@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5565: (2016-03-09 )
MDFPTRFDVIVIGGGHAGTEAALAAARMGVKTLLLTHNVETLGQMSCNPAIGGIGKSHLVKEIDALGGAMAEATDKGGIQFRILNSRKGPAVRATRAQADRVLYKAAIRHTLENQPNLWIFQQACDDLIVEQDQVRGVVTQMGLRFHADNVVLTTGTFLGGLIHIGLENYSGGRAGDPPSIALARRLRELPLRVGRLKTGTPPRIDGRSVDFSVMTEQPGDTPIPVMSFLGSKEQHPEQVSCWITHTNARTHEIIAANLDRSPMYSGVIEGIGPRYCPSIEDKIHRFADKESHQVFLEPEGLTTHELYPNGISTSLPFDVQLQIVRSIRGMENAHIVRPGYAIEYDFFDPRDLRYSLETKVIGGLFFAGQINGTTGYEEAGAQGLLAGANAALRSQGKDSWCPRRDEAYIGVLVDDLITLGTQEPYRMFTSRAEYRLILREDNADLRLTEKGRELGLVDDRRWAAFEAKREGIEREEQRLKSTWVRPNTPQGDAIAERFGTPLTHEYNLLNLLSRPEIDYAGLVEITGNAVDNPQVAEQVEIRTKYAGYIDRQQEEISRLRASEDTRLPVDIDYLGISGLSKEIQNKLNQARPETLGQASRIPGVTPAAISLLLIHLKKRASGRQLEQSA
Atome Classification :
(20 SA)
.........10........20........30....-...------.40..----------......50...------.----....60........70.------------.......80........90........100...--------....110.......120.-......130.......140.......150.......160.......170...-....180.......-190.......200.......210.......220-.......----230.--......240......-.250-.........----260.......270.......280.------.....--------.-----290.......300..----.....310.......320...-....330.......340.......-350.......360.......370....------...380.......390......---.400.......410.......420.......430.......440.......450.......460-........470.......480.....---..490.......500--........510.......520....-.--..530-----.-........540.......550.......560.......570.......580.......590.......600.......610.......620.......630
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDFP
T
R
F
D
V
I
V
IGGGHA
G
T
E
A
A
L
A
A
A
R
M
G
V
K
T
L
L
L
-THN------
V
E
T
L
G----------QMSCNPAIGGI------
G
----
K
S
H
L
V
K
E
I
D
A
LG
G
A
M
A
E------------ATDKG
G
I
Q
F
R
I
LNSRKGP
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
K
--------
A
A
I
R
H
T
LENQP
N
L
W
I
F
Q
Q-A
C
D
D
L
IV
E
Q
D
Q
V
R
G
V
V
T
Q
MG
L
R
FHAD
N
V
V
L
T
T
G
T
F
L
G
G
L
I
H
IGLENYSGGRA-GDP
P
S
I
A
L
A
R
R
L
R
E-L
P
L
RVGRLKTGTPPRIDGRSV
D
F
S
V
MTEQPGDT-P
I
P
V
M
S
F
----LGSK--EQHPE
Q
V
S
C
W
I
T
HTN-AR---
T
H
E
I
I
A
ANL----DRS
P
M
Y
S
G
V
I
EGIGPRYCP
S
I
E
D
K
------
I
H
R
F
A--------D-----KES
H
Q
V
F
LEPEG
L
T
T----HELYPNGISTSLP
F
D
V
Q
L
Q
I
V
-
R
S
IRGMEN
A
H
I
VRPG
Y
A
I
E
Y
DFFD-
P
R
D
L
R
Y
S
LET
K
V
I
G
G
L
F
F
A
G
QINGTTG------Y
E
E
AGAQG
L
L
AGA
N
A
A
L
RSQGK---DSWCPRRDEA
Y
I
G
V
L
V
D
D
L
I
T
LGTQ
E
P
Y
R
M
F
TSRA
E
Y
R
L
I
L
REDNA
D
L
R
L
TEKGRELGLVDDR--
R
W
A
A
F
E
A
K
R
EG
I
E
R
E
E
Q
R
L
K
S
TWVRP---NTPQ
G
D
A
I
A
E
R
FGT---PLT
H
E
Y
N
L
L
N
L
LSRPEIDY
A
G
L
V
E
I
-T--GNA-------V-D
N
P
Q
V
A
E
Q
V
E
I
R
T
K
Y
AG
Y
I
D
R
Q
Q
E
E
I
S
R
L
RASEDTRL
P
V
D
I
D
Y
LGIS
G
L
S
K
E
I
Q
N
K
L
N
QAR
P
E
TLGQASRIPGV
T
P
A
A
I
S
L
L
L
I
H
L
K
K
RASGRQLEQSA
136
HHSearch
90.74
70%
-77
- C3 -
3CES
-
MNMG_ECOLI
A:
[1-550]
M
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
------
I
D
T
L
G
----------
Q
M
S
C
N
P
A
I
G
G
I
------
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
------------
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
--------
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
-
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
-
P
M
P
V
F
S
F
----
M
G
N
A
--
S
Q
H
P
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
---
T
H
D
V
I
R
S
N
L
----
D
R
S
---------------
P
S
I
E
D
K
------
V
M
R
F
A
--------
D
-----
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
----
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
-
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
------
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
---
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
---
S
A
E
A
A
A
E
V
N
A
H
L
T
A
---
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
P
--
F
A
P
-------
A
L
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
----------------------------------------------------------------------------------
2
PsiBlast_PDB
90.69
70%
-78
- C3 -
3CES
-
MNMG_ECOLI
A:
[1-550]
M
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
------
I
D
T
L
G
----------
Q
M
S
C
N
P
A
I
G
G
I
------
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
------------
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
--------
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
-
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
-
P
M
P
V
F
S
F
----
M
G
N
A
--
S
Q
H
P
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
---
T
H
D
V
I
R
S
N
L
----
D
R
S
---------------
P
S
I
E
D
K
------
V
M
R
F
A
--------
D
-----
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
----
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
-
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
------
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
---
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
---
S
A
E
A
A
A
E
V
N
A
H
L
T
A
---
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
-
T
PF
A
P
A
-------
L
-
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
----------------------------------------------------------------------------------
21
PsiBlast_CBE
88.05
72%
-74
- C3 -
3G05
3
MNMG_ECO57
B:
[29-576]
--
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
------
I
D
T
L
G
----------
Q
M
S
C
N
P
A
I
G
G
I
------
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
------------
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
--------
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
-
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
-
P
M
P
V
F
S
F
----
M
G
N
A
--
S
Q
H
P
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
---
T
H
D
V
I
R
S
N
L
----
D
R
S
---------------
P
S
I
E
D
K
------
V
M
R
F
A
--------
D
-----
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
----
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
-
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
------
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
---
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
---
S
A
E
A
A
A
E
V
N
A
H
L
T
A
---
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
-
T
PF
A
P
A
-------
L
-
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
----------------------------------------------------------------------------------
25
PsiBlast_CBE
87.89
52%
-68
- C3 -
2ZXH
4
MNMG_AQUAE
B:
[28-634]
------
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
------
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
------
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
------------
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
--------
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
-
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
-
P
P
P
K
F
S
F
WTEP
V
G
S
Y
WF
P
K
G
K
E
Q
V
N
C
W
I
T
Y
T
T
-
P
K
---
T
H
E
I
I
R
K
N
L
----
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
------
I
V
K
F
P
--------
D
-----
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
----
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
-
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
------
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
---
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
------------
R
S
Y
S
V
A
T
---
L
M
T
M
N
Y
T
L
D
D
V
--
K
E
K
F
G
Y
-----------
E
V
-------
P
-
Q
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
------------
4
PsiBlast_PDB
87.83
52%
-66
- C3 -
2ZXH
3
MNMG_AQUAE
A:
[28-635]
------
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
------
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
------
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
------------
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
--------
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
-
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
-
P
P
P
K
F
S
F
WTEP
V
G
S
Y
WF
P
K
G
K
E
Q
V
N
C
W
I
T
Y
T
T
-
P
K
---
T
H
E
I
I
R
K
N
L
----
H
R
T
A
L
Y
G
G
L
I
K
G
I
G
P
R
Y
C
P
S
I
E
D
K
------
I
V
K
F
P
--------
D
-----
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
----
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
-
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
------
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
---
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
------------
R
S
Y
S
V
A
T
---
L
M
T
M
N
Y
T
L
D
D
V
--
K
E
K
F
G
Y
-----------
E
V
-------
P
-
Q
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
-----------
24
PsiBlast_CBE
87.72
52%
-66
- C3 -
2ZXI
1
MNMG_AQUAE
B:
[28-635]
------
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
------
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
------
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
------------
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
--------
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
-
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
-
P
P
P
K
F
S
F
WTEP
V
G
S
Y
WF
P
K
G
K
E
Q
V
N
C
W
I
T
Y
T
T
-
P
K
---
T
H
E
I
I
R
K
N
L
----
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
------
I
V
K
F
P
--------
D
-----
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
----
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
-
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
------
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
---
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
V
---
A
V
-
G
G
D
T
R
S
Y
S
V
A
T
---
L
M
T
M
N
Y
T
L
D
D
V
--
K
E
K
F
G
Y
-----------
E
V
-------
P
-
Q
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
-----------
3
PsiBlast_PDB
87.54
72%
-77
- C3 -
3G05
3
MNMG_ECO57
A:
[29-576]
--
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
------
I
D
T
L
G
----------
Q
M
S
C
N
P
A
I
G
G
I
------
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
------------
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
--------
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
-
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
L
D
------------
S
I
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
-
P
M
P
V
F
S
F
----
M
G
N
A
--
S
Q
H
P
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
---
T
H
D
V
I
R
S
N
L
----
D
R
S
P
--------------
P
S
I
E
D
K
------
V
M
R
F
A
--------
D
-----
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
----
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
-
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
------
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
D
D
K
---
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
---
S
A
E
A
A
A
E
V
N
A
H
L
T
A
---
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
-
T
PF
A
P
A
-------
L
-
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
----------------------------------------------------------------------------------
23
PsiBlast_CBE
86.97
52%
-66
- C3 -
2ZXI
1
MNMG_AQUAE
C:
[28-635]
------
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
------
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
------
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
------------
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
--------
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
-
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
-
P
P
P
K
F
S
F
WTEP
V
G
S
Y
WF
P
K
G
K
E
Q
V
N
C
W
I
T
Y
T
T
-
P
K
---
T
H
E
I
I
R
K
N
L
----
H
R
T
A
-----------
R
Y
C
P
S
I
E
D
K
------
I
V
K
F
P
--------
D
-----
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
----
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
-
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
------
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
---
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
V
---
A
V
-
G
--
T
R
S
Y
S
V
A
T
---
L
M
T
M
N
Y
T
L
D
D
V
--
K
E
K
F
G
Y
-----------
E
V
-------
P
-
Q
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
-----------
22
PsiBlast_CBE
86.75
52%
-67
- C3 -
2ZXI
1
MNMG_AQUAE
D:
[28-635]
------
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
-
V
L
N
------
A
D
T
I
G
----------
Q
M
S
C
N
P
A
I
G
G
I
------
A
----
K
G
I
V
V
R
E
I
D
A
L
G
G
E
M
G
K
------------
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
P
R
A
Q
A
D
K
K
R
Y
R
--------
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
-
E
V
V
D
I
I
V
K
N
N
Q
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
T
G
T
P
A
R
L
D
K
R
T
I
D
F
S
A
L
E
V
A
P
G
D
D
-
P
P
P
K
F
S
F
WTEP
V
G
S
Y
WF
P
K
G
K
E
Q
V
N
C
W
I
T
Y
T
T
-
P
K
---
T
H
E
I
I
R
K
N
L
----
H
R
--------------
Y
C
P
S
I
E
D
K
------
I
V
K
F
P
--------
D
-----
K
E
R
H
Q
I
F
L
E
P
E
G
L
D
T
----
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
-
R
S
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
T
T
G
------
Y
E
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
K
---
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
K
S
E
R
V
S
V
---
A
V
-
G
G
D
T
R
S
Y
S
V
A
T
---
L
M
T
M
N
Y
T
L
D
D
V
--
K
E
K
F
G
Y
-----------
E
V
-------
P
-
Q
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
-----------
1
PsiBlast_PDB
85.74
70%
-79
- C3 -
3CP2
1
MNMG_ECOLI
A:
[21-573]
M
F
Y
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
-
T
H
N
------
I
D
T
L
G
----------
Q
M
S
C
N
P
A
I
G
G
I
------
G
----
K
G
H
L
V
K
E
V
D
A
L
G
G
L
M
A
K
------------
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
T
R
A
Q
A
D
R
V
L
Y
R
--------
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
-
A
V
E
D
L
I
V
E
N
D
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
-----------------------
I
P
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
T
G
T
P
P
R
I
D
A
R
T
I
D
F
S
V
L
A
Q
Q
H
G
D
N
-
P
M
P
V
F
S
F
----
M
G
N
A
--
S
Q
H
P
Q
Q
V
P
C
Y
I
T
H
T
N
--------------------------------------------------------------
D
-----
R
N
Q
H
Q
I
F
L
E
P
E
G
L
T
S
----
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
-
R
S
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
T
T
G
------
Y
E
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
D
K
---
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
---
S
A
E
A
A
A
E
V
N
A
H
L
T
A
---
P
L
S
R
E
A
S
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
-
T
PF
A
P
A
-------
L
-
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
Y
I
A
-------------------------------------------------------------------------------
28
PsiBlast_CBE
85.46
47%
-64
- C3 -
3CP8
1
MNMG_CHLTE
B:
[22-639]
------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
------
L
S
A
V
A
----------
R
M
S
C
N
P
A
I
G
G
V
------
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
------------
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
--------
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
-
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
-
F
S
F
----
S
S
T
S
--
V
A
N
R
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
---
T
H
D
I
L
R
T
G
F
----
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
------
I
S
R
F
P
--------
D
-----
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
----
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
-
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
------
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
---
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
AEI
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
---
P
A
----
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
-
S
--
L
S
V
RSAAEEL
C
-
N
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
-------------
138
HHSearch
85.03
47%
-65
- C3 -
3CP8
1
MNMG_CHLTE
A:
[20-639]
----
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
------
L
S
A
V
A
----------
R
M
S
C
N
P
A
I
G
G
V
------
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
------------
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
--------
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
-
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
-
D
P
V
P
F
S
F
----
S
S
T
S
--
V
A
N
R
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
---
T
H
D
I
L
R
T
G
F
----
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
------
I
S
R
F
P
--------
D
-----
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
----
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
-
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
------
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
---
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
---
A
E
I
N
T
L
-
L
M
N
K
G
L
Q
---
E
L
K
T
P
A
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
L
--
S
V
R
S
A
AE
E
L
-
C
-
N
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
-------------
5
PsiBlast_PDB
84.84
47%
-65
- C3 -
3CP8
1
MNMG_CHLTE
A:
[22-639]
------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
------
L
S
A
V
A
----------
R
M
S
C
N
P
A
I
G
G
V
------
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
------------
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
--------
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
-
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
-
F
S
F
----
S
S
T
S
--
V
A
N
R
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
---
T
H
D
I
L
R
T
G
F
----
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
------
I
S
R
F
P
--------
D
-----
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
----
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
-
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
------
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
---
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
AEI
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
---
P
A
----
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
-
S
--
L
S
V
R
S
A
AE
E
L
C
-
N
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
-------------
27
PsiBlast_CBE
84.50
47%
-67
- C3 -
3CP8
1
MNMG_CHLTE
C:
[22-639]
------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
------
L
S
A
V
A
----------
R
M
S
C
N
P
A
I
G
G
V
------
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
------------
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
--------
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
-
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
-
F
S
F
----
S
S
T
S
--
V
A
N
R
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
---
T
H
D
I
L
R
T
G
F
----
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
------
I
S
R
F
P
--------
D
-----
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
----
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
-
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
------
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
---
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
AEI
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
---
P
A
----
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
-
S
--
L
S
V
RSAAEEL
C
-
N
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
-------------
26
PsiBlast_CBE
81.14
47%
-64
- C3 -
3CP8
1
MNMG_CHLTE
D:
[22-580]
------
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
-
T
S
D
------
L
S
A
V
A
----------
R
M
S
C
N
P
A
I
G
G
V
------
A
----
K
G
Q
I
T
R
E
I
D
A
L
G
G
E
M
G
K
------------
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
P
R
A
Q
A
D
K
T
Q
Y
S
--------
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
-
T
V
I
G
V
S
A
N
S
G
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
T
G
T
P
P
R
I
D
S
R
S
V
D
Y
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
-
F
S
F
----
S
S
T
S
--
V
A
N
R
N
L
V
S
C
Y
L
T
K
T
T
-
E
K
---
T
H
D
I
L
R
T
G
F
----
D
R
S
P
L
F
T
G
---------
C
P
S
I
E
D
K
------
I
S
R
F
P
--------
D
-----
K
S
S
H
H
I
F
L
E
P
E
G
T
D
T
----
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
-
R
S
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
T
S
G
------
Y
E
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
G
K
---
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
AEI
N
T
L
L
M
N
K
G
L
Q
E
L
K
T
---
P
A
----
R
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
-
S
--
L
S
V
RSAAEEL
C
-
N
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
------------------------------------------------------------------------
139
HHSearch
51.09
27%
-46
- C4 -
3G5S
8
TRMFO_THET8
A:
[1-427]
-----
M
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
V
P
V
R
L
F
-
E
M
R
------
P
K
-
R
M
TPAHGTDRFA
E
I
V
C
S
N
S
L
G
G
E
------
G
ETN
A
K
G
L
L
Q
A
E
M
R
R
A
G
S
L
V
M
E
------------
A
A
D
L
A
R
----------
V
P
--
A
G
G
A
L
A
V
D
R
E
E
F
S
--------
G
Y
I
T
E
R
L
T
G
H
P
-------------------
L
L
E
V
V
R
E
E
V
R
E
I
P
P
G
I
T
V
L
A
T
G
P
L
T
S
E
---------------------
A
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
D
A
A
S
P
I
V
L
Y
E
S
I
D
L
T
K
C
F
R
A
G
R
Y
------------------------
Y
L
N
C
P
M
T
E
E
E
Y
R
R
---
F
H
Q
A
L
L
E
A
Q
----
R
H
T
P
H
---------
F
E
A
C
V
P
V
E
E
L
A
R
R
GYQ
T
L
L
F
G
PMKPVGLV
D
PRTGK
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
----
R
M
W
S
L
V
G
F
Q
T
G
L
K
W
P
E
Q
K
R
L
I
-
Q
M
I
P
G
L
E
N
A
E
I
V
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
A
G
V
E
G
------
Y
L
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
G
L
---
P
P
V
A
P
-
P
E
E
S
M
L
G
G
L
V
R
Y
L
A
T
A
N
P
E
G
F
Q
P
M
-----------------------
Y
A
N
W
G
L
V
P
P
V
EG
R
M
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
S
A
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Fugue
44.89
20%
-26
- C2 -
4OPU
3
?
A:
[2-453]
M
-
K
E
L
K
Y
D
V
L
I
I
G
G
G
F
A
G
S
S
A
A
Y
Q
L
S
R
R
G
L
K
I
L
L
V
D
S
K
P
------
W
N
R
I
G
----------
D
K
P
C
G
D
A
V
S
-----------------
K
A
H
F
D
K
L
G
M
P
Y
-------------------------------
P
K
G
E
E
L
E
N
K
I
N
G
I
K
L
Y
--------
S
---------
P
D
M
----------------
Q
T
V
W
T
V
N
H
E
G
F
E
L
N
-----------------------------
A
P
L
Y
N
Q
R
V
L
K
E
A
Q
D
-
R
G
V
E
I
W
D
L
T
T
A
M
K
P
I
F
E
D
G
Y
V
K
G
A
V
L
F
N
R
R
T
N
E
-
E
L
T
V
Y
S
----------------
K
V
V
V
E
A
T
G
Y
S
-
R
S
---
F
R
S
K
L
P
P
E
L
----------------------
P
I
T
E
D
L
------
D
D
K
D
A
--------
D
-----
V
A
Y
R
E
V
L
L
T
K
E
D
I
E
D
----
H
D
--------------
Y
L
R
I
F
-
I
D
-------
Q
E
T
S
P
G
G
---
Y
W
W
Y
F
-
P
K
G
-----
K
N
K
V
N
V
G
L
G
I
Q
G
G
M
-
G
Y
P
S
------
I
H
E
Y
Y
K
K
Y
L
D
K
Y
A
P
D
V
D
K
S
K
L
L
V
K
G
G
A
L
V
P
T
R
R
P
L
Y
T
-
M
A
W
N
G
I
I
V
I
G
----
D
S
G
F
T
V
N
P
--------------
V
H
G
G
G
K
G
S
A
M
I
S
----
G
Y
C
A
A
K
A
I
L
S
A
F
E
T
G
D
F
S
A
S
G
L
W
--------
D
M
N
I
C
Y
V
N
E
Y
G
A
K
Q
A
S
L
D
I
F
R
R
F
L
Q
K
L
S
N
D
D
I
N
Y
G
M
K
-------
K
K
I
-------
I
-
K
E
E
D
L
L
E
A
S
E
K
G
D
L
H
L
S
V
A
D
K
A
M
R
V
I
S
G
L
G
R
P
S
------------
L
L
F
K
L
K
A
V
A
E
S
M
K
K
I
K
E
L
Y
L
N
Y
P
R
-----
S
P
S
S
L
G
S
W
R
R
E
V
D
N
V
L
T
E
F
N
K
S
L
S
-
9
PsiBlast_PDB
42.86
25%
-71
- C3 -
2CUL
1
?
A:
[4-137]
------
Y
Q
V
L
I
V
G
A
G
F
S
G
A
E
T
A
F
W
L
A
Q
K
G
V
R
V
G
L
L
-
T
Q
S
------
L
D
A
V
M
----------
M
P
F
L
P
P
K
P
P
F
P
------
P
----
G
S
L
L
E
R
A
Y
D
P
----------------------------------
K
D
E
R
V
W
A
F
H
A
R
A
-----------------
K
Y
L
L
E
G
L
R
P
L
H
L
F
Q
A
-
T
A
T
G
L
L
L
E
G
N
R
V
V
G
V
R
T
W
E
G
P
P
A
R
G
E
K
V
V
L
A
V
G
S
F
L
G
A
R
L
F
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
HHSearch
38.75
24%
-87
* C2 *
2I0Z
1
?
A:
[25-198]
----
M
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
-
D
K
G
------
N
K
-
L
G
----------
R
K
L
A
I
S
G
G
G
R
C
NVTNRL
P
----
L
D
E
I
V
K
H
I
P
G
N
G
R
F
L
Y
S
A
F
S
I
FN
N
E
D
I
I
T
F
F
E
N
L
G
V
K
L
K
E
E
--
D
H
G
R
M
F
--
P
-
V
S
N
K
A
Q
S
V
V
--------
D
A
L
L
T
R
L
K
D
-
L
G
V
K
I
R
T
N
T
P
V
E
T
I
E
Y
E
N
G
Q
T
K
A
V
I
L
Q
T
G
E
V
L
E
T
N
H
V
V
I
A
V
G
G
K
S
V
P
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Fugue
38.61
16%
-49
- C2 -
2I0Z
2
?
A:
[25-444]
----
M
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
-
D
K
G
NKLG
R
K
L
A
I
S
G
----------
G
G
R
C
N
V
T
N
R
L
-------
P
----
L
D
E
I
V
K
H
I
P
G
N
G
R
F
L
Y
S
------------
A
F
S
I
F
N
-
N
E
D
I
I
T
F
F
E
N
L
G
V
K
L
K
E
E
D
H
G
R
M
F
P
V
SNK
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
L
G
V
K
I
R
T
N
T
-
P
V
E
T
I
E
Y
E
N
G
Q
T
K
A
V
I
L
Q
T
G
E
V
L
E
T
N
H
V
V
I
A
V
G
G
K
S
V
P
Q
T
G
S
T
G
D
G
Y
A
W
A
E
K
-
A
G
H
T
I
T
E
L
F
P
T
E
V
P
-
I
L
S
N
E
P
F
I
R
D
R
S
L
Q
G
L
A
L
R
D
I
N
L
S
V
L
N
A
I
I
S
H
K
-
M
D
M
L
F
T
H
----
F
G
L
S
--
G
P
A
A
L
R
C
S
Q
F
V
V
K
A
L
-
K
K
F
KT
N
T
I
Q
M
S
I
D
A
LPEE
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
P
K
K
G
I
K
N
V
------
L
K
G
Y
V
--------
P
-----
E
R
Y
F
L
F
L
L
E
K
N
E
I
D
G
SEQA
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
--
V
S
V
K
E
I
N
-
P
K
----
E
M
S
S
K
F
T
N
G
L
Y
F
C
G
E
V
L
D
I
H
G
Y
T
GG
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------