Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence -----MIHPPQKNSDEGTLF-LSSNLFAPPKIPS-----------------NPRTPVLLAFYRIVNITQN-HTANKKRNIFSTHSLK-----AQTKHYKFEISWY----IFLHEFSTNCIFMIEFQLS------- 1VR8 Chain:A ((5-141)) KIHHHHHHPPEAYSLDTAIFVLETRDYRLSDVKEIDSYGDVEMKGKVAVFETEYGPVFLYVYKGEEAKKIWKKLNGRVSIRSVLDLPNMGKFSTVSNGKKIVAWWRKNWLFIVEGKNGVEEFVKHVYRVYEEMKQ

General information: TITO was launched using: RESULT: Template: 1VR8.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 315 -43302 -137.47 -455.81 target 2D structure prediction score : 0.59 Monomeric hydrophicity matching model chain A : 0.62 3D Compatibility (PKB) : -137.47 2D Compatibility (Sec. Struct. Predict.) : 0.59 1D Compatibility (Hydrophobicity) : 0.62 QMean score : 0.399

(partial model without unconserved sides chains): PDB file : Tito_1VR8.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1VR8-query.scw PDB file : Tito_Scwrl_1VR8.pdb: