Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAVKEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQKKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFE-ELTTIKN-TVKNAKTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG 1Q6Q Chain:A ((6-213)) --LQVALDNQTMDSAYETTRLIAEEVDIIEVGTILCVGEGVRAVRDLKALYPHKIVLADAKIADAGKILSRMCFEANADWVTVICCADINTAKGALDVAKEFNGDVQIELTGYWTWEQAQQWRDA-GIGQVVYHRSRDAQAA-VAWGEADITAIKRLSDMGFKVTVTGGLALEDLPLFKGIPIHVFIAGRSIRDAASPVEAARQFKRSIAE-

General information: TITO was launched using: RESULT: Template: 1Q6Q.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1101 -126122 -114.55 -615.23 target 2D structure prediction score : 0.49 Monomeric hydrophicity matching model chain A : 0.74 3D Compatibility (PKB) : -114.55 2D Compatibility (Sec. Struct. Predict.) : 0.49 1D Compatibility (Hydrophobicity) : 0.74 QMean score : 0.485

(partial model without unconserved sides chains): PDB file : Tito_1Q6Q.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1Q6Q-query.scw PDB file : Tito_Scwrl_1Q6Q.pdb: