@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5503: (2016-03-08 )
MIEFHDVHKTYRVAGREIPALQPTRLNIQAGQIFGLIGHSGAGKSTLLRLINRLEEPSGGRILVEGEDVTALDAEGLRRFRQRVGMIFQHFNLLSSKTVADNIAMPLRLAGGFSRAEVDARVSELLARVGLSDHARKYPAQLSGGQKQRVGIARALACRPSILLCDEATSALDPQTTASVLQLLAEINRELKLTIVLITHEMDVIRRVCDQVAVMDGGAIVEQGDVADVFLHPQHPTTRRFVFEAERVDEDERHDDFAHVPGLILRLTFRGEATYAPLLGTVARQTGVDYSILSGRIDRIKDTPYGQLTLALVGGDLEAAMSQLNAADVHVEVLR
Atome Classification :
(43 SA)
-.........10........20........30........40........50........60........70.----------.----------....-..80........90........100..-.------------....110-........120.......130.-..-.-...-----------140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......--250.-----..---....-------260.......270.......280.......290.......300.......310..--.--.--...320.......330...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MI
E
F
H
D
V
H
K
T
Y
R
VAGREIPALQ
P
T
R
L
N
I
QA
G
Q
I
F
G
L
IGHSGA
G
K
S
T
L
L
R
L
I
N
R
LEEPSG
G
R
I
L
V
EGEDVTAL----------
D
----------
A
E
G
L
-
R
R
F
R
Q
R
V
G
M
I
F
Q
H
F
N
L
LSSKTVADNI
A
-
M
------------
P
L
R
LAG--GF
S
R
A
E
V
D
A
R
V
S
E
L
L
A
RVG
L
S
D
-
H
A
-
R
-KY
P
-----------
A
QLSGGQ
K
Q
R
V
G
I
A
R
A
LACR
P
S
I
L
L
CDEATSALDP
Q
T
T
A
S
V
L
Q
L
L
A
E
INR
E
L
K
L
T
I
V
L
I
TH
E
M
D
V
I
R
R
V
C
D
Q
V
AVMDG
G
A
I
V
EQG
D
V
A
D
V
F
LHPQHPT
T
R
R
F
V
F
E
A
E
RVD--EDER-----HD---
D
F
A
H-------VP
G
L
I
L
R
L
T
FRGEATY
A
P
L
L
G
T
V
A
R
QTGVD
Y
S
I
L
SGR
I
D
RIKDTPY
G
Q
L
T
L
A
L
VG--
G
--
D
--
L
E
A
A
M
S
QLNAA
D
V
H
V
E
VLR
2
PsiBlast_PDB
94.72
47%
-123
- C1 -
3TUI
1
METN_ECOLI
C:
[24-363]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
-
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--
I
P
E
D
-----
Y
Q
---
E
R
L
Q
AEPFTDC
V
P
--
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
--
T
QQ
D
--
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-
3
PsiBlast_PDB
94.32
47%
-130
- C1 -
3TUZ
3
METN_ECOLI
C:
[24-363]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
-
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--
I
P
E
D
-----
Y
Q
---
E
R
L
Q
AEPFTDC
V
P
--
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
--
T
QQ
D
--
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-
24
PsiBlast_CBE
94.17
47%
-132
- C1 -
3TUI
1
METN_ECOLI
H:
[24-363]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
-
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--
I
P
E
D
-----
Y
Q
---
E
R
L
Q
AEPFTDC
V
P
--
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
--
T
QQ
D
--
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-
26
PsiBlast_CBE
93.89
47%
-126
- C1 -
3TUI
1
METN_ECOLI
D:
[24-363]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
-
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--
I
P
E
D
-----
Y
Q
---
E
R
L
Q
AEPFTDC
V
P
--
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
--
T
QQ
D
--
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-
112
HHSearch
93.19
48%
-125
- C1 -
3TUI
1
METN_ECOLI
C:
[24-364]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
IP
E
D
Y
Q
-----
E
R
LQA
E
P
F
T
-------
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
--
T
--
Q
QD
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
G
25
PsiBlast_CBE
93.18
47%
-125
- C1 -
3TUI
1
METN_ECOLI
G:
[24-363]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
-
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--
I
P
E
D
-----
Y
Q
---
E
R
L
Q
AEPFTDC
V
P
--
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
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G
V
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F
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M
L
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M
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--
T
QQ
D
--
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-
23
PsiBlast_CBE
92.73
47%
-126
- C1 -
3TUZ
3
METN_ECOLI
D:
[24-363]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
-
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--
I
P
E
D
-----
Y
Q
---
E
R
L
Q
AEPFTDC
V
P
--
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
--
T
QQ
D
--
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-
21
PsiBlast_CBE
91.85
47%
-127
- C1 -
3TUZ
3
METN_ECOLI
H:
[24-362]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
-
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--
I
P
E
D
-----
Y
Q
---
E
R
L
Q
AEPFTDC
V
P
--
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
--
T
QQ
D
--
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
--
22
PsiBlast_CBE
91.80
47%
-120
- C1 -
3TUZ
3
METN_ECOLI
G:
[24-363]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
-
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--
I
P
E
D
-----
Y
Q
---
E
R
L
Q
AEPFTDC
V
P
--
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
--
T
QQ
D
--
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-
133
Fugue
90.96
47%
-127
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
D
N
--
T
-
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--
I
P
E
D
YQERL
Q
A
---
E
P
F
T
-------
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
TQ
Q
--
D
--
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
--
1
PsiBlast_PDB
90.96
47%
-117
- C1 -
3DHW
-
METN_ECOLI
C:
[1-340]
-
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
----------
S
----------
E
S
E
L
-
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
-
L
------------
P
L
E
L
-
D
--
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
-
D
-
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
--
I
P
E
D
-----
Y
Q
---
E
R
L
Q
AEPFTDC
V
P
--
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
--
T
QQ
D
--
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-
129
HHSearch
69.37
43%
-122
- C1 -
1B0U
4
HISP_SALTY
A:
[7-254]
--
L
H
V
I
D
L
H
K
R
Y
G
G
----
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
----------
R
D
KDGQLKVAD
K
N
Q
L
-
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
-
E
------------
A
P
I
Q
V
L
--
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
-
R
A
Q
G
-
K
Y
P
-----------
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
-------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
67.15
40%
-121
- C1 -
4YMU
2
?
A:
[1-236]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
----------
K
----------
V
-
N
I
-
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
------------
A
P
V
K
V
K
--
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
-
Q
Y
P
-----------
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
--------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.63
42%
-119
- C1 -
1B0U
4
HISP_SALTY
A:
[11-253]
------
D
L
H
K
R
Y
--
G
G
H
E
V
--
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLKVA
D
----------
K
N
Q
L
-
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
------------
P
I
Q
V
L
G
---
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
-
R
A
-
Q
G
K
Y
P
-----------
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
--------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.35
40%
-122
- C1 -
4YMS
-
?
J:
[1-236]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
----------
K
----------
V
-
N
I
-
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
------------
A
P
V
K
V
K
--
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
-
Q
Y
P
-----------
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
--------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.29
40%
-122
- C1 -
4YMV
1
?
J:
[1-236]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
----------
K
----------
V
-
N
I
-
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
------------
A
P
V
K
V
K
--
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
-
Q
Y
P
-----------
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
--------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.28
40%
-121
- C1 -
4YMU
2
?
J:
[1-236]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
----------
K
----------
V
-
N
I
-
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
------------
A
P
V
K
V
K
--
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
-
Q
Y
P
-----------
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
--------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
65.88
43%
-118
- C1 -
4U02
1
?
A:
[4-238]
-
I
I
R
I
R
N
L
H
K
W
F
G
----
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
V
K
----------
D
----------
D
R
A
L
-
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
-
L
A-----------
P
M
R
V
R
R
---
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
-
R
-
K
Y
P
-----------
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
--------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.74
40%
-123
- C1 -
4YMT
-
?
J:
[1-236]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
----------
K
----------
V
-
N
I
-
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
------------
A
P
V
K
V
K
--
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
-
Q
Y
P
-----------
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
--------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
65.60
40%
-120
- C1 -
4YMV
1
?
A:
[1-236]
-
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
----------
K
----------
V
-
N
I
-
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
-
L
------------
A
P
V
K
V
K
--
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
-
D
-
Q
Y
P
-----------
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
--------------------------------------------------------------------------------------------------------------------
128
HHSearch
64.51
43%
-123
- C1 -
2OLJ
4
?
A:
[24-259]
-
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
----------
D
-----------
T
N
L
-
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
-
L
------------
A
P
M
K
V
R
--
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
-
H
-
A
Y
P
-----------
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
--------------------------------------------------------------------------------------------------------------------
131
HHSearch
58.29
36%
-119
- C1 -
3TIF
7
Y796_METJA
A:
[1-230]
-
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
----------
D
----------
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
-
L
------------
P
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
-
N
-
H
K
P
-----------
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
-----------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
53.19
30%
-112
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-245]
-
A
L
H
I
G
H
L
S
K
S
F
Q
N
----
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
----------
N
-----------
T
N
L
-
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
-
Y
------------
G
L
G
N
G
---
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
-
G
-
R
Y
P
-----------
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
-------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
50.28
35%
-107
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[373-598]
--
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
----------
N
----------
P
V
W
L
----
R
S
K
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
A
-
Y
------------
G
A
D
D
P
S
--
S
V
T
A
E
E
I
Q
-
R
V
A
E
V
A
N
A
V
A
F
----
I
-
R
-
N
F
P
QGFN
T
V
V
G
EKG
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
----------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
50.13
35%
-104
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[342-567]
--
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
----------
N
----------
P
V
W
L
----
R
S
K
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
A
-
Y
------------
G
A
D
D
P
S
--
S
V
T
A
E
E
I
Q
-
R
V
A
E
V
A
N
A
V
A
F
----
I
-
R
-
N
F
P
QGFNTVVGEKG
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
----------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
49.65
35%
-110
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[342-573]
--
L
E
F
K
N
V
H
F
A
Y
P
-
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
----------
N
----------
P
V
W
L
----
R
S
K
I
G
T
V
S
Q
E
-
P
I
L
F
S
C
S
I
A
E
N
I
A
-
Y
------------
G
A
D
D
P
S
--
S
V
T
A
E
E
I
Q
-
R
V
A
E
V
A
N
A
V
A
F
----
I
-
R
-
N
F
P
QGFN
T
V
V
G
EK
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
----------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
43.48
32%
-103
- C1 -
2FGJ
2
D:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMSVEKVIY
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
43.43
34%
-112
- C1 -
2PMK
1
A:
[21-231]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
----------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
43.28
32%
-100
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
42.96
32%
-108
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[19-241]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMSVEKVIY
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
42.96
32%
-101
- C1 -
2FFB
1
A:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
42.64
33%
-105
- C1 -
2FF7
1
A:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
42.61
32%
-108
- C1 -
1XEF
3
D:
[19-241]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMSVEKVIY
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
42.45
32%
-103
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[19-241]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
42.34
32%
-102
- C1 -
2FFA
2
A:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
41.96
32%
-106
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
41.89
32%
-102
- C1 -
2FGK
2
D:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMSVEKVIY
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
41.76
32%
-108
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMSVEKVIY
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
41.58
32%
-102
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMSVEKVIY
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
41.40
34%
-109
- C1 -
3B5J
1
A:
[21-231]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
----------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
41.30
32%
-107
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[19-241]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMSVEKVIY
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
40.86
32%
-104
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMSVEKVIY
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
40.58
32%
-105
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[25-247]
---------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
----------
D
----------
P
N
W
L
-
R
R
---
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
-
L
ANPGMSVEKVIY
A
A
K
L
A
G
--
A
H
D
------
F
I
S
E
L
--
R
E
G
Y
N
T
-
I
V
-
G
-
E
Q
G
-----------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
----------------------------------------------------------------------------------------------------------------