Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAI-DFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYAD--Q--PIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNL-RNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDD-YEEEELRISINEKCAKEFSEF 4DC2 Chain:A ((49-364)) --------------------------------------LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMRVVKKELVN----IDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGS-NTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQ

General information: TITO was launched using: RESULT: Template: 4DC2.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -175810 for 2427 contacts (-72.4/contact) + 2D Compatibility (PS) -31348 + (NN) -15247 + (LL) 2416 1D Compatibility (HY) -26400 + (ID) 5550 Total energy: -251939.0 ( -103.81 by residue) QMean score : 0.724

(partial model without unconserved sides chains): PDB file : Tito_4DC2.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4DC2-query.scw PDB file : Tito_Scwrl_4DC2.pdb: