
Q
V
I
Q
Q
E
R
F
L
K
K
L
A
W
I
E
D
E
Y
K
P
K
C
Q
A
H
KNG
Y
Y
D
S
F
K
V
S
N
E
E
N
D
F
K
A
N
V
K
R
A
E
L
A
G
V
F
D
E
V
L
G
L
L
K
K
C
Q
L
P
D
E
F
E
G
D
I
D
W
I
K
L
A
T
R
Y
R
R
L
V
E
P
L
D
I
A
N
Y
H
R
H
L
K
N
E
D
T
G
P
Y
M
K
R
G
--
R
P
T
R
Y
I
Y
A
Q
R
G
Y
E
H
H
I
L
K
P
N
G
M
I
A
E
D
V
F
W
N
K
V
N
G
L
NL
G
L
Q
L
E
E
I
Q
E
T
L
K
N
S
G
S
E
C
G
S
C
F
W
A
E
V
E
E
L
K
G
K
P
Y
E
E
V
E
V
R
V
K
T
L
E
G
M
L
R
E
W
I
T
A
G
-----------
E
V
D
E
K
E
I
F
L
E
G
S
T
F
R
K
W
W
I
T
L
P
K
N
H
K
S
H
S
P
L
R
D
Y
M
M
D
E
I
-
34
HHSearch
58.65
23%
-63
- C4 -
2H88
5
SDHB_CHICK
B:
[151-244]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
D
G
L
Y
E
C
I
L
C
A
C
C
S
T
S
C
P
S
Y
W
W
N
GD
K
Y
-
L
G
P
A
V
L
M
Q
A
Y
R
W
M
I
D
S
--
R
-----------
D
D
--------
Y
T
E
E
R
L
-----
A
Q
L
Q
D
P
F
S
L
Y
R
C
H
T
I
M
N
C
T
R
T
C
P
K
G
L
N
P
G
K
A
I
A
E
I
K
--
K
M
M
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
58.06
23%
-62
- C4 -
2WDQ
4
SDHB_ECOLI
B:
[141-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
G
L
Y
E
C
I
L
C
A
C
C
S
T
S
C
P
S
F
W
W
N
PD
K
F
-
I
G
P
A
G
L
L
A
A
Y
R
F
L
I
D
S
--
R
D
-------------------
T
E
T
D
S
R
L
-----
D
G
L
S
D
A
F
S
V
F
R
C
H
S
I
M
N
C
V
S
V
C
P
K
G
L
N
P
T
R
A
I
G
H
I
K
--
S
M
L
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
56.68
20%
-72
- C4 -
2BS2
2
FRDB_WOLSU
B:
[143-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
V
F
E
L
D
R
C
I
E
C
G
C
C
I
A
A
C
G
T
K
I
M
R
--
E
D
F
V
G
A
A
G
L
N
R
V
V
R
F
M
I
D
P
--
H
D
E
-------------------
R
T
D
E
D
Y
Y
----
E
L
I
G
D
D
D
G
V
F
G
C
M
T
L
L
A
C
H
D
V
C
P
K
N
L
P
L
Q
S
K
I
A
Y
L
R
--
R
K
M
V
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
55.56
24%
-61
* C4 *
1KF6
3
FRDB_ECOLI
B:
[140-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
Y
H
Q
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
L
N
P-
E
F
-
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
-------------
S
R
D
H
-------
G
K
-
K
E
R
M
-----
A
Q
L
N
S
Q
N
G
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
K
H
V
D
P
A
A
A
I
Q
Q
G
K
--
V
E
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
53.67
24%
-35
- C4 -
2BS3
2
FRDB_WOLSU
B:
[143-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
V
F
E
L
D
R
C
I
E
C
G
C
C
I
A
A
C
G
T
-------------
K
I
M
R
E
D
F
V
G
A
A
G
--
L
N
R
V
V
R
F
M
I
D
P
--------
H
D
E
R
T
D
E
D
Y
Y
E
L
I
G
----
D
D
D
G
V
F
G
C
M
T
L
L
A
C
H
D
V
C
P
K
N
L
P
L
Q
S
K
I
A
Y
L
R
--
R
K
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
53.57
24%
-36
- C4 -
1E7P
-
FRDB_WOLSU
B:
[143-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
V
F
E
L
D
R
C
I
E
C
G
C
C
I
A
A
C
G
T
-------------
K
I
M
R
E
D
F
V
G
A
A
G
--
L
N
R
V
V
R
F
M
I
D
P
--------
H
D
E
R
T
D
E
D
Y
Y
E
L
I
G
----
D
D
D
G
V
F
G
C
M
T
L
L
A
C
H
D
V
C
P
K
N
L
P
L
Q
S
K
I
A
Y
L
R
--
R
K
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
53.54
24%
-32
- C4 -
1QLB
2
FRDB_WOLSU
B:
[143-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
V
F
E
L
D
R
C
I
E
C
G
C
C
I
A
A
C
G
T
-------------
K
I
M
R
E
D
F
V
G
A
A
G
--
L
N
R
V
V
R
F
M
I
D
P
--------
H
D
E
R
T
D
E
D
Y
Y
E
L
I
G
----
D
D
D
G
V
F
G
C
M
T
L
L
A
C
H
D
V
C
P
K
N
L
P
L
Q
S
K
I
A
Y
L
R
--
R
K
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
53.44
24%
-31
- C4 -
2BS4
2
FRDB_WOLSU
B:
[143-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
V
F
E
L
D
R
C
I
E
C
G
C
C
I
A
A
C
G
T
-------------
K
I
M
R
E
D
F
V
G
A
A
G
--
L
N
R
V
V
R
F
M
I
D
P
--------
H
D
E
R
T
D
E
D
Y
Y
E
L
I
G
----
D
D
D
G
V
F
G
C
M
T
L
L
A
C
H
D
V
C
P
K
N
L
P
L
Q
S
K
I
A
Y
L
R
--
R
K
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
53.32
24%
-37
- C4 -
2BS2
2
FRDB_WOLSU
B:
[143-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
V
F
E
L
D
R
C
I
E
C
G
C
C
I
A
A
C
G
T
-------------
K
I
M
R
E
D
F
V
G
A
A
G
--
L
N
R
V
V
R
F
M
I
D
P
--------
H
D
E
R
T
D
E
D
Y
Y
E
L
I
G
----
D
D
D
G
V
F
G
C
M
T
L
L
A
C
H
D
V
C
P
K
N
L
P
L
Q
S
K
I
A
Y
L
R
--
R
K
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
53.31
30%
-30
- C4 -
1L0V
3
FRDB_ECOLI
B:
[145-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
-------
L
N
P
-
E
F
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
S
-
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
-------------------
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
---
K
H
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
52.75
30%
-40
- C4 -
2B76
2
FRDB_ECOLI
B:
[145-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
-------
L
N
P
-
E
F
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
S
-
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
-------------------
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
---
K
H
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
51.94
30%
-20
- C4 -
4KX6
3
?
B:
[145-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
-------
L
N
P
-
E
F
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
S
-
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
-------------------
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
---
K
H
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
51.77
30%
-20
- C4 -
1KFY
3
FRDB_ECOLI
B:
[145-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
-------
L
N
P
-
E
F
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
S
-
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
-------------------
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
---
K
H
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
51.61
30%
-24
- C4 -
3P4Q
2
FRDB_ECOLI
B:
[145-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
-------
L
N
P
-
E
F
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
S
-
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
-------------------
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
---
K
H
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
50.58
30%
-19
- C4 -
3P4R
2
FRDB_ECOLI
B:
[145-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
-------
L
N
P
-
E
F
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
S
-
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
-------------------
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
---
K
H
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
50.53
30%
-24
- C4 -
1KF6
3
FRDB_ECOLI
B:
[145-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
-------
L
N
P
-
E
F
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
S
-
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
-------------------
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
---
K
H
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.49
30%
-17
- C4 -
3P4P
2
FRDB_ECOLI
B:
[145-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
-------
L
N
P
-
E
F
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
S
-
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
-------------------
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
---
K
H
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
49.92
30%
-41
- C4 -
3P4S
2
FRDB_ECOLI
B:
[145-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
-------
L
N
P
-
E
F
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
S
-
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
-------------------
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
---
K
H
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
49.58
30%
-31
- C4 -
3CIR
2
FRDB_ECOLI
B:
[145-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
G
C
I
N
C
G
L
C
Y
A
A
C
P
Q
F
G
-------
L
N
P
-
E
F
I
G
P
A
A
I
T
L
A
H
R
Y
N
E
D
S
-
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
-------------------
V
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
---
K
H
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------