@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5443: (2016-03-07 )
MNDDLSLLLNSLNDPQRQAVAAPLGRQLVLAGAGSGKTRVLVHRIAWLIQVEHASPYSILSVTFTNKAAAEMRHRIEQLLGINPAGMWVGTFHGLAHRLLRAHWREAGLSENFQILDSDDQQRLVKRVIRELGLDEQRWPARQAQWFINGQKDEGLRPQHIQPGGDLFLATMLKIYEAYEAACARAGVIDFSELLLRALDLWRDHPGVLEHYQRRFRHILVDEFQDTNAVQYAWLRILAKGGDSLMVVGDDDQSIYGWRGARIENIQQFSDDFADAEVIRLEQNYRSTASILKAANALIANNQGRLGKELWTDGEDGESLSLYAAFNEHDEARYVVESIESALKGGLARSEIAILYRSNAQSRVLEEALLREKIPYRIYGGQRFFERAEIKNAMAYLRLLDGRGNDAALERVVNVPARGIGEKTVESIREFARGNDVSMWEAIRLMIANKVLPGRAASALTGFVELIENLSAKVMDMPLHLMTQTVIEQSGLISYHKEEKGEKGQARVENLEELVSAARAFENSEEEEDLTPLQAFLSHASLEAGETQADAHEDSVQLMTLHSAKGLEFPLVFLVGMEEGLFPHKMSLEESGRLEEERRLAYVGVTRAMQRLVLTYAETRRLYGSETYNKVSRFIREIPPALIQEVRLSNTVSRPYGGTSRSAGGNLFSGAGVPETPFSLGQRVRHALFGEGTILNFEGAGAQARVQVNFESEGSKWLMLGYAKLEAL
Atome Classification :
(24 SA)
.........10........20.-.......30........40........50--.--------.......60........70........80.-------------------------------------...-....90........100.......110.......120-----......------------..130-..------.---.----------.-----------------------------------.---------.---140-------------------------------.----...----....150...-------------------------------...-----------------------------.---160----..-------------..----....170..-----.....180.......190.......200...-----....210.......220.......230.......240--........250.......260.......270..-----.....280.......290.......300.....---..-------------310--------------.....-..320.-.--------.....330....-...340.-.---------------.-....-350.......360.......370.......-380.......390.......400.......410.......420.......430.......440------.......450.......460....---...470.......480.......490.......--500.......510....-...520.....-----..530....---....540-----...----..-.---------.550-.........560.......570.....-----..580......----------------------------------.----------------590.........600.......610.......620.......630......--------.640.......650.......660.......670.......680.......690.......700.......710.......720......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
D
D
L
S
L
L
L
N
SLN
D
P
Q
R
Q
A
V
A
A-PLG
R
Q
L
V
L
A
GAGSGK
T
R
V
L
V
H
R
I
A
W
L
I
Q
V
--E--------HASP
Y
S
I
L
S
V
T
FT
N
K
A
A
A
E
M
R
H
R
I
E
Q
L
LGI-------------------------------------NPA-
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
W
R
EAGLSEN
F
Q
ILDSD
D
Q
------
Q
R
L
V
K
R
------------
V
I
R
EL-GL------D---E----------Q-----------------------------------R---------W---PA--------------------------------
R
----
Q
A
Q
----
W
F
I
NGQKDEG-------------------------------LRP-----------------------------Q---HI-----QP-------------G
G
----
D
L
F
L
A
T
M
L
K
-----
I
Y
E
A
Y
E
A
A
C
ARAGVI
D
F
S
E
L
L
L
R
A
L
D
L
WRDH-----
P
G
V
L
E
H
Y
Q
R
R
F
R
H
I
L
V
D
EFQDT
N
A
V
Q
Y
A
W
L
R
I
L
AKG---G
D
S
L
M
V
VGDDDQSIYGWRG
A
R
I
E
N
I
Q
Q
F
S
D
DFA-----D
A
E
V
I
R
L
E
Q
N
Y
R
S
T
A
S
I
L
K
A
A
N
A
L
IANNQGRLG---
K
E
-------------LWT--------------DGEDG-E
S
L
S
L
Y
-
A
--------AFNEHD
E
A
R
Y
V
V
-
E
S
I
E
S
A
L
-
K
---------------G-GLAR-
S
E
I
A
I
L
Y
RSN
A
Q
S
R
V
L
E
E
A
L
L
R
EKI
P
Y
R
IY-G
G
Q
R
F
F
E
R
A
E
I
K
N
A
M
A
Y
L
R
LLDGRG
N
D
A
A
L
E
R
V
V
NVPARGI
G
E
K
T
V
E
S
I
R
E
F
ARGND
V
S
M
W
E
A
------
I
R
L
M
I
ANKVLPG
R
A
A
S
A
L
T
G
F
V
E
L
---
I
E
N
L
S
A
K
V
M
D
M
P
L
H
L
M
T
Q
T
V
I
E
QSGLI
S
Y
H
K
EE--KGEK
G
Q
A
R
V
E
N
L
E
E
L
V
S
-
A
A
R
AFENSEEE-----ED
L
-
T
P
L
Q
A
---
F
L
S
H
ASL-----EAG----ET-Q---------AD---AHED
S
V
Q
L
M
T
L
HSAKGLE
F
P
L
V
F
L
V
GM-----EEGLFPHKMS
L
----------------------------------
E
----------------E--SGR
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
R
L
V
L
T
Y
A
E
T
R
R
LYGS
E
T
Y
N
K
V
S
R
F
I
R
EI--------
P
P
A
L
I
Q
E
V
R
LSNTVSRPYGGTSRSAGGNLFSGAGVPET
P
F
S
L
G
Q
R
V
R
H
A
LFGEG
T
I
L
N
FEGAG
A
Q
A
R
V
Q
V
N
FESEG
S
K
W
L
M
L
G
Y
A
K
LEAL
3
PsiBlast_PDB
99.43
64%
-94
- C6 -
2IS6
6
UVRD_ECOLI
A:
[2-656]
---
D
V
S
Y
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
-
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
--
E
--------
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
-------------------------------------
S
Q
G
-
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
------
L
R
L
L
K
R
------------
L
I
K
A
M
-
N
L
------
D
---
E
----------
K
-----------------------------------
Q
---------
W
---
P
P
--------------------------------
R
----
Q
A
M
----
W
Y
I
N
S
Q
K
D
E
G
-------------------------------
L
R
P
-----------------------------
H
---
H
I
-----
Q
S
-------------
Y
G
----
N
P
V
E
Q
T
W
Q
K
-----
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
-----
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
---
K
K
-------------
L
W
T
--------------
D
G
A
D
G
-
E
P
I
S
L
Y
-
C
--------
A
F
N
E
L
D
E
A
R
F
V
V
-
N
R
I
K
T
W
Q
-
D
---------------
N
-
G
G
A
L
-
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
-
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
------
C
R
E
L
L
Q
E
K
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
---
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
--
K
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
-
A
T
R
Q
F
S
Y
N
E
E
D
-------
L
-
M
P
L
Q
A
---
F
L
S
H
A
A
L
-----
E
A
G
----
E
G
-
Q
---------
A
D
---
T
W
Q
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
-----
E
E
G
M
F
P
S
Q
M
S
L
----------------------------------
D
----------------
E
--
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
--------
P
E
E
C
V
E
E
V
R
L
R
A
T
V
S
R
P
V
--
S
H
--------------------------------------------------------------------
2
PsiBlast_PDB
98.63
64%
-99
- C6 -
2IS2
2
UVRD_ECOLI
A:
[2-646]
---
D
V
S
Y
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
-
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
--
E
--------
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
-------------------------------------
S
Q
G
-
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
------
L
R
L
L
K
R
------------
L
I
K
A
M
-
N
L
------
D
---
E
----------
K
-----------------------------------
Q
---------
W
---
P
P
--------------------------------
R
----
Q
A
M
----
W
Y
I
N
S
Q
K
D
E
G
-------------------------------
L
R
P
-----------------------------
H
---
H
I
-----
Q
S
-------------
Y
G
----
N
P
V
E
Q
T
W
Q
K
-----
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
-----
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
---
K
K
-------------
L
W
T
--------------
D
G
A
D
G
-
E
P
I
S
L
Y
-
C
--------
A
F
N
E
L
D
E
A
R
F
V
V
-
N
R
I
K
T
W
Q
-
D
---------------
N
-
G
G
A
L
-
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
-
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
------
C
R
E
L
L
Q
E
K
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
---
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
--
K
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
-
A
T
R
Q
F
S
Y
---
D
-----
E
D
L
-
M
P
L
Q
A
---
F
L
S
H
A
A
L
-----
E
A
G
----
E
G
-
Q
---------
A
D
---
T
W
Q
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
-----
E
E
G
M
F
P
S
Q
M
S
L
----------------------------------
D
----------------
E
--
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
--------
P
E
E
C
V
E
E
V
R
L
--------------------------------------------------------------------------------
1
PsiBlast_PDB
98.60
64%
-101
- C6 -
2IS1
9
UVRD_ECOLI
A:
[2-653]
---
D
V
S
Y
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
-
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
--
E
--------
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
-------------------------------------
S
Q
G
-
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
------
L
R
L
L
K
R
------------
L
I
K
A
M
-
N
L
------
D
---
E
----------
K
-----------------------------------
Q
---------
W
---
P
P
--------------------------------
R
----
Q
A
M
----
W
Y
I
N
S
Q
K
D
E
G
-------------------------------
L
R
P
-----------------------------
H
---
H
I
-----
Q
S
-------------
Y
G
----
N
P
V
E
Q
T
W
Q
K
-----
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
-----
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
---
K
K
-------------
L
W
T
--------------
D
G
A
D
G
-
E
P
I
S
L
Y
-
C
--------
A
F
N
E
L
D
E
A
R
F
V
V
-
N
R
I
K
T
W
Q
-
D
---------------
N
-
G
G
A
L
-
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
-
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
------
C
R
E
L
L
Q
E
K
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
---
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
--
K
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
-
A
T
R
Q
F
S
Y
N
--------
E
D
L
-
M
P
L
Q
A
---
F
L
S
H
A
A
L
-----
E
A
G
----
E
G
-
Q
---------
A
D
---
T
W
Q
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
-----
E
E
G
M
F
P
S
Q
M
S
L
----------------------------------
D
----------------
E
--
G
G
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
--------
P
E
E
C
V
E
E
V
R
L
R
A
T
V
S
R
P
-------------------------------------------------------------------------
21
PsiBlast_CBE
94.95
64%
-101
- C6 -
2IS1
7
UVRD_ECOLI
B:
[3-644]
----
V
S
Y
L
L
D
S
L
N
D
K
Q
R
E
A
V
A
A
-
P
R
S
N
L
L
V
L
A
G
A
G
S
G
K
T
R
V
L
V
H
R
I
A
W
L
M
S
V
--
E
--------
N
C
S
P
Y
S
I
M
A
V
T
F
T
N
K
A
A
A
E
M
R
H
R
I
G
Q
L
M
G
T
-------------------------------------
S
Q
G
-
G
M
W
V
G
T
F
H
G
L
A
H
R
L
L
R
A
H
H
M
D
A
N
L
P
Q
D
F
Q
I
L
D
S
E
D
Q
------
L
R
L
L
K
R
------------
L
I
K
A
M
-
N
L
------
D
---
E
----------
K
-----------------------------------
Q
---------
W
---
P
P
--------------------------------
R
----
Q
A
M
----
W
Y
I
N
S
Q
K
D
E
G
-------------------------------
L
R
P
-----------------------------
H
---
H
I
-----
Q
S
---------------------
V
E
Q
T
W
Q
K
-----
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
-----
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
---
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
---
K
K
-------------
L
W
T
--------------
D
G
A
D
G
-
E
P
I
S
L
Y
-
C
--------
A
F
N
E
L
D
E
A
R
F
V
V
-
N
R
I
K
T
W
Q
-
D
---------------
N
-
G
G
A
L
-
A
E
C
A
I
L
Y
R
S
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
Y
R
I
Y
-
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
R
N
D
D
A
A
F
E
R
V
V
N
T
P
T
R
G
I
G
D
R
T
L
D
V
V
R
Q
T
S
R
D
R
Q
L
T
L
W
Q
A
------
C
R
E
L
L
Q
E
K
A
L
A
G
R
A
A
S
A
L
Q
R
F
M
E
L
---
I
D
A
L
A
Q
E
T
A
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
R
T
M
Y
E
Q
E
--
K
G
E
K
G
Q
T
R
I
E
N
L
E
E
L
V
T
-
A
T
R
Q
F
S
Y
---
D
-----
E
D
L
-
M
P
L
Q
A
---
F
L
S
H
A
A
L
-----
E
A
G
----
E
G
------------------
Q
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
G
M
-----
E
E
G
M
F
P
S
Q
M
----------------------------------------------------------
R
L
E
E
E
R
R
L
A
Y
V
G
V
T
R
A
M
Q
K
L
T
L
T
Y
A
E
T
R
R
L
Y
G
K
E
V
Y
H
R
P
S
R
F
I
G
E
L
--------
P
E
E
C
V
E
E
V
----------------------------------------------------------------------------------
26
PsiBlast_CBE
86.56
41%
-80
- C6 -
4C2U
8
?
D:
[9-659]
-------
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
--
Y
--------
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
--------------------------------------
G
A
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
------
L
D
I
I
K
E
------------
V
M
G
S
I
P
G
----------------------
E
-----------------------------------
T
---------
Q
---
P
---------------------------------
R
----
V
I
R
----
G
I
I
D
R
A
K
S
N
L
-------------------------------
W
T
P
-----------------------------
D
---
D
L
-----
D
R
-------------
S
R
----
E
P
F
I
S
G
L
P
R
DAAAE
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
---
K
T
-------------
L
K
P
--------------
V
K
E
A
G
-
Q
P
V
T
F
H
-
R
--------
A
T
D
H
R
A
E
G
D
Y
V
A
-
D
W
L
T
R
L
H
-
G
---------------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
-
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
------
C
A
N
A
A
E
Q
N
I
L
-
D
R
G
A
H
K
A
T
E
F
A
G
L
---
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
---
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
-
A
A
E
E
W
S
Q
D
E
A
N
VGGSI
A
D
F
-
L
D
D
A
A
---
L
L
S
--
S
V
-----
D
D
M
----
R
T
-
K
---------
A
E
NKG
A
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
-----
E
Q
G
L
L
P
S
K
G
A
I
----------------------------------
A
----------------
E
GP
S
G
-
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
--------
E
G
-------
L
F
D
T
V
D
-
P
Y
G
-----------------------------------------------------------------------
7
PsiBlast_PDB
86.56
41%
-79
- C6 -
4C2U
8
?
A:
[9-659]
-------
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
--
Y
--------
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
--------------------------------------
G
A
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
------
L
D
I
I
K
E
------------
V
M
G
S
I
P
G
----------------------
E
-----------------------------------
T
---------
Q
---
P
---------------------------------
R
----
V
I
R
----
G
I
I
D
R
A
K
S
N
L
-------------------------------
W
T
P
-----------------------------
D
---
D
L
-----
D
R
-------------
S
R
----
E
P
F
I
S
G
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
---
K
T
-------------
L
K
P
--------------
V
K
E
A
G
-
Q
P
V
T
F
H
-
R
--------
A
T
D
H
R
A
E
G
D
Y
V
A
-
D
W
L
T
R
L
H
-
G
---------------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
-
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
------
C
A
N
A
A
E
Q
N
I
L
-
D
R
G
A
H
K
A
T
E
F
A
G
L
---
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
---
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
-
A
A
E
E
W
S
Q
D
E
A
N
VGGS
I
A
D
F
-
L
D
D
A
A
---
L
L
S
--
S
V
-----
D
D
M
----
R
T
-
K
---------
A
E
N
KG
A
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
-----
E
Q
G
L
L
P
S
K
G
A
I
----------------------------------
A
----------------
E
G
P
S
G
-
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
--------
E
G
-------
L
F
D
T
V
D
-
P
Y
G
-----------------------------------------------------------------------
25
PsiBlast_CBE
85.90
41%
-84
- C6 -
4C30
3
?
D:
[9-659]
-------
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
--
Y
--------
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
--------------------------------------
G
A
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
------
L
D
I
I
K
E
------------
V
M
G
S
I
P
G
----------------------
E
-----------------------------------
T
---------
Q
---
P
---------------------------------
R
----
V
I
R
----
G
I
I
D
R
A
K
S
N
L
-------------------------------
W
T
P
-----------------------------
D
---
D
L
-----
D
R
-------------
S
R
----
E
P
F
I
S
G
L
P
R
DAAAE
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
---
K
T
-------------
L
K
P
--------------
V
K
E
A
G
-
Q
P
V
T
F
H
-
R
--------
A
T
D
H
R
A
E
G
D
Y
V
A
-
D
W
L
T
R
L
H
-
G
---------------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
-
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
------
C
A
N
A
A
E
Q
N
I
L
-
D
R
G
A
H
K
A
T
E
F
A
G
L
---
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
---
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
-
A
A
E
E
W
S
Q
D
E
A
-GSI--
A
D
F
-
L
D
D
A
A
---
L
L
S
--
S
V
-----
D
D
--------------------G--
A
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
-----
E
Q
G
L
L
P
S
K
G
A
I
----------------------------------
A
----------------
E
GP
S
G
-
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
--------
E
G
-------
L
F
D
T
V
D
-
P
Y
G
-----------------------------------------------------------------------
6
PsiBlast_PDB
85.12
40%
-77
- C6 -
4C2T
4
?
A:
[9-662]
-------
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
--
Y
--------
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
--------------------------------------
G
A
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
------
L
D
I
I
K
E
------------
V
M
G
S
I
P
G
I
------
G
---
A
----------
E
-----------------------------------
T
---------
Q
---
P
---------------------------------
R
----
V
I
R
----
G
I
I
D
R
A
K
S
N
L
-------------------------------
W
T
P
-----------------------------
D
---
D
L
-----
D
R
-------------
S
R
----
E
P
F
I
S
G
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
---
K
T
-------------
L
K
P
--------------
V
K
E
A
G
-
Q
P
V
T
F
H
-
R
--------
A
T
D
H
R
A
E
G
D
Y
V
A
-
D
W
L
T
R
L
H
-
G
---------------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
-
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
------
C
A
N
A
A
E
Q
N
I
L
-
D
R
G
A
H
K
A
T
E
F
A
G
L
---
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
---
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
-
A
A
E
--
E
W
S
Q
D
E
-----
A
N
V
G
G
S
I
A
D
---
F
L
D
D
A
A
L
-----
L
S
S
DM--
R
T
-
K
---------
A
------
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
-----
E
Q
G
L
L
P
S
K
G
A
I
----------------------------------
A
----------------
E
G
P
S
G
-
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
EGL
F
D
T
V
D
P
Y
G
Q
P
I
------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.97
40%
-79
- C6 -
4C2T
2
?
C:
[9-662]
-------
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
--
Y
--------
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
--------------------------------------
G
A
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
------
L
D
I
I
K
E
------------
V
M
G
S
I
P
G
I
------
G
---
A
----------
E
-----------------------------------
T
---------
Q
---
P
---------------------------------
R
----
V
I
R
----
G
I
I
D
R
A
K
S
N
L
-------------------------------
W
T
P
-----------------------------
D
---
D
L
-----
D
R
-------------
S
R
----
E
P
F
I
S
G
L
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
---
K
T
-------------
L
K
P
--------------
V
K
E
A
G
-
Q
P
V
T
F
H
-
R
--------
A
T
D
H
R
A
E
G
D
Y
V
A
-
D
W
L
T
R
L
H
-
G
---------------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
-
R
I
V
-
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
------
C
A
N
A
A
E
Q
N
I
L
-
D
R
G
A
H
K
A
T
E
F
A
G
L
---
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
-----
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
-
A
A
E
--
E
W
S
Q
D
E
-----
A
N
---
S
I
A
D
---
F
L
D
D
A
A
L
-----
L
S
S
VD
D
M
R
T
-
K
---------
A
E
----
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
-----
E
Q
G
L
L
P
S
K
G
A
I
----------------------------------
A
----------------
E
G
P
S
G
-
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
EGL
F
D
T
V
D
P
Y
G
Q
P
I
------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.84
41%
-85
- C6 -
4C30
3
?
I:
[9-659]
-------
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
--
Y
--------
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
--------------------------------------
G
A
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
------
L
D
I
I
K
E
------------
V
M
G
S
I
P
G
----------------------
E
-----------------------------------
T
---------
Q
---
P
---------------------------------
R
----
V
I
R
----
G
I
I
D
R
A
K
S
N
L
-------------------------------
W
T
P
-----------------------------
D
---
D
L
-----
D
R
-------------
S
R
----
E
P
F
I
S
G
L
P
R
DAAAE
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
---
K
T
-------------
L
K
P
--------------
V
K
E
A
G
-
Q
P
V
T
F
H
-
R
--------
A
T
D
H
R
A
E
G
D
Y
V
A
-
D
W
L
T
R
L
H
-
G
---------------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
-
G
----
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
------
C
A
N
A
A
E
Q
N
I
L
-
D
R
G
A
H
K
A
T
E
F
A
G
L
---
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
---
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
-
A
A
E
E
W
S
Q
D
E
A
-GSI--
A
D
F
-
L
D
D
A
A
---
L
L
S
--
S
V
-----
D
D
--------------------G--
A
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
-----
E
Q
G
L
L
P
S
K
G
A
I
----------------------------------
A
----------------
E
GP
S
G
-
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
--------
E
G
-------
L
F
D
T
V
D
-
P
Y
G
-----------------------------------------------------------------------
8
PsiBlast_PDB
84.08
41%
-80
- C6 -
4C30
5
?
A:
[9-659]
-------
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
--
Y
--------
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
--------------------------------------
G
A
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
------
L
D
I
I
K
E
------------
V
M
G
S
I
P
G
I
------
G
---
A
----------
E
-----------------------------------
T
---------
Q
---
P
---------------------------------
R
----
V
I
R
----
G
I
I
D
R
A
K
S
N
L
-------------------------------
W
T
P
-----------------------------
D
---
D
L
-----
D
R
-------------
S
R
----
E
P
-----
P
R
D
A
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
---
K
T
-------------
L
K
P
--------------
V
K
E
A
G
-
Q
P
V
T
F
H
-
R
--------
A
T
D
H
R
A
E
G
D
Y
V
A
-
D
W
L
T
R
L
H
-
G
---------------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
-
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
------
C
A
N
-----------
A
H
K
A
T
E
F
A
G
L
---
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
---
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
-
A
A
E
E
W
S
Q
D
E
A
-I----
A
D
F
-
L
D
D
A
A
---
L
L
S
--
S
V
-----
D
D
M
----
R
T
-
K
---------
A
E
----
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
-----
E
Q
G
L
L
P
S
K
G
A
I
----------------------------------
A
----------------
E
G
P
S
G
-
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
--------
E
G
-------
L
F
D
T
V
D
-
P
Y
G
-----------------------------------------------------------------------
24
PsiBlast_CBE
83.97
41%
-77
- C6 -
4C30
5
?
F:
[9-659]
-------
L
L
Q
A
L
N
P
T
Q
A
Q
A
A
D
H
-
F
T
G
P
A
L
V
I
A
G
A
G
S
G
K
T
R
T
L
I
Y
R
I
A
H
L
I
G
H
--
Y
--------
G
V
H
P
G
E
I
L
A
V
T
F
T
N
K
A
A
A
E
M
R
E
R
A
G
H
L
V
P
--------------------------------------
G
A
G
-
D
L
W
M
S
T
F
H
S
A
G
V
R
I
L
R
T
Y
G
E
H
I
G
L
R
R
G
F
V
I
Y
D
D
D
D
Q
------
L
D
I
I
K
E
------------
V
M
G
S
I
P
G
I
------
G
---
A
----------
E
-----------------------------------
T
---------
Q
---
P
---------------------------------
R
----
V
I
R
----
G
I
I
D
R
A
K
S
N
L
-------------------------------
W
T
P
-----------------------------
D
---
D
L
-----
D
R
-------------
S
R
----
E
P
-----
P
R
DAAAE
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
-----
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
---
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
D
---
K
T
-------------
L
K
P
--------------
V
K
E
A
G
-
Q
P
V
T
F
H
-
R
--------
A
T
D
H
R
A
E
G
D
Y
V
A
-
D
W
L
T
R
L
H
-
G
---------------
E
-
G
R
A
W
-
S
E
M
A
I
L
Y
R
T
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
-
G
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
G
R
P
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
H
T
S
V
L
T
A
------
C
A
N
-----------
A
H
K
A
T
E
F
A
G
L
---
M
E
A
M
S
E
A
A
D
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
Y
L
D
L
L
R
Q
E
---
G
Q
E
G
Q
V
R
L
E
N
L
E
E
L
V
S
-
A
A
E
E
W
S
Q
D
E
A
-I----
A
D
F
-
L
D
D
A
A
---
L
L
S
--
S
V
-----
D
D
M
----
R
T
-
K
---------
A
E
----
P
E
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
G
V
-----
E
Q
G
L
L
P
S
K
G
A
I
----------------------------------
A
----------------
E
GP
S
G
-
I
E
E
E
R
R
L
F
Y
V
G
I
T
R
A
M
E
R
L
L
M
T
A
A
Q
N
R
M
Q
F
G
K
T
N
A
A
E
D
S
A
F
L
E
D
I
--------
E
G
-------
L
F
D
T
V
D
-
P
Y
G
-----------------------------------------------------------------------
33
HHSearch
83.74
40%
-85
- C6 -
1PJR
-
PCRA_GEOSE
A:
[1-651]
M
N
F
L
S
E
Q
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
-
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
--
K
--------
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
-------------------------------------
A
A
E
-
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
------
L
S
V
M
K
T
------------
I
L
K
E
K
-
N
I
------
D
---
P
----------
K
-----------------------------------
K
---------
F
---
E
P
--------------------------------
R
----
T
I
L
----
G
T
I
S
A
A
K
N
E
L
-------------------------------
L
P
P
-----------------------------
E
---
Q
F
-----
A
K
R------------------
Y
-
Y
E
K
V
V
S
D
-----
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
---
K
R
-------------
I
W
T
--------------
E
N
P
E
G
-
K
P
I
L
Y
Y
-
E
--------
A
M
N
E
A
D
E
A
Q
F
V
A
-
G
R
I
R
E
A
V
-
E
---------------
R
G
E
R
R
Y
-
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
-
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
------------
L
F
E
A
------
L
G
E
L
E
M
I
-
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
---
L
E
Q
W
T
Q
L
Q
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
--
R
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
-
V
T
K
H
F
E
N
V
S
--------
D
D
-
K
S
L
I
A
---
F
L
T
D
L
A
L
-----
I
S
-------------------------
G
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
-----
E
E
G
I
F
P
H
N
R
S
L
----------------------------------
E
----------------
D
--
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
--------
P
A
H
L
L
E
T
A
S
R
--------------------------------------------------------------------------------
4
PsiBlast_PDB
83.43
40%
-86
- C6 -
3PJR
2
?
A:
[8-652]
-------
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
-
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
--
K
--------
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
-------------------------------------
A
A
E
-
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
------
L
S
V
M
K
T
------------
I
L
K
E
K
-
N
I
------
D
---
P
----------
K
-----------------------------------
K
---------
F
---
E
P
--------------------------------
R
----
T
I
L
----
G
T
I
S
A
A
K
N
E
L
-------------------------------
L
P
P
-----------------------------
E
---
Q
F
-----
A
K
-------------
R
A
----
S
T
Y
Y
E
K
V
V
S
D
----
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
---
K
R
-------------
I
W
T
--------------
E
N
P
E
G
-
K
P
I
L
Y
Y
-
E
--------
A
M
N
E
A
D
E
A
Q
F
V
A
-
G
R
I
R
E
A
V
-
E
---------------
R
-
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
-
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
L
EM
I
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
---
Q
E
Y
V
S
V
T
E
-------
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
--
R
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
-
V
T
K
H
F
E
N
V
S
D
D
-----
K
S
L
-
I
---
A
---
F
L
T
D
L
A
L
ISDLD
E
-------
T
-
E
---------
Q
A
---
A
E
G
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
-----
E
E
G
I
F
P
H
N
R
S
L
----------------------------------
E
----------------
D
--
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
--------
P
A
H
L
L
E
------
T
A
S
R
R
-------------------------------------------------------------------------
5
PsiBlast_PDB
81.64
40%
-83
- C6 -
1PJR
-
PCRA_GEOSE
A:
[8-651]
-------
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
-
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
--
K
--------
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
-------------------------------------
A
A
E
-
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
------
L
S
V
M
K
T
------------
I
L
K
E
K
-
N
I
------
D
---
P
----------
K
-----------------------------------
K
---------
F
---
E
P
--------------------------------
R
----
T
I
L
----
G
T
I
S
A
A
K
N
E
L
-------------------------------
L
P
P
-----------------------------
E
---
Q
F
-----
A
K
-------------
R
-------
Y
Y
E
K
V
V
S
D
----
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
---
K
R
-------------
I
W
T
--------------
E
N
P
E
G
-
K
P
I
L
Y
Y
-
E
--------
A
M
N
E
A
D
E
A
Q
F
V
A
-
G
R
I
R
E
A
V
-
E
---------------
R
-
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
-
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
------------
L
F
E
A
L
G
E
LEM
I
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
---
Q
E
Y
V
S
V
T
E
-------
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
--
R
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
-
V
T
K
H
F
E
N
V
S
D
D
-----
K
S
L
-
I
---
A
---
F
L
T
D
L
A
L
I
S------------------------------
G
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
-----
E
E
G
I
F
P
H
N
R
S
L
----------------------------------
E
----------------
D
--
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
--------
P
A
H
L
L
E
------
T
A
S
R
--------------------------------------------------------------------------
35
HHSearch
81.35
38%
-85
- C6 -
1UAA
1
REP_ECOLI
A:
[2-638]
----------
R
L
N
P
G
Q
Q
Q
A
V
E
F
-
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
--
C
--------
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
G
R
K------------------------------------
E
A
R
-
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
F
S
L
F
D
D
T
D
Q
------
L
A
L
L
K
E
------------
L
T
E
G
L
-
I
-------
E
---
D
----------
D
-----------------------------------
K
---------
V
---
L
L
--------------------------------
Q
----
Q
L
I
----
S
T
I
S
N
W
K
N
D
L
-------------------------------
K
T
P
-----------------------------
S
---
Q
A
-----
A
A
S
A-----------
I
G
----
E
-
R
D
R
I
F
A
H
-----
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
-----
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
---
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
-----
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
---
K
R
-------------
L
F
S
--------------
E
L
G
Y
G
-
A
E
L
K
V
L
-
S
--------
A
N
N
E
E
H
E
A
E
R
V
T
-
G
E
L
I
A
H
H
F
V
---------------
N
-
K
T
Q
Y
-
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
-
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
E
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
------
S
F
D
M
G
L
S
Q
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
---
L
A
E
I
Q
R
L
A
-
E
R
E
P
I
A
A
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
Y
E
T
SP
S
P
K
A
A
E
M
R
M
K
N
V
N
Q
L
F
S
-
W
M
T
E
M
L
E
G
S
E
L
-----
D
E
P
-
M
T
L
T
Q
---
V
V
T
R
F
T
L
-----
R
D
M
----
M
E
R-----------
E
---
E
E
L
D
Q
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
-----
E
E
G
F
L
P
H
Q
S
S
I
----------------------------------
D
-------------------
E
D
N
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
E
P
S
R
F
L
L
E
L
--------
P
Q
D
D
L
-------------------------------------------------------------------------------------
36
HHSearch
81.04
28%
-89
* C6 *
3U4Q
-
ADDA_BACSU
A:
[10-936]
----------
T
W
T
D
D
Q
W
N
A
I
V
S
-
T
G
Q
D
I
L
V
A
A
A
A
G
S
G
K
T
A
V
L
V
E
R
M
I
R
K
I
T
A
EE
N
--------
P
I
D
V
D
R
L
L
V
V
T
F
T
N
A
S
A
A
E
M
K
H
R
I
A
E
A
L
E
K
E
L
V
Q
R
PGS
L
H
I
R
R
Q
L
S
---------------------
L
L
N
-
R
A
S
I
S
T
L
H
S
F
C
L
Q
V
L
K
K
Y
Y
Y
L
I
D
L
D
P
G
F
R
I
A
D
Q
T
E
G
------
E
L
I
G
D
E
------------
V
L
D
E
L
-
F
E
------
D
---
E
----------
Y
A
K
GE
K
A
F
F
E
L
V
D
R
YTTDRHD
L
D
L
Q
F
L
V
K
Q
V
Y
E
Y
S
R
S
HP-------
N
P
E
A
W
L
E
S
FVHLYDVSEKSAIEELPFY
Q
Y
V
K
E
D
I
A
M
V
L
N
G
A
K
E
K
L
L
----
R
A
L
E
L
T
----D
N
F
L
D
D
L
A
Q
I
D
E
L
I
Q
H
Q
DD
F
S
E
L
Y
K
R
VPAVS-
D
P
A
L
L
D
E
A
T
D
L
R
N
G
A
K
K
L
L
E
K
L
K
T
D
YFTRS
P
E
---
Q
H
-----
L
K
S
L
A
E
M
K
P
V
-----
I
E
----
T
-
L
V
Q
L
V
I
S
-----
Y
G
K
R
F
E
A
A
K
Q
E
K
S
I
I
D
F
S
D
L
E
H
Y
C
L
A
I
L
T
A
E
NDREP
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
G
PEE
T
G
N
L
F
M
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
T
ESGEG
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
L
M
G
G
K
I
---
G
E
V
D
Y
D
E
QAELKLGA
A
Y
P
--------------
D
N
D
E
T
E
T
E
L
L
L
I
D---------
L
E
T
V
Q
F
E
A
K
A
I
A
-
K
E
I
R
K
L
I
-
S
S
PFKVYK
K
T
H
-----
R
-
N
I
Q
Y
-
R
D
I
V
I
L
L
R
S
M
P
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
V
Y
A
N
-
L
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
A
S
V
L
R
S
P
I
V
G
A
D
E
N
E
L
S
L
I
R
L
E
N
K
--
K
A
P
Y
Y
E
A
------
M
K
D
Y
L
A
A
G
D
R
S
D
E
L
Y
Q
K
L
N
T
F
Y
G
H
---
L
Q
K
W
R
A
F
S
K
N
H
S
V
S
E
L
I
W
E
V
Y
R
D
T
K
Y
M
D
Y
V
G
G
M
----
P
G
G
K
Q
R
Q
A
N
L
R
V
L
Y
D
-
R
A
R
Q
Y
E
S
T
A
---------
F
-
R
G
L
F
R
---
F
L
R
F
I
E
R
-----
M
Q
E
----
R
G
D----------------
Q
E
D
V
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
G
L
-----
G
R
N
F
N
M
M
D
L
N
K
S
Y
L
L
D
KEL
G
F
G
T
K
YIHPQLR
I
S
Y
P
T
L
P
L
I
A
M
K
K
K
M
----------------
R
--
R
E
L
L
S
E
E
L
R
V
L
Y
V
A
L
T
R
A
K
E
K
L
F
L
I
G
S
C
K
D
--------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.42
39%
-82
- C6 -
1UAA
1
REP_ECOLI
A:
[3-634]
-----------
L
N
P
G
Q
Q
Q
A
V
E
F
-
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
--
C
--------
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
G
R
-------------------------------------
K
E
A
R
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
F
S
L
F
D
D
T
D
Q
------
L
A
L
L
K
E
------------
L
T
E
G
L
--
I
------
E
---
D
----------
D
-----------------------------------
K
---------
V
---
L
L
--------------------------------
Q
----
Q
L
I
----
S
T
I
S
N
W
K
N
D
L
-------------------------------
K
T
P
-----------------------------
S
---
Q
A
-----
A
A
-------------
S
A
IG
E
R
D
R
I
F
A
H
C
Y
G
-----
L
Y
D
A
H
L
K
A
C
---
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
-----
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
---
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
-----
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
---
K
R
-------------
L
F
S
--------------
E
L
G
Y
G
-
A
E
L
K
V
L
-
S
--------
A
N
N
E
E
H
E
A
E
R
V
T
G
E
L
I
A
H
H
F
-
V
---------------
N
-
K
T
Q
Y
-
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
-
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
E
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
------
S
F
D
M
G
L
S
Q
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
L
A
E
I
Q
R
L
A
E
R
E
P
I
A
A
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
--
Y
E
T
S
P
--
S
P
K
A
A
E
M
R
M
K
N
V
N
Q
L
F
S
W
M
T
E
M
L
E
G
S
E
L
D
-----
E
P
M
-
T
L
T
Q
V
V
T
R
F
T
L
R
D
M
M
-----
E
R
--------
E
---------
E
E
---
L
--
D
Q
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
-----
E
E
G
F
L
P
H
Q
S
S
I
----------------------------------
D
----------------
E
--
D
N
-
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
E
P
S
R
F
L
L
E
L
--------
P
-----------------------------------------------------------------------------------------
28
PsiBlast_CBE
79.55
39%
-81
- C6 -
1UAA
1
REP_ECOLI
B:
[3-634]
-----------
L
N
P
G
Q
Q
Q
A
V
E
F
-
V
T
G
P
C
L
V
L
A
G
A
G
S
G
K
T
R
V
I
T
N
K
I
A
H
L
I
R
G
--
C
--------
G
Y
Q
A
R
H
I
A
A
V
T
F
T
N
K
A
A
R
E
M
K
E
R
V
G
Q
T
L
G
R
-------------------------------------
K
E
A
R
G
L
M
I
S
T
F
H
T
L
G
L
D
I
I
K
R
E
Y
A
A
L
G
M
K
A
N
F
S
L
F
D
D
T
D
Q
------
L
A
L
L
K
E
------------
L
T
E
G
L
--
I
------
E
---
D
----------
D
-----------------------------------
K
---------
V
---
L
L
--------------------------------
Q
----
Q
L
I
----
S
T
I
S
N
W
K
N
D
L
-------------------------------
K
T
P
-----------------------------
S
---
Q
A
-----
A
A
-------------
S
A
IGER
D
R
I
F
A
H
C
Y
G
-----
L
Y
D
A
H
L
K
A
C
---
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
-----
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
---
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
-----
A
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
---
K
R
-------------
L
F
S
--------------
E
L
G
Y
G
-
A
E
L
K
V
L
-
S
--------
A
N
N
E
E
H
E
A
E
R
V
T
G
E
L
I
A
H
H
F
-
V
---------------
N
-
K
T
Q
Y
-
K
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
K
I
S
-
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
N
T
P
K
R
E
I
G
P
A
T
L
K
K
L
G
E
W
A
M
T
R
N
K
S
M
F
T
A
------
S
F
D
M
G
L
S
Q
T
L
S
G
R
G
Y
E
A
L
T
R
F
T
H
W
LAE
I
Q
R
L
A
E
R
E
P
I
A
A
V
R
D
L
I
H
G
M
D
Y
E
S
W
L
--
Y
E
T
S
P
--
S
P
K
A
A
E
M
R
M
K
N
V
N
Q
L
F
S
W
M
T
E
M
L
E
G
S
E
L
D
-----
E
P
M
-
T
L
T
Q
V
VTR
F
T
L
R
D
---------------------------
E
E
---
L
--
D
Q
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
G
M
-----
E
E
G
F
L
P
H
Q
S
S
I
----------------------------------
D
----------------
E
--
D
N
-
I
D
E
E
R
R
L
A
Y
V
G
I
T
R
A
Q
K
E
L
T
F
T
L
C
K
E
R
R
Q
Y
G
E
L
V
R
P
E
P
S
R
F
L
L
E
L
--------
P
-----------------------------------------------------------------------------------------
37
HHSearch
72.84
22%
-93
- C6 -
1W36
-
RECB_ECOLI
B:
[9-822]
-----------------
D
P
L
R
L
P
L
Q
G
E
R
L
I
E
A
S
A
G
T
G
K
T
F
T
I
A
A
L
Y
L
R
L
L
L
G
--
L
GGSAAFPR
P
L
T
V
E
E
L
L
V
V
T
F
T
E
A
A
T
A
E
L
R
G
R
I
R
S
N
I
H
E
LRIACLRETTDNPLYERLLEEIDDKAQAAQWLLLAER
Q
M
D
-
E
A
A
V
F
T
I
H
G
F
C
Q
R
M
L
N
L
N
A
F
E
S
G
M
L
F
E
Q
Q
L
I
E
D
E
S
L
LRYQAC
A
D
F
W
R
R
HCYPLPREIAQV
V
F
E
T
W
-
K
G
PQALLR
D
INR
Y
LQGEAPVIKA
P
PP---------------------------------
D
DETLASRHA
