Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRANCSDFKGLRTIRQMIYQPHAFEA------------VTHGYFYQRARDSERALARRSINGERRWPAKFSLWYFRPQGD--CPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF 1LI7 Chain:A ((127-198)) -------------------------------------------------------QLIAKGHAYVADNGDVMFDVPTDPTYGVLSRQ----------------KRNPMDFVLWKMSKEGEPSWPSPW-----------------------------

General information: TITO was launched using: RESULT: Template: 1LI7.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 53 -9039 -170.55 -215.21 target 2D structure prediction score : 0.50 Monomeric hydrophicity matching model chain A : 0.61 3D Compatibility (PKB) : -170.55 2D Compatibility (Sec. Struct. Predict.) : 0.50 1D Compatibility (Hydrophobicity) : 0.61 QMean score : 0.049

(partial model without unconserved sides chains): PDB file : Tito_1LI7.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1LI7-query.scw PDB file : Tito_Scwrl_1LI7.pdb: