Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYYHFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEGLPV-GLLAAETSLK---------SEPLREACHEAYKEWASVYEEKLR----QTGCSESRAKEASTVVNAMIEGGILLSLTAKNSTPLLHISSCIPDLLKR 4ICH Chain:A ((120-303)) ----EARRRILETAWRLIARRGYHNVRIHDIASELGTSNATIHYHFPSKKDILLEALRRNVKLAFDRQVAE-LHTIADARERL-VRLVELQ-----------LPTPGLLRDEWSVWLQVWTESTLNPKIRDLYNDAYDRWYQTIAMTIRTGQKQGVFRDQDADELATRLSALIDGLGIQVLTGKRGCSVDHMRQHLNDFIE-

General information: TITO was launched using: RESULT: Template: 4ICH.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 560 -60005 -107.15 -352.97 target 2D structure prediction score : 0.74 Monomeric hydrophicity matching model chain A : 0.74 3D Compatibility (PKB) : -107.15 2D Compatibility (Sec. Struct. Predict.) : 0.74 1D Compatibility (Hydrophobicity) : 0.74 QMean score : 0.457

(partial model without unconserved sides chains): PDB file : Tito_4ICH.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4ICH-query.scw PDB file : Tito_Scwrl_4ICH.pdb: