@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5493: (2016-03-08 )
MSQAPLVLVDGSSYLYRAFHALPPLTTSTGKPTGAVKGVLNMLLSLRKQYPDSPFAVVFDAKGPTFRDELFAEYKANRPSMPDDLRVQVEPLHASVRALGLPLLCVEGVEADDVIGTLARSSAAADRPVVISTGDKDMAQLVDGHITLVNTMTGSRLDVDGVKEKFGVGPELIIDFLALMGDKVDNIPGVPGVGEKTALGLLTGVGGGLEVLYASLDKVPELPIRGAKGLPAKLEENREQAFLSYQLATIKTDVELDVEIDKLYPGEPQREALIALYRELEFKNWLDDLLREAKEAGENGEAETPIQAEVDYDVVLDQAGFDAWLKKLEEAELIAFDTETTSIDAQQAQVVGVSFAVKEGEAAYVPLAHSYMGVPEQLDRDAVLRALKPLLEDPKKLKVGQHAKYDINVLANASTPIALRGVAYDTMLESYVLDSTATRHDMDSLALKYLGHSTIRFEDIAGKGAKQLTFDQIAIEQAGPYAAEDADVTLRLHQALWQKLEAIPSLARVLTDIEMPLVPVLARIERNGALVDANLLGIQSRELGEKMVALERQAYDLAGQEFNLGSPKQLGAILYDKLGLPVLSKTATGQPSTAEAVLAELAEQDFELPKVIMQYRSMSKLKSTYTDRLPEQINPRTGRIHTSYHQAVAATGRLSSSDPNLQNIPIRTAEGRRIRQAFVAPQGYKLLAADYSQIELRIMAHLAKDDGLLDAFRHDLDVHRATAAEVFGVPLEDVSGDQRRSAKAINFGLIYGMSAFGLAKQIGVERKEAQAYIDRYFARYPGVLAYMERTRAQAAEQGFVETLFGRRLYLPEIHSKNGAMRKAAERTAINAPMQGTAADIMKRAMVAVDNWLQESGLDARVILQVHDELVLEVREDLVEQVCEGIRPLMSGAATLDVPLVVEAGVGSNWDEAH
Atome Classification :
(98 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......-360.......370.......380.......390.......400.-......410..-..---...420...----.....430.......440.......450.-......460.......470.....------------..480........490.......500..--...--------..510.......520.......530.......540.......550.......560.......570.......580....-...590.......600.......610.......620......-.630--......--.640.......650.......660...-----....670..---.....680-.-......690.......700....-...710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850..-----------..-...860------.........870.......880.......890.-------.-.....900.......910.----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQA
P
L
V
L
V
DG
S
S
Y
L
Y
R
A
F
HALPPLTTSTGKP
T
G
A
V
K
G
V
L
N
M
L
L
S
L
R
K
QYPDS
P
F
A
V
V
F
DAKGP
T
F
R
D
E
L
F
A
E
Y
KANRPSMPDD
L
R
V
Q
V
E
P
L
H
A
S
V
R
A
LG
L
P
L
L
C
VEGV
E
A
D
D
V
I
G
T
L
A
RSSAAADR
P
V
V
I
STG
D
K
D
M
A
Q
LVDG
H
I
T
L
V
N
TMTGSRLDVD
G
V
K
E
K
FGV
G
P
E
L
I
I
D
F
L
A
L
MGDKVDNIPGVPGVGE
K
T
A
L
G
L
L
TGVGG
G
L
E
V
L
Y
A
S
L
DKVPELPIRGAKGLP
A
K
L
E
E
N
R
E
Q
A
F
L
S
Y
Q
L
A
T
I
K
T
D
V
E
L
D
V
E
IDKLYPGE
P
Q
R
E
A
L
I
A
L
Y
R
E
L
E
F
K
N
W
L
D
D
L
L
R
E
A
K
EAGENGEAET
P
I
Q
A
EV
D
Y
D
V
V
LDQA
G
F
D
A
W
L
K
K
LEEA
E
L
I
A
FDTETTSIDAQQ
A
Q
V
V
G
V
S
F
A
VKE-G
E
A
A
Y
V
P
L
A
H
S
YMG
V
P
E
QL
D
R
D
A
V
L
R
A
L
K
P
L
LED
P
K
KLKVGQHA-
K
Y
D
I
N
V
L
ANAS-T
P
---
I
A
L
R-
G
V
A
Y
----
D
T
M
L
E
S
Y
VLDSTATRH
D
M
D
S
L
A
L
K
Y
LGHS-
T
I
R
F
EDIAGKGAK
Q
L
T
F
D
Q
I
A
I
EQ------------AGPY-AAEDA
D
V
T
L
R
L
H
Q
A
L
W
Q
K
L
E
A
I
P
--
S
L
A
--------
R
V
L
T
DIEM
P
L
V
P
V
L
A
R
I
ERN
G
A
L
V
D
A
N
LLGI
Q
S
R
E
L
G
E
K
M
V
A
L
E
R
Q
A
YDLAGQEFNLG
S
P
K
Q
L
G
A
I
L
Y
D
KLGL
P
V
LSKT-ATGQP
S
T
A
E
A
V
L
A
E
L
A
E
QDF
E
L
P
K
V
I
M
Q
Y
R
S
M
S
K
L
K
S
T
Y
T
DR-L
P
E
Q--INPRT
G
--
R
I
H
T
S
Y
H
Q
A
V
A
ATGRLSSSDPNLQNIP-----IRTAEG
R
R
I
---
R
Q
A
FVAPQ-G-
Y
K
L
L
AAD
Y
S
Q
I
E
L
R
I
M
A
H
L
AKDD-
G
L
L
D
A
F
R
H
D
L
D
V
H
R
A
T
A
A
E
V
FGVPLEDVSGDQRRSAKAIN
F
G
L
I
Y
G
M
S
A
F
G
L
A
K
Q
IGV
E
R
K
E
A
Q
A
Y
I
D
R
Y
F
A
RY
P
G
V
L
A
Y
M
E
R
T
R
A
Q
A
A
E
Q
G
F
V
E
T
L
FGRRLYLPEIHSKN
G
A
M
R
K
A
A
E
R
TAINAPMQG
T
A
A
D
I
M
K
R
A
M
V
A
V
D
N
W
L
Q
E-----------SG-L
D
A
R
--------
V
I
L
Q
V
H
D
E
L
V
L
E
V
R
E
D
L
V
E
Q
V
C
E
G
I
R
P
L
MSGA
A
-------
T
-LD
V
P
L
V
V
EAGVGSNWDEAH----
4
PsiBlast_PDB
94.89
63%
-87
- C4 -
1KRP
5
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
11
PsiBlast_PDB
94.85
63%
-90
- C4 -
1D9D
10
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
7
PsiBlast_PDB
94.77
63%
-91
- C4 -
2KFZ
6
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
6
PsiBlast_PDB
94.77
63%
-91
- C4 -
2KFN
6
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
5
PsiBlast_PDB
94.75
63%
-89
- C4 -
1KSP
3
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
3
PsiBlast_PDB
94.71
63%
-90
- C4 -
1KFS
-
A:
[6-B]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
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Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
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--
R
V
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Y
H
Q
A
V
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A
T
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R
L
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S
T
D
P
N
L
Q
N
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P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
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A
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Y
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L
R
I
M
A
H
L
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K
-
G
L
L
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A
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A
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A
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A
A
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L
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L
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T
V
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S
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R
R
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A
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A
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N
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L
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Y
G
M
S
A
F
G
L
A
R
Q
L
N
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A
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Y
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L
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R
T
R
A
Q
A
K
E
Q
G
Y
V
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T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
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R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
121
Fugue
94.63
63%
-93
- C4 -
2KFZ
6
DPO1_ECOLI
A:
[1-605]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
S
Y
D
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
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K
A
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F
A
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G-
V
A
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N
L
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Y
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R
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L
A
N
Y
----G
I
E
L
R
---
G
I
A
F
----
D
T
M
L
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S
Y
I
L
N
S
V
A
G
R
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D
M
D
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L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
------------NQLTFNQIA
L
E
E
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
--H
K
G
P
L
--------
N
V
F
E
N
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M
P
L
V
P
V
L
S
R
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Q
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L
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K
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-----
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V
L
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L
A
-
L
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Y
P
L
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L
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--
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--
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L
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-----
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R
R
I
---
R
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D
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Y
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Y
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A
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L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
--------R
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
12
PsiBlast_PDB
94.34
63%
-91
- C4 -
1D9F
6
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
8
PsiBlast_PDB
94.32
63%
-89
- C4 -
2KZM
3
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
14
PsiBlast_PDB
94.22
63%
-88
- C4 -
1D8Y
5
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
A
T
A
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
9
PsiBlast_PDB
93.97
63%
-89
- C4 -
2KZZ
4
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
10
PsiBlast_PDB
93.94
63%
-90
- C4 -
1QSL
2
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
102
HHSearch
93.33
63%
-88
- C4 -
2KFN
6
DPO1_ECOLI
A:
[4-605]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
--
Y
D
R
G
I
L
A
N
-
Y
G
---
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
T
K
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
K
T
-
P
----
S
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
13
PsiBlast_PDB
92.62
63%
-90
- C4 -
1KLN
3
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
A
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
G
E
E
F
N
L
S
S
--
Q
L
Q
T
I
L
F
E
K
Q
G
I
K
P
L
K
---------
T
S
E
E
V
L
E
E
L
A
-
L
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
2
PsiBlast_PDB
88.80
63%
-87
- C4 -
1KFD
1
DPO1_ECOLI
A:
[6-605]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
T
I
L
D
E
E
T
L
K
A
W
I
A
K
L
E
K
A
P
V
F
A
F
D
T
E
T
D
S
L
D
N
I
S
A
N
L
V
G
L
S
F
A
I
E
P
-
G
V
A
A
Y
I
P
V
A
H
D
Y
L
D
A
P
D
Q
I
S
R
E
R
A
L
E
L
L
K
P
L
L
E
D
E
K
A
L
K
V
G
Q
N
L
-
K
Y
D
R
G
I
L
A
N
Y
G
------
I
E
L
R
-
G
I
A
F
----
D
T
M
L
E
S
Y
I
L
N
S
V
A
G
R
H
D
M
D
S
L
A
E
R
W
L
K
H
K
-
T
I
T
F
E
E
I
A
G
K
G
K
N
Q
L
T
F
N
Q
I
A
L
E
E
------------
A
G
R
Y
-
A
A
E
D
A
D
V
T
L
Q
L
H
L
K
M
W
P
D
L
Q
K
H
K
--
G
P
L
--------
N
V
F
E
N
I
E
M
P
L
V
P
V
L
S
R
I
E
R
N
G
V
K
I
D
P
K
V
L
H
N
H
S
E
E
L
T
L
R
L
A
E
L
E
K
K
A
H
E
I
A
-----------------------------------------------
D
Y
P
L
P
K
V
I
L
E
Y
R
G
L
A
K
L
K
S
T
Y
T
D
K
-
L
P
L
M
--
I
N
P
K
T
G
--
R
V
H
T
S
Y
H
Q
A
V
T
A
T
G
R
L
S
S
T
D
P
N
L
Q
N
I
P
-----
V
R
N
E
E
G
R
R
I
---
R
Q
A
F
I
A
P
E
-
D
-
Y
V
I
V
S
A
D
Y
S
Q
I
E
L
R
I
M
A
H
L
S
R
D
K
-
G
L
L
T
A
F
A
E
G
K
D
I
H
R
A
T
A
A
E
V
F
G
L
P
L
E
T
V
T
S
E
Q
R
R
S
A
K
A
I
N
F
G
L
I
Y
G
M
S
A
F
G
L
A
R
Q
L
N
I
P
R
K
E
A
Q
K
Y
M
D
L
Y
F
E
R
Y
P
G
V
L
E
Y
M
E
R
T
R
A
Q
A
K
E
Q
G
Y
V
E
T
L
D
G
R
R
L
Y
L
P
D
I
K
S
S
N
G
A
R
R
A
A
A
E
R
A
A
I
N
A
P
M
Q
G
T
A
A
D
I
I
K
R
A
M
I
A
V
D
A
W
L
Q
A
-----------
E
Q
-
P
R
V
R
--------
M
I
M
Q
V
H
D
E
L
V
F
E
V
H
K
D
D
V
D
A
V
A
K
Q
I
H
Q
L
M
E
N
C
T
-------
R
-
L
D
V
P
L
L
V
E
V
G
S
G
E
N
W
D
Q
A
H
----
101
HHSearch
87.00
41%
-72
- C3 -
1BGX
-
DPO1_THEAQ
T:
[11-831]
--
K
G
R
V
L
L
V
D
G
H
H
L
A
Y
R
T
F
H
A
L
K
G
L
T
T
S
R
G
E
P
V
Q
A
V
Y
G
F
A
K
S
L
L
K
A
L
K
E
-
D
G
D
A
V
I
V
V
F
D
A
K
A
P
S
F
R
H
E
A
Y
G
G
Y
K
A
G
R
A
P
T
P
E
D
F
P
R
Q
L
A
L
I
K
E
L
V
D
L
L
G
L
A
R
L
E
V
P
G
Y
E
A
D
D
V
L
A
S
L
A
K
K
A
E
K
E
G
Y
E
V
R
I
L
T
A
D
K
D
L
Y
Q
L
L
S
D
R
I
H
V
L
H
P
E
-
G
Y
L
I
T
P
A
W
L
W
E
K
Y
G
L
R
P
D
Q
W
A
D
Y
R
A
L
T
G
D
E
S
D
N
L
P
G
V
K
G
I
G
E
K
T
A
R
K
L
L
E
E
W
G
-
S
L
E
A
L
L
K
N
L
D
R
------
L
K
P
A
-
I
R
E
K
I
L
A
H
M
D
D
L
K
L
S
W
D
L
A
K
V
R
T
D
L
P
L
E
V
D
F
--
A
K
R
R
E
P
D
R
E
R
L
R
A
F
L
E
R
L
E
F
G
S
L
L
H
E
F
G
L
L
E
S
P
K
A
L
E
E
------------------
A
P
W
---
P
P
--
P
E
G
A
F
V
G
F
V
L
S
R
K
E
P
--
M
W
A
D
L
L
A
L
A
A
A
R
G
--
G
R
V
H
R
A
P
E
P
-------------------
Y
K
A
L
R
--
D
L
K
E
A
R
G
L
L
-
A
--
K
D
L
S
V
L
A
L
R
E
G
---
L
G
L
--
P
P
G
D
----
D
P
M
L
L
A
Y
L
L
D
P
S
N
--
T
T
P
E
G
V
A
R
R
Y
G
G
E
--------------------------------------
W
T
E
E
-
A
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
--
R
L
L
--------
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
-
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
-
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
-----
V
R
T
P
L
G
Q
R
I
---
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
--------------
M
G
A
R
--------
M
L
L
Q
V
H
D
E
L
V
L
E
A
----
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
-------
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
15
PsiBlast_PDB
85.58
40%
-72
- C3 -
1BGX
-
DPO1_THEAQ
T:
[14-827]
-----
V
L
L
V
D
G
H
H
L
A
Y
R
T
F
H
A
L
K
G
L
T
T
S
R
G
E
P
V
Q
A
V
Y
G
F
A
K
S
L
L
K
A
L
K
E
D
G
D
A
-
V
I
V
V
F
D
A
K
A
P
S
F
R
H
E
A
Y
G
G
Y
K
A
G
R
A
P
T
P
E
D
F
P
R
Q
L
A
L
I
K
E
L
V
D
L
L
G
L
A
R
L
E
V
P
G
Y
E
A
D
D
V
L
A
S
L
A
K
K
A
E
K
E
G
Y
E
V
R
I
L
T
A
D
K
D
L
Y
Q
L
L
S
D
R
I
H
V
L
H
P
-
E
G
Y
L
I
T
P
A
W
L
W
E
K
Y
G
L
R
P
D
Q
W
A
D
Y
R
A
L
T
G
D
E
S
D
N
L
P
G
V
K
G
I
G
E
K
T
A
R
K
L
L
E
E
-
W
G
S
L
E
A
L
L
K
N
L
D
R
L
-------
K
P
A
I
R
E
K
I
L
A
H
M
D
D
L
K
L
S
W
D
L
A
K
V
R
T
D
L
P
L
E
V
D
F
A
K
R
R
--
E
P
D
R
E
R
L
R
A
F
L
E
R
L
E
F
G
S
L
L
H
----------
E
F
G
L
L
E
S
P
--------------------
K
A
L
E
E
A
----------
P
W
P
P
P
E
G
A
F
V
G
F
V
L
S
R
K
E
-
P
M
W
A
D
L
L
A
L
A
A
A
R
G
-------
G
R
V
H
R
A
P
E
P
Y
----
K
A
L
R
D
L
K
E
A
-
R
---
G
L
L
A
K
D
L
-
S
V
---
L
A
L
R
E
G
L
G
L
PPGD
D
P
M
L
L
A
Y
L
L
D
P
S
N
T
--
T
P
E
G
V
A
R
R
Y
G
G
E
W
-
T
---------------------
E
E
------------
A
G
-----
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
L
E
G
E
E
--
R
L
L
--------
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
-
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
-
L
P
D
L
--
I
H
P
R
T
G
--
R
L
H
T
R
F
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
P
-----
V
R
T
P
L
G
Q
R
I
---
R
R
A
F
I
A
E
E
-
G
-
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
-
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
E
E
-----------
M
G
---
A
R
--------
M
L
L
Q
V
H
D
E
L
V
L
E
A
----
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
Y
-------
P
-
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
--------
27
PsiBlast_CBE
77.93
46%
-89
- C4 -
2HHV
9
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
32
PsiBlast_CBE
77.77
46%
-91
- C4 -
1XWL
1
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
68
PsiBlast_CBE
77.55
46%
-89
- C4 -
2BDP
5
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
52
PsiBlast_CBE
77.52
46%
-89
- C4 -
1L3S
9
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
60
PsiBlast_CBE
77.46
46%
-89
- C4 -
1U4B
6
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
25
PsiBlast_CBE
77.46
46%
-88
- C4 -
2HW3
8
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
45
PsiBlast_CBE
77.40
46%
-88
- C4 -
1NJY
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
67
PsiBlast_CBE
77.36
46%
-86
- C4 -
3BDP
4
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
66
PsiBlast_CBE
77.36
46%
-87
- C4 -
4BDP
5
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
94
PsiBlast_CBE
77.25
46%
-87
- C4 -
3EYZ
5
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
35
PsiBlast_CBE
77.26
46%
-87
- C4 -
1NKC
6
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
48
PsiBlast_CBE
77.25
46%
-89
- C4 -
1L5U
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
19
PsiBlast_PDB
77.20
46%
-89
- C4 -
2HHT
9
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
50
PsiBlast_CBE
77.18
46%
-88
- C4 -
1L3U
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
20
PsiBlast_PDB
77.16
46%
-87
- C4 -
2HHU
9
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
62
PsiBlast_CBE
77.09
46%
-89
- C4 -
1U48
6
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
41
PsiBlast_CBE
77.03
46%
-88
- C4 -
1NK5
6
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
51
PsiBlast_CBE
76.98
46%
-87
- C4 -
1L3T
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
37
PsiBlast_CBE
76.97
46%
-87
- C4 -
1NK9
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
56
PsiBlast_CBE
76.96
46%
-88
- C4 -
4DSI
10
?
A:
[131-580]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
44
PsiBlast_CBE
76.96
46%
-87
- C4 -
1NJZ
8
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
34
PsiBlast_CBE
76.87
46%
-87
- C4 -
1NKE
10
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
49
PsiBlast_CBE
76.82
46%
-87
- C4 -
1L3V
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
16
PsiBlast_PDB
76.78
46%
-89
- C4 -
4O0I
6
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
124
Fugue
76.74
31%
-77
- C4 -
4XVK
4
DPOLN_HUMAN
A:
[1-666]
----------------------------------------------
K
K
H
F
C
D
I
R
-------------------------
H
L
D
D
W
A
K
S
Q
L
I
E
M
L
K
Q
A
A
A
L
V
I
T
V
M
Y
T
D
G
-----------
S
T
Q
L
G
A
D
Q
T
P
V
S
S
---------
V
R
G
I
V
V
L
V
K
--------------
R
Q
A
C
G
P
V
L
--------
E
G
F
V
S
D
D
P
----------------------
C
I
Y
I
Q
I
E
H
S
A
I
W
D
---------
Q
E
Q
E
A
H
Q
Q
F
A
R
N
V
L
F
Q
T
M
K
C
K
C
P
V
I
C
---------------------
F
N
A
K
D
F
V
R
I
V
L
Q
F
F
G
N
D
G
-------------
S
W
K
H
V
A
D
F
I
G
L
D
------------------------------------------------------------------------------------------------------------------
P
R
I
A
A
W
L
I
D
P
S
D
A
T
P
S
F
E
D
L
V
E
K
Y
C
E
K
S
I
T
V
K
V
N
S
---------
T
Y
G
N
S
S
R
N
I
------------
V
N
Q
N
-
V
R
E
N
L
K
T
L
Y
R
L
T
M
D
L
C
S
K
L
K
D
-
Y
--
G
L
W
--------
Q
L
F
R
T
L
E
L
P
L
I
P
I
L
A
V
M
E
S
H
A
I
Q
V
N
K
E
E
M
E
K
T
S
A
L
L
G
A
R
L
K
E
L
E
Q
E
A
H
F
V
A
G
E
R
F
L
I
T
S
N
N
Q
L
R
E
I
L
F
G
K
L
K
L
H
L
L
S
Y
------
P
S
T
S
E
A
V
L
N
A
L
R
D
L
H
-
P
L
P
K
I
I
L
E
Y
R
Q
V
H
K
I
K
S
T
F
V
D
G
-
L
L
A
C
--
M
--
K
K
G
--
S
I
S
S
T
W
N
Q
T
G
T
V
T
G
R
L
S
A
K
H
P
N
I
Q
G
I
S
K
H
P
I
Q
I
T
T
P
K
K
I
L
T
I
S
P
R
A
M
F
V
S
S
K
-
G
-
H
T
F
L
A
A
D
F
S
Q
I
E
L
R
I
L
T
H
L
S
G
D
P
-
E
L
L
K
L
D
----
D
V
F
S
T
L
T
S
Q
W
K
D
V
P
V
E
Q
V
T
H
A
D
R
E
Q
T
K
K
V
V
Y
A
V
V
Y
G
A
G
K
E
R
L
A
A
C
L
G
V
P
I
Q
E
A
A
Q
F
L
E
S
F
L
Q
K
Y
K
K
I
K
D
F
A
R
A
A
I
A
Q
C
H
Q
T
G
C
V
V
S
I
M
G
R
R
R
P
L
P
R
I
H
A
H
D
Q
Q
L
R
A
Q
A
E
R
Q
A
V
N
F
V
V
Q
G
S
A
A
D
L
C
K
L
A
M
I
H
V
F
T
A
V
A
A
-----------
S
H
T
L
T
A
R
--------
L
V
A
Q
I
H
D
E
L
L
F
E
V
E
D
P
Q
I
P
E
C
A
A
L
V
R
R
T
M
E
S
L
E
QVQALEL
Q
-
L
Q
V
P
L
K
V
S
L
S
A
G
R
S
W
G
H
L
V
PLQ-
58
PsiBlast_CBE
76.73
46%
-85
- C4 -
1UA1
5
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
46
PsiBlast_CBE
76.73
46%
-87
- C4 -
1NJX
8
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
61
PsiBlast_CBE
76.72
46%
-88
- C4 -
1U49
6
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
38
PsiBlast_CBE
76.70
46%
-85
- C4 -
1NK8
8
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
36
PsiBlast_CBE
76.70
46%
-88
- C4 -
1NKB
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
42
PsiBlast_CBE
76.63
46%
-85
- C4 -
1NK4
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
33
PsiBlast_CBE
76.55
46%
-86
- C4 -
1XC9
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
29
PsiBlast_CBE
76.55
46%
-91
- C4 -
4DSK
5
?
A:
[129-578]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
-----
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
64
PsiBlast_CBE
76.53
46%
-88
- C4 -
1U45
6
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
26
PsiBlast_CBE
76.51
46%
-90
- C4 -
2HHX
7
DPO1_BACCA
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
------
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
76
PsiBlast_CBE
76.49
49%
-88
- C4 -
4B9L
7
?
A:
[215-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
63
PsiBlast_CBE
76.48
46%
-87
- C4 -
1U47
6
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
55
PsiBlast_CBE
76.43
46%
-90
- C4 -
4DWI
10
?
A:
[131-580]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
77
PsiBlast_CBE
76.39
49%
-90
- C4 -
2XO7
6
?
A:
[176-579]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
47
PsiBlast_CBE
76.38
46%
-85
- C4 -
1NJW
7
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
17
PsiBlast_PDB
76.38
46%
-85
- C4 -
2HHQ
8
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
39
PsiBlast_CBE
76.35
46%
-87
- C4 -
1NK7
8
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
18
PsiBlast_PDB
76.35
46%
-85
- C4 -
2HHS
7
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
97
PsiBlast_CBE
76.28
46%
-89
- C4 -
3HP6
4
?
D:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
43
PsiBlast_CBE
76.26
46%
-84
- C4 -
1NK0
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
82
PsiBlast_CBE
76.22
46%
-88
- C4 -
4F2S
5
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
40
PsiBlast_CBE
76.22
46%
-86
- C4 -
1NK6
6
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
83
PsiBlast_CBE
76.15
46%
-89
- C4 -
4F2R
6
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
81
PsiBlast_CBE
76.06
46%
-91
- C4 -
4F3O
4
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
91
PsiBlast_CBE
76.03
46%
-90
- C4 -
3PX4
5
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
69
PsiBlast_CBE
75.97
49%
-88
- C4 -
2XY5
6
?
A:
[177-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
78
PsiBlast_CBE
75.85
49%
-91
- C4 -
2XY6
5
?
A:
[177-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
59
PsiBlast_CBE
75.75
46%
-85
- C4 -
1UA0
5
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
87
PsiBlast_CBE
75.73
46%
-89
- C4 -
4DSE
5
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
89
PsiBlast_CBE
75.71
46%
-87
- C4 -
3THV
6
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
93
PsiBlast_CBE
75.69
46%
-87
- C4 -
3PV8
5
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
86
PsiBlast_CBE
75.66
46%
-88
- C4 -
4DSF
5
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
90
PsiBlast_CBE
75.67
46%
-86
- C4 -
3PX6
5
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
85
PsiBlast_CBE
75.66
46%
-88
- C4 -
4EZ6
4
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
31
PsiBlast_CBE
75.64
46%
-86
- C4 -
4DSJ
4
?
A:
[129-578]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
84
PsiBlast_CBE
75.60
46%
-88
- C4 -
4EZ9
3
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
71
PsiBlast_CBE
75.60
49%
-87
- C4 -
4B9U
7
?
A:
[215-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
92
PsiBlast_CBE
75.53
46%
-88
- C4 -
3PX0
5
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
72
PsiBlast_CBE
75.52
49%
-88
- C4 -
4B9T
5
?
A:
[215-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
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F
I
E
R
Y
F
E
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F
P
G
V
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E
N
I
V
Q
E
A
K
Q
K
G
Y
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T
T
L
L
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R
R
Y
L
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D
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T
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R
N
F
N
V
R
S
F
A
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M
A
M
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T
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I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
80
PsiBlast_CBE
75.52
46%
-89
- C4 -
4F4K
6
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
65
PsiBlast_CBE
75.53
49%
-87
- C4 -
4UQG
6
?
A:
[175-578]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
28
PsiBlast_CBE
75.52
46%
-87
- C4 -
4DSL
3
?
A:
[129-578]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
88
PsiBlast_CBE
75.47
46%
-86
- C4 -
3TI0
4
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
75
PsiBlast_CBE
75.40
49%
-85
- C4 -
4B9M
7
?
A:
[215-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
98
PsiBlast_CBE
75.39
46%
-89
- C4 -
3HP6
4
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
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T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
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N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
70
PsiBlast_CBE
75.21
49%
-86
- C4 -
4B9V
8
?
A:
[215-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
96
PsiBlast_CBE
75.16
46%
-87
- C4 -
2HHW
5
?
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
74
PsiBlast_CBE
75.14
49%
-84
- C4 -
4B9N
8
?
A:
[215-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
73
PsiBlast_CBE
75.14
49%
-85
- C4 -
4B9S
8
?
A:
[215-618]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
53
PsiBlast_CBE
74.99
46%
-87
- C4 -
1LV5
6
DPO1_GEOSE
B:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
95
PsiBlast_CBE
74.96
46%
-85
- C4 -
2HHW
5
?
D:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
57
PsiBlast_CBE
74.94
49%
-88
- C4 -
2XY7
4
?
A:
[176-579]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
R
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
54
PsiBlast_CBE
74.85
46%
-85
- C4 -
1LV5
7
DPO1_GEOSE
A:
[130-579]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
125
Fugue
73.96
33%
-75
- C4 -
4X0Q
7
DPOLQ_HUMAN
A:
[6-772]
--------------------------------------------------
S
L
S
I
I
D
V
---
A
S
D
Q
N
L
F
Q
T
F
I
K
E
W
R
C
K
K
R
-----------------------------------------------------------------------------------------------
F
S
I
S
L
A
C
E
K
I
R
D
D
T
L
V
V
G
---------
L
A
V
C
W
G
G
R
D
A
Y
Y
F
S
L
-------------
L
D
P
S
L
T
L
K
D
R
M
W
Y
L
Q
S
C
L
-----------------
R
K
E
S
D
K
E
C
S
V
V
I
Y
------
D
F
I
Q
S
Y
K
I
L
L
L
S
C
G
--------------------------------------------------------------------
I
S
L
E
Q
S
Y
E
------
D
P
K
V
A
C
W
L
L
D
P
D
S
Q
E
P
T
--------------------------------------------------------
L
H
S
I
V
T
S
F
L
P
H
E
-
L
P
L
L
E
G
M
E
T
S
Q
G
I
Q
S
L
G
L
N
A
G
S
E
H
------------
S
G
R
Y
R
A
S
V
E
S
I
L
I
F
N
S
M
N
Q
L
N
S
L
L
Q
K
-
E
--
N
L
Q
--------
D
V
F
R
K
V
E
M
P
S
Q
Y
C
L
A
L
L
E
L
N
G
I
G
F
S
T
A
E
C
E
S
Q
K
H
I
M
Q
A
K
L
D
A
I
E
T
Q
A
Y
Q
L
A
G
H
S
F
S
F
T
S
S
D
D
I
A
E
V
L
F
L
E
L
K
L
P
--------
P
Q
F
S
T
S
K
D
V
L
N
K
L
K
A
L
H
-
P
L
P
G
L
I
L
E
W
R
R
I
T
N
A
I
T
K
V
V
F
P
-
L
Q
R
E
KC
L
N
P
F
L
G
M
E
R
I
Y
P
V
S
-
Q
S
H
T
A
T
G
R
I
T
F
T
E
P
N
I
Q
N
V
P
R
D
F
E
-
I
K
M
G
M
P
F
S
I
S
M-
R
H
A
F
V
P
F
P
-
G
-
G
S
I
L
A
A
D
Y
S
Q
L
E
L
R
I
L
A
H
L
S
H
D
R
-
R
L
I
Q
V
L
N
T
G
A
D
V
F
R
S
I
A
A
E
W
K
M
I
E
P
E
S
V
G
D
D
L
R
Q
Q
A
K
Q
I
C
Y
G
I
I
Y
G
M
G
A
K
S
L
G
E
Q
M
G
I
K
E
N
D
A
A
C
Y
I
D
S
F
K
S
R
Y
T
G
I
N
Q
F
M
T
E
T
V
K
N
C
K
R
D
G
F
V
Q
T
I
L
G
R
R
R
Y
L
P
G
I
K
D
N
N
P
Y
R
K
A
H
A
E
R
Q
A
I
N
T
I
V
Q
G
S
A
A
D
I
V
K
I
A
T
V
N
I
Q
K
Q
L
E
T
F
H
STFKS
H
G
H
R
E
G
-
M
L
Q
S
DC
P
I
R
G
G
F
F
I
L
Q
L
H
D
E
L
L
Y
E
V
A
E
E
D
V
V
Q
V
A
Q
I
V
K
N
E
M
E
S
A
V
-------
K
-
L
S
V
K
L
K
V
K
V
K
I
G
A
S
W
G
E
L
K
D
F
D
V
30
PsiBlast_CBE
73.86
46%
-86
- C4 -
4DSJ
2
?
B:
[129-578]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
E
L
R
R
N
EQ
D
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
-----
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
D
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----
79
PsiBlast_CBE
73.35
46%
-92
- C4 -
4F8R
2
?
D:
[142-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
-------------------
P
V
-
L
A
E
H
---
L
V
R
K
A
A
A
I
W
E
-
L
E
R
-
P
--
F
L
D
ELRRNEQD
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
Y
S
T
S
A
D
-
V
L
E
K
L
A
P
Y
H
-
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
-
L
L
K
V
--
V
R
P
A
T
K
--
K
V
H
T
I
F
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
P
-----
I
R
L
E
E
G
R
K
I
---
R
Q
A
F
V
P
S
E
-
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
-
N
L
M
E
A
F
R
R
D
L
D
I
--------------------------
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
E
-----------
E
R
-
L
Q
A
H
--------
L
L
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
V
-------
T
-
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
-----