Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MESHIYRIIKNKLTIIIFTII--ILIPCVDISLLLMTNTEYHPAYAFFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTG----YHYILISKVGRKKYCLEKIFTSFIISFLTMFLSLILNFL---LVQVFFFKGTFKNDLD----QIKFPDNSLYTFSMAHPYIAIVLFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFF---IWFVLILKNKSLMFLFQPFTEYGYNVLLPILCLSIFIFLIII------------------SSIVLYEAKYNEN-------- 1QXM Chain:A ((18-300)) --TNANDLRNNEVFFISPSNNTNKVLDKISQSEVKLWNKLSGANQKWRLIYDTNKQAYKIKVMDNTSLILTWNAPLSSVSVKTDTNGDNQYWYLLQNYISRNVIIRNYMNPNLVLQYNIDDTLMVSTQTSSSNQFFKFSNCIYEALNNRNCKLQTQLNSDRFLSKNLNSQIIVLWQ--------WFDSSRQKWIIEYNETKSAYTLKCQENNRYLTWIQNSNNYVETYQSTDSLIQYWNINYLDNDASKYILYNLQDTNRVLDVYNSQIANGTHVIVDSYHGNTNQQWIINLI

General information: TITO was launched using: RESULT: Template: 1QXM.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1170 -75388 -64.43 -312.81 target 2D structure prediction score : 0.32 Monomeric hydrophicity matching model chain A : 0.63 3D Compatibility (PKB) : -64.43 2D Compatibility (Sec. Struct. Predict.) : 0.32 1D Compatibility (Hydrophobicity) : 0.63 QMean score : 0.218

(partial model without unconserved sides chains): PDB file : Tito_1QXM.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1QXM-query.scw PDB file : Tito_Scwrl_1QXM.pdb: