Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS 4AN2 Chain:A ((5-281)) ----------------------------ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEF-VGTRSYMSPER----LQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAI-FELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG---

General information: TITO was launched using: RESULT: Template: 4AN2.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -186753 for 2198 contacts (-85.0/contact) + 2D Compatibility (PS) -29168 + (NN) -9874 + (LL) 440 1D Compatibility (HY) -28000 + (ID) 5950 Total energy: -259305.0 ( -117.97 by residue) QMean score : 0.437

(partial model without unconserved sides chains): PDB file : Tito_4AN2.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4AN2-query.scw PDB file : Tito_Scwrl_4AN2.pdb: