Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSAGDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNS---SATQCVFVTSS------G-KAAVSLETA----LNSIVHFSEAGKPIQ--EGGPVHIYFEDPVHHKQPITDVKEIEII 1SOX Chain:A ((215-309)) ---------------------------------------------------------------------------------GGARLRDVLLHAGFPEELQGEWHVCFEGLDADPGGAPYGASIPYGRALSPAADVLLAYEMNGTELPRDHGFPVRVVVPGVVGARS-VKWLRRVAVS

General information: TITO was launched using: RESULT: Template: 1SOX.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 360 -54996 -152.77 -696.15 target 2D structure prediction score : 0.63 Monomeric hydrophicity matching model chain A : 0.63 3D Compatibility (PKB) : -152.77 2D Compatibility (Sec. Struct. Predict.) : 0.63 1D Compatibility (Hydrophobicity) : 0.63 QMean score : 0.568

(partial model without unconserved sides chains): PDB file : Tito_1SOX.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1SOX-query.scw PDB file : Tito_Scwrl_1SOX.pdb: