Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MEGVENKVIVLAGMIGAGKSSYT----------ELIANELGTKAFYESIKD--------NRILEMFYDDPKRWAFALQIYFLNTRFR----SIKAALTDQNN---VLDRSIYEDA-LFTQINFEEGNISEPEMDTYLDLLDNMMEELAYMPKKAPDLLIYLRGSLDTVLSRIALRGRPYEQIDDNPGL-LEYYKHLHSRYDSWFASYDKSETLVINIDEIDINKPNDADYVMQLIHEKLKR 4Q18 Chain:A ((41-246)) -----IKKISIEGNIAAGKSTFVNILKQLSEDWEVVPEPVARWSN------LTMEQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESESMNETEWTIYQDWHDWMNNQFG--QSLELDGIIYLQATPETCLHRIYLRGRNEEQ-----GIPLEYLEKLHYKHESWLL----HRTLKTNFD-----------------------

General information: TITO was launched using: RESULT: Template: 4Q18.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output 3D Compatibility (PKB) -75147 for 1204 contacts (-62.4/contact) + 2D Compatibility (PS) -18162 + (NN) -8626 + (LL) 2716 1D Compatibility (HY) -13600 + (ID) 3050 Total energy: -115869.0 ( -96.24 by residue) QMean score : 0.375

(partial model without unconserved sides chains): PDB file : Tito_4Q18.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4Q18-query.scw PDB file : Tito_Scwrl_4Q18.pdb: