Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSLLYKGTNWKEAIEKTEFARNEFAKLIGAEP-DEVAIVPSVSDALVSVASSL---TAFGKKHVVYTDMDFPAVPHVWQ---AHSDYTVSVIP-SIDGVLPLEQYETHISDETVLTCVPHVHYRDGYVQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFLYVRKELADALKPKASAWFGRESGF-------DGAYAKVARRFQTGTPAFISVYAAAAALSLLNHIGVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKVICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK 1C0N Chain:A ((64-309)) ----------------------------------------------------QATEKMENVRKRASLFINARSAEELVFVRGTTEGINLVANSWGNSNVRAGDNIIISQMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLETLPTLFDAATRLLAITHVSNVLGTENPLAEMITLAHQHGAKVLVDGAQAVMHHPVDVQALDCDFYVFSGHK-LYGPTGIGILYVKEALLQEMPP----WEGGGSMIATVSLSEGTTWTKAPWRFEAGTPNTGGIIGLGAALEYVSALGLNNIAEYEQNL----------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 1C0N.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1188 -167783 -141.23 -726.33 target 2D structure prediction score : 0.68 Monomeric hydrophicity matching model chain A : 0.68 3D Compatibility (PKB) : -141.23 2D Compatibility (Sec. Struct. Predict.) : 0.68 1D Compatibility (Hydrophobicity) : 0.68 QMean score : 0.504

(partial model without unconserved sides chains): PDB file : Tito_1C0N.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1C0N-query.scw PDB file : Tito_Scwrl_1C0N.pdb: