Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEAPGPAQAAAAESNSREVTEDAADWAPALCPSPEARSPEAPAYRLQDCDALVTMGTGTFGRVHLVKEKTAKH---FFALKVMSIPDVIRR-KQEQHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPGGELFSYLRNRGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKLYFPRHLDFHVKTGRMM 4L45 Chain:A ((10-245)) ------------------------------------RGPEK--IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKES--------GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKK

General information: TITO was launched using: RESULT: Template: 4L45.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -138224 for 1613 contacts (-85.7/contact) + 2D Compatibility (PS) -23398 + (NN) -10134 + (LL) 2688 1D Compatibility (HY) -22800 + (ID) 5000 Total energy: -196868.0 ( -122.05 by residue) QMean score : 0.371

(partial model without unconserved sides chains): PDB file : Tito_4L45.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4L45-query.scw PDB file : Tito_Scwrl_4L45.pdb: