@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5445: (2016-03-07 )
MYRDRVRLPSLLDKVMSAAEAADLIQDGMTVGMSGFTRAGEAKAVPQALAMRAKERPLRISLMTGASLGNDLDKQLTEAGVLARRMPFQVDSTLRKAINAGEVMFIDQHLSETVEQLRNHQLKLPDIAVIEAAAITEQGHIVPTTSVGNSASFAIFAKQVIVEINLAHSTNLEGLHDIYIPTYRPTRTPIPLTRVDDRIGSTAIPIPPEKIVAIVINDQPDSPSTVLPPDGETQAIANHLIDFFKREVDAGRMSNSLGPLQAGIGSIANAVMCGLIESPFENLTMYSEVLQDSTFDLIDAGKLRFASGSSITLSPRRNADVFGNLERYKDKLVLRPQEISNHPEVVRRLGIIGINTALEFDIYGNVNSTHVGGTKMMNGIGGSGDFARNAHLAIFVTKSIAKGGNISSVVPMVSHVDHTEHDVDILVTEQGLADLRGLAPRERARVIIENCVHPSYQAPLLDYFEAACAKGGHTPHLLREALAWHLNLEERGHMLAG
Atome Classification :
(20 SA)
.........10........20........30........40........50.---....--...60........70........80........90........100.......110.......120........130.......140.......150.......160.......170.......180..--.....190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.........480.......490.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MYRDRVR
L
P
S
L
L
D
K
V
M
S
A
A
E
A
A
D
L
I
Q
D
G
M
T
VGMSGFTRAGEA
K
A
V
P
Q
A
L
A
M
R---AKER--
P
L
R
I
S
L
MTGASLG
N
D
L
D
K
Q
L
T
E
A
G
V
L
A
RRMPF
Q
V
D
S
T
L
R
K
AINAG
E
V
M
F
I
D
Q
H
L
S
E
T
V
E
Q
L
R
NH-QLKLP
D
I
A
V
I
E
A
A
A
ITEQG
H
I
V
P
TTSVGNS
A
S
F
A
I
F
A
K
Q
V
I
V
E
I
N
LAHSTNLEG
L
H
D
IYIPTYR--PTRTPIP
L
T
R
V
DDRIGSTAIPI
P
P
E
K
I
V
A
I
V
I
NDQPDSPSTVLPPDG
E
T
Q
A
I
A
N
H
L
I
D
F
F
K
R
E
VDAGRMSNSL
G
P
L
Q
A
G
I
G
S
I
A
N
A
V
M
C
G
L
I
ES
P
F
E
N
L
T
M
Y
S
E
V
L
Q
DSTF
D
L
IDAG
K
L
R
FASG
S
S
I
T
LSPRRNADVFG
N
L
E
R
Y
K
D
K
L
V
L
R
P
Q
E
ISN
H
P
E
V
V
R
R
LGI
I
G
IN
T
A
L
E
F
D
I
YGNVNSTHVGG
T
K
M
MNGIGGSGDFARN
A
H
L
A
I
F
V
T
K
S
IAKGGN
I
S
S
V
V
P
M
V
S
HVDHTEHD
V
D
I
L
V
TEQ
G
L
A
D
L
RGL
A
P
R
E
R
A
R
V
I
I
E
NCVHPSYQA
P
L
L
D
Y
F
E
A
A
C
AK--GGH
T
P
H
L
L
R
E
A
L
A
W
HL
N
L
E
ERGHMLAG
39
HHSearch
99.49
100%
-92
- C4 -
2G39
7
?
A:
[3-497]
--
R
D
R
V
R
L
P
S
L
L
D
K
V
M
S
A
A
E
A
A
D
L
I
Q
D
G
M
T
V
G
M
S
G
F
T
R
A
G
E
A
K
A
V
P
Q
A
L
A
M
R
---
A
K
E
R
--
P
L
R
I
S
L
M
T
G
A
S
L
G
N
D
L
D
K
Q
L
T
E
A
G
V
L
A
R
R
M
P
F
Q
V
D
S
T
L
R
K
A
I
N
A
G
E
V
M
F
I
D
Q
H
L
S
E
T
V
E
Q
L
R
N
H
Q
L
K
-
L
P
D
I
A
V
I
E
A
A
A
I
T
E
Q
G
H
I
V
P
T
T
S
V
G
N
S
A
S
F
A
I
F
A
K
Q
V
I
V
E
I
N
L
A
H
S
T
N
L
E
G
L
H
D
I
Y
I
P
T
Y
R
--
P
T
R
T
P
I
P
L
T
R
V
D
D
R
I
G
S
T
A
I
P
I
P
P
E
K
I
V
A
I
V
I
N
D
Q
P
D
S
P
S
T
V
L
P
P
D
G
E
T
Q
A
I
A
N
H
L
I
D
F
F
K
R
E
V
D
A
G
R
M
S
N
S
L
G
P
L
Q
A
G
I
G
S
I
A
N
A
V
M
C
G
L
I
E
S
P
F
E
N
L
T
M
Y
S
E
V
L
Q
D
S
T
F
D
L
I
D
A
G
K
L
R
F
A
S
G
S
S
I
T
L
S
P
R
R
N
A
D
V
F
G
N
L
E
R
Y
K
D
K
L
V
L
R
P
Q
E
I
S
N
H
P
E
V
V
R
R
L
G
I
I
G
I
N
T
A
L
E
F
D
I
Y
G
N
V
N
S
T
H
V
G
G
T
K
M
M
N
G
I
G
G
S
G
D
F
A
R
N
A
H
L
A
I
F
V
T
K
S
I
A
K
G
G
N
I
S
S
V
V
P
M
V
S
H
V
D
H
T
E
H
D
V
D
I
L
V
T
E
Q
G
L
A
D
L
R
G
L
A
P
R
E
R
A
R
V
I
I
E
N
C
V
H
P
S
Y
Q
A
P
L
L
D
Y
F
E
A
A
C
A
K
--
G
G
H
T
P
H
L
L
R
E
A
L
A
W
H
L
N
L
E
E
R
G
H
M
L
A
G
1
PsiBlast_PDB
99.21
97%
-92
- C4 -
2G39
7
?
A:
[3-497]
--
R
D
R
V
R
L
P
S
L
L
D
K
V
M
S
A
A
E
A
A
D
L
I
Q
D
G
M
T
V
G
M
S
G
F
T
R
A
G
E
A
K
A
V
P
Q
A
L
A
M
R
---
A
K
E
R
--
P
L
R
I
S
L
M
T
G
A
S
L
G
N
D
L
D
K
Q
L
T
E
A
G
V
L
A
R
R
M
P
F
Q
V
D
S
T
L
R
K
A
I
N
A
G
E
V
M
F
I
D
Q
H
L
S
E
T
V
E
Q
L
R
N
H
-
Q
L
K
L
P
D
I
A
V
I
E
A
A
A
I
T
E
Q
G
H
I
V
P
T
T
S
V
G
N
S
A
S
F
A
I
F
A
K
Q
V
I
V
E
I
N
L
A
H
S
T
N
L
E
G
L
H
D
I
Y
I
P
T
Y
R
--
P
T
R
T
P
I
P
L
T
R
V
D
D
R
I
G
S
T
A
I
P
I
P
P
E
K
I
V
A
I
V
I
N
D
Q
P
D
S
P
S
T
V
L
P
P
D
G
E
T
Q
A
I
A
N
H
L
I
D
F
F
K
R
E
V
D
A
G
R
M
S
N
S
L
G
P
L
Q
A
G
I
G
S
I
A
N
A
V
M
C
G
L
I
E
S
P
F
E
N
L
T
M
Y
S
E
V
L
Q
D
S
T
F
D
L
I
D
A
G
K
L
R
F
A
S
G
S
S
I
T
L
S
P
R
R
N
A
D
V
F
G
N
L
E
R
Y
K
D
K
L
V
L
R
P
Q
E
I
S
N
H
P
E
V
V
R
R
L
G
I
I
G
I
N
T
A
L
E
F
D
I
Y
G
N
V
N
S
T
H
V
G
G
T
K
M
M
N
G
I
G
G
S
G
D
F
A
R
N
A
H
L
A
I
F
V
T
K
S
I
A
K
G
G
N
I
S
S
V
V
P
M
V
S
H
V
D
H
T
E
H
D
V
D
I
L
V
T
E
Q
G
L
A
D
L
R
G
L
A
P
R
E
R
A
R
V
I
I
E
N
C
V
H
P
S
Y
Q
A
P
L
L
D
Y
F
E
A
A
C
A
K
--
G
G
H
T
P
H
L
L
R
E
A
L
A
W
H
L
N
L
E
E
R
G
H
M
L
A
G
27
PsiBlast_CBE
85.38
48%
-79
- C4 -
4EU5
5
SCACT_ACEAC
B:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
MEA
A
H
D
R
GE
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
4
PsiBlast_PDB
85.12
48%
-82
- C4 -
4EUD
5
SCACT_ACEAC
A:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
10
PsiBlast_PDB
85.04
48%
-80
- C4 -
4FAC
6
SCACT_ACEAC
A:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
13
PsiBlast_PDB
85.03
48%
-79
- C4 -
4EUC
5
SCACT_ACEAC
A:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
A
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
8
PsiBlast_PDB
84.98
48%
-79
- C4 -
4EU6
6
SCACT_ACEAC
A:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
11
PsiBlast_PDB
84.95
48%
-80
- C4 -
4EU8
5
SCACT_ACEAC
A:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
A
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
21
PsiBlast_CBE
84.88
48%
-80
- C4 -
4EUA
5
SCACT_ACEAC
B:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
MEA
A
H
D
R
GE
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
E
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
31
PsiBlast_CBE
84.83
48%
-80
- C4 -
4EUC
5
SCACT_ACEAC
B:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
MEA
A
H
D
R
GE
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
A
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
7
PsiBlast_PDB
84.82
48%
-79
- C4 -
4EU5
5
SCACT_ACEAC
A:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
25
PsiBlast_CBE
84.73
48%
-79
- C4 -
4EU7
6
SCACT_ACEAC
B:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
MEA
A
H
D
R
GE
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
9
PsiBlast_PDB
84.68
48%
-80
- C4 -
4EU7
6
SCACT_ACEAC
A:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
22
PsiBlast_CBE
84.65
48%
-79
- C4 -
4EU9
5
SCACT_ACEAC
B:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
MEA
A
H
D
R
GE
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
E
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
12
PsiBlast_PDB
84.65
48%
-79
- C4 -
4EUB
5
SCACT_ACEAC
A:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
A
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
5
PsiBlast_PDB
84.51
48%
-80
- C4 -
4EU3
4
SCACT_ACEAC
A:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
29
PsiBlast_CBE
84.44
48%
-80
- C4 -
4EU3
5
SCACT_ACEAC
B:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
MEA
A
H
D
R
GE
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
23
PsiBlast_CBE
84.43
48%
-80
- C4 -
4EUD
6
SCACT_ACEAC
B:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
MEA
A
H
D
R
GE
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
32
PsiBlast_CBE
84.32
48%
-80
- C4 -
4EUB
5
SCACT_ACEAC
B:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
MEA
A
H
D
R
GE
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
A
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
--
2
PsiBlast_PDB
84.29
48%
-80
- C4 -
4EU9
5
SCACT_ACEAC
A:
[3-503]
---
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
E
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
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K
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