Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence VTEVSMSLTGHLKELRTRLLIILLSFFLAFFVGLFVSKPLILFLQKDDLPK--EVILHVFKVTDAFQIYIEMAFVIGLVLVFPVILYQLWAFVKPGLHASEQRITLRYIPI---TFLLFLFGVVFSYLITFPFILKFMFQFA-AELGVETTIGLATYFQFLLQIVLSFGVLFELPMVIMLLTRLSLITPNGMRHSRKYAYFCLLIIAAFIAPPEILSHLMITIPLIGLYEISIVVSGLTVRRMDKEMNNV 4HTT Chain:A ((7-231)) ---------EHLRELRYRLIISIIAFLIGSGIAFYFAKYVFEILKEPILKSYPEVELITLSPTEPLFILIKISLAVGFIIASPVILYQFWRFIEPALYSHEKRA---FIPLLLGSILLFMLGALFAYFIVLPLALKFLLGLGFTQLLATPYLSVDMYISFVLKLVVAFGIAFEMPIVLYVLQKAGVITPEQLASFRKYFIVIAFVIGAIIA-PDVSTQVLMAIPLLLLYEISIFLGKL------------

General information: TITO was launched using: RESULT: Template: 4HTT.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -238609 for 1525 contacts (-156.5/contact) + 2D Compatibility (PS) -22548 + (NN) -6618 + (LL) 2092 1D Compatibility (HY) -36400 + (ID) 3850 Total energy: -305933.0 ( -200.61 by residue) QMean score : 0.338

(partial model without unconserved sides chains): PDB file : Tito_4HTT.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4HTT-query.scw PDB file : Tito_Scwrl_4HTT.pdb: