Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MIRHFLRDDDLSPAEQAEVLELAAELKKDP---V-SRRPLQGPRGVAVIFDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDETLQDTAKVLSRYVDAIVWRTFGQERLDAMASVATVPVINALSDEFHPCQVLADLQTIAERKGALRGLRLSYFGDGANNMAHSLLLGGVTAGIHVTVAAPEGFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGADVLVTDTWTSMGQENDGLDRVKPFRPFQLNSRLLALADSDAIVLHCLPAHRGDEITDAVMDGPASAVWDEAENRLHAQKALLVWLLERS 1OTH Chain:A ((5-311)) KGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQG-KSLGMIFEKRSTRTRLSTETGFALLGGHPCFLTTQDIHLGVNESLTDTARVLSSMADAVLARVYKQSDLDTLAKEASIPIINGLSDLYHPIQILADYLTLQEHYSSLKGLTLSWIGDGN-NILHSIMMSAAKFGMHLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGREEEKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKP-EEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTD-

General information: TITO was launched using: RESULT: Template: 1OTH.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -167921 for 2683 contacts (-62.6/contact) + 2D Compatibility (PS) -34101 + (NN) -25148 + (LL) -420 1D Compatibility (HY) -24000 + (ID) 6200 Total energy: -257790.0 ( -96.08 by residue) QMean score : 0.655

(partial model without unconserved sides chains): PDB file : Tito_1OTH.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1OTH-query.scw PDB file : Tito_Scwrl_1OTH.pdb: