Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTDRIAAVKTYLLDLQDRICAALEAEDGKARFAEDAWERPAGGGGRTRVIGDGALIEKGGVNFSHVFGDSLPPSASAHR----PELAGRGFQALGVSLVIHPENPHVPTSHANVRFFCA-EKEGEEPVWWFGGGFDLTPYYAHEEDCVHWHRVARDACAPFGADVYPRYKEWCDRYFHLKHRNEPRGIGGLFFDDLNQWDFDTCFAFIRAIGDAYIDAYLPIVQRRKHTPFDERQREFQAYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSLPPQVRWGYDWKPEPGSEEARLTEYFLADRDWLAGQP 1TK1 Chain:A ((24-265)) ---------------QAEITQGLESID-TVKFHA--------GGGTSMVIQDGTTFEKGGVNVSVVYGQLSPAAVSAMKADHK---DGVKFFACGLSMVIHPVNPHAPTTHLNYRYFETWNQDGTPQTWWFGGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKK---------------GIGGIFFDDYDERDPQEILKMVEDCFDAFLPSYLTIVKRRKDMPYTKEEQQWQAIRRGR-----------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 1TK1.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -92856 for 1478 contacts (-62.8/contact) + 2D Compatibility (PS) -21196 + (NN) -7037 + (LL) 6132 1D Compatibility (HY) -14400 + (ID) 4500 Total energy: -133857.0 ( -90.57 by residue) QMean score : 0.521

(partial model without unconserved sides chains): PDB file : Tito_1TK1.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1TK1-query.scw PDB file : Tito_Scwrl_1TK1.pdb: