@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5567: (2016-03-09 )
MQAATETIVAIATAQGRGGVGIVRVSGPLAGQMAVAVSGRQLKARHAHYGPFLDAGGQVIDEGLSLYFPGPNSFTGEDVLELQGHGGPVVLDLLVQRCLELGARQARPGEFSERAFLNDKLDLAQAEAIADLIEASSEQAARNALRSLQGEFSRRVHALTEQLISLRIYVEAAIDFPEEEIDFLADGHVLGLLEKVRTELSTVQREASQGALLRDGMTVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHVVDTAGLRDTEDHVEKIGVERALKAIGEADRVLLVVDATAPEAADPFSLWPEFLDQRPEPGKVTLIRNKADLSTESIGLEESADGHVTITLSARTGAGLELLREHLKACMGFEQTAESGFSARRRHLEALRLAGQALEHGHSQLIHNGAGELLAEDLRQAQQHLGEITGAFTPDDLLGRIFSSFCIGK
Atome Classification :
(25 SA)
--.........10...--.....20.......----.30--......--...40---.--------........50..--..-....60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......-180.......190.......200.......210-------.......220.......230.......240.......250.......260........270...---..-..--280.......290.......300.......310.......320.......330.......340-....--..--.---------.-----.-350...--....360.......370.--..-..--..380--..-.....390.......400.......410.......420.......430.......440.......450...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MQAA
T
E
T
I
V
A
I
A
TA--QGRG
G
V
G
I
V
R
VSGP----LA---G
Q
M
A
V
A
--VSG
R
----
Q
--------
L
K
ARHAHYGPFL--DA-G
G
Q
V
I
D
EG
L
S
L
Y
FPGPNSFTGE
D
V
L
E
LQGHG
G
P
V
V
L
D
L
L
V
Q
R
C
L
E
LGARQARPGEF
S
E
R
A
FLNDK
L
D
L
A
Q
A
E
A
I
A
D
L
I
E
AS
S
E
Q
A
A
R
N
A
L
R
S
L
Q
G
E
F
S
R
R
V
H
A
L
T
E
Q
L
I
S
L
R
I
Y
V
E
A
AIDF
P
E
E
-
E
I
D
F
LAD
G
H
V
L
G
L
L
E
K
V
R
T
E
L
S
T
V
Q
R
E
A
SQGAL-------LRD
G
M
T
V
V
I
AGRPNA
G
K
S
S
L
L
N
A
L
AGR
E
A
A
I
V
TDIAG
T
T
R
D
V
L
R
E
HIHI-DG
M
P
L
H
V
V
DTAGLR---D
T
-
E
D
--
H
V
E
K
I
G
V
E
R
A
L
K
AIGEA
D
R
V
L
L
V
V
DATAPEAA
D
P
F
S
L
W
P
E
F
L
DQRPEPG
K
V
T
L
I
RNKADLS---TESI--GL--E---------E-----S-ADG
H
V
T
--
I
T
L
SART
G
A
G
L
E
L
L
R
E
H
L
--
K
A
-CM--
G
F
E
Q
T
--
A
E
-
S
G
F
S
A
R
R
R
H
L
E
A
L
R
L
A
G
Q
A
L
E
H
G
H
S
Q
L
I
HNG
A
G
E
L
L
A
E
D
L
R
Q
A
Q
Q
H
L
G
E
I
TGAF
T
P
D
D
L
L
G
R
I
F
S
S
FCIGK
1
PsiBlast_PDB
94.59
40%
-88
- C3 -
3GEH
4
MNME_NOSS1
A:
[5-462]
----
A
I
T
G
T
I
A
A
I
A
T
A
I
V
P
Q
Q
G
S
V
G
I
V
R
V
S
G
S
----
Q
A
I
A
I
A
Q
T
L
F
D
--
A
P
G
K
----
Q
--------
V
W
E
S
H
R
I
L
Y
G
Y
I
RH
P
Q
-
T
R
Q
I
V
D
E
A
L
L
L
L
M
K
A
P
R
S
Y
T
R
E
D
V
V
E
F
H
C
H
G
G
I
I
A
V
Q
Q
V
L
Q
L
C
L
E
S
G
A
R
L
A
Q
P
G
E
F
T
L
R
A
F
L
N
G
R
L
D
L
T
Q
A
E
S
I
A
D
L
V
G
A
R
S
P
Q
A
A
Q
T
A
L
A
G
L
Q
G
K
L
A
H
P
I
R
Q
L
R
A
N
C
L
D
I
L
A
E
I
E
A
R
I
D
F
-
E
E
-
D
L
P
P
L
D
D
E
A
I
I
S
D
I
E
N
I
A
A
E
I
S
Q
L
L
A
T
K
D
K
G
E
L
-------
L
R
T
G
L
K
V
A
I
V
G
R
P
N
V
G
K
S
S
L
L
N
A
W
S
Q
S
D
R
A
I
V
T
D
L
P
G
T
T
R
D
V
V
E
S
Q
L
V
V
-
G
G
I
P
V
Q
V
L
D
--------------------------
Q
A
A
N
T
A
D
L
V
L
L
T
I
D
A
A
T
G
W
T
T
G
D
Q
E
I
Y
-
E
Q
V
K
H
R
P
----
L
I
L
V
M
N
K
I
D
L
V
---
E
K
Q
L
IT
S
L
--
E
---------
Y
-----
P
-
E
N
I
T
Q
I
--
V
H
T
A
A
A
Q
K
Q
G
I
D
S
L
E
T
A
I
--
L
E
-
I
V
QT
G
K
V
Q
A
--
A
D
-
M
D
L
A
I
N
Q
R
Q
A
A
A
L
T
Q
A
K
M
S
L
E
Q
V
Q
A
T
I
T
Q
Q
L
P
L
D
F
W
T
I
D
L
R
G
A
I
Q
A
L
G
E
I
T
G
E
E
V
T
E
S
V
L
D
R
I
F
S
R
F
C
I
G
K
72
HHSearch
93.72
37%
-78
- C3 -
1XZP
3
MNME_THEMA
A:
[30-482]
---
D
K
L
M
D
T
I
V
A
V
A
T
P
--
P
G
K
G
A
I
A
I
L
R
L
S
G
P
----
D
S
---
W
K
I
V
Q
K
--
H
L
R
T
----
R
SK------
I
V
P
R
K
A
I
H
G
W
I
H
--
E
--
N
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
D
M
V
E
V
M
C
H
G
G
P
L
V
V
K
K
L
L
D
L
F
L
K
S
G
A
R
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
--
I
E
T
N
T
-
G
E
V
V
T
R
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
-------
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
-
R
G
I
L
F
R
I
V
D
T
A
G
V
R
---
S
E
T
N
D
--
L
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
D
I
V
L
F
V
L
D
A
S
S
P
L
D
E
E
D
R
----
K
I
L
E
R
I
-
K
N
K
R
Y
L
V
V
I
N
K
V
D
V
V
---
E
K
I
N
--
E
E
--
E
I
K
N
------
K
-----
L
-
G
T
D
R
H
M
--
V
K
I
S
A
L
K
G
E
G
L
E
K
L
E
E
S
I
--
Y
R
-
E
T
--
Q
E
I
F
E
R
-
G
S
-
D
S
L
I
T
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
60
Fugue
93.59
36%
-79
- C3 -
1XZP
3
MNME_THEMA
A:
[27-482]
SS
V
D
K
L
M
D
T
I
V
A
V
A
T
P
--
P
G
K
G
A
I
A
I
L
R
L
S
G
P
----
D
S
---
W
K
I
V
Q
K
H-
L
R
T
R
----
S
--------
K
I
V
P
R
K
A
I
H
G
W
I
--
H
E
-
N
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
D
M
V
E
V
M
C
H
G
G
P
L
V
V
K
K
L
L
D
L
F
L
K
S
G
A
R
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
-
I
E
--
T
N
T
G
E
V
V
T
R
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
-------
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
-
R
G
I
L
F
R
I
V
D
T
A
G
V
R
S--
E
T
-
N
D
--
L
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
D
I
V
L
F
V
L
D
A
S
S
P
L
D
E
E
D
R
K
I
L
E
R
I
-----
K
N
K
R
Y
L
V
V
I
N
K
V
D
V
V
EKI
N
E
E
E
--
I
K
--
N
---------
K
-----
L
-
G
T
D
R
H
M
--
V
K
I
S
A
L
K
G
E
G
L
E
K
L
E
E
S
I
--
Y
R
E
T
Q
--
E
I
F
E
R
--
G
S
-
D
S
L
I
T
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
71
HHSearch
93.38
40%
-85
- C3 -
3GEH
4
MNME_NOSS1
A:
[3-462]
--
H
M
A
I
T
G
T
I
A
A
I
A
T
A
I
V
P
Q
Q
G
S
V
G
I
V
R
V
S
G
S
----
Q
A
---
I
A
I
A
Q
T
--
L
F
D
A
----
P
GKQV----
W
E
S
H
R
I
L
Y
G
Y
I
R
--
H
P
Q
T
R
Q
I
V
D
E
A
L
L
L
L
M
K
A
P
R
S
Y
T
R
E
D
V
V
E
F
H
C
H
G
G
I
I
A
V
Q
Q
V
L
Q
L
C
L
E
S
G
A
R
L
A
Q
P
G
E
F
T
L
R
A
F
L
N
G
R
L
D
L
T
Q
A
E
S
I
A
D
L
V
G
A
R
S
P
Q
A
A
Q
T
A
L
A
G
L
Q
G
K
L
A
H
P
I
R
Q
L
R
A
N
C
L
D
I
L
A
E
I
E
A
R
I
D
F
E
E
D
--
L
P
P
L
D
D
E
A
I
I
S
D
I
E
N
I
A
A
E
I
S
Q
L
L
A
T
K
D
K
G
E
L
-------
L
R
T
G
L
K
V
A
I
V
G
R
P
N
V
G
K
S
S
L
L
N
A
W
S
Q
S
D
R
A
I
V
T
D
L
P
G
T
T
R
D
V
V
E
S
Q
L
V
V
-
G
G
I
P
V
Q
V
L
D
--------------------------
Q
A
A
N
T
A
D
L
V
L
L
T
I
D
A
A
T
G
W
T
T
G
D
Q
----
E
I
Y
E
-
Q
V
K
H
R
P
L
I
L
V
M
N
K
I
D
L
V
---
E
K
Q
L
--
I
T
--
S
LE-------
Y
-----
P
-
E
N
I
T
Q
I
--
V
H
T
A
A
A
Q
K
Q
G
I
D
S
L
E
T
A
I
--
L
E
-
I
V
--
Q
T
G
K
V
QA
A
D
-
M
D
L
A
I
N
Q
R
Q
A
A
A
L
T
Q
A
K
M
S
L
E
Q
V
Q
A
T
I
T
Q
Q
L
P
L
D
F
W
T
I
D
L
R
G
A
I
Q
A
L
G
E
I
T
G
E
E
V
T
E
S
V
L
D
R
I
F
S
R
F
C
I
G
K
4
PsiBlast_PDB
92.39
37%
-79
- C3 -
1XZP
3
MNME_THEMA
A:
[34-482]
-------
D
T
I
V
A
V
A
T
P
--
P
G
K
G
A
I
A
I
L
R
L
S
G
P
----
D
S
---
W
K
I
V
Q
K
H
L
R
T
R
S
----
K
--------
I
V
P
R
K
A
I
H
G
-
W
I
--
H
E
-
N
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
D
M
V
E
V
M
C
H
G
G
P
L
V
V
K
K
L
L
D
L
F
L
K
S
G
A
R
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
I
E
T
N
---
T
G
E
V
V
T
R
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
-------
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
-
R
G
I
L
F
R
I
V
D
T
A
G
V
R
S--
E
T
-
N
D
--
L
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
D
I
V
L
F
V
L
D
A
S
S
P
L
D
E
E
D
R
K
I
L
-----
E
R
I
K
N
K
R
Y
L
V
V
I
N
K
V
D
V
----
V
E
K
I
--
N
E
--
E
---------
E
I
K
N
K
L
G
-
T
D
R
H
M
---
V
K
I
S
A
L
K
G
E
G
L
E
K
L
E
E
S
I
Y
R
E
T
-
Q
E
--
I
F
E
R
G
--
S
D
-
S
L
I
T
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
-
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
5
PsiBlast_PDB
91.64
37%
-82
- C3 -
1XZQ
2
?
A:
[34-482]
-------
D
T
I
V
A
V
A
T
P
--
P
G
K
G
A
I
A
I
L
R
L
S
G
P
----
D
S
---
W
K
I
V
Q
K
HL
R
T
R
S
----
K
--------
I
V
P
R
K
A
I
H
G
-
W
I
--
H
E
-
N
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
D
M
V
E
V
M
C
H
G
G
P
L
V
V
K
K
L
L
D
L
F
L
K
S
G
A
R
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
I
E
T
N
---
T
G
E
V
V
T
R
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
-------
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
-
R
G
I
L
F
R
I
V
D
T
A
G
V
R
S--
E
T
-
N
D
--
L
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
D
I
V
L
F
V
L
D
A
S
S
P
L
D
E
E
D
R
K
I
L
-----
E
R
I
K
N
K
R
Y
L
V
V
I
N
K
V
D
V
----
V
E
K
I
--
N
E
--
E
---------
E
I
K
N
K
L
G
-
T
D
R
H
M
---
V
K
I
S
A
L
K
G
E
G
L
E
K
L
E
E
S
I
Y
R
E
T
-
Q
E
--
I
F
E
R
G
--
S
D
-
S
L
I
T
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
-
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
3
PsiBlast_PDB
88.39
37%
-90
- C3 -
3GEI
2
MNME_CHLTE
A:
[18-476]
---------
I
A
A
I
A
T
P
--
V
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
---
D
R
V
F
R
K
--
V
H
G
S
GKLA
E
--------
A
A
G
Y
T
A
H
F
G
R
L
Y
--
D
--
G
E
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
Q
M
V
E
F
T
C
H
G
G
P
V
V
V
G
R
V
L
R
L
M
L
D
N
G
C
R
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
V
E
F
Q
S
R
D
E
L
T
M
Q
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
-------
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
------------------
E
E
C
F
I
H
-
D
K
T
M
F
R
L
T
D
--------------------------
M
K
M
A
E
A
D
L
I
L
Y
L
L
D
L
G
T
E
R
L
D
D
E
L
T
E
I
R
E
L
K
A
A
H
P
-
A
A
K
F
L
T
V
A
N
K
L
D
R
A
---
A
N
A
D
--
A
L
--
I
---------
R
-----
A
I
A
D
G
T
G
T
E
V
I
G
I
S
A
L
N
G
D
G
I
D
T
L
K
Q
H
M
G
-
D
L
-
V
K
--
N
L
------
E
A
S
V
L
V
T
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
Q
N
A
L
E
L
I
A
H
E
S
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
2
PsiBlast_PDB
88.01
37%
-86
- C3 -
3GEE
2
MNME_CHLTE
A:
[18-476]
---------
I
A
A
I
A
T
P
--
V
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
---
D
R
V
F
R
K
--
V
H
G
S
GKLA
E
--------
A
A
G
Y
T
A
H
F
G
R
L
Y
--
D
--
G
E
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
Q
M
V
E
F
T
C
H
G
G
P
V
V
V
G
R
V
L
R
L
M
L
D
N
G
C
R
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
V
E
F
Q
S
R
D
E
L
T
M
Q
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
-------
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
------------------
E
E
C
F
I
H
-
D
K
T
M
F
R
L
T
D
--------------------------
M
K
M
A
E
A
D
L
I
L
Y
L
L
D
L
G
T
E
R
L
D
D
E
L
T
E
I
R
E
L
K
A
A
H
P
-
A
A
K
F
L
T
V
A
N
K
L
D
R
A
---
A
N
A
D
--
A
L
--
I
---------
R
-----
A
I
A
D
G
T
G
T
E
V
I
G
I
S
A
L
N
G
D
G
I
D
T
L
K
Q
H
M
G
-
D
L
-
V
K
--
N
L
D
K
L
--
H
E
A
S
V
L
V
T
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
Q
N
A
L
E
L
I
A
H
E
S
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
21
PsiBlast_CBE
87.50
37%
-89
- C3 -
3GEI
1
MNME_CHLTE
B:
[18-476]
---------
I
A
A
I
A
T
P
--
V
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
---
D
R
V
F
R
K
--
V
H
G
S
GKLA
E
--------
A
A
G
Y
T
A
H
F
G
R
L
Y
--
D
--
G
E
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
Q
M
V
E
F
T
C
H
G
G
P
V
V
V
G
R
V
L
R
L
M
L
D
N
G
C
R
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
V
E
F
Q
S
R
D
E
L
T
M
Q
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
-------
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
------------------
E
E
C
F
I
H
-
D
K
T
M
F
R
L
T
D
--------------------------
M
K
M
A
E
A
D
L
I
L
Y
L
L
D
L
G
T
E
R
L
D
D
E
L
T
E
I
R
E
L
K
A
A
H
P
-
A
A
K
F
L
T
V
A
N
K
L
D
R
A
---
A
N
A
D
--
A
L
--
I
---------
R
-----
A
I
A
D
G
T
G
T
EV
I
G
I
S
A
L
N
G
D
G
I
D
T
L
K
Q
H
M
G-
D
L
-
V
K
------------
S
V
L
V
T
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
Q
N
A
L
E
L
I
A
H
E
S
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
70
HHSearch
86.28
36%
-77
- C3 -
3GEE
2
MNME_CHLTE
A:
[12-476]
---
P
V
P
G
H
P
I
A
A
I
A
T
P
--
V
G
V
G
A
L
A
I
V
R
I
S
G
A
----
G
V
---
L
D
L
A
D
R
--
V
F
R
K
----
V
HGSGKLAE
A
A
G
Y
T
A
H
F
G
R
L
Y
--
D
--
G
E
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
Q
M
V
E
F
T
C
H
G
G
P
V
V
V
G
R
V
L
R
L
M
L
D
N
G
C
R
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
V
E
F
Q
S
R
D
E
L
T
M
Q
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
-------
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
------------------
E
E
C
F
I
H
-
D
K
T
M
F
R
L
T
D
--------------------------
M
K
M
A
E
A
D
L
I
L
Y
L
L
D
L
G
T
E
R
L
D
D
E
L
T
-
E
I
R
E
L
K
A
A
H
P
A
A
K
F
L
T
V
A
N
K
L
D
R
A
---
A
N
A
D
--
A
L
--
I
R
A
I
------
A
-----
D
-
G
T
G
T
E
V
--
I
G
I
S
A
L
N
G
D
G
I
D
T
L
K
Q
H
M
--
G
D
-
L
V
--
K
N
L
D
K
L
H
E
A
-
S
V
L
V
T
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
Q
N
A
L
E
L
I
A
H
E
S
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
24
PsiBlast_CBE
72.12
65%
-94
- C3 -
2GJ9
4
MNME_ECOLI
C:
[4-164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
-
D
G
M
P
L
H
I
I
D
T
A
G
L
R
---
E
A
-
S
D
--
E
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
T
T
T
D
A
V
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
---
G
E
T
L
--
G
M
--
S
---------
E
-------
V
N
G
H
A
L
--
I
R
L
S
A
R
T
G
E
G
V
D
V
L
R
N
H
L
--
K
Q
-
S
M
-----------------------------------------------------------------------------------
8
PsiBlast_PDB
72.10
65%
-93
- C3 -
2GJA
4
MNME_ECOLI
A:
[4-170]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
-
D
G
M
P
L
H
I
I
D
T
A
G
L
R
---
E
A
-
S
D
--
E
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
T
T
T
D
A
V
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
---
G
E
T
L
--
G
M
--
S
---------
E
-------
V
N
G
H
A
L
--
I
R
L
S
A
R
T
G
E
G
V
D
V
L
R
N
H
L
--
K
Q
-
S
M
--
G
F
D
T
N
--
M
-------------------------------------------------------------------------
7
PsiBlast_PDB
71.29
65%
-88
- C3 -
2GJ9
4
MNME_ECOLI
A:
[4-164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
-
D
G
M
P
L
H
I
I
D
T
A
G
L
R
---
E
A
-
S
D
--
E
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
T
T
T
D
A
V
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
---
G
E
T
L
--
G
M
--
S
---------
E
-------
V
N
G
H
A
L
--
I
R
L
S
A
R
T
G
E
G
V
D
V
L
R
N
H
L
--
K
Q
-
S
M
-----------------------------------------------------------------------------------
80
HHSearch
71.20
66%
-87
- C3 -
2GJ8
5
MNME_ECOLI
A:
[4-164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
-
D
G
M
P
L
H
I
I
D
T
A
G
L
R
---
E
A
-
S
D
--
E
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
T
T
T
D
A
V
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
---
G
E
T
L
--
G
M
------------
S
-----
E
-
V
N
G
H
A
L
--
I
R
L
S
A
R
T
G
E
G
V
D
V
L
R
N
H
L
--
K
Q
-
S
M
-----------------------------------------------------------------------------------
9
PsiBlast_PDB
70.79
63%
-86
- C3 -
2GJ8
5
MNME_ECOLI
A:
[4-164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
-
D
G
M
P
L
H
I
I
D
T
A
G
L
R
---
E
A
-
S
D
--
E
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
T
T
T
D
A
V
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
---
G
E
T
L
--
G
M
--
S
---------
E
-------
V
N
G
H
A
L
--
I
R
L
S
A
R
T
G
E
G
V
D
V
L
R
N
H
L
--
K
Q
-
S
M
-----------------------------------------------------------------------------------
22
PsiBlast_CBE
70.50
65%
-89
- C3 -
2GJA
4
B:
[4-163]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
-
D
G
M
P
L
H
I
I
D
T
A
G
L
R
---
E
A
-
S
D
--
E
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
T
T
T
D
A
V
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
---
G
E
T
L
--
G
M
--
S
---------
E
-------
V
N
G
H
A
L
--
I
R
L
S
A
R
T
G
E
G
V
D
V
L
R
N
H
L
--
K
Q
-
S
------------------------------------------------------------------------------------
25
PsiBlast_CBE
70.27
65%
-89
- C3 -
2GJ9
4
MNME_ECOLI
B:
[5-164]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
-
D
G
M
P
L
H
I
I
D
T
A
G
L
R
---
E
A
-
S
D
--
E
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
T
T
T
D
A
V
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
---
G
E
T
L
--
G
M
--
S
---------
E
-------
V
N
G
H
A
L
--
I
R
L
S
A
R
T
G
E
G
V
D
V
L
R
N
H
L
--
K
Q
-
S
M
-----------------------------------------------------------------------------------
23
PsiBlast_CBE
69.52
65%
-90
- C3 -
2GJ9
4
D:
[5-164]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
-
D
G
M
P
L
H
I
I
D
T
A
G
L
R
---
E
A
-
S
D
--
E
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
T
T
T
D
A
V
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
---
G
E
T
L
--
G
M
--
S
---------
E
-------
V
N
G
H
A
L
--
I
R
L
S
A
R
T
G
E
G
V
D
V
L
R
N
H
L
--
K
Q
-
S
M
-----------------------------------------------------------------------------------
78
HHSearch
60.47
33%
-92
- C3 -
1MKY
3
DER_THEMA
A:
[177-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
D
A
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
V
S
P
I
P
------
V
D
D
E
V
F
I
-
D
G
R
K
Y
V
F
V
D
T
A
G
L
-------------
E
K
Y
S
N
Y
R
V
V
D
S
I
E
K
A
D
V
V
V
I
V
L
D
A
T
Q
G
I
T
R
Q
D
Q
R
M
A
-
G
L
M
--
E
R
R
G
R
A
S
V
V
V
F
N
K
W
D
L
V
---
V
H
R
E
--
K
R
Y
D
E
F
T
K
L
F
R
E
K
L
Y
-----
F
-
I
D
Y
S
P
L
--
I
F
T
S
A
D
K
G
W
N
I
D
R
M
I
D
A
M
--
N
L
-
A
Y
--
A
S
Y
------------------------------------------------------------------------------
77
HHSearch
59.81
27%
-72
* C3 *
3IEV
2
ERA_AQUAE
A:
[10-184]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
Y
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
G
V
K
N
I
P
N
E
A
Q
I
I
F
L
D
T
P
G
I
Y
---
E
P
-
K
K
SD
V
L
G
H
S
M
V
E
I
A
K
Q
S
L
E
E
A
D
V
I
L
F
M
I
D
A
T
E
G
W
R
P
R
D
E
E
I
Y
Q
N
F
I
--
K
P
L
N
K
P
V
I
V
V
I
N
K
I
D
K
I
---
G
P
A
K
--
N
V
--
L
P
L
I
D
E
I
H
K
-
K
-----
H
-
P
E
L
T
E
I
--
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
--
L
K
-
Y
L
--
P
E
G
E
-----------------------------------------------------------------------------
10
PsiBlast_PDB
45.71
40%
-82
- C3 -
1MKY
2
DER_THEMA
A:
[155-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
L
E
T
I
I
K
K
L
E
E
K
G
L
DLES
K
P
E
I
T
D
A
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
V
S
P
I
P
------
V
D
D
E
V
F
I
-
D
G
R
K
Y
V
F
V
D
T
A
G
L
-------------
E
K
Y
S
N
Y
R
V
V
D
S
I
E
K
A
D
V
V
V
I
V
L
D
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
41.26
44%
-60
- C3 -
4DCT
1
DER_BACSU
A:
[200-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
N
------
D
A
V
D
T
S
F
T
Y
-
N
Q
Q
E
F
V
I
V
D
T
A
G
M
R
KKG
K
V
-
Y
E
--
T
T
E
K
Y
S
V
L
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
40.27
44%
-52
- C3 -
4DCS
1
DER_BACSU
A:
[200-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
N
------
D
A
V
D
T
S
F
T
Y
-
N
Q
Q
E
F
V
I
V
D
T
A
G
M
R
KKG
K
V
-
Y
E
--
T
T
E
K
Y
S
V
L
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
39.48
44%
-51
- C3 -
4DCV
1
DER_BACSU
A:
[200-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
N
------
D
A
V
D
T
S
F
T
Y
-
N
Q
Q
E
F
V
I
V
D
T
A
G
M
R
KKG
K
V
-
Y
E
--
T
T
E
K
Y
S
V
L
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
38.97
44%
-47
- C3 -
4DCU
1
DER_BACSU
A:
[200-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
N
------
D
A
V
D
T
S
F
T
Y
-
N
Q
Q
E
F
V
I
V
D
T
A
G
M
R
KKG
K
V
-
Y
E
--
T
T
E
K
Y
S
V
L
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------