Q
---
I
V
ARIDTVK-------------------------
Q
----
Q
W
R
DAVG
E
L
D
A
L
I
E
S
S
G
-------------------------------
I
D
R
RKFNRSNQAKWIDKISAWAEEETNSYQLP
E
SLE
K
-PRHPL
F
E
AIDQLLAEPLSIR
D
L
----
V
-
I
T
R
A
L
A
E
-----
I
R
E
T
V
A
R
E
K
R
R
R
G
E
L
G
F
D
D
M
L
S
R
L
D
S
A
L
R
S
E
SG---
E
V
L
A
A
A
I
R
T
R
F
P
V
A
M
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
I
F
R
R
I
W
H
H
QP-
E
T
A
L
L
L
I
G
D
P
K
Q
A
I
Y
A
F
R
G
A
D
I
F
T
Y
M
K
A
R
S
E
V
-------
H
A
H
Y
T
L
D
T
N
W
R
S
A
P
G
M
V
N
S
V
N
K
L
F
S
Q
T
D
D
A
F
M
FRE
I
P
-------------
F
I
P
VKSAGKNQALRFVF
K
G
E
T
Q
-
P
A
M
K
M
W
-
L
MEGESCGV
G
D
Y
Q
S
T
M
A
Q
V
C
A
-
A
Q
I
R
D
W
L
-
Q
AGQRGEALLMNGDDA
R
-
P
V
R
A
-
S
D
I
S
V
L
V
R
S
R
Q
E
A
A
Q
V
R
D
A
L
T
L
L
E
I
P
S
V
Y
L
S
N
R
D
S
V
F
E
T
L
E
A
Q
E
M
L
W
L
L
Q
A
V
M
T
P
E
R
E
N
T
L
R
S
A
L
A
T
S
M
M
G
L
N
A
L
D
I
E
T
L
N
N
D
-----
E
H
A
W
D
V
------
V
--------------------
V
E
E
---
F
D
G
Y
R
Q
I
W
R
K
R
G
V
M
P
M
L
R
A
L
M
S
A
R
N
I
A
E
N
L
L
A
T
----
A
G
G
E
R
R
L
T
D
I
L
H
I
S
E
-
L
L
Q
E
A
G
T
Q
----------
L
-
E
S
E
H
A
---
L
V
R
W
L
S
Q
-----
H
I
L
----
E
P
-
D
SNASSQQMR
L
E
---
S
D
K
H
L
V
Q
I
V
T
I
H
K
S
K
G
L
E
Y
P
L
V
W
L
P
F
I
TNFRV
Q
E
Q
A
F
Y
H
D
R
H
S
----------------------------------
F
EAVLDLNAAPESVDLA
E
--
A
E
R
L
A
E
D
L
R
L
L
Y
V
A
L
T
R
S
V
W
H
C
S
L
G
V
A
P
L
V
R
-------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.01
39%
-81
- C6 -
2PJR
2
?
A:
[8-540]
-------
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
-
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
--
K
--------
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
-------------------------------------
A
A
E
-
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
------
L
S
V
M
K
T
------------
I
L
K
E
K
-
N
I
------
D
---
P
----------
K
-----------------------------------
K
---------
F
---
E
P
--------------------------------
R
----
T
I
L
----
G
T
I
S
A
A
K
N
E
L
-------------------------------
L
P
P
-----------------------------
E
---
Q
F
-----
A
K
-------------
R
A
----
S
T
Y
Y
E
K
V
V
S
D
----
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
---
K
R
-------------
I
W
T
--------------
E
N
P
E
G
-
K
P
I
L
Y
Y
-
E
--------
A
M
N
E
A
D
E
A
Q
F
V
A
-
G
R
I
R
E
A
V
-
E
---------------
R
-
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
-
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
L
G
E
LEM
I
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
---
Q
E
Y
V
S
V
T
E
-------
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
--
R
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
-
V
T
K
H
F
E
N
V
S
D
D
-----
K
S
L
-
I
---
A
---
F
L
T
D
L
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
71.42
39%
-82
- C6 -
2PJR
3
?
F:
[8-540]
-------
L
L
A
H
L
N
K
E
Q
Q
E
A
V
R
T
-
T
E
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
E
--
K
--------
H
V
A
P
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
-------------------------------------
A
A
E
-
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
L
D
P
T
D
Q
------
L
S
V
M
K
T
------------
I
L
K
E
K
-
N
I
------
D
---
P
----------
K
-----------------------------------
K
---------
F
---
E
P
--------------------------------
R
----
T
I
L
----
G
T
I
S
A
A
K
N
E
L
-------------------------------
L
P
P
-----------------------------
E
---
Q
F
-----
A
K
-------------
R
A
----
S
T
Y
Y
E
K
V
V
S
D----
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
-----
P
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
---
F
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
-----
N
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
---
K
R
-------------
I
W
T
--------------
E
N
P
E
G
-
K
P
I
L
Y
Y
-
E
--------
A
M
N
E
A
D
E
A
Q
F
V
A
-
G
R
I
R
E
A
V
-
E
---------------
R
-
G
E
R
R
Y
R
D
F
A
V
L
Y
R
T
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
-
G
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
I
G
A
S
T
I
D
K
L
V
R
Y
A
A
D
H
E
L
S
L
F
E
A
LGELEM
I
G
L
G
A
K
A
A
G
A
L
A
A
F
R
S
Q
L
E
Q
W
T
Q
L
---
Q
E
Y
V
S
V
T
E
-------
L
V
E
E
V
L
D
K
S
G
Y
R
E
M
L
K
A
E
--
R
T
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
-
V
T
K
H
F
E
N
V
S
D
D
-----
K
S
L
-
I
---
A
---
F
L
T
D
L
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
36.76
61%
-18
- C6 -
2PJR
2
?
G:
[2-92]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
-----
E
E
G
I
F
P
H
N
R
S
L
----------------------------------
E
----------------
D
--
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
--------
P
A
H
L
L
E
------------------------------------------------------------------------------------
32
PsiBlast_CBE
35.20
61%
-12
- C6 -
2PJR
2
?
B:
[2-92]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
G
M
-----
E
E
G
I
F
P
H
N
R
S
L
----------------------------------
E
----------------
D
--
D
D
E
M
E
E
E
R
R
L
A
Y
V
G
I
T
R
A
E
E
E
L
V
L
T
S
A
Q
M
R
T
L
F
G
N
I
Q
M
D
P
P
S
R
F
L
N
E
I
--------
P
A
H
L
L
E
------------------------------------------------------------------------------------